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Body fluid exposure in an urban tertiary care medical center.

The increasing prevalences of the human immunodeficiency (HIV) and hepatitis B viruses have focused attention on the risks that health care workers face when exposed to potentially infective body fluids. This study establishes a profile of 320 parenteral exposure incidents and 47 exposure incidents to mucous membranes or abraded skin, reported in our medical center between July 1988 and July 1990. We found that 102 (27.8%) of the incidents involved an HIV-positive patient, that 130 (35.4%) of the reporting employees had completed their hepatitis B vaccination at the time of the incident, and that, although the majority of incidents involved employees with patient contact, unfortunately, service workers also were represented (4.6%, n = 17). Factors contributing to incidents included recapping (10.9%, n = 40), full needle-boxes (7.6%, n = 28), and inappropriate disposal (13.1%, n = 48). A health fair featuring walk-in hepatitis B immunization attracted 260 participants, 90% of whom completed the entire immunization series. This significantly improved the immunization rate of employees subsequently reporting body fluid exposure.

Adult↗

The main neutrophil and neutrophil-related functions may compensate for each other following exercise-a finding from training in university judoists.

In order to clarify the relationship between exercise and neutrophil function, we measured three major neutrophil and neutrophil-related functions, viz. the reactive oxygen species (ROS) production capability and phagocytic activity (PA) of neutrophils and serum opsonic activity (SOA), simultaneously before and after a unified loading exercise under three different sets of conditions. Thirteen female collegiate judoists were examined with a unified exercise loading (2 h) immediately before and after a 64 day training period. Immediately thereafter, the athletes took part in a 6 day intensified training camp, following which the same exercise loading was repeated. Responses from circulating neutrophils were estimated by comparing the two sets of values obtained before and after the two instances of exercise loading. The parameters assessed included neutrophil count, SOA, PA and ROS production capability. ROS production increased after the exercise loading performed immediately before and after the 64 day training period just before the camp, (p < 0.01) but decreased following the exercise loading performed after the camp (p < 0.05). This suggested depressed bacteriocidal capability of the circulating neutrophils. PA decreased after the exercise loading sessions imposed prior to and after the 64 day training period (p < 0.01) but did not change in the loading session after the camp. No changes were seen in SOA produced with the loading exercise either before the 64 day exercise period or before the camp, but increased significantly following the post-camp session (p < 0.05). In conclusion, athletic training-induced changes in immune functional activities of neutrophils, such as ROS production and PA, and neutrophil-related factors, such as SOA, may compensate for each other to maintain the overall integrity of the neutrophil immune function.

Adult↗

Electrical stimulation of the preoptic area in Eigenmannia: evoked interruptions in the electric organ discharge.

The functional role of the basal forebrain and preoptic regions in modulating the normally regular electric organ discharge was determined by focal brain stimulation in the weakly electric fish, Eigenmannia. The rostral preoptic area, which is connected with the diencephalic prepacemaker nucleus, was examined physiologically by electrical stimulation in a curarized fish. Electrical stimulation of the most rostral region of the preoptic area with trains of relatively low intensity current elicits discrete bursts of electric organ discharge interruptions in contrast to other forebrain loci. These responses were observed primarily as after-responses following the termination of the stimulus train and were relatively immune to variations in the stimulus parameters. As the duration and rate of these preoptic-evoked bursts of electric organ discharge interruptions (approximately 100 ms at 2 per s) are similar to duration and rate of natural interruptions, it is proposed that these bursts might be precursors to natural interruptions. These data suggest that the preoptic area, consistent with its role in controlling reproductive behaviors in vertebrates, may be influencing the occurrence of electric organ discharge courtship signals by either direct actions on the prepacemaker nucleus or through other regions that are connected with the diencephalic pre-pacemaker nucleus.

Action Potentials↗

Personal antimosquito measures plus proguanil for malaria prophylaxis in southern Malaysia.

During the early months of 1985 and 1986, 408 non-immune British soldiers undertook training in the jungles north of Kota Tinggi, in southern Malaysia. In this geographical location, where malaria transmission is now light, a combination of strict personal antimosquito measures plus proguanil 200 mg daily produced effective, safe protection, with only a single case of vivax malaria occurring. Given the limited malaria risk, however, the results of this study should be extrapolated only with caution to other areas of Malaysia.

Clothing↗

A perspective on the progression of immunotoxicology.

Immunotoxicology originated in the early 1970s, when scientists began investigating chemicals. During the 1970s and early 1980s, a few investigators determined that chemicals were immunotoxic, developed and/or refined immunoassays, and began to characterize immunotoxic responses. In the 1980s, many new investigators entered the field, graduates were being trained as immunotoxicologists, the immune system was identified as a primary target organ, mechanisms of action studies proliferated, a comprehensive immunotoxicological panel was validated, the discipline gained universal credibility, and human studies emerged. The 1990s were ushered in with the concept of biological markers in immunotoxicology, a better understanding of "immune function", inclusion of immunotoxicology in risk assessment analysis, and a focus on molecular immunology. Future investigations will continue to improve and expand this foundation, pursue the relationship of immunotoxic chemicals and adverse health effects in humans, utilize genetically altered rodent models, and use gene expression technology to better understand the pathogenesis of immunotoxicological processes. Immunotoxicology has not only matured since its inception nearly 30 yr ago, but has become a prominent and respected discipline with global recognition; one that has made significant contributions to the advancement of the biomedical sciences.

Allergy and Immunology↗

A postevent smallpox mass vaccination clinic exercise.

Emergency response plans require careful planning and testing. The exercises can be in the form of tabletop, functional, and full-scale activities. To test a regional plan, various agencies from Louisiana, Arkansas, and Texas conducted a postevent mass smallpox vaccination clinic that incorporated federal, state, and local resources. An evaluation of the exercise is provided along with the recommendations for improving a similar future exercise.

Bioterrorism↗

The effect of high intensity exercise on the functional capacity of equine pulmonary alveolar macrophages and BAL-derived lymphocytes.

The effect of strenuous exercise on the functional capacity of pulmonary alveolar macrophages (PAM) and bronchoalveolar lavage-derived lymphocytes was determined in eight horses prior to and after 7 weeks of training. Strenuous exercise had no effect on the total cell count or the percentage of live cells in bronchoalveolar lavage (BAL) samples prior to or following training. However, training was associated with a significant increase in the total cell count of pre-exercise BAL samples and a significant reduction in the percentage of live cells in post-exercise samples. Strenuous exercise was associated with impaired phagocytosis by PAM after 7 weeks of training but had no effect on similar samples obtained from untrained horses. The oxidative burst activity of PAM was significantly increased following strenuous exercise for both untrained and trained horses. BAL -derived lymphocyte oxidative burst was similarly affected following training. These results suggest that strenuous exercise and training may influence pulmonary immune cell function.

Animals↗

A Survey of Travel Clinics Throughout the World.

Background: The growth of travel medicine as a specialty has been marked by a dramatic increase in the number of travel clinics worldwide. A survey was conducted of travel clinics to assess the current practice of travel medicine. Methods: A questionnaire was sent to members of the International Society of Travel Medicine, asking questions about clinic demographics, categories of advice given and immunizations available, and educational training of clinic personnel. Results: Responses from 341 clinics were analyzed; 57% were located in the United States; 21% in Europe; 6% in the United Kingdom or Ireland; 6% in Canada; and 11% from other areas of the world. Most clinics were private (41%); however, many other affiliations were represented, including schools of medicine (20%), hospitals (10%), and occupational medicine and student health practices (10%). The median number of patients seen per year was 750; however, the range was 6 to 50,000. Each clinic offered many vaccines, and advice for the prevention of malaria, diarrhea, and insect avoidance was given over 95% of the time. Providers of advice were nurses (57% of the time) and physicians (83%); however, in the United States nurses gave advice independently more frequently (22% vs. 8%, p <.001) than in other parts of the world. Clinics also frequently gave telephone advice (15% charged for this service) and evaluated ill returned travelers. Over 60% of physicians had trained in infectious diseases and/or tropical medicine, although there were training differences between regions of the world. Conclusions: Travel clinics throughout the world demonstrate similarities as well as differences in practice. Defining these will help in determining practice needs in the growing field of travel medicine.

Journal Article↗

Lung transplantation at the turn of the century.

Lung transplantation has become a viable treatment option for patients with end-stage lung disease. Donor selection and organ allocation must follow specific guidelines. Single, bilateral, and living-donor lobar transplantation have all been performed successfully for a variety of diseases. Complications include reimplantation response and airway complications. Rejection may occur in the hyperacute, acute, or chronic settings and requires judicious management with immunosuppression. Infection and malignancy remain potential complications of the commitment to lifelong systemic immunosuppression. Survival statistics have remained encouraging and continue to improve with experience. Improved exercise tolerance and quality of life have been demonstrated in the years following transplantation. Remaining obstacles include limited donor organ availability, long-term graft function, and patient survival. However, ongoing advances in immune tolerance and standardized training of physicians in the care of transplant patients should carry lung transplant forward in the twenty-first century.

Forecasting↗

Providers issue brief: automated external defibrillators.

With expanded access to automatic external defibrillators, hundreds of lives could be saved on a daily basis. By training nonphysician providers, such as emergency medical service personnel or first responders, this life-saving medical equipment could help improve the survival rates for people suffering from cardiac arrest. During the last two years, state lawmakers have begun to enact legislation that develops training standards and provides immunity from civil liability for automatic external defibrillator users.

Electric Countershock↗

Education needs of immunization nurses.

A survey was conducted to identify the various levels of responsibility, experience and management tasks of registered nurses (RNs) involved in immunization services in South Australia. Questionnaires were sent to 109 RNs and 94 were completed. Educational deficits were common: 68% of respondents had received no orientation to immunization; 49% indicated five years or less experience in such programs and 86% expressed interest in inservice education.

Australia↗

[Action-oriented versus state-oriented reactions to experimenter-induced failures].

The present study assessed different effects of action-oriented versus state-oriented styles of coping with failure on achievement-related performance and cognition. In a learned helplessness experiment, students were exposed to an academic failure situation and were then tested on a series of problem-solving tasks, either immediately after the pretreatment or after a delay of 24 hours. Performance and cognitive concomitants were measured during both experimental periods. Results demonstrated that action orientation was associated with self-immunizing cognitions during helplessness training. Action-oriented participants improved their performance level even after repeated failure feedbacks. Moreover, action-oriented students assigned to the delayed test condition responded with increased striving for success and showed performance increments, even in comparison with control subjects. In contrast, state-oriented participants developed symptoms of helplessness and showed impaired performance during failure inductions. In later tests on problem-solving tasks, state-oriented groups responded with increased fear of failure. Independent of immediate or delayed test conditions, they soon lapsed into new performance decrements.

Achievement↗

Countertransference and the myth of the perfectly analyzed analyst.

Countertransference is an inevitable feature of every psychoanalysis. Psychoanalysts are (and need to be) only human; psychoanalytic work is arduous and replete with stresses, strains, and deprivations; analysands tend to probe for vulnerabilities in their analysts that can be exploited in the interest of acting out neurotic wishes instead of analyzing them; and a training analysis cannot completely immunize a psychoanalyst against countertransferential reactions that impede analytic progress. Psychoanalysts must be vigilant to the emergence of countertransference reactions so that they can analyze and overcome them. Two illustrative clinical examples are provided.

Adult↗

Interaction between infection and exercise with special reference to myocarditis and the increased frequency of sudden deaths among young Swedish orienteers 1979-92.

Infection and fever evoke a cytokine-mediated host response resulting in negative nitrogen balance, muscle protein degradation, which includes the skeletal muscles as well as the heart muscle, and deteriorated muscle function. Physical training has an opposite effect. Moderate physical training also stimulates the immune system, whereas exhaustive and longlasting exercise is followed by a temporary immunodeficiency and an increased susceptibility to respiratory tract infections. Exercise in the acute phase of an infection may promote complications including myocarditis. Exercise in myocarditis is associated with increased organism-associated as well as immune mediated tissue damage. An increased sudden death (SUD) rate among young Swedish male orienteers existed in 1979-92, suggesting (a) common underlying cause(s). Myocarditis was one of the most conspicuous histopathological features. Chlamydia pneumoniae, or a similar organism cross reacting in diagnostic tests, is hypothesized to be a factor causing this increased death rate. High frequency of intense exercise sessions, which was a common practice among the deceased, may have been immunosuppressive, promoting the development of severe myocardial disease.

Adolescent↗

Acute intensive interval training and T-lymphocyte function.

Immune suppression has been suggested to occur as a result of acute exercise although results of previous studies are variable, possibly due to the failure of some researchers to control exercise intensity and duration. Most of the studies so far have investigated immediate effects after bouts of exercise mainly in subjects undertaking lower body exercise (running or cycling), and the time course of recovery has rarely been determined. We chose two groups of athletes for our studies. One group represented subjects of a range of fitness levels from recreational runners to high-performance runners. The second group represented kayakists with a similar range of fitness levels. Following interval training designed to stress either the lower or upper body anaerobically, we have now shown that upper body exercise (kayaking) induces similar in vitro responses to those described for lower body exercise. There were no differences between the responses of low-fitness versus high-fitness subjects. In addition we have studied the in vitro responses of leukocytes following acute anaerobic exercise over a 24-h recovery period. The results showed that the reduced lymphocyte proliferative response, in vitro, to the T-cell mitogen CONA experienced immediately after exercise returned to normal levels within 2 h of recovery time. This suggests that the reduction in lymphocyte proliferative response is a short transient one.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Influence of physical activity on the cellular immune system: mechanisms of action.

This review deals with the effect of acute physical exercise and training status on different components of the immune system. Predominantly studies in humans are mentioned. In relation to acute physical exercise (75% of VO2max, 1 hour) the leukocyte concentration increased; following exercise the neutrophils increased fourfold. The lymhphocyte concentration increased during and decreased following exercise. The percentage of CD3+ cells (pan T cells) declined during exercise, mainly due to a fall in the %CD4+ cells. The %CD16+ cells (NK cells) increased two-fold and returned to prevalue two hours after exercise. The %CD20+ cells (B cells) did not change in relation to exercise, whereas the %CD14+ cells (monocytes) increased two to threefold following exercise. The NK cell activity increased during but decreased following exercise. These increases were due to recruitment of NK cells with a high IL-2 response capacity, whereas the decreased NK activity post-exercise was due to downregulation by prostaglandins released by the elevated concentration of monocytes. During severe, moderate as well as light exercise, the NK cell activity increased, but the post-exercise suppression of the NK cell function was found only following severe exercise, and not after moderate or light exercise, furthermore, only following severe exercise, an increased monocyte concentration was demonstrated. The IL-2-stimulated lymphocyte proliferative response increased due to stimulation of CD16+ cells and did not reflect expression of IL-2 receptors.

Cytokines↗

Childhood immunization availability in primary care practices. Effects of programs providing free vaccines to physicians.

OBJECTIVE: To examine state immunization distribution programs, along with physician practice, training, and attitudinal factors that influence the availability of childhood immunizations in community practices. DESIGN: Multistate survey stratified by rural and urban practice. PARTICIPANTS: Family physicians in community practices in three states that offer free vaccines to physicians for use in Medicaid recipients (n = 287) and three geographically matched states that do not offer free vaccines (n = 266). RESULTS: Physicians practicing in states that offer free vaccines for use in Medicaid populations were more likely to offer immunizations to patients in their practices (92% vs 75%, respectively; P < .001). This difference persisted even after adjusting for other practice variables that are associated with immunization availability. Physicians who did not offer immunizations cited cost factors as the primary reason for not offering this service. Public health departments were used as the referral site for immunization services, but only 59% of the physicians performed follow-up to determine whether patients received immunizations. CONCLUSIONS: State immunization programs that provide vaccines free to physicians are highly associated with practice policies that increase immunization availability.

Child↗