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[Anti-arrhythmia therapy of acute heart rhythm disorders in the early period after heart valve prosthesis].

The paper reports the results of a comparative study of the efficiency of antiarrhythmic drugs with different mechanisms of action and quickening electric cardiostimulation (ECS) in 640 patients with acute heart rhythm and conductivity disorders that had developed at early dates after the introduction of valvular prostheses. Beta-adrenoblockers and isoptin were shown to be effective in the control of supraventricular tachysystolic rhythm disorders, membrane-stabilizing agents are indicated in ventricular extrasystole, and ECS combined with trimecaine, in bradyarrhythmias. Arterial hypotension associated mostly with obsidan administration, and functional central nervous disturbances observed with membrane-stabilizing agents are reported as the most common side effects. Transformation of arrhythmias into a more severe condition--ventricular tachysystole, fibrillation and asystole--is possible when obsidan or ECS are used.

Adolescent↗

The pathology of wear in the Beall model 104 heart valve prosthesis.

We examined 13 Beall model 104 prostheses recovered at surgery or autopsy 10 to 84 1/2 months after insertion and observed the pattern of prosthesis wear. We defined wear as "mild" when the disc was notched but neither the metal of the struts was exposed not the cloth seat torn. In "moderate" wear the disc was notched, the Teflon coating of the struts was worn away exposing the underlying metal but the cloth of the set was not torn. The cloth seat was torn in "severe" wear, exposing the metal seat and causing a different pattern of disc erosion. In one case this allowed the disc to tilt into the valve lumen and, later, to escape from its cage. Most of the prostheses studied showed "moderate" or "severe" wear. We believe that some degree of wear is inevitable. Clinical signs and symptoms were not specific but a rough correlation existed between the severity of hemolysis, as indicated by serum LDH levels, and the degree of prosthesis wear. When wear was "severe", the results of cardiac catheterization studies usually mirrored the change, but there were a few exceptions. All patients with the Beall model 104 prosthesis may eventually develop "severe" wear, and we recommend regular reassessment with a view toward prosthesis replacement.

Adult↗

[Heart valve prosthesis in mitral valve defects of patients with chronic circulatory insufficiency].

The data of long-term follow-up of 67 patients subjected to mitral valve replacement for severe heart diseases support the rationale of surgical management of chronic circulatory insufficiency in mitral disease. A prosthetic replacement of the mitral valve helps to return the majority of operated on patients to active live patterns. Improvements of the patients' state within 5 years after surgery was recorded in 58 cases, 9 patients died within 2 to 34 months. Actuarial statistics showed that the 5-year survival rate comprised 75.9% following prosthetic mitral valve replacement.

Adolescent↗