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PubMed1982

Granuloma annulare with follicular perforation.

An instance of perforating granuloma annulare was observed in a 42-year-old female patient in which the necrobiotic material in the dermis was eliminated by a hair follicle. This had previously been described by the author in only 1 other case of perforating granuloma annulare. Transepithelial elimination may occur by the transepidermal and/or transfollicular route. Both pathways are possible in perforating granuloma annulare. Some factors are discussed which may be responsible for the predominance of one route over the other in various disorders of transepithelial elimination.

Adult↗
PubMed1980

Elastosis perforans serpiginosa.

Elastosis perforans serpiginosa (EPS) is a cutaneous connective tissue disorder featuring transepidermal elimination of altered elastic tissue. Morphologically and histologically EPS presents characteristic patterns; the case reported herein classically illustrates these patterns. In approximately one-fourth of reported cases, EPS has been associated with systemic connective tissue disorders and may thus be a useful clue in the early recognition of diseases such as Down's syndrome or pseudoxanthoma elasticum.

Adolescent↗
PubMed2002

[Pathogenetic basis for using prodectin and teonicol, redergin and aescuzan in complex treatment of chronic gastritis].

The study of the microvessels in bioptates of gastric mucosa and micro haemocirculation in the conjunctiva of 254 patients with chronic gastritis revealed that exacerbation of the gastric process is going on the background of hard terminal bloodstream disorders. They have the generalized character and picture of the typical chronic relapsing trombohaemorrhagic syndrome. The use of Prodectin (250 mg), Teonicolum (150 mg), Redergin (1 tab.) and Aescuzan (25 dr.) 4 times per day during 3 weeks helps to eliminate the microcirculatory disorders and exacerbation of the chronic gastritis.

Drug Therapy, Combination↗
PubMed2004

Structure and dynamics of neutral beta-H agostic nickel alkyls: a combined experimental and theoretical study.

Addition of BF(3).OEt(2) to ethereal solutions of the Ni(II) beta-diketiminates [Me(2)NN]Ni(R)(2,4-lutidine) (R = Et (1), Pr (2)) allows the isolation of the neutral beta-H agostic monoalkyls [Me(2)NN]Ni(R) (R = Et (3), Pr (4)). X-ray studies of primary alkyls 3 and 4a reveal acute Ni-C(alpha)-C(beta) angles with short Ni-C(beta) distances, indicating structures along the beta-H elimination pathway. Positional disorder of the alkyl group in the X-ray structure of 4 corresponds to partial (22%) occupancy by the secondary alkyl [Me(2)NN]Ni(CHMe(2)) (4b). Variable-temperature NMR spectra of 3 and 4 reveal fluxional behavior that result from beta-H elimination, in-plane rotation of the beta-CH(3) group, and a tetrahedral triplet structure for 3 that were investigated by density functional theory calculations at the Becke3LYP/6-31G level of theory without simplifications on the beta-diketiminate ancillary ligand. Calculations support low temperature NMR studies that identify the linear beta-H agostic propyl isomer 4a as the ground state with the branched beta-H agostic isomer 4b slightly higher in energy. NMR studies and calculations show that the beta-agostic 3 reluctantly coordinates ethene and that 3 is the ground state for this ethylene oligomerization catalyst. The thermodynamic isotope effect K(H)/K(D) = 1.3(2) measured for the loss of 2,4-lutidine from 1 to form beta-agostic 3 was also examined by DFT calculations.

Journal Article↗
PubMedDate not supplied

[The role of antioxidant defense system in the development of glycemic disorders in patients with lung tuberculosis].

The development of different carbohydrate metabolism disorders in patients with lung tuberculosis occurs against a background of significant derangements in oxidation-reduction system, caused by hypoxia and intoxication. The classical antituberculosis treatment within 2 months doesn't succeed in normalization of functional activity of enzymes of the antioxidant defense system and doesn't eliminate carbohydrate metabolism disorders.

Antioxidants↗
PubMed2002

Sleep and long-term ventilation.

The development of sleep-disordered breathing is common in patients with chronic respiratory insufficiency due to neuromuscular and restrictive disorders, as well as in those with COPD. Nocturnal hypoventilation and obstructive and central apneas result in daytime symptoms of hypersomnolence and fatigue, and contribute to abnormalities in awake gas exchange. Long-term mechanical ventilation, delivered invasively by tracheostomy or more recently by NPPV, has been shown to eliminate sleep-disordered breathing and correct abnormalities in nocturnal gas exchange, resulting in an improvement in sleep quality. Improved daytime symptoms and gas exchange, with the suggestion of a decrease in morbidity and mortality, support the use of long-term mechanical ventilation during sleep in selected patients with these disorders.

Female↗
PubMed1999

Angulate lysosomes in skin biopsies of patients with degenerative neurological disorders: high frequency in neuronal ceroid lipofuscinosis.

Angulate lysosomes with intralysosomal trilamellar structures were first described in patients with metabolic peroxisomal disorders. In this ultrastructural study of skin biopsies of 139 patients with degenerative neurological disorders and 45 patients with static encephalopathies, we observed angulate lysosomes with similar ultrastructure exclusively in degenerative neurological disorders. They were found in only a few cases (8%), but especially in patients with degenerative metabolic disorders (72%). Because they were never observed in patients with static encephalopathies, angulate lysosomes in the skin would seem to be a sign of progressive encephalopathy. The great majority (75%) of angulate lysosomes were associated with neuronal ceroid-lipofuscinosis (NCL). Their presence in skin biopsy could suggest the diagnosis of NCL and eliminate a peroxisomal disorder. In the latter pathology, angulate lysosomes, numerous in the liver and in the brain, were never observed in the skin. As described in pigmentary retinopathy, a conspicuous feature of NCL, we suggest that in this lysosomal storage disorder, the angulate lysosomes in skin biopsies could result from the phagocytosis of melanin.

Age of Onset↗
PubMed2004

[Trends of mental and somatic diseases during therapy of endemic goiter].

The trend of mental and somatic diseases was studied in 70 patients with epidemic goiter (EG) treated with L-thyroxine or iodides during 1-5-year follow-up. Borderline mental disorders (diminished memory and attention, emotional and intellectual disorders) were found to be stable in these patients. The most delicate functions of the brain, such as the capacity for analysis and synthesis, are particularly vulnerable. Irrespective of the age of a patient, his/her educational level, occupation, the size of goiter, concrete rather than abstract logic thinking are prevalent in patients with EG. Drug treatment of EG only improves the patients' health status, but fails to eliminate evolving mental disorders even if the sizes of the thyroid can be brought to the normal values, the use of L-thyroxine is more effective that that of iodides.

Adaptation, Psychological↗
PubMed2006

[Viral infection and myocardial pathology].

A viral infection is the most frequent cause of myocarditis. A viral invasion and viral-mediated cardiomyocyte lesion stimulate an immune system response directed towards the elimination of viral particles, the destruction of infected myocytes, and the limitation of viral dissemination. Numerous studies have shown that the balance of two subpopulations of CD4+ lymphocytes (T-helpers types 1 and 2) determines the character of the immune response in myocarditis, and that this balance is important at the initial stages of immunization, while the cytotoxic CD8+ lymphocytes participate in the myocardial lesion directly. Disorder in the elimination of activated lymphocytes' clones, the degree of which correlates with the degree of cardiac insufficiency, may be one of the mechanisms of myocarditis progression. Disbalance or defects in the system of the regulatory cytokine network also may lead to the activation of potentially autoreactive T-lymphocytes. A connection between viral myocarditis and dilated cardiomyopathy (DCMP) has been discussed for many years. One of the reasons for DCMP development is a viral invasion into the myocardium. Proteinase A, which induces dystrophin proteolysis, which impedes its function, is an ingredient of enteroviruses. Hence, a viral infection may cause two myocardial diseases: viral (infective-and-immune) myocarditis and DCMP.

Acute Disease↗
PubMed2002

[Favourable effect of a standard elimination diet on the behavior of young children with attention deficit hyperactivity disorder (ADHD): a pilot study].

OBJECTIVE: To determine whether a standard elimination diet can decrease the ADHD-symptoms in a heterogeneous group of young children with ADHD. DESIGN: Open, descriptive. METHOD: 40 children, 36 boys and 4 girls, aged 3-7 (average 4.8 years), who met the DSM-IV-criteria for ADHD, followed their usual diet for two weeks and thereafter for two weeks an elimination diet, based on the few foods diet (rice, turkey, pear and lettuce). The behaviour of the child was evaluated at study entry, after the baseline period and at the end of the diet. Parents completed the 10-item Conners list, the ADHD Rating Scale and a physical complaints list. The teachers completed the 10-item Conners list and the ADHD Rating Scale twice, at the beginning and at the end of the diet. RESULTS: According to the parent-ratings, 25 children (62%) showed an improvement in behaviour of at least 50% on both the Conners list and the ADHD Rating Scale at the end of the elimination diet. Nine children (23%) withdrew from the study because the parents were unable to stick to the diet or because the child fell ill. Among the 15 children with both parent and teacher ratings, 10 responded both at home and in school. CONCLUSION: In young children with ADHD an elimination diet can lead to a statistically significant decrease in symptoms.

Attention Deficit Disorder with Hyperactivity↗
PubMed1994

The dental impact of eating disorders.

Our self-perceptions are all influenced to some extent by the media. The increase in sales of diet plans immediately after Christmas only serves to highlight the fact that many people (consciously or subconsciously) are aware of the effect that advertisements have on our lives. The weight of most people is controlled by a combination of diet and homoeostatic control and remains relatively constant, but weight loss has a more profound and sinister effect for others. Unexplained dental erosion can occasionally be found during dental examinations and, despite careful questioning, a definitive diagnosis may prove elusive. In these patients, once the more common causes of dental erosion have been eliminated, the eating disorders should be considered. In this paper, the effects of psychological conditions affecting the diet on the dentition will be discussed.

Anorexia Nervosa↗
PubMed1998

Aortic valve disease in Marfan syndrome.

The Marfan syndrome patient undergoes care by many different physicians for the treatment of the varied systems affected by this connective tissue disorder. The most frequent visits are to a cardiologist, with referral to a cardiovascular surgeon who attends to the problems of dilatation and dissection of the ascending aorta. Follow-up is lifelong. Although currently some surgeons prefer to resuspend rather than replace the aortic valve, composite valve graft replacement for aortic root dilatation and aortic valve insufficiency has steadily improved patient outcome. At the same time, the almost daily discoveries of genetic science show great promise in eliminating connective tissue disorders such as Marfan syndrome in the not-too-distant future.

Aortic Valve↗
PubMed2001

Endemic goiter and cretinism: an update on iodine status.

Iodine deficiency is the most prevalent correctable cause of brain damage in the world. Over the past 15 years, great progress has been made towards the elimination of iodine deficiency, principally through universal salt iodization. Much more needs to be done for countries that are lagging in the effort or that have weak systems for sustaining it. The key to maintaining optimal iodine intake is regular monitoring, usually by the measurement of urinary iodine concentration, linked to a prompt response in the event of abnormal results. If the present momentum continues then global iodine sufficiency is possible and, in a landmark achievement, iodine deficiency will be the first major non-infectious disorder to be eliminated.

Congenital Hypothyroidism↗
PubMed2003

Effect of carotid operations on regression of motor disorders in patients with a history of ischemic stroke.

This paper is concerned with an evaluation of the clinical effect of reconstructions on the brachiocephalic vessels in patients who suffered ischemic stroke. Altogether 143 patients with the above pathology were operated on. Of these, mild hemiparesis was present in 72 patients, moderate hemiparesis in 49, and severe hemiparesis was recognized in 17 subjects. The postoperative lethality accounted for 1.4% (2 subjects). Intraoperative development of repeated stroke was ascertained in three more subjects. The follow up of the operated patients lasted from three months to two years. In the postoperative period, a study was made of the time course of changes in motor pyramidal deficit. The study allowed the conclusion to be drawn that reconstructions on the brachiocephalic vessels are not only of preventive importance but also favour the elimination of motor disorders in patients who suffered ischemic stroke.

Brachiocephalic Trunk↗
PubMed2005

[Thinking and challenge induced by the hypothesis of breaking stagnant and eliminating blood stasis in Treating acute cerebral hemorrhage by rF VII a].

Definite therapeutic effect has obtained by TCM in treating acute cerebral hemorrhage (ACH) according the TCM theory of "blood circulating outside the vessels is the stasis" using breaking stagnant and eliminating blood stasis (Poxue Zhuyu) method, but no material involving the natural development of stoke in superacue stage (0 - 4 hrs after onset of the disease) being presented so far. It has been proved by randomized, double-blinded multi-centeric clinical trials that recombinant activated factor VII (rF VII a) could decreased the morbidity and disability of patients suffered from ACH, suggesting that use hemostasis treatment in ACH during superacu stage should be stressed, and the drugs for Poxue Zhuyu should be used cautiously in the period of 0 - 4 hrs after onset. The hemorrhagic disorder could be eliminated by using drugs for Poxue Zhuyu and other medicines in rational combination.

Cerebral Hemorrhage↗
PubMed1998

Disorders associated with clinically severe obesity: significant improvement after surgical weight reduction.

BACKGROUND: Surgical treatment for patients with clinically severe obesity mainly aims to reduce morbidity. METHODS: Sixty-two patients were examined for disorders associated with morbid obesity before and after surgical weight reduction by vertical banded gastroplasty. All patients were followed-up for 12 to 48 months. RESULTS: At the end of the first postoperative year, 84% of the patients had lost at least 50% of their excess weight. Of the 218 weight-related pathologic conditions existing before the operation, 131 (60%) were completely cured, 50 (23%) showed significant improvement, and only 37 (17%) remained unchanged. The same percentages were obtained for patients followed tip for 24, 36, and 48 postoperative months. CONCLUSIONS: Surgical treatment of clinically severe obesity has a significant effect on the health of the patients by eliminating the associated disorders.

Adult↗
PubMed2005

The almond milk: a new approach to the management of cow-milk allergy/intolerance in infants.

AIM: Elimination of the offending food is imperative in the management of children with cow-milk allergy/intolerance (CMA/CMI). Herein we report the result of randomized clinical trial carried out to test the efficacy and safety of a new almond-based food (hereinafter named almond milk) in a group of infant with CMI/CMA. METHODS: A group of 52 infants aged 5 to 9 months and with documented CMI/CMA was enrolled and randomized to: almond milk (Group A, n=26); soy-based formula (Group B, n=13); protein hydrolysate-based formula (n=13). The main efficacy outcomes were the improvement in clinical symptoms and the decrease in serum levels of soluble CD30 (a potential marker for atopic disorders; sCD30). RESULTS: Elimination of the offending food and supplementation with a milk protein-free formula produced a considerable improvement of clinical manifestations within 5-12 days in all cases examined (at the onset of the study: 26.4+/-5.4 U/mL and 7.9+/-5.2 U/mL in IgE+ and IgE- infants respectively, after 6 months of supplementation: 16.6+/-4.8 U/mL and 7.1+/-4.5 U/mL in IgE+ and IgE- infants respectively). No difference in growth rate (increment of weight, length and head circumference) was found, during the entire study, between infants given the almond milk and babies given the soy-based formula or the protein hydrolysate-based formula. Supplementation with the soy-based and protein hydrolysate-based formulas caused the development, in some subjects, of a secondary sensitization (23% to soy-based and 15% protein hydrolysate-based formula), whereas supplementation with the almond milk did not. CONCLUSIONS: Though preliminary, the present findings seem to demonstrate that the almond milk may an efficacious substitute of cow milk in infants with CMA/CMI. One could speculate that some active principles contained in the almond milk could contribute to its beneficial effect observed in CMI/CMA-affected infants.

Animals↗