[LH-excretion in healthy omen and in patients with gynecologic-endocrine diseases].
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Cardiovascular bioactive peptides constitute life activity of human beings. They play important roles in regulating the development of cardiovascular system, and controlling disease progression. Recently, interests have arised on the adjusting effects of cardiovascular bioactive peptides on endocrine metabolism, its changes during disease course, influence on disease pathogenesis, as well as its effects on the diagnosis, treatment, and early interventions. New advances have been increasingly achieved in basic and clinical researches. It has become one of the most active areas in life sciences.
The surgical diagnosis and treatment of endocrine tumors is individually described in each session of this journal. I will described the recent topics of endocrine surgery. In thyroid, ultrasonography has developed rapidly, and increases the diagnostic ability of thyroid and parathyroid tumors enable minimally invasive thyroidectomy and parathyroidectomy. Unfortunately, recombinant human TSH and 131I high dose therapy are not widely used in Japan. In hyperparathyroidism, whole PTHH assay is currently available. Intraoperative quick whole PTH assay is essential for direct mini-incision parathyroidectomy. Although MIBI scintigraphy is useful to detect parathyroid tumors, but this use is not approved by the government. Somatoscintigraphy is promising method to detect neuroendocrine tumors. Differential diagnosis of Cushing syndrome and Preclinical Cushing syndrome have been clearly. Adrenal venous sampling by fine catheter is useful to detect micro mass of primary aldosteronism.
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The discovery of specific behavioral effects of several neuropeptides and the expanded appreciation of a wide range of endocrine disturbances in depressive illness have recently renewed interest in the nature of the relationship between mood and endocrine changes. Major depressive disorders are a major and life-threatening complication of Cushing's syndrome, Addison's disease, hyperthyroidism, hypothyroidism and hyperprolactinemic amenorrhea. A treatment primarily directed to the physical condition may be more effective than antidepressant drugs in such organic affective syndromes. The influence of hormonal disturbances in the development of depression in Conn's disease, pheochromocytoma, parathyroid disturbances, SIADH, acromegaly, hirsutism and other endocrine diseases should be individually evaluated. Antidepressant drugs remain the most specific and readily available treatment of major depressive disorders in the setting of endocrine illness.