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At least 217 records · Page 12Linked to original sources
PubMed1978

Receptivity of female rats.

Receptivity of female rats has been investigated under chronic experimental conditions. A receptivity index has been worked out for quantitative evaluation. It proved suitable for disclosing stimulatory (2.5 mg noretynodrel, oestradiol propionate) as well as inhibitory (etynodiol diacetate) effects. 2.5 mg noretynodrel has a biphasic effect; causing an inhibition and later an increase in receptivity. Receptivity of untreated female rats is low and can be increased by various steroids; the best treatment was 50 micrograms oestradiol monopropionate administered twice weekly, but this resulted in an inverse mating reaction, with frequent copulations in every phase of the cycle. In untreated females the number of copulations varied widely. Previous deliveries did not influence receptivity and frigidity was also observed.

Animals↗
PubMed1983

The effect of oral contraceptive therapy and of pregnancy on serum folate levels of rural Sri Lankan women.

Serum folate level, packed cell volume and haemoglobin concentration of apparently healthy rural Sri Lankan women, between 20 and 45 years and earning up to Rs. 500 (Sri Lankan Rs. 35 congruent to 1 pound Sterling) per month, were estimated during pregnancy and when on oral contraceptive (OC) treatment with Ovulen 50 (ethinyl oestradiol 0.05 mg, ethinodiol diacetate 1 mg). Ovulen 50 administration led to a fall in serum folate levels which occurred very rapidly during the first 6 months and more slowly thereafter, stabilizing at 2.2 ng/ml in women of very low economic status and at 2.9 ng/ml in the more privileged. There was a steady fall in serum folate concentrations during pregnancy, the levels at the end of pregnancy being higher than those in women under OC treatment for 9 months. The need for folate supplementation during OC treatment is stressed.

Adult↗
PubMed1975

[Estroprogestational drugs and the ultimate embyogenesis in the rat].

Cyclic female rats were fed with ethinodiol diacetate plus mestranol (EDM) for periods of 45 to 180 days. They were mated during prooestrus, on the first cycle following the end of the treatment. Results were as follows: 1. The cycle is blocked about eight days after starting E.D.M. The longer the treatment, the later rats resume their cycle. 2. Degeneration of the ova before implantation and embryonic mortality are slightly augmented when fecundation takes place within two days after stopping E.D.M.; whereas from the third cycle on, the quality of th ova is identical to the control group. The ova are euploid; they are more fragile to hypotonic shock than the ova of the control animals. No influence of E.D.M. upon meiotic or mitotic processes could be demonstrated. Those experiments do no allow any inference to the human species, but they are inkeeping with the observations of Boué et al. on women.

Animals↗
PubMedDate not supplied

Hepatocellular carcinoma in women: probable lack of etiologic association with oral contraceptive steroids.

To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as "fibrolamellar" carcinoma. This subtype of HCC occurs predominantly in young people, both male and female. The apparent increase in HCC in young women can be explained by the presence of cases of fibrolamellar carcinoma in this age group, an the apparent association with CS is probably coincidental.

Adult↗
PubMed1980

Maternal hormone therapy and congenital heart disease.

Exogenous female sex hormone exposure was studied in the mothers of 110 infants with conotruncal malformations of the heart, born in the years 1972-75. Cases were ascertained throughout the referral area of the Maryland State Intensive Care Neonatal Program. For each case, three normal controls were chosen from the birth population: Two matched on eight characteristics related to the likelihood of hormone-taking (race, maternal age, parity, fetal losses, gestational age, delivery mode, time of prenatal registration, private/service), and one also on the infant's sex and birthweight; the third control was chosen at random. In personal interviews, information was obtained on the mother's general health, family history, reproductive characteristics, pregnancy health, and environmental exposures. Identification of hormonal products was aided by a display of pills and packages. Maternal recall was examined in comparison to the responses of a group of mothers of infants with hypoplastic left heart ("disease controls"). Regression analysis on time elapsed since the infant's birth revealed no difference in recall between the mothers of cases and of controls. Multilogistic regression analysis, controlling for confounding variables and for scores constructed for reproductive, malformation, and exposure risks, showed no increase in relative risk for cases when compared with matched controls. When compared to random controls, the analysis suggested a possible increase in relative risk with increased environmental exposure scores; components of the risk score were excess smoking and alcohol intake, exposure to X-ray, drugs, paints, insecticides, and chemicals. The possible significance of this finding needs to be further investigated.

Abortion, Threatened↗