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The development of specialized brain systems in reading and oral-language.

Functional magnetic resonance imaging (fMRI) was used to examine differences between children (9-12 years) and adults (21-31 years) in the distribution of brain activation during word processing. Orthographic, phonologic, semantic and syntactic tasks were used in both the auditory and visual modalities. Our two principal results were consistent with the hypothesis that development is characterized by increasing specialization. Our first analysis compared activation in children versus adults separately for each modality. Adults showed more activation than children in the unimodal visual areas of middle temporal gyrus and fusiform gyrus for processing written word forms and in the unimodal auditory areas of superior temporal gyrus for processing spoken word forms. Children showed more activation than adults for written word forms in posterior heteromodal regions (Wernicke's area), presumably for the integration of orthographic and phonologic word forms. Our second analysis compared activation in the visual versus auditory modality separately for children and adults. Children showed primarily overlap of activation in brain regions for the visual and auditory tasks. Adults showed selective activation in the unimodal auditory areas of superior temporal gyrus when processing spoken word forms and selective activation in the unimodal visual areas of middle temporal gyrus and fusiform gyrus when processing written word forms.

Adult↗

Familiarity affects visual processing of words.

While previous research has demonstrated that words can be processed more rapidly and/or more accurately than random strings of letters, it has not been convincingly demonstrated that the superior processing of words is a visual effect. In the present experiment, the cases of letters were manipulated in letter strings that were to be compared on the basis of physical identity. Mean response time was shorter for words than for nonwords even for pairs of letter strings that differed only in case (e.g., site-site). This finding implies that the advantage of words over nonwords (the familiarity effect) typically observed in the simultaneous matching task is not due solely to comparison of either the word names or the letter names and, thus, that at least part of the familiarity effect must be due to more rapid formation and/or comparison of visual representations of the two letter strings when they are words. Further analysis failed to reveal a significant involvement of phonemic or lexical codes in the comparison judgments.

Adolescent↗

Neuromagnetic spectral distribution of implicit processing of words.

Neuromagnetic spectral distributions when silently viewing words and non-words were investigated using a 151-channel whole head MEG system. The data were analyzed with synthetic aperture magnetometry (SAM). The dominant changes of spectral power were identified in the parietal and occipital cortices in 15-30 Hz, 30-60 Hz and 60-125 Hz bands following both word and non-word stimulations. The changes in Broca's and Wernicke's areas were consistently observed in 60-125 Hz bands, mainly following word stimulation. The results indicated that the occipital and parietal cortices were most probably involved in visuospatial processing of words and non-words. The language areas, particularly Broca's and Wernickes's areas, might be involved in implicit word processing such as verbal searching and/or internal speech.

Adult↗

Brain activation modulated by the comprehension of normal and pseudo-word sentences of different processing demands: a functional magnetic resonance imaging study.

Recent data from lesion and brain imaging studies have questioned the well-established assumption of a close functional-anatomic link between syntax and Broca's area and semantics and Wernicke's area. In the present study we used functional magnetic resonance imaging (fMRI) to investigate the neuroanatomical correlates of semantic and syntactic functions and possible interdependencies between the related brain systems. In a completely crossed design we varied syntactic processing demands (easy vs difficult to process word order sequences) and the meaningfulness of sentences (real- vs pseudo-word sentences). In comparison to a backward speech condition we found an activation of the left perisylvian region, including the left inferior frontal cortex and the left superior and middle temporal gyri. Semantic in contrast to pseudo-word sentences elicited a stronger activation in both the anterior and the posterior perisylvian cortex. Syntactic difficulty had its strongest effect within the left inferior frontal region and this effect was more pronounced for semantic than nonsemantic speech. These results suggest that semantic and syntactic language functions are mediated by partly specialized brain systems but that there nevertheless exists a substantial functional overlap of the involved brain structures.

Adult↗

Can automatic picture processing influence word judgments?

Two experiments were undertaken in order to evaluate the influence of automatic semantic processing of pictures on word judgments. In both studies, picture-word analogs of the Stroop task were employed. In Experiment 1, subjects were required to make a semantic category judgment about the word; in Experiment 2, they were simply to respond yes or no to whether the word was DOG. Taken together, the results of these experiments indicated that (a) perceptual factors such as lateral masking influence responding in these types of tasks and their contributions must be partialed out from the effects of semantic factors, (b) picture processing can facilitate word processing but only in a restricted set of circumstances, and (c) background pictures incompatible with the correct response can interfere with word judgments. The facilitation observed was attributed to the effects automatic picture processing has on an initial input process, while the interference appears to arise at a response selection and execution stage. Further, the results suggest that the semantic nature of automatic picture processing is at least somewhat different from that of automatic word processing.

Adult↗

[Representation of letter position in visual word recognition process].

Two experiments investigated the representation of letter position in visual word recognition process. In Experiment 1, subjects (12 undergraduates and graduates) were asked to detect a target word in a briefly-presented probe. Probes consisted of two kanji words. The latters which formed targets (critical letters) were always contained in probes. (e.g. target: [symbol: see text] probe: [symbol: see text]) High false alarm rate was observed when critical letters occupied the same within-word relative position (left or right within the word) in the probe words as in the target word. In Experiment 2 (subject were ten undergraduates and graduates), spaces adjacent to probe words were replaced by randomly chosen hiragana letters (e.g. [symbol: see text]), because spaces are not used to separate words in regular Japanese sentences. In addition to the effect of within-word relative position as in Experiment 1, the effect of between-word relative position (left or right across the probe words) was observed. These results suggest that information about within-word relative position of a letter is used in word recognition process. The effect of within-word relative position was explained by a connectionist model of word recognition.

Adult↗

Adult age differences in letter-level and word-level processing.

Older and young adults' letter detection and lexical decision performance were examined as word frequency varied to determine whether there were age differences in word recognition. Allen and Madden (1989) found that older adults' pattern of reaction time (RT) across word frequency categories was different from young adults' pattern for a letter detection task. In this study, for both letter detection and lexical decision tasks, older adults exhibited a monotonically decreasing RT function as word frequency increased. However, young adults exhibited a nonmonotonic RT function across word frequency for the letter detection task but a monotonically decreasing RT function as word frequency increased for the lexical decision task. An expanded parallel input serial analysis model of word processing was hypothesized.

Adolescent↗

Processing of words presented simultaneously to eye and ear.

The simultaneous processing of auditorily and visually presented messages was examined in three experiments. Subjects searched lists of words for a target word while processing auditorily presented information. Across conditions, subjects searched for (a) target words in a list of words presented auditorily, (b) the same target words in lists presented visually, (c) a member of a taxonomic category in a visually presented list, and (d) a rhyme in a list of words presented visually. The level of processing of a simultaneous auditory message varied across experiments. In experiment 1, subjects shadowed lists of digits. In Experiment 2, subjects reported the antonym of each word in a list. In Experiment 3, subjects named the taxonomic category of each word in a list. In all three experiments, subject had high detection rates for target words presented visually and for category targets but low detection rates for target words presented auditorily and for rhyme targets. These results suggest that processing the semantic properties, but not the acoustic properties, of words presented to the visual modality is independent of simultaneous processing in the auditory modality. Implication for models of selective attention are discussed.

Attention↗

[Electronic data processing-assisted text processing at the clinic and in general practice].

Word processing is currently the most frequent application for personal computers, and a wide variety of standard software is available. The capabilities of modern word-processing software includes the convenient typing and correction of all routine correspondence, as well as the professional layout of scientific manuscripts. The decision to purchase a certain word-processing programm should be made according to local needs and prerequisities. Three to six months may be necessary to fully adapt the organization of a clinic or private practice to the new technology.

Computer Systems↗

Explicit and implicit processing of words and pseudowords by adult developmental dyslexics: A search for Wernicke's Wortschatz?

Two groups of male university students who had been diagnosed as dyslexic when younger, and two groups of control subjects of similar age and IQ to the dyslexics, were scanned whilst reading aloud and during a task where reading was implicit. The dyslexics performed less well than their peers on a range of literacy tasks and were strikingly impaired on phonological tasks. In the reading aloud experiment, simple words and pseudowords were presented at a slow pace so that reading accuracy was equal for dyslexics and controls. Relative to rest, both normal and dyslexic groups activated the same peri- and extra-sylvian regions of the left hemisphere that are known to be involved in reading. However, the dyslexic readers showed less activation than controls in the left posterior inferior temporal cortex [Brodmann area (BA) 37, or Wernicke's Wortschatz], left cerebellum, left thalamus and medial extrastriate cortex. In the implicit reading experiment, word and pseudoword processing was contrasted to visually matched false fonts while subjects performed a feature detection paradigm. The dyslexic readers showed reduced activation in BA 37 relative to normals suggesting that this group difference, seen in both experiments, resides in highly automated aspects of the reading process. Since BA 37 has been implicated previously in modality-independent naming, the reduced activation may indicate a specific impairment in lexical retrieval. Interestingly, during the reading aloud experiment only, there was increased activation for the dyslexics relative to the controls in a pre-motor region of Broca's area (BA 6/44). We attribute this result to the enforced use of an effortful compensatory strategy involving sublexical assembly of articulatory routines. The results confirm previous findings that dyslexic readers process written stimuli atypically, based on abnormal functioning of the left hemisphere reading system. More specifically, we localize this deficit to the neural system underlying lexical retrieval.

Adult↗

Computers in anatomic pathology. A survey of California hospitals.

The anatomic pathology services of 434 health care institutions in California were surveyed about their use of computers. Of 200 (46%) respondents, 106 (53%) did not use computers at all. Of 94 (47%) respondents who used computers, 77 (82%) used them for administrative purposes; 74 (79%), for any routine processing of surgical specimens; 43 (45%), for processing surgical specimens other than word processing (eg, database); 52 (55%), for processing cytology specimens; and 60 (63%), for processing autopsy specimens (including word processing). Computer use was slightly greater with higher work loads. Among nonusers, on a scale of 1 to 5 the average interest in using computers was 3.5 for surgical pathology data, 3.4 for cytology data, and 2.8 for autopsy data. The interest rate also increased with work load, and was nearly 4 for laboratories with greater than 4000 surgical or cytology cases per year. The average interest in controlling and/or making decisions about computer hardware and software was 3.9 for hardware and 4 for software. Reasons for low computer use in anatomic pathology despite interest in utilization are discussed, including the limited selection of affordable commercial software for anatomic pathology and difficulties of in-house software development.

Autopsy↗

A comparison of conscious and automatic memory processes for picture and word stimuli: a process dissociation analysis.

Four experiments were conducted to evaluate explanations of picture superiority effects previously found for several tasks. In a process dissociation procedure (Jacoby, 1991) with word stem completion, picture fragment completion, and category production tasks, conscious and automatic memory processes were compared for studied pictures and words with an independent retrieval model and a generate-source model. The predictions of a transfer appropriate processing account of picture superiority were tested and validated in "process pure" latent measures of conscious and unconscious, or automatic and source, memory processes. Results from both model fits verified that pictures had a conceptual (conscious/source) processing advantage over words for all tasks. The effects of perceptual (automatic/word generation) compatibility depended on task type, with pictorial tasks favoring pictures and linguistic tasks favoring words. Results show support for an explanation of the picture superiority effect that involves an interaction of encoding and retrieval processes.

Adult↗

Parafoveal processing in word recognition.

Two experiments investigated the degree to which properties of a word presented in the parafovea influenced the time to process a word undergoing concurrent foveal inspection. In Experiment 1, subjects viewed a set of five-letter words at a fixed point, with words in parafoveal vision varying in length, word frequency, and both the type and token frequency of occurrence of their initial three letters. The results showed that the frequency of the target and the type frequency of its initial letters influenced foveal fixation time. In Experiment 2, subjects executed a sequence of saccades before initial fixation on the experimental items. Under these circumstances, fixation time was shorter overall. Lexical properties of parafoveal words had no effect on foveal processing, but the length and the type frequency of their initial letters exerted a strong influence. Parafoveal-on-foveal effects of this form are incompatible with models of reading in which attention is allocated sequentially to successive words. The data are more consistent with the proposition that foveal and parafoveal processing occurs in parallel, with processing distributed over a region larger than a single word. Subsidiary analyses showed little influence of any of the manipulated variables on saccade extent.

Adult↗

Exposure to print and word recognition processes.

The effect of exposure to print on the efficiency of phonological and orthographic word recognition processes was examined by comparing two groups of university students having similar reading comprehension scores but different levels of exposure to print. Participants with a high level of exposure to print were faster and more accurate in naming pseudowords, in choosing the correct member of a homophone pair, and in making lexical decisions when nonwords were pseudohomophones. In the lexical decision task, low-print-exposure participants were more sensitive to the frequency of the orthographic patterns in the stimuli. The results of a form priming task demonstrated that high-print-exposure participants more quickly and strongly activated the orthographic representations of common words and subsequently more strongly activated the corresponding phonological representations. Even among successful students, differences in exposure to print produce large differences in the efficiency of both orthographic and phonological word recognition processes.

Adult↗

Differences in auditory processing of words and pseudowords: an fMRI study.

Although there has been great interest in the neuroanatomical basis of reading, little attention has been focused on auditory language processing. The purpose of this study was to examine the differential neuroanatomical response to the auditory processing of real words and pseudowords. Eight healthy right-handed participants performed two phoneme monitoring tasks (one with real word stimuli and one with pseudowords) during a functional magnetic resonance imaging (fMRI) scan with a 4.1 T system. Both tasks activated the inferior frontal gyrus (IFG), the posterior superior temporal gyrus (pSTG) and the inferior parietal lobe (IPL). Pseudoword processing elicited significantly more activation within the posterior cortical regions compared with real word processing. Previous reading studies have suggested that this increase is due to an increased demand on the lexical access system. The left inferior frontal gyrus, on the other hand, did not reveal a significant difference in the amount of activation as a function of stimulus type. The lack of a differential response in IFG for auditory processing supports its hypothesized involvement in grapheme to phoneme conversion processes. These results are consistent with those from previous neuroimaging reading studies and emphasize the utility of examining both input modalities (e.g., visual or auditory) to compose a more complete picture of the language network.

Acoustic Stimulation↗

[Initial experiences with a new kind of computer compatible coding and analysis system for inpatient and ambulatory services].

This paper describes a new concept of an operational database management system including the word processing program "Word Star". The system structure is composed of patients identities and linked MIR's (medical information records) to follow a patient's history in space and time. In- and out-patient's data are collected on a special data sheet with numeric responses from the following areas: demographics including risk factors, diagnosis, surgical procedure, intra- and postoperative morbidity analysis. Data are entered using a DBS-16 concurrent dos system and stored on a 105 Megabytes hard disk. The software program in its compiled version allows for processes like outpatients clinic management, appointments organisation and statistical analysis of different variables thus providing detailed information on patients postoperative morbidity.

Ambulatory Care↗

The late positive component of the evoked waveform: relationship to word recognition processes.

Averaged evoked potentials were collected from Cz, C3', C4', and Pz while subjects made perceptual and cognitive decisions about pairs of visually presented words. The nature and level of the decision being made was manipulated by varying the relationships between the two words presented Decisions were made at three different levels within the word recognition process. These levels corresponded to feature detection and synthesis, lexical access and naming, and semantic memory access at the superordinate category level. The late positive component of the evoked waveform varied systematically with the nature of the perceptual and cognitive decisions being made. The late positive component of the waveform was highly correlated with the response times associated with each of the three decision types. It would appear that the late positive component provides an internal index of the neural processes which accompany cognitive decisions. Specifically, the late positive component appears to reflect the time course of stimulus evaluation and comparison processes. The response time data and the evoked waveform provide converging sources of evidence in support of the notion that the word recognition process can be selectively tapped at several different levels within the information processing system.

Adult↗