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Medical education in the former Soviet Union.

After World War I, medical education in the Soviet Union and medical education in the United States headed in strikingly divergent directions. In keeping with the recommendations of the Flexner report, medical education in the United States became a university-based academic discipline based in the natural sciences. In contrast, the Soviet Union created a series of free-standing medical institutes whose admission, curricular, and pedagogic policies were centrally controlled in strict conformity with political doctrine. Notable features of the Soviet system were narrowly defined professional education; early specialization, beginning in the first year of medical school; and emphasis on empirical clinical training at the expense of scientifically based education. Despite the historical differences between Soviet and American medical education, there are several issues that face present-day medical educators in both the United States and the Soviet successor states. These include an overabundance of specialists, the need to provide equitable professional opportunities for physicians of both sexes, and the need to provide access to medical education for qualified candidates from underrepresented social or ethnic groups or from geographically remote regions.

Academic Medical Centers↗

Using ethnography to investigate life scientists' information needs.

Designing information resources that actually meet the information needs of individuals requires detailed knowledge of these needs. This poses a challenge for developers. Because the meaning of particular terms can vary by field, professional knowledge differs to some extent in different disciplines, and the questions that people ask assume a certain amount of unarticulated background knowledge, understanding the information needs of life scientists is not a trivial undertaking. One source of help in meeting this challenge is ethnography, a set of research methods and an associated conceptual stance developed and used by anthropologists for investigating uncontrolled real-world settings. Drawing on the author's experience in using ethnographic techniques to study clinicians' information needs, this paper describes why such research is necessary, why it requires particular research methods, what an ethnographic perspective has added to the study of information needs, and what this broader approach has revealed about the types of information sought by clinicians in the course of their daily practice.

Anthropology, Cultural↗

Using a database to analyze core basic science content in a problem-based curriculum.

As medical schools critically reevaluate their methods of instruction and as the number of innovative programs increases, the content delivered across disciplines must be carefully reviewed. However, few methods of content analysis have been applied to problem-based programs. In 1989-90 and 1990-91, the authors analyzed the distribution of basic science content in the 53 cases in the problem-based curriculum of Rush Medical College of Rush University. They developed a content vocabulary and created a database using a widely available computer software program. The content areas specific to each case were identified by faculty using the content vocabulary. To determine whether these content areas were actually identified by the students participating in the problem-solving sessions, the authors surveyed the 36 student participants in the classes of 1993 and 1994 and also interviewed the 15 faculty facilitators of the sessions. The surveys and interviews demonstrated that over 90% of the content areas identified by the faculty were actually covered by the students. The authors conclude that the database assists in their review of the curriculum for omission and redundancy. Other uses and limitations of this method are also discussed.

Biological Science Disciplines↗

Graduate education in the biomedical sciences: critical observations on training for research careers.

Several aspects of the processes for the pre- and postdoctoral training of PhDs and the postdoctoral research training of MDs are critically examined. The size of the predoctoral pipeline, the sources of support for the students in it, trends in the annual production of bioscience PhDs, and prospects for growth in opportunities, as defined in increases in availability of public and private funds for research, are catalogued. Evidence for the existence of a surplus of research scientists--based on the size and growth of the pool of postdoctorals, the success rates now being experienced by young postdoctorals in competing for National Institutes of Health (NIH) grants, and the success of young postdoctorals in securing career employment--is evaluated, and the conclusion that the nation is producing too many research scientists is suggested. The pros and cons of "downregulating" the production of scientists are explored, the difficulties of reaching a national consensus on the degree of reduction and the partition of reduction among fields of science and academic institutions and academic departments are described, and the mechanisms conceivably available for accomplishing the task--reducing NIH training funds, autoregulation by academic institutions and/or scientific disciplines, and reliance on the decisions of well-informed (probably by the National Academy of Sciences) degree candidates--are enumerated; a preference for the last of these mechanisms is indicated. The NIH's formal training programs are compared with its informal support of training under research grants; questions that the latter practice raises are identified. The striking disparity between the duration of training for conventional predoctoral PhD candidates and that for dual-degree (MD-PhD) aspirants is noted. The measurement problems of assessing the duration of postdoctoral training are highlighted. The fact that dual-degree scientists seem to compete little, if any, more successfully for the great bulk of NIH research grants than do singly-degreed MDs or PhDs is noted, suggesting the advisability of a fresh and objective review of these dual-degree programs, especially the NIH's Medical Scientist Training Program, to reassess their value in the light of their cost. Some characteristics of careers in the biomedical sciences are outlined. Data are presented on the high turnover rates of first-time-ever entrants into the pool of NIH grantees or, stated otherwise, the relatively low rates of survival of principal investigators (PIs) in the NIH research grant system; a method of estimating the steady-state number of NIH ex- PIs "around" at any given moment is proposed.(ABSTRACT TRUNCATED AT 400 WORDS)

Biological Science Disciplines↗

Looking a gift horse in the mouth: corporate gifts supporting life sciences research.

CONTEXT: Throughout the last decade a number of studies have been conducted to examine academic-industry research relationships. However, to our knowledge, no studies to date have empirically examined academic scientists' experience with research-related gifts from companies. OBJECTIVE: To examine the frequency, importance, and potential implications of research-related gifts from companies to academic life scientists. DESIGN: A mailed survey conducted in 1994 and 1995 of 3394 faculty who conduct life science research at the 50 universities that received the most research funding from the National Institutes of Health in 1993. SETTING: Research-intensive universities. PARTICIPANTS: A total of 2167 of the 3394 faculty responded to the survey (response rate, 64%). MAIN OUTCOME MEASURES: The percentage of faculty who received a research-related gift from a company in the last 3 years, the perceived importance of gifts to respondents' research, and what, if anything, the recipient thought the donor(s) expected in return for the gift. RESULTS: Forty-three percent of respondents received a research-related gift in the last 3 years independent of a grant or contract. The most frequently received gifts were biomaterials (24%), discretionary funds (15%), research equipment and trips to meetings (11% each), support for students (9%), and other research-related gifts (3%). Of those who received a gift, 66% reported the gift was important to their research. More than half of the recipients reported that donors expected the following in return for the gift: acknowledgment in publications (63%), that the gift not be passed on to a third party (60%), and that the gift be used only for the agreed-on purposes (59%). A total of 32% of recipients reported that the donor wanted prepublication review of any articles or reports stemming from the use of the gift, 30% indicated the company expected testing of their products, and 19% indicated that a donor expected ownership of all patentable results from the research in which a gift was used. However, what recipients thought donors expected differed by the type of gift received. CONCLUSIONS: Research-related gifts are a common and important form of research support for academic life scientists. However, recipients frequently think that donors place restrictions and expect returns that may be problematic for recipients as well as institutions.

Academic Medical Centers↗

Enlivening basic-science learning with current journal articles.

Pre-clinical medical students are often unconvinced that the basic sciences are clinically valuable. Also, they are hesitant about formulating ideas on their own from non-textbook sources. First-year medical students taking histology or neurobiology were persuaded to consult articles from the current biomedical literature. I set brief short-answer and labeled-sketch questions well before the course theoretical examinations, where the answers counted toward the score. The answers could only be found by reading in articles made available in the laboratory. The articles were chosen to display basic-science knowledge in action in clinical contexts. The questions offer an additional curriculum that can be steered toward, for example, concerns of family practice, mechanisms of common diseases, and topics of fast-increasing clinical importance.

Biological Science Disciplines↗

Cancer risk in laboratory workers: an emphasis on biological research.

BACKGROUND: At the end of the 1980s, several cancer clusters were observed in biological research laboratories. Over time, biological research and the technologies used have been diverse and have involved a wide range of mutagenic or carcinogenic chemical, physical and biological agents. METHODS: We reviewed 45 published studies on cancer risk among biological research personnel and workers in closely related fields, and numerous reports based on routinely collected data. RESULTS: Biological research could be associated with an elevated risk for pancreatic cancer, brain tumors, and certain hemopathies. A common limitation of available studies was low statistical power and the absence or inaccuracy of data on individual past exposure. CONCLUSIONS: Overall, this study suggests a low overall risk of cancer, albeit a higher risk may be suggested for cancers of the pancreas (risk ratios ranging from 0.5 to 6.3) and brain (0.7-9.4), and for non-Hodgkin's lymphoma (0.6-51.5). We suggest ways in which multiple past exposures could be assessed more precisely and emphasize a pressing need to take into account known confounders.

Biological Science Disciplines↗

Avoiding the postdoctoral glut: an alternative route to a career in academia.

Dramatic increases in the number of PhDs granted during the last several decades have not been balanced by comparable increases in the number of academic positions, producing a glut of postdoctoral fellows. One major reason for the burgeoning numbers of postdoctoral fellows is a widespread perception that there is no alternative route to a career in academia other than through gaining expertise in bench research. This paper suggests that considerable numbers of postdoctoral fellows who are interested in securing a tenure-track position at a major medical or research university should consider directing their postgraduate training toward teaching. Teaching at universities is becoming a specialized field partly because researchers are unable to keep up with the explosion of information, new instructional theories, methodologies, and technology. Thus, some individuals who are currently in a postdoctoral holding pattern could use those years to increase their teaching competence. Such an "educational" postdoctoral position may offer a faster route to a career in academia as universities continue to recognize the need for teaching specialists.

Biological Science Disciplines↗

Intellectual property conundrum for the biological sciences.

Policy regarding academically generated biomedical intellectual property (IP) has been shaped by two important events: the Vannevar Bush report to then President Roosevelt in 1945 and the Bayh-Dole Act of 1980. This policy, which vests the intellectual property produced from federally funded biomedical research from the government to the academic institution, was designed to promote technology transfer and thus promote the health of the U.S. economy. However, the policy has led to significant challenges, particularly in implementation. Here it is argued that the difficulties are due to differences in the structure of motivations between biomedical scientists, institutional officials, and private sector entrepreneurs. Understanding these differences may lead to a review of policy with the goal of enhancing technology transfer for the future.

Biological Science Disciplines↗

From genes to therapeutics: educating the government and the public on biomedical sciences-a Singapore experience.

Singapore has a highly developed economy and has been recognized to have one of the best business environments in Asia. Her success is based largely on focused developments of key industries in traded services and manufacturing sectors. The challenge for Singapore is to utilize her small human resource to transform the present economy to a more knowledge-intensive economy. Singapore has recently embarked on the ambitious goal of developing Biomedical Sciences as an industry. Educating the government and the public on various aspects of this new industry was identified as one of the essential steps towards this goal. The challenge was to inspire non-biologists to embrace the life sciences. This review describes how a series of workshops were developed to address the needs and the challenges of educating the public and the government.

Biological Science Disciplines↗

Raman spectroscopy--a prospective tool in the life sciences.

Although the physics of Raman spectroscopy and its application to purely chemical problems is long established, it offers a noninvasive, nondestructive, and water-insensitive probe to problems in the life sciences. Starting from the principles of Raman spectroscopy, its advantages, and methods for signal enhancement, the bulk of the review highlights recent applications. Structural investigations of a hormone receptor, testing the biocompatibility of dental implants, probing soil components and plant tissue alkaloids, and localization of single bacteria are just four problems in which Raman spectroscopy offers a solution or complements existing methods.

Animals↗

Conducting biological research to advance rehabilitation nursing practice.

Rehabilitation nursing practice is concerned with many clinical manifestations that have an underlying biological impairment. Advances in managing these manifestations will depend in part on research that incorporates the biological dimension. The purpose of this article is to encourage more rehabilitation nurses to engage in biological research. To achieve this aim, several different categories of biological nursing research are described using rehabilitation nursing examples, biological measures and approaches are discussed, and possible general clinical outcomes, with examples from previously published biological nursing research, are described. Biological nursing research may enhance professional competence, improve patient care, and improve patient safety.

Biological Science Disciplines↗

Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology.

Analytical characteristics of DESI are summarized. Examples of applications to small and large molecules, to in situ analysis, and to high-throughput analyses are presented. Evidence is provided for both a heterogeneous charge-transfer mechanism and a droplet pick-up mechanism of ionization. The speed, lack of the need for sample preparation, selectivity, and sensitivity of DESI are all demonstrated and discussed. Instrumentation is also discussed. Forensic applications as well as emerging areas of application including tissue imaging are given emphasis.

Animals↗