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Results for “DIGITALIS GLYCOSIDES”

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At least 217 records · Page 12Linked to original sources
PubMed1980

Review of the use of digitalis glycosides in ventricular dysrhythmia.

The present publication reviews actual knowledge of the electrophysiological properties of low doses of digitalis in perspective of its use in patients with ventricular dysrhythmia. Both animal experiments and observations in humans have demonstrated that increased adrenergic and decreased cholinergic tone predispose to ventricular arrhythmia. An increased cholinergic tone on the other hand has been shown to protect against increased ventricular vulnerability, especially in situations of increased adrenergic tone. Therefore the combination of the cholinergic and anti-adrenergic actions of digitalis may help to control situations of increased ventricular vulnerability. This principle is especially attractive because digitalis, in contrast to classical anti-arrhythmics is devoid of any cardiodepressive effects. The clinical experience with digitalis in ventricular dysrhythmia as documented by the group of Lown is discussed in detail. The studies presently available do not yet allow digitalis to be accepted as a drug of first choice in this indication, but its careful use is not longer to be rejected for patients with non-digitalis induced ventricular dysrhythmia.

Arrhythmias, Cardiac↗
PubMed1994

[Role of digitalis glycosides in the treatment of cardiac failure].

While no doubt has ever been cast on the usefulness of digitalis in cardiac failure with atrial fibrillation and a fast ventricular rate, they are periodically brought into question regarding chronic cardiac failure in sinus rhythm. While they have not been supplanted by new positive inotropic agents, they are in competition with converting enzyme inhibitors. Recent therapeutic trials have shown that digitalis preparations, alone or in association with converting enzyme inhibitors, have beneficial effects on symptoms and exercise duration in patients with symptomatic impaired left ventricular systolic function. While the effects of digitalis preparations on mortality remain unknown, a large North American study should soon provide an answer to this question.

Chronic Disease↗