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PubMedDate not supplied

In vitro microleakage of dentin adhesives.

This in vitro study measured the microleakage of current dentin bonding agents and glass-ionomer bases. Freshly extracted human molars were prepared to a flat surface, and dentin adhesives and composite resins were applied in a plastic matrix. Samples were stored in water at 37 degrees C, thermocycled, stained with AgNO3, embedded in epoxy resin, and sectioned for evaluation of stain penetration at the composite resin/tooth interface. The reliability index of the dentin adhesives varied significantly between materials. The enamel control had essentially no microleakage, and the aluminum oxalate dentin adhesive on dentin had significantly less microleakage than other dentin adhesives tested. Present dentin adhesives were unable to prevent, but may reduce, microleakage.

Acrylic Resins↗
PubMedDate not supplied

In vitro shear bond strength of dentin adhesives.

This in vitro study compared the shear bond strengths of current dentin adhesives. Freshly extracted human molars were prepared to a flat surface and treated with dentin adhesives and composite resin light polymerized in a plastic matrix. Completed samples were stored in 37 degrees C water and thermocycled 1,500 times. Samples were sheared at the tooth/composite resin interface using a wire loop. The reliability index varied significantly between materials. Large coefficients of variation were found for all dentin adhesives. One dentin adhesive was able to achieve a bond strength to dentin that was 47% of the control bond strength of enamel.

Acrylic Resins↗
PubMedDate not supplied

Root surface marginal microleakage of composites: comparison of Cavosurface finishes.

The effect on microleakage of a modification of the cavosurface finish was evaluated using extracted thermalcycled teeth. Composite resin was placed in cavity preparations on root surfaces of teeth and finished to leave either a flash of material on the margin or finished flush to the margin. The teeth were thermalcycled for 10 days at 5 and 55 degrees C. The teeth were evaluated for microleakage using the silver nitrate staining procedure. Results showed a significant decrease in the amount of microleakage on the margins finished leaving a flash of composite resin. Clinical trials placing these restorations on root surfaces will be necessary to evaluate the impact on the periodontal health.

Composite Resins↗
PubMed1991

[Bonding of crown fragments with dentin bonding agents and porcelain veneers].

Measurements of fracture strengths of incisors from sheep, previously fractured and then restored by reattaching the fragments with a light-curable resin, revealed that pretreatment of the fracture surfaces with dentin bonding agents such as Gluma, Tenure or Scotchbond2 and acid-etching of the enamel, gave values of about half the fracture strength of intact teeth. Measurements furthermore demonstrated that pretreatment by a combination of dentin bonding agents and acid-etching of the enamel yielded higher fracture strengths of the restored teeth, than that of teeth restored using only one of the two pretreatments. Fractured incisors, restored by Gluma-treatment of the dentin, acid-etching of the enamel and fragment-bonding with a light-curable resin, were further restored with porcelain veneers after preparation. Fracture strength measurements of such restored teeth revealed strength not significantly different from that of intact teeth. It is suggested that such restorations, could have a reasonably long period of function clinically.

Acid Etching, Dental↗
PubMed1991

Microleakage of three dentinal bonding systems: a 6-month evaluation.

This study evaluated the marginal sealing ability of three of the latest generation of dentinal bonding agents following 6 months of storage in a 37 degree C water bath. Class V preparations were placed at the cementoenamel junction of extracted human molars. Herculite XR was used to restore cavities that had been pretreated with Gluma, Tenure, or XR Bond. The restored teeth were thermally stressed every 30 days during the following 6 months, and then microleakage was assessed by dye penetration. Under the experimental conditions, the microleakage associated with XR Bond and Gluma was not statistically significantly different. XR Bond performed statistically significantly better than Tenure (a = 0.01).

Composite Resins↗
PubMed1991

Bond strength evaluation of a Class V composite resin restoration.

A three-dimensional cavity design was used to test the bond strength between restorative materials and tooth structure. Results indicated that bonding agents that rely on mechanical retention to the dentinal smear layer produced relatively low bond strengths. Bonding agents that require smear layer modification yielded mixed results, possibly because of differences in chemical formulation. The three-dimensional cavity design employed in this study is a replicable one, allowing the creation of standardized, clinically relevant preparations.

Acrylic Resins↗
PubMed1990

Shear bond strength and SEM evaluation of dentinal bonding systems.

Shear bond strength of seven dentin bonding systems (DBS) was evaluated. After shear bond testing, the specimens were analyzed under scanning electron microscope (SEM). Buccal dentin just below the dentin-enamel junction of erupted third molars of young subjects were used. A statistical difference was observed among the material bond values. SEM examination of both sides of the sheared bonds frequently showed an adhesive failure between dentin and bonding agents in the specimens where resin penetrated into the opened dentinal tubules. A complex cohesive fracture of both resin and dentin was observed for bonding agents that required the treatment of the smear layer, while a cohesive fracture in the smear layer thickness was noted when dentin was not altered by primer solutions. The study demonstrated that the DBS that require the removal of the smear layer showed a significantly higher shear bond strength and that the bond value reflects the mode of material fracture and the presence of smear layer.

Composite Resins↗
PubMed1990

Marginal leakage and marginal gap dimensions of three dentinal bonding systems.

Standardized cylindrical Class V preparations, 3 mm in diameter and 1.5 mm deep, were made on the roots of 60 extracted human maxillary permanent canines. The teeth were restored with Scotchbond 2/Silux (S); Gluma/Lumifor (G); and Tenure/Perfection (T), respectively. The root apices were sealed with Copalite/amalgam and two coats of nail varnish applied to the teeth except for 1 mm around the restorations. For the qualitative microleakage evaluation the teeth were thermocycled x500 in 0.5% basic fuchsin between 8 degrees C and 50 degrees C and for the quantitative microleakage evaluation in 2% methylene blue solution. The marginal gap dimensions were measured on cylindrical restorations placed on the facial surfaces of ground root surfaces of 30 teeth. Epoxy replicas were made of the restorations, coated with gold/palladium and examined with the SEM. The maximum marginal gap dimensions were measured. The data were analyzed by ANOVA, Duncan's and their nonparametric analogues. In the qualitative microleakage evaluation the total microleakage was: S: 16; G: 50; T: 18. The quantitative microleakage (micrograms) was: S: 3.1 +/- 2.9; G: 16.1 +/- 5.3; T: 4.4 +/- 4.1. The maximum marginal gap dimensions (microns) were: S: 4.1 +/- 3.6; G: 9.3 +/- 3.4; T: 16.4 +/- 7.0.

Analysis of Variance↗
PubMed1991

Dentine bonding agents--optimizing the use of composite materials.

The latest generation of dentine adhesives appear to show improved bonding to dentine than did their predecessors. Therefore, in clinical situations where there is little enamel, and instead large areas of dentine to bond to, or in situations where there are smaller areas of 'critical' dentine, dentine bonding agents may be of value in optimizing the use of a wide range of composite materials. This article reviews the mode of action of dentine adhesives, and details the clinical technique for some applications.

Benzoates↗
PubMed2003

pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles.

PURPOSE: pH-triggered microparticles release their therapeutic payloads at acidic pH (e.g., in the phagosome), making intracellular drug delivery more efficient. Here we modify lipid-based microparticles that are safe and efficacious in nerve and brain and are potentially inhalable, making them pH-triggerable by incorporating an acid-soluble polymethacrylate, Eudragit E100 (E100). METHODS: Microparticles were produced by spray-drying and characterized by electron microscopy, Coulter counting, density measurement, and release kinetics of fluorescently labeled proteins. In addition, biocompatibility and cellular uptake were observed in rats. RESULTS: Microparticles were spheroids 3 to 5 microm in diameter with densities of 0.12 to 0.25 g/L. Microparticles with 20% (w/w) or more E100 demonstrated slow release of fluorescently labeled proteins at pH 7.4 but rapid release at pH 5. pH-triggerability was maintained for over 2 weeks in solution. Protein loadings of 0.2-20% (w/w) were pH-triggerable. Histologic examination of particles in rat connective tissue near nerve and muscle demonstrated biocompatibility aside from muscle edema in the cell layers adjacent to the particles and a localized inflammatory reaction with macrophages laden with microparticles. CONCLUSIONS: Microparticles containing E100 were pH-triggerable for many days and were taken up by macrophages, suggesting that they may be useful for intracellular drug delivery.

Acrylates↗
PubMed2003

pH-sensitive polymeric physical-mixture for possible site-specific delivery of ibuprofen.

Delivery of drugs to the large bowel has been extensively investigated during the last decade. The aim of this work was to study polymethacrylic acid-co-methylmethacrylate substituted with fatty acids (lauric, myristic, palmitic and stearic) at 20% substitution degree (PMA-LAUR20, PMA-MIR20, PMA-PALM20 and PMA-STEA20) or 40% substitution degree (PMA-LAUR40, PMA-MIR40, PMA-PALM40 and PMA-STEA40) for preparing a pH-sensitive physical mixture for site-specific delivery of ibuprofen chosen as a model drug. The preparation and characterization of the substituted polymers were described. In vitro release studies were conducted at different pH levels (3 h at pH 2.0, 2 h at pH 5.5, 4 h at pH 7.4 and until 24 h at pH 7.0) and phase-solubility diagrams of ibuprofen with the different substituted polymers were obtained at pH 7.0 to obtain information on the influence of amphiphilic polymers in increasing drug solubility and drug availability in the colon.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2005

Binding of adenosine to pendant phenylboronate groups of thermoresponsive copolymer: a quantitative study.

Binding of adenosine to the thermosensitive copolymer of N-isopropylacrylamide and 3-(acrylamido)aminophenylboronic acid (82:18, Mn = 47,000 g . mol(-1)) was studied by equilibrium dialysis at 22 degrees C and 37 degrees C, in a 0.1 M glycine buffer containing 0.1 M NaCl at pH 9.2. The copolymer exhibited a the phase transition temperature (T(p)) of 26.5 degrees C under the above conditions. At 22 degrees C the binding of adenosine to the water-soluble copolymer was well described by a Langmuir model, accounting for preferential ionisation of the boronate-nucleoside complexes and, therefore, restricted reactivity of the rest of boronates. At saturation, the copolymer contained 38% of its phenylboronic acid groups in the form of complexes, whereas the association constant was 1,400 M(-1). At 37 degrees C no binding of adenosine to thermally precipitated copolymer was found, presumably owing to interaction of the phenylboronates with hydrophobic segments of polyNIPAM. At high loading of the copolymer by the reversibly bound adenosine the T(p) steeply increases with increasing fraction of the phenylboronate-adenosine complexes in the chains. The increase of the T(p) observed above the saturating adenosine concentration (>1 x 10(-3) M, 22 degrees C) very probably testifies to competition of the nucleoside with hydrophobic polyNIPAM segments for binding to the pendant phenylboronates.

Adenosine↗
PubMed2004

Affinity parameters of amino acid derivative binding to molecularly imprinted nanospheres consisting of poly[(ethylene glycol dimethacrylate)-co-(methacrylic acid)].

The binding of L-Boc-phenylalanine anilide (BFA) and L-Boc-phenylalanine (phe) to molecularly imprinted and non-imprinted polymer nanoparticles consisting of poly[(ethylene glycol dimethacrylate)-co-(methacrylic acid)] has been investigated by adsorption experiments and mathematical modeling. The experimental isotherms have been mathematically adapted following the models of Freundlich, Langmuir, Langmuir-Freundlich, Bi-Langmuir, and extended Langmuir. The extended Langmuir model differentiated between specific and nonspecific binding of the ligand to the receptor nanoparticles and rendered excellent fitting of the experimental data. It delivered a thermodynamic and kinetic parameter set on the experimental association curves of L-BFA by L-BFA-imprinted nanospheres in suspension experiments with the equilibrium constant KD= 4.09 +/- 0.69 micromol L(-1) and the kinetic association rate constant Ka= 5.60 mL micromol(-1) min(-1).

Adsorption↗
PubMed2000

The effect of phosphoric acid concentration on resin tag length and bond strength of a photo-cured resin to acid-etched enamel.

OBJECTIVES: To determine the relationship between depth of penetration and tensile bond strength of a photo-cured resin to phosphoric acid etched enamel, and the efficacy of enamel etchants that are less aggressive than a concentration of 10% H3PO4. METHODS: The tensile bond strength and length of tags produced by a photo-cured (20 s) resin consisting of pre-polymerized TMPT/silica in 3% HNPM-TEGDMA on acid-etched enamel was determined. The enamel etchants tested were various concentrations (3-65%) of phosphoric acid. The resin was applied to enamel samples that had been abraded with No. 600-grit SiC paper and acid etched (30 s) to create test specimens that were loaded to fracture on a testing device. The HCl-treated, then cut specimens, were examined under scanning electron microscopy and light microscopy. RESULTS: The tensile bond strength (10 MPa) of resin to enamel, pre-treated with various acid concentrations did not vary significantly. But resin tag length was found to decrease significantly from 22 microns for 35% H3PO4 to 12 microns for 20% H3PO4 to 9 microns for 5, 10 and 65% H3PO4 to 5 microns for 3% H3PO4. SIGNIFICANCE: These findings suggest that the length of the tags created by the tested photo-cured resin on phosphoric acid-etched enamel contributes little to the bond strength of the test specimens, and that the adhesive strength of the resin to H3PO4 etched enamel is mainly attributable to the resin's ability to penetrate between the enamel crystallites and rods. Further, enamel pre-treatment by phosphoric acid etchants of concentrations lower than 10% may be satisfactorily employed. The use of less aggressive acid concentrations might minimize any potential adverse effects to enamel substrates.

Acid Etching, Dental↗
PubMed1996

Effect of phosphoric acid concentration on wet-bonding to etched dentin.

OBJECTIVE: This study was conducted to investigate the influence of phosphoric acid (H3PO44) demineralization of dentin during smear layer removal prior to dentin bonding. METHODS: Bovine dentin was pre-treated with either 10 wt% or 35 wt% phosphoric acid for 30 s. Substrates were then rinsed and either kept moist or air-dried before a light-cured bonding system was applied. The adhesive system consisted of a 5 wt% 4-methacryloyloxyethyl trimellitate anhydride (4-META) in acetone primer, and a photocured bonding agent, 4-META/triethylene glycol dimethacrylate-camphorquinone/N-phenylglycine (4-META/TEGDMA-CQ/NPG). Tensile bond strengths of bonded specimens were measured, and specimens were examined with a scanning electron microscope (SEM). Data obtained were subjected to two-way ANOVA and Duncan's New Multiple Range test to examine statistically significant differences (p < 0.05). RESULTS: Improved tensile bond strengths were measured when the 4-META/acetone primer was applied to wet dentin that had been etched with 10 wt% H3PO4 compared with similarly etched but dry dentin samples. However, when the dentin was etched with 35 wt% H3PO4, there was no significant difference in tensile bond strength between wet and dry specimens. SEM examination of the fractured surfaces revealed a number of cohesive failures in the demineralized dentin. Microscopic examination of cross sections of these surfaces indicated that resin impregnation was inadequate and that the hybrid layers in the cohesively fractured specimens were defective. SIGNIFICANCE: Phenomena observed in this investigation suggest that the channels between the H3PO4-denatured collagen fibers were difficult to preserve, so adhesive monomer impregnation of these substrates was impaired in a considerable number of test specimens.

Acid Etching, Dental↗