SEARCH · PubMed Health

Results for “Staging”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 199 records · Page 11Linked to original sources

PubMed1998

[Preoperative staging of esophageal carcinoma: comparison of endoesophageal ultrasonography, computerized tomography and conventional clinical staging].

OBJECTIVE: To evaluate the value of different methods in preoperative staging of esophageal carcinoma. METHOD: Thirty-six patients undergoing resection of esophageal carcinoma were examined with endoesophageal ultrasonography (EU) before operation. Eight of 36 patients could not be evaluated because of severe esophageal stenosis. Computerized tomography (CT) was performed in 21 patients. Comparison was made between stagings based on EU, CT as well as the conventional clinical staging system, respectively with surgical-pathological staging after resection. RESULT: The accuracy of conventional clinical staging for esophageal cancer was only 36%. The accuracy of CT in T, N and pTNM staging was 38.1%, 57.1% and 47.6% respectively. For EU, the figures were 77.8%, 72.2% and 72.2%, and were improved to be 85.7%, 78.6% and 83.1% when untraversable patients were excluded. CONCLUSION: While conventional clinical staging system lacks accuracy in evaluating esophageal carcinoma, CT makes only moderate improvement. Based on direct morphological examination of lesions, EU is highly accurate in preoperative staging of esophageal carcinoma, especially in evaluating the extent of luminal wall invasion and regional lymph node involvement. Therefore, EU is of critical value in the therapeutic selection for esophageal carcinoma.

Endosonography↗

PubMed1983

Clinical staging versus operative staging in cervical cancer.

The Authors analyse the correlations between clinical staging (FIGO) and surgical staging in 152 patients affected by cervical cancer who underwent primary surgical therapy at the Gynecologic Institute of Padua University between 1974 and 1982. In the examined series clinical staging agrees with surgical staging in 2/3 of cases. The error percentage of clinical staging does not change significantly, from a statistical point of view, when staging varies. In those cases in which the two systems disagree the overstaging figure tends to decrease as staging becomes more severe while the clinical understaging figure tends to increase accordingly. On the basis of these results the Authors advocate a rational resort to operative staging in cervical cancer so as to evaluate the real topography of the original focus more accurately and plan the most adequate treatment.

Female↗

PubMed1995

Improved accuracy of computerized tomography based clinical staging in low stage nonseminomatous germ cell cancer using size criteria of retroperitoneal lymph nodes.

PURPOSE: We evaluated the significance of retroperitoneal lymph nodes detected by computerized tomography (CT) of low stage nonseminomatous germ cell tumor patients. MATERIALS AND METHODS: A blind retrospective review of 143 CTs of low stage nonseminomatous germ cell tumor revealed pathological stage A disease on 89 (62.2%) and pathological stage B disease on 54 (37.8%). A multivariate logistic regression model was used to evaluate the relationships between diameter of the retroperitoneal nodes detected in these CTs and pathological stage. RESULTS: Based on this model, as the diameter of the nodes increased within a 0 to 25 mm. range, the likelihood of pathological stage B disease increased in a continuous fashion. Using a 3 mm. threshold to define nonmetastatic nodes the sensitivity and negative predictive value of CT based staging was 90%. CONCLUSIONS: This measurement scheme improves the accuracy of staging compared to conventional methods.

Algorithms↗

PubMed1995

Staging concepts for gastrointestinal malignancies: the importance of preoperative locoregional T- and N-staging.

Preoperative locoregional staging of gastrointestinal tumors is of special significance for evaluation of resectability that means complete tumor removal without residual tumor (R0-resection). This is especially important within a multimodal therapeutic concept including neoadjuvant therapy of nonresectable tumors. In esophageal cancer above the bifurcation, tumors that are staged T3 or T4 should have neoadjuvant radiochemotherapy in order to achieve a down-staging and increase the chance for a complete tumor resection. Preoperative chemotherapy is further established in esophageal carcinomas below the bifurcation and gastric carcinomas in stage T4. As in pancreatic carcinoma, neoadjuvant treatment has no proven indication. Preoperative locoregional staging mainly concerns the infiltration of retroperitoneal veins, which represents the crucial point for resectability. Concerning carcinomas of the lower GI tract the T- and N-staging is of special relevance for rectal cancer because preoperative radiochemotherapy in T4-stage is an accepted indication. The T- and N-staging of gastrointestinal tumors has important clinical consequences; the demands for accuracy of endosonographic examinations are therefore very high.

Combined Modality Therapy↗

PubMed1998

Stage classifications of pancreatic cancer: comparison of the Japanese and UICC classifications and proposal for a new staging system. Union Internationale Contre le Cancer.

In the 4th edition of General Rules for the Study of Pancreatic Cancer by the Japan Pancreas Society (JPS), published in 1993 (English version published in 1996), a system resembling the TNM classification by the Union Internationale Contre le Cancer (UICC) was adopted, based on the results of precise analysis of data from 11,317 cases of carcinoma of the pancreas registered by the JPS during the 10-year period from 1981 to 1990. We compare the two TNM classifications and staging groups, focusing on the simplicity and reproducibility of the diagnostic criteria and the reliability of predicting outcome. To compare the prognostic value of the two classification systems, we analyzed the published data on resected cases registered by Pancreatic Cancer Registration Committee of the JPS. The results showed that a major drawback of the JPS classification is that is difficult to apply and has poor reproducibility. Survival rates differed significantly among the four stages in the JPS classification, whereas the UICC staging system did not reflect differences in outcome among the four stages, especially between stages II and III. The prognostic value of the UICC T category is better than that of the JPS T category, whereas the N category of JPS has better prognostic value than that of the UICC system. Believing that a combination of the two systems would solve this problem, we propose a new TNM classification and stage-grouping system that draws on the merits of both. This new system may provide improvements in staging classification that will lead to the establishment of a more practical and universal staging system for ductal carcinoma of the pancreas.

Humans↗

PubMed1994

A scanning electron microscopic study of the normal development of the chick wing from stages 19 to 36. A supplement to the Hamburger and Hamilton staging system.

The purpose of a staging system is to stage embryos by morphology rather than chronology. This is particularly useful when embryos do not develop exactly synchronously, as in the case of the chick. At present the Hamburger and Hamilton (1951) series is universally used to stage chick embryos. The aim of the present study was to provide a series of morphological descriptions of the normal stages of development of the chick wing bud from stages 19 to 36, and to correct some errors of the original system which may be overlooked by those new to the chick wing bud as an experimental model, and who rely primarily on the Hamburger and Hamilton stage series. In addition, Summerbell's (1976) observations on the appearance of the cartilaginous elements made from alcian green-stained whole mounts have been correlated with the external appearance of the wing bud to provide a more complete understanding of the skeletal development that influences, and to some degree accounts for, the changes in external morphology. Scanning electron microscopy (SEM) has been used to obtain images of much greater resolution and detail than those available from Hamburger and Hamilton, whilst using comparable magnifications to those attainable using conventional dissecting microscopes. The number of somites across which the proximal part of the wing bud extends has been provided as a measure of the limb width at early stages (19-24). At certain stages there were clear differences between the characteristic wing bud features described by Hamburger and Hamilton and those observed in the present study.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1999

E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi.

BACKGROUND: The current management of patients with gallstone disease and ductal calculi consists of endoscopic stone extraction (ESE) followed by laparoscopic cholecystectomy (LC). Following the advent of techniques of laparoscopic ductal stone clearance, an alternative single-stage laparoscopic treatment was introduced for these patients. The European Association of Endoscopic Surgery (E.A. E.S.) set up a ductal stone trial to compare the relative efficacy and outcome of these two management options. METHODS: A prospective randomized controlled clinical trial compared two management options. Group A (n = 150) received preoperative endoscopic retrograde cholangiography (ERC) with ESE followed by LC during the same hospital admission, and group B (n = 150) received single-stage laparoscopic management. RESULTS: There were no significant differences between the two groups in the clinical demographic details and the pretreatment biochemical findings. In group A, 14 of 150 patients received single-stage treatment; in group B, 17 of 150 were managed by the two-stage approach (protocol violation = 31/300, 10%). In group A patients managed in accordance with randomization, ERC was successful in 129/136 (95%) and preoperative ESE succeeded in 82/98 (84%) with ductal calculi detected by the ERC. Two patients had malignancies and one refused surgery. Thus, 133 patients underwent surgery. Of this group, 116 had LC only and 17 had LC and attempted laparoscopic duct exploration. There were eight conversions to open surgery (6%), 17 complications for both stages (12.8%), and two postoperative deaths (1.5%). In group B patients managed in accordance with randomization, intraoperative cholangiography was successful in 132/133 (99%). Twenty-one (16%) had normal findings, ductal calculi were found in 109, and other pathology was noted in two (periampullary cancer, severe pancreatitis). These two patients and one other (who had gross adhesion in the triangle of Calot) were converted at the start of the procedure. Transcystic ductal stone clearance was successful in 45 of 56 patients (80%), and laparoscopic direct common duct (CBD) exploration was successful in 47 of 55 patients (85%). This group includes 53 patients who underwent primary direct exploration and two failed attempts at transcystic extraction. The conversion rate was 13%. Postoperative complications were encountered in 21 patients (15.8%), and one patient died of a major myocardial infarction (0. 75%). The one postoperative death and the 10/11 biliary complications occurred in the laparoscopic supraduodenal CBD exploration subgroup. The conversion rate was higher in group B (17 vs eight; p = 0.08). Laparotomy in the postoperative period was required in three patients in group A and four patients in group B. The group B patients were in hospital for 3 days less than patients who had two-stage management (median, 6.0, IQR = 4.25-12 vs median, 9.0, IQR = 5.5-14; p < 0.05). CONCLUSIONS: The results demonstrate equivalent success rates and patient morbidity for the two management options but a significantly shorter hospital stay with the single-stage laparoscopic treatment. The findings indicate that in fit patients (ASA I and II), single-stage laparoscopic treatment is the better option, and preoperative ESE should be confined to poor-risk patients-i.e., those with cholangitis or severe pancreatitis.

Adolescent↗

PubMed2005

Removing the infected aortofemoral graft using a two-stage procedure with a delay between the stages.

This study describes the results of a procedure for removing the infected aortofemoral graft using a two-stage procedure with a delay between the stages. The objective was to lessen the morbidity and mortality associated with removing an infected graft through a single operation. Eight consecutive patients were treated in this manner over a 6-year span. The indications for surgery were infected groin false aneurysms in three, chronic draining sinuses involving the prosthetic graft in four, and an open groin infection involving graft in one. There were five males and three females, with ages ranging 47-83 years (mean = 63). The mean operative time of the first-stage operation was 5.1 hr (range 3.0-7.7), and the mean blood transfusion requirement was 1.7 units. The mean operative time of the second stage operation was 3.5 hr (range 3.5-7.6), and the mean blood transfusion requirement was 2.5 units. In six patients, the hospital course was uncomplicated, with a mean hospital stay of 8.4 days for the initial stage and 9.2 days for the second stage. Two patients had complicated postoperative courses with hospital stays of >30 days. There was no operative or graft-related late mortality. No patients were lost to follow-up. One patient died of unrelated causes with a patent graft at 22 months postsurgery. All other patients remain well with patent grafts, without requiring revisions at a mean follow-up of 33 months (range 6-73). A two-stage approach with a delay between the stages may reduce the morbidity and mortality associated with the removal of an infected aortobifemoral graft.

Aged↗

PubMed1990

Angiostrongylus cantonensis: in vitro cultivation from the first-stage to infective third-stage larvae.

The first-stage larvae of Angiostrongylus cantonensis were cultured in various media at 27 degrees C. The most suitable medium for the development was Chernin's balanced salt solution supplemented with 10% L-15, 10% tryptose phosphate broth, 20% fetal calf serum, and 26 mM sodium bicarbonate. Addition of sodium bicarbonate to the medium facilitated early development of the first-stage larvae. When the first-stage larvae were cultured in the medium under 5% CO2 in air, the worms developed gradually to become quiescent and showed the C shape. Thereafter, the larvae developed to the second stage, retaining their first sheath. About 23 days later, the larvae began to develop to the third stage, being enclosed within the sheaths of the first and second molts. Under these conditions, the larvae developed uniformly and 82% of the larvae reached the third stage 50 days later. About 70% of the third-stage larvae discarded their two sheaths, showing almost the same size as those obtained in vivo. When these exsheathed larvae were inoculated into rats, they developed into adult worms and deposited numerous first-stage larvae.

Angiostrongylus↗

PubMed2002

Iron augments stage-I and stage-II tumor promotion in murine skin.

Free radical generating organic peroxides and hydroperoxides are known to promote tumors in mouse skin and iron has been shown to participate in free radical generating reactions. In the present study, we have used various peroxides and hydroperoxides as stage-I and -II tumor promoters and have studied the effect of iron-overload on the two stages of tumor promotion. Swiss albino mice were iron-overloaded by injecting iron-dextran (1.0 mg Fe/mouse per day for 15 days). Twenty-four hours after the last injection of iron-dextran, the animals were initiated with 40 microg 7,12 dimethylbenz[a]anthracene. One week following initiation stage-I tumor promotion was accomplished by applying 12-O-tetradecanoyl phorbol-13-acetate (TPA), benzoyl peroxide (BPO), cumene hydroperoxide (COOH) or H(2)O(2) to mice twice weekly for 2 weeks. Stage-II tumor promotion was accomplished by applying mezerein, BPO, COOH or H(2)O(2) to these mice twice weekly for 40 weeks. The appearance of the first papilloma and the number of tumors/mouse were recorded weekly. When compared to non-iron-overloaded mice, the iron-overloaded mice showed a higher tumor incidence and number of tumors/mouse. The order in which iron-overload was effective in increasing tumor promotion by stage-I tumor promoters was H(2)O(2)>COOH>BPO>TPA and the order in which iron-overload was effective in increasing tumor promotion by stage-II tumor promoters was COOH>mezerein>BPO. Induction in ornithine decarboxylase (ODC) activity, [(3)H]thymidine incorporation in cutaneous DNA and cutaneous lipid peroxidation were also higher in the iron-overloaded mice. TPA was the most effective in inducing epidermal ODC activity and [(3)H]thymidine incorporation followed by mezerein, COOH and BPO. In addition, the level of epidermal reduced glutathione and the activities of antioxidant enzymes were lower in iron-overloaded mice. Besides this, cutaneous iron levels were higher in iron-overloaded mice. Thus, we conclude from this study that iron-overload augments stage-I and stage-II of tumor promotion in murine skin.

Animals↗

PubMed1998

Comparison of Brånemark fixture integration and short-term survival using one-stage or two-stage surgery in completely and partially edentulous mandibles.

The aim of this prospective study was to compare the clinical integration and survival of Brånemark fixtures when using the conventional 2-stage surgical procedure to 1-stage surgical approach in completely and partially edentulous mandibles. A total of 85 patients were consecutively treated for partial (n = 35) or complete (n = 50) mandibular edentulousness. Fixtures removed because of mobility, pain or infection were counted as failures. The first 10 patients of each group were selected for radiographical analysis of crestal bone changes 1 year after prosthesis insertion. In 33 patients with edentulous mandibles, 170 fixtures were placed in a 1-stage approach. In this group, 4 fixtures (2.4%) were lost prior to prosthetic restoration. Seventeen edentulous patients received a total of 70 fixtures in a 2-stage procedure. Out of these, 5 fixtures (7.1%) were lost at abutment connection. In 17 partially edentulous patients, 41 fixtures were inserted in a 1-stage approach. Two fixtures (5%) were lost in this group. Finally, 18 partially edentulous patients received a total of 49 fixtures in a 2-stage procedure. Out of these, 6 fixtures (12%) were lost at abutment connection. In total 313 of the 330 installed mandibular implants were loaded between 6 and 12 months (94.8% success). No further losses occurred in the implants functioning at least 1 year (267 implants) or at least 2 years (59 implants). Statistical analysis (Chi square test) revealed no difference in fixture survival between the treatment modalities. Radiographical analysis after 1 year of functional loading showed the typical bone resorption changes up to the most coronal implant thread in both modalities. Although this study pertains to relatively early loading of 2 years, the results seem to indicate that in the mandible a 1-stage surgical approach with Brånemark fixtures may be as predictable as the conventional 2-stage procedure.

Adult↗

PubMed1993

Inhibition of both stage I and stage II skin tumor promotion in SENCAR mice by a polyphenolic fraction isolated from green tea: inhibition depends on the duration of polyphenol treatment.

The polyphenolic fraction isolated from green tea (GTP) is a potent inhibitor of phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced tumor promotion in mouse skin. In this study, we assessed the effect of GTP on both stage I and stage II skin tumor promotion, and also analyzed the effect of duration of GTP treatment on skin tumor promotion in SENCAR mice. Topical application of GTP (6 mg/animal) concurrently with each application of either TPA (3.2 nmol) or mezerein (3.2 nmol) in stage I or stage II of the murine skin tumor promotion protocol, respectively, resulted in significant protection against skin papilloma formation in terms of both tumor multiplicity (42-50%) and tumor growth (43-54%). More profound and sustained protective effects of GTP were evident when it was applied continuously during both stage I and stage II of the skin tumor promotion protocol concurrently with TPA or mezerein treatments, respectively. Under this treatment regimen, compared to non-GTP-treated positive controls, GTP application showed 71%, 37% and 74% protection in terms of tumor multiplicity, tumor incidence and tumor growth, respectively. These data indicate that GTP inhibits both stage I and stage II of skin tumor promotion and that the inhibition of tumor promotion depends on the duration of GTP treatment.

Animals↗

PubMed1994

A multi-component stage model for matching drug prevention strategies and messages to youth stage of use.

The purpose of this paper was to describe the development of a comprehensive, stage-based model for the prevention of drug use titled the multi-component motivational stages (McMOS) model. The McMOS model is proposed as a multi-element, integrative theoretical framework for the development of prevention strategies and content which are matched to the developmental stages of drug use among youth, based on previous work by Prochaska and DiClemente. The major components of the McMOS drug prevention model include: (1) a stage-based framework which permits the matching of prevention strategies and messages to youths' stage of development in the change process; (2) the delineation of a continuum of stages ranging from the acquisition of drug use through the successful modification of drug use; (3) a two-level prevention schema for targeting a broader range of youth for intervention, including those regularly using drugs as well as those not yet regularly using drugs; (4) a drug specific emphasis for proposing prevention strategies targeting the most prevalently used drugs, based on epidemiologic research; (5) the delineation of major theoretical constructs influencing the movement of youth through the stages, based on three prominent behavioral theories; and (6) a framework for selecting a range of prevention delivery modes for youth at all stages and levels of behavioral change.

Adolescent↗

PubMed2006

Comparison of 1-stage versus 2-stage anterior and posterior spinal fusion for severe and rigid idiopathic scoliosis--a randomized prospective study.

STUDY DESIGN: A randomized prospective study. OBJECTIVE: To compare safety, efficacy, and cost between 1-stage and 2-stage anterior and posterior spinal fusion in treating rigid thoracic adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Retrospective study issued different outcomes comparing 1-stage with 2-stage surgical procedures in treating neuromuscular and congenital scoliosis. A randomized prospective study in AIS has rarely been reported. METHODS.: Twenty-four patients were randomly divided into 2 groups. Group A underwent a 2-stage procedure, group B a 1-stage procedure. Inclusion criteria were: (1) AIS; (2) rigid single thoracic curve, > or =90 degrees on anteroposterior and > or =60 degrees on side bending view; and (3) pulmonary function tests, vital capacity > or =500 mL or FEV1 > or =50%. Exclusion criteria were: (1) curves either <90 degrees on anteroposterior or <60 degrees on bending view; and (2) pulmonary function tests, both vital capacity <500 mL and FEV1 <50%. The mean follow up was 3.3 years (range 2-5.1). Clinical outcomes between the 2 groups were analyzed. RESULTS: A statistical t test demonstrated no significant difference in age (P = 0.299), curves on anteroposterior (P = 0.908), on bending (P = 0.905), after surgery (P = 0.699), and at last follow-up (P = 0.946). No significant difference in blood loss (P = 0.089), transfusion (P = 0.334), operation time (P = 0.172), fusion segments anterior (P = 0.161), posterior (P = 0.546), wound drainage (P = 0.557), thoraco drainage (P = 0.948), and loss of correction at follow-up (P = 0.596). However, significant differences were found in length of stay (P < 0.001), patient cost of hospitalization (P < 0.001) between 2 groups, and curve correction (P < 0.001) in each group. Perioperative complications included 1 patient each with pneumonia, pneumothorax (group A), and ileus (group B). Screw nut loosing was found in 1 patient in group B, but no curve deteriorated. No neurologic deficit occurred in either group. CONCLUSION: A comparison of 1-stage versus 2-stage fusion in treating rigid thoracic curves in AIS did not show significant differences in safety or efficacy but did demonstrate significant difference in length of stay and patient cost.

Adolescent↗

PubMed1984

Is it an E lesion or stage IV? An unsettled issue in Hodgkin's disease staging.

To determine whether recognized experts in the area of Hodgkin's disease would agree on the determination of stage when various types of extranodal disease are present, we asked senior investigators at 15 major centers to assign a stage to four different patients. In general, these experts agreed in cases representing the extremes of difference between localized and distant extranodal disease. However, when presented with patients with nearby but not contiguous extranodal disease of lung or bone, one half of the experts classified this as an E lesion and one half as stage IV. This disagreement in stage assignment has implications not only for individual patient treatment, but also for reporting of clinical trials. Over-assignment of stage IV has the practical result of "improving" the results of treatment of both low stage (by removing higher risk patients) and advanced stage patients (by including better risk patients). Papers reporting the results of treatment of Hodgkin's disease should include information concerning how patients with extranodal disease were separated into those with E lesions and those with stage IV disease.

Hodgkin Disease↗

PubMed2005

Staged laparoscopic Roux-en-Y: a novel two-stage bariatric operation as an alternative in the super-obese with massively enlarged liver.

In a subset of super-obese patients, the one-stage laparoscopic Roux-en-Y gastric bypass (RYGBP) can be associated with significant morbidity and mortality. In a previous effort to reduce the perioperative risks associated with the super-obese, a two-stage operation was devised. This two-stage operation consisted of a sleeve gastrectomy (1st stage) followed by a RYGBP or duodenal switch procedure (2nd stage). We find that the primary limiting factor making laparoscopic gastric bypass challenging in the super-obese is the volume of the left lobe of the liver. A greatly thickened left lobe of the liver obscures visualization of the gastroesophageal junction and angle of His so that a sleeve gastrectomy is difficult to construct. In this report, we describe a novel method utilizing a staged Roux-en-Y procedure. Instead of performing a restrictive operation (sleeve gastrectomy) as the initial procedure, we fashion a modified Roux-en-Y with a low gastrojejunal anastomosis and a larger gastric pouch encompassing the gastric fundus. The low anastomosis obviates the need for exposure of the gastro-esophageal junction and angle of His. At the 2nd stage procedure, completion sleeve gastrectomy of the gastric fundus is performed at an interval of 6-12 months after the 1st stage operation.

Anastomosis, Roux-en-Y↗

PubMed1999

Modified stages of acquisition of gateway drug use: a primary prevention application of the stages of change model.

The purpose of the study was to identify the stages of acquisition of gateway drugs in fourth, fifth, and sixth graders. The Stages of Acquisition model is a primary prevention application of the Stages of Change model. The subjects in the study were 811 students from seventeen elementary schools in Arkansas and Missouri. The instrument elicited information regarding the stages of acquisition and individual self-reported drug use. The data were analyzed using frequency, distribution, discriminant analysis, and correlation analyses. Stage placement was confirmed using a series of drug use measures. Results confirmed the existence of discrete stages of acquisition. Results supported the concept of gateway drugs in that subjects indicated they had progressed further through the stages of acquisition of alcohol use than through the stages of acquisition of cigarettes use, smokeless tobacco use, or marijuana use.

Arkansas↗

PubMed2006

Lens-sparing vitrectomy for stage 4 and stage 5 retinopathy of prematurity.

PURPOSE: To describe the results of lens-sparing vitrectomy for the correction of retinal detachment associated with retinopathy of prematurity (ROP) and its associated complications. METHODS: Seventeen patients who underwent a lens-sparing vitrectomy for stage 4 and stage 5 ROP with plus disease at Seoul National University Children' s Hospital between 1999 and 2003 were enrolled in this study. The patients who had bilateral retinal detachment of ROP underwent a lens-sparing vitrectomy in one eye and a scleral buckling surgery or lensectomy-vitrectomy in the other eye. The patients who had a retinal detachment in one eye and a regressed ROP in the other eye underwent unilateral lens-sparing vitrectomies. A review of their preoperative clinical findings (including the status of retinal detachment and plus disease), post-operative results, and any complications encountered was performed. RESULTS: In 17 patients, the postoperative success rate of lens-sparing vitrectomy was 58.8%. However, lens-sparing vitrectomy as a treatment for stage 5 ROP (25.0%) produced more negative post-operative results than it did when used to treat either those for stage 4a (75,0%) or 4b (66.7%) ROP. Among the 10 eyes in which the retina was attached, form vision was shown in six eyes, light could be followed by three eyes, and no light perception was present in one eye. Intra- and post-operative complications included retinal break formation, cataracts, vitreous hemorrhages, and glaucoma in patients with stages 4b and stage 5 ROP. CONCLUSIONS: Lens-sparing vitrectomy resulted in encouraging surgical outcomes in the correction of retinal detachment of ROP, especially in stage 4 patients. Therefore, a lens-sparing vitrectomy for stage 4 ROP patient may be beneficial, although it is still associated with some intra- and post-operative complications.

Child, Preschool↗