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At least 217 records · Page 12Linked to original sources
PubMed1984

"Ultrasensitive" silver stains: their use exemplified in the study of normal human cerebrospinal fluid proteins separated by two-dimensional electrophoresis.

We have developed a series of photochemical silver stains that are more than 100 times as sensitive as the Coomassie Blue stains. These stains facilitate the quantitative estimation of proteins in two-dimensional gel patterns. Recently, we discovered that by using light (photodevelopment) to catalyze the reduction of ionic silver to metallic silver, we could produce an image of proteins on polyacrylamide gels within 10 min after their electrophoretic separation. We used these stains to detect proteins resolved in two-dimensional electrophoretograms of lumbar cerebrospinal fluid from 51 normal human volunteers, finding no qualitative protein changes in the more than 300 CSF polypeptides resolved on each individual's electrophoretogram. We quantified 67 of these proteins per individual with computer-assisted densitometry, only five of which showed significant quantitative age-related alterations. We saw no sex-related differences. This consistency in the protein pattern for cerebrospinal fluid from normal individuals allows it to serve as a baseline for comparisons with disease states.

Adult↗
PubMed1970

Alterations in lumbar cerebrospinal fluid protein during air encephalography.

A significant fall occurred in the protein content of successive specimens of lumbar cerebrospinal fluid (C.S.F.) withdrawn during the course of air encephalography in 57% of cases. No correlation was found between the fall in the protein concentration and the total volume of air injected or the total volume of C.S.F. withdrawn, but the size of the fall was greater when the initial lumbar C.S.F. protein concentration was raised. The importance of taking specimens for routine laboratory analysis before the injection of any air is emphasized.

Adolescent↗
PubMed1992

Goldfish ependymins: cerebrospinal fluid proteins of meningeal origin.

Ependymins are unique secretory proteins from the goldfish brain which have calcium binding capacity. They are synthesized in the leptomeninx and appear subsequently as the predominant protein constituents in the cerebrospinal fluid (CSF). In contrast, the serum is nearly devoid of ependymins. The perimeningeal fluid (PMF) between the meninx and the skull represents a mixture of CSF and serum. The different composition of PMF and CSF implies that there is no open communication between these two compartments. Separation is probably achieved by an arachnoid-like meningeal barrier as proposed from ultrastructural studies. This basic CSF system of fish is compared with that of higher vertebrates.

Animals↗