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PubMed1954

Toxicosis.

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Humans↗
PubMedDate not supplied

[Rheologic properties of the blood in infants with complicated pneumonia].

Blood rheology was assessed in 23 infants with acute pneumonia complicated with respiratory infectious toxicosis during hospitalization to intensive care wards, a control group consisted of 19 healthy infants. Plasma viscosity, red cell deformability, surface architectonics, and aggregation were studied. Patients developed increased plasma viscosity, marked reduction of red cell deformability, and increased aggregation index parallelled by reduced rate of aggregate formation. Changed red cell surface architectonics was associated with a reduced count of discocytes and parallel increase of echinocytes and cupola-like red cell forms. These data evidence marked disorders of blood rheology which should be not disregarded when choosing therapeutic policy.

Humans↗
PubMed1989

[Neurosonography of the brain in infectious toxicoses in infants].

Brain neurosonography was performed in 15 babies with toxicosis-+-linked nervous disorders. Three types of the brain structure were established in the patients: 1, marked brain swelling in all patients; 2, concomitant perinatally induced brain structures' changes; 3, intracranial hemorrhage focuses resulting from the DIC syndrome. The technique is useful for precise diagnosis and prognosis of the outcome of the neurotoxic coma.

Acute Disease↗
PubMed1983

Early introduction of copper-contaminated animal milk feeds as a possible cause of Indian childhood cirrhosis.

Brass and copper household utensils are a possible source of the gross hepatic copper accumulation characteristic of Indian childhood cirrhosis (ICC). In 107 families with a child with ICC, the use of copper or brass for water storage (97%) and of brass for milk storage (90%) or milk boiling (67%) resembled that of neighbouring village control families. However, the feeding history of 132 children with ICC differed from that of 70 children with other hepatic disorders and 311 children in 2 rural control groups. No child with ICC was exclusively breast-fed whereas 10%, 32%, and 25% of the control children were. Duration of breast-feeding was shorter in children with ICC and animal milk was introduced earlier. 57% were started on animal milk before 3 months of age. The age at introduction of animal milk correlated with the age at presentation with ICC. 66 urban Pune children had a feeding history similar to those with ICC, but in these families brass vessels were not used for milk. Experimentally, milk took up copper from utensils more avidly than water did. The copper concentration in milk samples obtained from ICC households, and those obtained experimentally, would supply a copper intake 6 to 20 times greater than that of the breast-fed infant, and similar to that producing copper toxicosis in the lamb. The hypothesis that early introduction of copper contaminated animal milk is of aetiological importance explains many of the epidemiological features of ICC.

Alloys↗
PubMed1999

Familial clustering of infantile cirrhosis in Northern Germany: A clue to the etiology of idiopathic copper toxicosis.

Two cases of infantile liver cirrhosis of unknown origin occurred in a circumscribed rural area of Northern Germany. Both children had increased dietary copper exposure. The search for additional cases of what appeared to be idiopathic copper toxicosis (ICT) revealed a cluster of affected infants in this region, raising questions about the relative importance of genetic and environmental factors that are considered to be etiologic. We gathered clinical and pathologic data concerning the patients, analyzed the pedigrees of affected families, and searched for possible environmental factors contributing to the pathologic process. We encountered 8 cases of infantile liver cirrhosis in 5 families in Emsland, a circumscribed and predominantly rural area of Northern Germany; ICT was definitely proven in 2 cases. Clinical presentation and liver pathology in 6 additional cases were consistent with the diagnosis of ICT. Pedigrees of affected families revealed complex relationships with occasional consanguinity of parents, suggesting autosomal recessive inheritance. The households were served by private wells with water of low pH flowing through copper pipes, suggesting the possibility of increased alimentary copper exposure. These findings support earlier conclusions that ICT develops when an infant with a genetic predisposition is exposed to a copper-enriched diet.

Age of Onset↗