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Results for “Yang Deficiency”

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PubMed1998

[Clinical observation of yugengongyu decoction in treatment of coronary heart disease with angina pectoris].

OBJECTIVE: To observe the clinical effect of Yugengtongyu Decoction (YGTY) in treatment of coronary heart disease (CHD) with Qi deficiency, Blood stasis and phlegm stagnancy type and Qi deficiency and Blood stasis type. METHODS: Patients were divided into two groups, 45 cases in the YGTY group and 38 cases in the control group. In alleviating angina pectoris and improving symptom of CHD, the serum total cholesterol (TC), serum triglyceride (TG) were determined before and after treatment. RESULTS: The total effective rate of spontaneous angina pectoris were significantly better in the treated group than those in the control group (P < 0.005). In improving symptom of CHD were significantly better in the treated group than those in the control group (P < 0.005), and it was better the type of Qi deficiency, Blood stasis and phlegm stagnancy than type of Qi deficiency and Blood stasis in treated group (P < 0.05). TC of the treated group was lowered markedly after treatment, as compared with that before treatment, the difference was significant (P < 0.005). CONCLUSIONS: YGTY was effective for alleviating angina pectoris and improving symptom of CHD. It is best for the type of Qi deficiency, Blood stasis and phlegm stagnancy. It also has regulatory effect on the blood lipid.

Adult↗

PubMed1998

[Clinical study on Shenqi Fuzheng injection combined with chemotherapy in treating malignant tumor of digestive tract].

OBJECTIVE: To assess the clinical effect and safety of Shenqi Fuzheng Injection (SQFZI) combined with chemotherapy in treating malignant tumor of digestive tract. METHODS: One hundred and eighty-two patients were randomly divided into 3 groups, the combined therapy group (Group A), the SQFZI group (Group B) and the chemotherapy group (Group C). The remission and stabilization effect on cancer were observed. RESULTS: The remission rate and stabilizing rate of Group A were 20.2% and 87.9%, and those of the Group C were 15.6% and 68.9%, the difference between the two groups was significant, P < 0.05. The symptom and living quality improving rate of Group A were 78.8% and 42.4% separately, those of the Group B were 73.7% and 68.4% and of the Group C 37.8% and 26.7% respectively, the inter-group differences were significant, P < 0.05. The weight gain rate and effective rate of Group A were 45.5% and 90.9%, of Group C were 13.3% and 40.0%, P < 0.05. SQFZI showed good protective effect on hematopoietic system, 7.7% patients in Group A with WBC count lower than 4 x 10(9)/L after treatment, while in Group C, the percentage reached 22.2%. Moreover, SQFZI could raise activity of NK cell, macrophage and T-lymphcyte subgroups, without any injury on heart, liver and kidney function or other adverse reaction. CONCLUSION: SQFZI combined with chemotherapy has certain effect of remitting and stablizing on digestive tract tumor, the clinical effect is significant to patients with Qi-Deficiency, and is safe and reliable.

Adult↗

PubMed1991

[Prediction and prevention of hypertension syndrome of pregnancy].

Analysis of mean artery pressure (MAP-2) according to the differentiation of symptom complex of TCM can predict the occurrence of hypertension syndrome of pregnancy (HSP) at patients' first visit to hospital during their middle gestational period (less than 24 pregnant weeks). 424 pregnant women (MAP-2 greater than or equal to 12kPa) were divided into 4 groups and given preventive treatment as follows: (1) The control group, 122 women, no drugs were given; (2) the Theragan group, 102 women; (3) the TCM (A) group, 100 women, those with Liver-Kidney deficiency of Yin or no apparent signs were given Qiju Dihuang Wan, and those with Spleen-Kidney deficiency of Yang were given Shenqiwan; (4) the TCM(B) group, 100 women, were given Salvia miltiorrhiza plus (A) group's drugs. The results of prediction: (1) The occurrence rate of HSP in the MAP-2 less than 12kPa group was 10. 5%; in the MAP-2 greater than or equal to 12kPa group, 49.2%. The difference was significant. (2) The rate of deficiency of Yin in the MAP-2 greater than or equal to 12kPa was significantly higher than in the MAP-2 less than 12kPa. The rate of HSP in the deficiency of Yin was higher than in the nondeficiency of Yin. The rate of HSP increased to 70. 7% in the MAP-2 greater than or equal to 12kPa with deficiency of Yin. The results of prevention: (1) The occurrence rates of HSP in 4 groups were 49.2%, 30.4%, 15% and 14% respectively. (2) There was no side effect for mother and infant after preventive treatment. No eclampsia occurred.

Drugs, Chinese Herbal↗

PubMed2004

[Study on relationship between cellular immunity and TCM typing in patients with minimal residual leukemia].

OBJECTIVE: To analyse the correlation between the cellular immunity and TCM Syndrome typing of patients with minimal residual leukemia (MRI). METHODS: The analysis was performed by detecting cellular immunological parameters in 30 MRI patients, 55 healthy persons and 36 patients with acute leukemia (AL) using three fluoresceine-conjugated monoclonal antibodies and flow cytometer. RESULTS: As compared with those in the healthy persons, universal reductions of various parameters were shown in the MRI patients, including WBC count, absolute value of total T-lymphocytes, T-helper lymphocyte (P < 0.05) and total lymphocytes; the percentage and absolute value of NK cells (P < 0.01); and the percentages of total T-lymphocytes, CD4+ CD29+, T-suppressor cells and T-memory cells (P < 0.05 or P < 0.01), but without any rising of absolute value. As compared with those in the patients with AL, parameters were similar in the two groups with insignificant difference. The disturbances, including the lowering on ratio of T-helper/T-suppressor lymphocytes, in MRI patients of Qi-blood insufficiency type was the severest, that in the patients of Qi-Yin deficiency type was the mildest, and that in patients of Yin-deficiency with excess Fire type located between them. CONCLUSION: The immune function of MRI patients is low, belonging to the TCM Syndrome of vital energy deficiency with evil-lingering. Since the degree of cellular immune disturbance is different in various TCM Syndrome types, therefore, they should be treated with different dosages of different drugs.

Adolescent↗

PubMed2006

Establishment of a discriminant mathematical model for diagnosis of deficiency-cold syndrome using gene expression profiling.

OBJECTIVE: To screen diagnostic markers of Deficiency-Cold syndrome by gene expression profile and to establish a discriminant mathematical milliliters model for the clinical diagnosis of this syndrome based on a support vector machine (SVM). METHODS: A family suffering from Deficiency-Cold syndrome is chosen for this study. This family has 5 patients with Deficiency-Cold syndrome and 10 normal members. The peripheral blood samples for these 5 patients and 5 normal members are tested by using cDNA microarray with 18,816 clones to get their differential expression genes. These genes are further explored to understand their biological functions and pathways through existing databases. A SVM model for clinical diagnosis is then developed based on these differential expression genes. RESULTS: A total of 83 differential expression genes were identified between patients and normal members, in which 21 genes were recorded in the FATIGO database and 16 genes were related to metabolism. Eight (8) pathways were sorted out in the KEGG database, and half pathways were associated with human metabolism. A discriminant mathematical model based on a support vector machine successfully predicted a normal person and a patient with heavy Deficiency-Cold syndrome based on their gene differential expression profiles. Thus, this model may classify the Deficiency-Cold syndrome. CONCLUSION: This work demonstrates that the differential expression genes can be used to identify normal persons and patients with Deficiency-Cold syndrome. Deficiency-Cold syndrome is mainly associated with the metabolism-related gene regulations. In addition, the discriminant mathematical model based on a support vector machine is applicable to the clinical diagnosis for Deficiency-Cold syndrome.

Adolescent↗

PubMed1995

[Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation].

Sanhuang mixture (Xinmai capsule) is composed of Astragalus membranaceus, Coptis chinensis and Scutellaria baicalensis. It could inhibit platelet aggregation (PAG) induced by ADP in rats or by ADP and ADR in vivo. Patients with high PAG took Xinmai capsule for 4 weeks, the effective rate was 88.7%, which was same as the efficacy of aspirin 50 mg/day. In Syndrome Differentiation of TCM, the effective rate was the highest (92.3%) in the Syndrome of Qi Deficiency-Blood Stasis, and the lowest (72.7%) in the Syndrome of Stasis Phlegm and combined together.

Adult↗

PubMed1993

[Changes in some elements, enzymes and energy charge in skeletal muscle of rats with spleen qi deficiency].

In order to investigate the relationship between spleen and muscle, the changes of trace elements, enzyme activity, adenine nucleotides and energy charge (EC) in the skeletal muscle of rats with Syndrome of Spleen Qi Deficiency (SQD) were studied, the curative effects of Sijunzi Tang (SJZT) for SQD were observed too. Results showed that in comparing with normal rats, the levels of ATP and EC lowered significantly (ATP P < 0.01, EC P < 0.001), the enzyme activity of the anaerobic glycolysis increased significantly (P < 0.05), the zinc and iron concentrations were higher (P < 0.01) while the copper, potassium and sodium concentrations were lower than normal significantly (P < 0.05). These changes could be corrected after treatment with SJZT for strengthening spleen and tonifying qi. Above-mentioned results suggested that the mechanism of spleen qi deficiency is closely related to the abnormal energy metabolism, and the TCM theory of spleen dominating muscles might have its scientific basis.

Animals↗

PubMed1999

[Study on prevention and treatment of middle and aged women diabetes with kidney deficiency and bone metabolic disturbance].

OBJECTIVE: To Study the therapeutic effect of Chinese herbal medicine (CHM) for supplementing Qi, activating blood circulation and tonifying Kidney on prevention and treatment of middle and aged women diabetes with Kidney Deficiency and bone metabolic disturbance. METHODS: Clinical observation was taken in 52 patients, who were divided into two groups, the control group (treated with hypoglycemic agent alone) and the treated group (treated with hypoglycemic agent and CHM). RESULTS: Before treatment, patients of both groups showed obvious higher blood alkaline phosphatase, beta 2-microglobulin (beta 2-MG) level, urinary beta 2-MG, calcium and phosphorus level, but lower serum estradiol level than those in normal subjects. After 3 months' treatment, no apparent change on serum estradiol level was observed, but other parameters were all lowered obviously in the two groups, the changes revealed more obvious in the treated group. The symptoms of Kidney Deficiency, such as lumbodorsal pain, general fatigue, palpitation and vertigo, were improved after treatment, and the improvement was also more obvious in the treated group. CONCLUSION: CHM for supplementing Qi, activating blood circulation and tonifying Kidney was effective in improving Kidney Deficiency and mineral substance loss of bone in middle and aged women diabetes patients. The CHM and western drugs may acted synergistically.

Aged↗

PubMed1993

[Effect of baoyuantang on level of serum lipid peroxide and vitamin E in chronic glomerulonephritis].

Serum lipid peroxide (LPO) and vitamin E (VE) were determined in 18 patients with chronic glomerulonephritis (CGN) before and after treatment with Baoyuantang (BYT). It was found that before treatment the level of serum LPO (4.89 +/- 1.85 mumol/L) was higher, while the content of serum VE (4.27 +/- 1.84 micrograms/ml) was lower than those of normal controls (3.36 +/- 0.59 mumol/L, P < 0.001; 7.03 +/- 0.69 microgram/ml, P < 0.05). After treatment with BYT, the level of LPO lowered to 3.76 +/- 1.49 mumol/L, P < 0.05, as compared with the value before treatment, while the content of VE was increased to 5.33 +/- 2.45 micrograms/ml, but without statistical significance. A negative correlation was found between LPO level and VE content both before and after treatment (r = -0.495,P < 0.05; r = -0.522, P < 0.05). The results indicated chronic deficiency of VE in association with an increase in the level of LPO in the kidney in CGN patients and inhibition of LPO by BYT. After treatment complete remission was observed in 5 cases, basic remission in 3, and partial remission in 7.

Adult↗

PubMed2003

Clinical observation in 31 cases of chronic bronchitis at remission stage treated with bufei keli.

To observe the therapeutic effects of a Chinese drug Bufei Keli ([symbol: see text] granules for invigorating the lung) in the treatment of chronic bronchitis at remission stage, 62 cases were randomly divided into a treatment group (treated with Bufei Keli) and a control group (treated with Yupingfeng Keli [symbol: see text]). The results turned out to be that the short-term clinically controlled and markedly effective rate was 77.42% and the long-term relapse-resisting markedly effective rate was 74.2% in the treatment group, which were obviously higher than 45.16% and 38.71% respectively in the control group (P < 0.05). And the increase in contents of SOD and CD3 and the decrease in LPO content in the treatment group were also bigger than that in the control group (P < 0.01). It is therefore concluded that Bufei Keli can improve qi deficiency syndrome and raise the immunity of patients with chronic bronchitis, hence its effect of resisting relapse of chronic bronchitis.

Adjuvants, Immunologic↗

PubMed1991

[Exploring the substantial basis of the features yinxu huowang in girls with precocious puberty].

Differential diagnosis to 75 girls with true precocious puberty was made using method of TCM. It was observed that each girl had Yinxu Huowang (intense internal heat due to deficiency of vital essence) to a certain extent, these features were very remarkable in most of them. To explore the substantial basis of the features, the functions of hypothalamic-pituitary-ovarian axis were determined. The results showed that the levels of serum FSH, LH, E2 in the girls rise significantly than those in normal girls of the same age, and LHRH stimulating test displays characteristic changes of excessive activity. Treated with TCM of Ziyin Xiehuo, (nourish vital essence reducing intense internal heat) and remitted, the levels of serum FSH, LH, E2 descend significantly, the volume of uterus and ovary reduce markedly, secondary sexual characteristics retrogress evidently, while the features of intense internal heat due to deficiency of vital essence mitigate obviously. According to the above mentioned, the authors consider that the hypothalamic-pituitary-ovarian axis starting beforehand and being hyperfunction are likely to be the substantial basis of the features--that deficiency of Shen Yin, (vital essence) accompanied with intense Fire of the Vital Gate--of the girls with true precocious puberty.

Child↗

PubMed2000

[Therapeutic effect of weikangfu on gastric precancerous disorder with spleen deficiency syndrome and its effect of gastric mucosal zinc, copper, cyclic adenosine monophosphate, superoxide dismutase, lipid peroxide and 3H-TdR lymphocyte conversion test].

OBJECTIVE: To observe the clinical therapeutic effect of Weikangfu granule (WKF) on intestinal metaplasia (IM), atypical proliferation (ATP) and its therapeutic mechanism. METHODS: Sixty-one patients (treated group) were diagnosed by integrated TCM and western medicine (WM), and treated according to Syndrome Differentiation, the amount of WKF was adjusted according to various Syndromes. The control group consisted of 54 patients, took Weisu granule without considering their Syndromes. Besides, 15 healthy subjects comprised of the control group. Gastroscopy was conducted both before and after the treatment, mucosal sample was taken from antral region of stomach for pathological changes, for IM classification through histochemical staining and for determination of gastric mucosal Zn, Cu, cAMP, SOD, serum LPO and 3H-TdR lymphocyte conversion test (LCT). RESULTS: (1) The symptomatic and pathologic therapeutic effect of the treated group were markedly better than those of the control group (P < 0.05, P < 0.01). (2) The levels of gastric mucosal Zn, Cu, cAMP, SOD and 3H-TdR LCT of the treated group before treatment were all lower than that of the healthy control group, but they were markedly increased after treatment, while serum LPO, however, increased before treatment, significant difference existed between the above groups (P < 0.05, P < 0.01). CONCLUSION: WKF can reverse IM and ATP of Spleen Deficiency Syndrome through the mechanism of improving the level of gastric mucosal Zn, Cu, cAMP and SOD, promoting cytodifferentiation, improving cytoimmunity, reducing superoxide and LPO.

Adult↗

PubMed1997

A clinical study on the effect of reinforcement of kidney on senile brain functions.

In this study, Wu Zi Yan Zong ([symbol: see text] WZYZ) fluid was used as the main recipe for reinforcement of the kidney. Six weeks after the therapy, the abilities of instantaneous memory and the memory of the segments of logical story were elevated, the time of upright standing with one leg and closure of the eye was prolonged, and the hand tremor and degree of kidney deficiency were improved, but the memory width (memory in sequence and in reverse sequence of a figure) showed no significant difference in comparison with that before treatment.

Aged↗

PubMed2005

[Primary exploration on immune associated genome of patients with Pi-Qi deficiency syndrome].

OBJECTIVE: To investigate the abnormal change of immune function in patients with Pi-Qi deficiency Syndrome, and to explore the genomic mechanism of its genesis by cDNA chip techniques. METHODS: The cross probe was made by extracting and microamplifying the total RNA and mRNA of peripheral white blood cells (WBC) in healthy subjects and patients with chronic gastritis and ulcerative colitis, which were labeled by Cy3 and Cy5 respectively. Then equal quantity of the two labeled probes were mixed and hybridized with cDNA chip, fluorescent signal of the chips were scanned with scanner. Data obtained were analyzed for comparing the difference of the expressive levels of immune associated genome in peripheral WBC in healthy subjects with those in patients. RESULTS: Expressions of CD9, CD164, PF4 and RARB gene in WBC of patients, both gastritis and colitis, were down-regulated while those of IGKC, DEFA1 and GNLY were up-regulated. CONCLUSION: The genesis of Pi-Qi deficiency syndrome has its immune associated genomic basis, and the immune functions are disordered in patients with that syndrome.

Adult↗

PubMed1991

[Statistical analysis of age-related macular degeneration (AMD) in the differentiation of symptoms and signs].

Ninety-eight individuals according with entry criterion were allowed to participate in the study. Their clinical symptoms and signs were classified to seven symptoms by means of epidemiology. The results indicated syndrome of vital energy in patient group had more significant than controlled group, the others had not. In the syndrome of deficiency of vital energy, the frequency that the corpalent tongue or margin and tip of the tongue look jagged and the pulse lost its vitality emerged in the patient group surpassed significantly the controlled group. So, we initially considered that traditional Chinese medicine syndrome of AMD patient is mainly the deficiency of vital energy. The happening and development of AMD is probably related to the physique of deficiency of vital energy, it is a key point of determination of treatment with traditional chinese medicine based on differentiation of symptoms and signs.

Adult↗

PubMed1993

[Clinical study of traditional Chinese medicine susceptible factors for senile lipid metabolic disturbance].

The syndromes among 674 cadres over 45 years in age with case-control study were investigated, and the TCM susceptible factors (TCM-SF) of senile lipid metabolic disturbance (SLMD) were analysed statistically, which indicated that Kidney-Deficiency, Phlegm-Turbid and Blood-Stasis were the main TCM-SF for SLMD. Compared with the results of presenility, it indicated that the Deficiency in origin was the intrinsic factors in development of LMD in presenile and senile period. Among which, Kidney-Deficiency possibly was the main factor. It is inferred the Deficiency in origin might cause the LMD in presenile and senile stage, and develop gradually as Syndrome of Deficiency in origin and Excess in superficiality, the latter aggravate the former as well. Both of these two Syndromes in origin affected the process of lipid metabolism. The results provided the prevention and treatment of SLMD, for further exploring the pathogenic factor and pathogenesis of the disease.

Aged↗

PubMed2003

[Clinical investigation on characteristics of traditional Chinese medical syndrome of hepatocirrhosis].

OBJECTIVE: To explore the characteristics of traditional Chinese medical syndrome (TCM syndrome) of hepatocirrhosis. METHODS: Clinical information from the four diagnosis methods of traditional Chinese medicine (TCM) and related laboratorial indexes were systematically collected from 223 hepatocirrhosis cases, and the multi-statistical methods including systematic cluster analysis, principal component analysis, stepwise discrimination and variance analysis were made with the software SAS 6.11. RESULTS: Multi-analysis showed that there were 3 categories of syndrome characteristics. Type 1 (134 cases): damp heat, blood stasis, deficiency of liver and spleen Qi; Type 2 (62 cases): deficiency of both Qi and Yin with severe deficiency of Qi, heat with severe dampness, blood stasis; Type 3 (27 cases): deficiency of both Qi and Yin with severe deficiency of Yin, stasis and heat or dampness. Analysis of the changes of the related laboratorial indexes among the three types of syndrome showed that Type 1 mainly manifested asthenia syndrome with sthenia syndrome, and its indexes of AST, ALT, GGT levels were markedly higher than those of Type 2 and Type 3, both of which mainly showed sthenia syndrome with asthenia syndrome, and that Type 3 was in active inflammation, deficiency of both Qi and Yin (deficiency of Yin > deficiency of Qi), and its FN, Alb, FV, FVII, PLT, PCT levels were obviously reduced. CONCLUSION: The multi-statistical methods can reveal the characteristics and regularity of TCM syndrome of hepatocirrhosis, and the 3 categories of syndrome characteristics basically conform to clinical manifestations. The result of TCM syndrome distribution and laboratorial indexes infer that damp heat is the pathological basis of hepatocirrhosis, and the degree of liver function disorder and liver damage may be the pathological basis of deficiency of Yin of both liver and kidney.

Adult↗

PubMed2005

Relationship between bone mineral density and syndrome types described in traditional chinese medicine in chronic obstructive pulmonary disease: a preliminary clinical observation.

Osteoporosis is a common finding following chronic obstructive pulmonary disease (COPD), but there are few reports on the relationship between bone mineral density (BMD) and the syndrome types described in traditional Chinese medicine (TCM) in patients with COPD. A cross-sectional medical survey was used in this study. Twenty-six male patients with COPD and 26 age-matched male healthy subjects were recruited. The symptom questionnaire survey of TCM was implemented, and thereafter the COPD patients were divided into two subgroups: type of deficiency of the lung and spleen (TDLS) and type of deficiency of the lung, spleen and kidney (TDLSK). BMD of lumbar spine (L2-4), non-dominant femoral neck (Neck), Ward's triangle (Ward's), and great trochanter (Troch) were measured by dual-energy x-ray absorptiometry. In addition, the other bone turnover markers were also examined. The results showed that BMD was much more decreased in TDLSK than that in TDLS patients (p < 0.05), and BMD in the patients of the TDLS subgroup without symptoms of kidney-vacuity has showed the decreased trend from healthy subjects to TDLS patients. Furthermore, there was a higher incidence of osteoporosis in patients with TDLSK compared with that in TDLS (p < 0.05, OR > 2.0). Therefore, the data suggest that: (1) BMD might be a marker more sensitive than the symptom for the diagnosis of kidney-vacuity in COPD patients; (2) the deficiency of kidney would be the key factor of bone mineral loss; and (3) that invigorating the kidney should be performed in the phase of TDLS in COPD patients in advance.

Absorptiometry, Photon↗