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PubMed2001

Occupational asthma as identified by the Surveillance of Work-related and Occupational Respiratory Diseases programme in South Africa.

BACKGROUND: The nationwide Surveillance of Work-related and Occupational Respiratory Diseases in South Africa, SORDSA, was established in 1996 to provide systematic information on occupational respiratory diseases. OBJECTIVE: SORDSA's objectives are to monitor the nature, extent and distribution of occupational respiratory diseases, and to increase awareness of their diagnosis and prevention. This paper describes the programme and results obtained for occupational asthma in the first 2 years, ending in October 1998. METHODS: SORDSA identifies newly diagnosed cases of occupational respiratory disease through voluntary reporting by pulmonologists, occupational medicine doctors and occupational health nurses. Initially, recruitment of the above health care providers was done through the membership infrastructure of their respective professional societies. Booklets with prescribed monthly reporting forms were distributed annually to all reporting members and a core of reporting providers was established through a proactive method of data collection. Information dissemination and reporting feedback takes place through quarterly newsletters and issue-specific brochures on certain hazardous agents. RESULTS: Over the initial 2-year period, 3285 cases of occupational respiratory disease were reported to SORDSA by 203 doctors and 97 occupational health nurses. After pneumoconiosis and associated respiratory conditions, occupational asthma was the second most commonly reported disease with 225 cases (6.9%). The average annual incidence for occupational asthma in South Africa was 13.1 per million employed people, with the highest incidence reported from the Western Cape province (37.6 per million). Latex was the most frequently reported agent for occupational asthma, followed by isocyanates and platinum salts. Low molecular weight agents accounted for 59.6% of the cases of occupational asthma. CONCLUSION: The results from this initial phase show that despite some limitations, SORDSA has the potential to obtain useful data on the industries, agents and occupations causing occupational asthma in South Africa.

Asthma↗
PubMed1979

Mortality and autopsy rate for respiratory diseases in Finland in 1955--1973.

Mortality from respiratory diseases in Finland in 1955--1973 was investigated using the official statistics and original death certificates. Total mortality from respiratory diseases in men was significantly higher than in women. Total respiratory mortality in men has increased slightly since 1963, whereas in women it decreased between 1955 and 1963 but has since remained almost constant. Mortality from lung cancer increased in men constantly in the years 1955--1973, but this was not found in women. Mortality from obstructive lung diseases in men increased slightly between 1955 and 1969 but not since. This increase was recorded only for the elderly whereas the opposite trend was found in younger people. The number of deaths from pneumonia decreased between 1955 and 1963. After 1963 these deaths increased again but only in the older age groups. Mortality from pulmonary tuberculosis showed a steady decrease. In 1973 the autopsy rate was 80.6% in pneumococcal pneumonia, 65.6% in pulmonary embolism, 48.1% in bronchiectasis, and 47.0% in pulmonary tuberculosis, exceeding significantly the mean national autopsy rate which was 38.3%. This might mean that at least some of these respiratory diseases are underdiagnosed clinically as the performance of an autopsy seems to increase their relative proportion in mortality statistics.

Age Factors↗
PubMed2005

The effect of coarse ambient particulate matter on first, second, and overall hospital admissions for respiratory disease among the elderly.

The objective of this article is to examine differences in the effect of ambient particulate matter on first, second, and overall hospital admissions for respiratory disease among the elderly. We studied 8989 adults 65 yr of age or older living in the greater Vancouver area who were admitted to hospital for any acute respiratory disease (ICD-9 codes 460-519) between June 1, 1995, and March 31, 1999. Time-series analysis was used to evaluate the association between respiratory admissions and daily measures of particulate matter (PM10, PM2.5, and PM10 - 2.5) in urban air, after adjustment for gaseous copollutants (CO, O3, NO2, and SO2) and meteorological variables. Repeated admissions for respiratory disease were common among the elderly. Approximately 30% of the subjects were readmitted to hospital after the first admission; 9% had more than 2 admissions for respiratory disease during the 4-yr study period. PM10 - 2.5 was significantly associated with the second and overall admissions for respiratory disease, but not with the first admission. The adjusted relative risks for an increment of 4.2 microg/m(3) in -day average PM10 - 2.5 concentrations were 1.03 (95% confidence interval: 0.98-1.09) for the first admission, 1.22 (1.10-1.36) for the second admission, and 1.06 (1.02, 1.11) for overall admissions. There was no significant association between PM2.5 and hospital admissions for respiratory disease among the elderly. Our data suggest that (1) people with a history of respiratory admissions are at a higher risk of respiratory disease in relation to particulate air pollution in urban areas, (2) analyses based on overall rather than repeated hospital admissions lead to lower estimates of the risk of respiratory disease associated with particulate air pollution, and (3) PM10 - 2.5 has a larger effect on respiratory admissions than PM2.5.

Aged↗
PubMedDate not supplied

Factors affecting the development of respiratory disease complex in chickens.

Factors playing a part in the development of respiratory disease complex in chickens were investigated in a series of experiments. The experimental infection was produced by exposing chickens to Mycoplasma gallisepticum and the B1 vaccine strain of Newcastle disease virus and later exposing them to aerosols containing the O1:K1 serotype of Escherichia coli. Chickens became susceptible (pericarditis or death) to E. coli 8 days after mixed respiratory disease challenge. One day after respiratory disease challenge, lesions consisted of edema and infiltration with lymphoid cells and heterophils. At the time of susceptibility to E. coli, the lesions were strongly lymphoid with many dense follicular areas and very few heterophils. The incidence of pericarditis and death was similar when the concentration of bacteria in the aerosol inoculum ranged between 10(9)/ml and 10(5)/ml. At the time of maximum susceptibility to aerosol challenge, chickens were less susceptible to intravenously administered E. coli than were the uninfected controls. Resistance of chickens that had been selectively bred for a high (HA) or low (LA) antibody response to sheep erythrocytes was compared. HA chickens were more resistant to respiratory agents and less resistant to E. coli than LA line chickens. When the lines were exposed to respiratory disease followed by exposure to aerosols containing E. coli, the HA line had the lowest incidence of pericarditis and death.

Aerosols↗
PubMed1975

Protection by natural infection and vaccination against respiratory diseases caused by mycoplasmas.

Following recovery from mycoplasmal respiratory disease animals are resistant to reinfection. The mechanism of this immunity is not well understood; usually there is poor correlation between circulating antibody levels and the degree of resistance to reinfection, but more work is needed to both man and animals on the significance of the different classes and types of circulating antibody. Because mycoplasmal infection of the respiratory tract is largely confined to the epithelial surface, it seems likely that local immunity will prove to be important. The levels of specific immunoglobulins, particularly IgA, in respiratory tract secretions may be related to immunity. It is probably, however, that cell-mediated immunity is the main determinant of resistance to mycoplasmal respiratory disease: firstly, there is evidence in several diseases that lymphocytes can be transformed by mycoplasmal antigen and there are some indications thatthe degree of this cell-mediated immunity might correlate with resistance to infection; secondly, antigen has produced skin reactions indicative of delayed hypersensitivity in some mycoplasmal diseases. Vaccination with inactivated vaccines has not produced satisfactory immunity; attenuated mycoplasma strains or temperature-sensitive mutants seem more likely to afford adequate protection against respiratory diseases caused by mycoplasmas.

Animals↗
PubMed2004

[Chronic respiratory disease in patients with GERD].

The association between gastroesophageal reflux disease and chronic respiratory diseases are proved in many report. Patient with GERD have a higher prevalence of asthma, chronic cough, lung fibrosis. Recently, it was reported patients with OSAS had significantly more GER event than controls. Antireflux therapy in asthma and chronic cough patient with GERD results in improvement in symptoms. In this paper, I comments and report about influence of GERD on chronic respiratory illness, and influence of an antireflux therapy for an asthmatic having GERD.

Asthma↗
PubMed2004

IL-4-independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease.

BACKGROUND: Mycoplasma respiratory infections are associated with wheezing and exacerbation of airway hyperresponsiveness (AHR) in asthmatic patients. IL-4 is a key cytokine in the development of AHR and airway reconstruction in asthmatic patients and might be an important component in exacerbation of AHR during pulmonary mycoplasma infection. OBJECTIVE: This study evaluates the effect of IL-4 on the severity of methacholine-induced AHR associated with mycoplasma pulmonary mycoplasma infection. METHODS: BALB/c and IL-4 knockout (KO) mice were infected with Mycoplasma pulmonis, and their enhanced pause scores were monitored before and after methacholine inhalation with whole-body plethysmography. RESULTS: IL-4 KO mice showed no difference in histopathology of the lungs before or after Mycoplasma pulmonis infection when compared with BALB/c mice. There was an increase in airway obstruction from days 7 to 21 after infection in both strains of mice, but there was no strain difference in airway resistance-associated mycoplasma disease. However, IL-4 KO mice had significantly higher methacholine-induced AHR after M pulmonis infection when compared with BALB/c mice. There was no difference in AHR between uninfected IL-4 KO and control mice. CONCLUSION: In contrast to our hypothesis, IL-4-independent pathways exacerbate methacholine-induced AHR and promote airway obstruction during the pathogenesis of mycoplasma respiratory disease.

Animals↗
PubMed1991

Viral respiratory disease of the horse.

The diagnosis of any viral respiratory disease relies on laboratory procedures to isolate the virus and demonstrate a significant rise in serum antibody titers. To isolate viruses from the upper respiratory tract, it is imperative that nasopharyngeal swabs are obtained from animals in the early acute stage of illness, i.e., during the pyrexic phase when the virus is replicating. Nasopharyngeal swabs must be placed in a virus transport medium and forwarded immediately to the laboratory at refrigerated temperature. Equine influenza, rhinopneumonitis, and equine viral arteritis are the three viral infections causing outbreaks of respiratory disease in North America. African horse sickness, although foreign to North America, could be introduced despite stringent horse importation regulations. Specific antiviral therapy is not available to treat viral respiratory disease in the horse. A variety of inactivated and modified live vaccines, however, are available to prevent clinical disease and the spread of infection caused by the common viral respiratory pathogens. A considerable amount of research is underway to enhance the potency and duration of immunity of the present vaccines against influenza and rhinopneumonitis. This research is directed at defining and characterizing the importance of specific glycoprotein antigens on the surface of the virus, which trigger the various host immune responses, and determining whether they are stimulatory or suppressive.

Adenoviridae Infections↗
PubMed2005

The genetics of neonatal respiratory disease.

This chapter reviews some of the genetic predispositions that may govern the presence or severity of neonatal respiratory disorders. Respiratory disease is common in the neonatal period, and genetic factors have been implicated in some rare and common respiratory diseases. Among the most common respiratory diseases are respiratory distress syndrome of the newborn and transient tachypnoea of the newborn, whereas less common ones are cystic fibrosis, congenital alveolar proteinosis and primary ciliary dyskinesias. A common complication of neonatal respiratory distress syndrome is bronchopulmonary dysplasia or neonatal chronic lung disease. This review examines the evidence linking known genetic contributions to these diseases. The value and success of neonatal screening for cystic fibrosis is reviewed, and the recently characterised contribution of polymorphisms and mutations in the surfactant protein genes to neonatal respiratory disease is evaluated. The evidence that known variability in the expression of surfactant protein genes may contribute to the risk of development of neonatal chronic lung disease or bronchopulmonary dysplasia is examined.

ATP-Binding Cassette Transporters↗
PubMed1981

Diagnostic methods in infectious respiratory disease.

For laboratory diagnosis of respiratory disease it is of overwhelming importance that the specimens taken are adequate, taken from the correct site and at the correct time. The lower regions of the respiratory tract are particularly difficult to sample but are more likely to yield the causative agent of a pneumonia. Infections involving the upper respiratory tract are much easier to sample and appropriate aspiration apparatus can be used. Consideration must be given to the timing of sample collection in relation to the life cycle of the causative micro-organism. Sampling of several animals is recommended. Diagnosis may be achieved by isolation in culture of the causative agent or the demonstration of the agent by indirect methods such as electron microscopy and ELISA. Clinical biochemical tests may reflect systemic metabolic changes induced by microbial infections and give an indication of the severity of the disease and its prognosis. Pulmonary function tests have limited application in animals and are only likely to be used under experimental conditions and in horses and small animals.

Animals↗
PubMed2006

Ambroxol for the prevention of acute upper respiratory disease.

Although acute upper respiratory diseases (AURDs) such as common cold and influenza are common, few interventions have been proven to be effective in their prevention and treatment. The aim of this study was to assess the efficacy of ambroxol for preventing AURD. Fifty-four patients were randomly divided into 3 groups: a rebamipide (non-mucoactive drug) group (300 mg/day), carbocisteine group (1500 mg/day) and ambroxol group (45 mg/day). The study was divided into 2 terms, the first half-year (summer season) and the second half-year (winter season). In the preceding winter, only 19.5% of the patients had been vaccinated against influenza viruses (flu). The primary goal of this study was to evaluate the effectiveness of mucoactive drugs in decreasing the frequency of AURD. Treatment with ambroxol, but not carbocisteine, significantly reduced the median number of AURD episodes (P=0.0049 vs. rebamipide). Thirty-three patients without vaccination against flu were assessed especially during the second half-year. Treatment with ambroxol also significantly reduced the median number of AURD episodes in this assessment (P=0.0028 vs. rebamipide in the second half-year). In conclusion, ambroxol may be useful for preventing AURD.

Aged↗
PubMed1996

Severe respiratory disease in dairy cows caused by infection with bovine respiratory syncytial virus.

Outbreaks of severe respiratory disease caused by bovine respiratory syncytial virus (BRSV) were recorded in dairy herds throughout Sweden in 1988 and subsequently. The virus was demonstrated in nasopharyngeal swab material from animals in the acute stage of the disease by culture, the polymerase chain reaction (PCR) and by immunofluorescence. Serological data from the herds investigated showed that the cows had seroconverted to BRSV rather than to bovine coronavirus, bovine viral diarrhoea virus or parainfluenza-3 virus. It was predominantly dairy herds in isolated areas that contracted a severe primary BRSV infection, often after the purchase of new animals. A nationwide survey for BRSV antibodies in bulk milk samples showed the highest prevalence, of 84 to 89 per cent, in the southernmost regions of Sweden and the lowest prevalence, of 41 to 51 per cent, in the north of the country. The prevalence of BRSV was highest in areas with the highest populations of cattle.

Acute Disease↗
PubMed1985

Persistent lower respiratory disease in children.

Recurrent or persistent lower respiratory disease in children may present in various ways. The differential diagnosis includes reactive airways disease (asthma), prolonged viral pneumonia (in the young infant) and foreign body aspiration-the most common causes of persistent respiratory symptoms. The differential diagnosis also includes a long list of rare conditions. Because of the many diagnostic possibilities, the evaluation of a child with persistent lower respiratory disease should be carried out in a systematic, stepwise fashion.

Asthma↗
PubMedDate not supplied

[Assessing the relationship between the air pollution and incidence of respiratory diseases in the Primor'e territory].

The prevalence of respiratory diseases in the Primorye territory is discussed. Ecological risk of air pollution effects on respiratory morbidity is estimated. High ecological risk of respiratory diseases in the cities of the region is determined by car transport waste discharge. Children and adolescents are more sensitive to air pollution and more often suffer from respiratory diseases.

Adolescent↗
PubMed2002

Biosecurity and bovine respiratory disease.

Although biosecurity practices play a role in minimizing respiratory disease in cattle, they must be used in combination with other management strategies that address the many other risk factors. Because the pathogens involved in bovine respiratory disease are enzootic in the general cattle population, biosecurity practices aimed at the complete elimination of exposure are currently impractical. Several animal husbandry and production management practices can be used to minimize pathogen shedding, exposure, and transmission within a given population, however. Various combinations of these control measures can be applied to individual farms to help decrease the morbidity and mortality attributed to respiratory disease.

Animal Husbandry↗
PubMed1997

Serum total cholesterol and risk of hospitalization, and death from respiratory disease.

BACKGROUND: In earlier studies, serum total cholesterol was inversely associated with death due to respiratory diseases. METHODS: Relationships of cholesterol with risk of respiratory diseases were examined between 1978 and 1993 in a health maintenance organization in Northern California (48,188 men, 55,276 women, about 60% white, age range 25-89). Incident and fatal endpoints were ascertained using hospital discharge diagnostic codes and underlying cause of death, respectively. RESULTS: An inverse association of cholesterol level with pneumonia/influenza hospitalization was found among men and women except that, contrary to hypothesis, a positive association was seen in women under 55 years of age. Inconsistent inverse associations were found in men, but not women, between cholesterol level and hospitalization for chronic obstructive pulmonary disease (COPD). Hospitalization for asthma was unrelated to cholesterol level. An inverse association existed between cholesterol level and hospitalization for miscellaneous respiratory diseases among men, but not women. Exclusion of early hospitalizations tended to attenuate risk for cholesterol level below 4.14 mmol/l, but not the risk gradient across higher cholesterol levels. For deaths, cholesterol level was statistically significantly inversely associated only with COPD. CONCLUSIONS: Cholesterol had graded inverse associations with some respiratory diseases, but not others, tending to be stronger in men than in women, and in older than in younger participants. Associations varied for hospitalizations compared to deaths. More epidemiological and basic research is needed to elucidate the potential mechanisms underlying the observed associations.

Adult↗
PubMed1992

Respiratory disease surveillance in Hungary.

In October 1989, the Hungarian National Institute of Hygiene initiated the Children's Acute Respiratory Morbidity (CHARM) Surveillance System to assess the association between nine reportable respiratory diseases and air pollution. The weekly number of physician-diagnosed, reportable respiratory diseases among four age groups of children (less than 1, 1-2, 3-5, and 6-14 years) was tabulated for Sopron, a city with 60,000 residents. We calculated the proportion of diseases occurring during weeks with low, moderate, and high sulfur dioxide (SO2) and nitrogen dioxide (NO2) concentrations. The weekly averages of the 24-hour median SO2 concentrations were divided into thirds at less than or equal to 17.6, greater than 17.6 to less than or equal to 26.3, and greater than 26.3 micrograms/m3 (range: 0.9-79.6 micrograms/m3), and the NO2 concentrations at less than or equal to 29.8, greater than 29.8 to less than or equal to 44.1, and greater than 44.1 micrograms/m3 (range: 4.2-90.1 micrograms/m3). During 1990, 11,474 respiratory disease cases occurred among the 4,020 children less than 15 years of age living in Sopron and monitored by the CHARM system. The two most frequently reported disease categories were rhinitis/tonsillitis/pharyngitis (71.5%) and acute bronchitis (8.5%). Sixty-seven percent of pneumonia cases occurred when SO2 concentrations were highest. We found no association between levels of NO2 and respiratory diseases. The CHARM Surveillance System may characterize more fully which groups of children develop particular respiratory diseases following exposure to air pollution.

Acute Disease↗