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Results for “LYMPHOSARCOMA”

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At least 217 records · Page 12Linked to original sources

PubMed1978

Tumor-associated antigen and cell surface marker in cells of bovine lymphosarcoma.

The detection of tumor-associated antigen and B cell surface marker was attempted in lymphoid cells of peripheral blood (PBL) and lymph nodes obtained from cattle with lymphosarcoma, cattle infected with bovine leukosis virus (BLV), and clinically normal cattle. As a result, specific tumor-associated antigen was found in PBL and lymphoid tumor cells from cattle with the adult form of lymphosarcoma (ALS) using anti-ALS serum. The antigen was also detected in PBL of BLV-infected cattle. A weak reaction for the antigen was found in 2 of 5 cases of calf form. No significant reaction for the tumor-associated antigen of neoplastic lymphoid cells from ALS was found in the thymic and skin forms. The percentage of B cells in PBL and lymph nodes from ALS was higher than that in normal cattle. However, a loss of B cell surface marker was suggested in some ALS cases. A good relation was obtained between an increased B cell percentage and an appearance of the tumor-associated antigen in PBL of BLV-infected cattle. In lymphoid cells of PBL and lymph nodes from sporadic cases, the percentage of B cells was lower than that observed in normal cattle.

Animals↗

PubMed1990

[Electron microscopy in the differential diagnosis of chronic lympholeukemia and differentiated (lymphocytic) lymphosarcoma in the leukemization stage].

By electron microscopy, globular structures of varying size and moderate electron density were revealed in cells of peripheral blood, bone marrow and lymph nodes in patients with differentiated (lymphocytic) lymphosarcoma at the stage of leukemization, which were located in both cytoplasm of lymphoid cells and intercellular spaces. Plasmocyte-like cells with bizarre outlines of rough endoplasmatic reticulum were also observed in patients with leukemized lymphosarcoma. The above globular structures are not observed in patients with chronic lymphocytic leukemia.

Bone Marrow↗

PubMedDate not supplied

[Interferon deficiency syndrome in children with lymphosarcoma].

The capacity of the peripheral blood mononuclears to produce leukocyte (alpha) and immune (gamma) interferons as well as interferon concentrations in the serum were studied in 101 children suffering from lymphosarcoma. In the blood serum of the patients interferon titres did not exceed 4 units/ml. The lowered capacity of the peripheral blood mononuclears to produce one of the interferon species in titres below 32 units/ml is a bad prognostic factor. The syndrome of interferon deficiency in children suffering from lymphosarcoma is observed in one per 5 cases.

Child↗

PubMedDate not supplied

[Lymphosarcoma--nodular form, localized in cervical region].

The authors describe three patients with lymphosarcoma--nodular form for a 13-year period, involving the cervical lymph nodes. The rarity of the disease is emphasized as well as the difficulties in the differential diagnosis with the chronic sialadenitis and lymphopathies. The clinical interpretation of the disease is difficult because of the lack of specificity in the clinical course and paraclinical studies. The accurate diagnosis is only possible by a pathohistological study. The authors underine that the nodular form of lymphosarcoma should be given consideration in the differential diagnosis of the diseases of lymph apparatus in cervical region.

Adolescent↗

PubMed1989

[Effect of cyclophosphane on polyamine excretion in rats with Guérin's carcinoma and Pliss' lymphosarcoma].

Polyamines were determined in the urine of rats with the Guerin carcinoma and Pliss lymphosarcoma treated with cyclophosphamide. Alterations in polyamine distribution and rise of the spermidine/putrescine ratio were caused by the tumor regression or partial inhibition of the tumor growth. Regression of the Guerin carcinoma was accompanied by a rise of spermidine concentration in urine. Delay of the Pliss lymphosarcoma growth led to the putrescine level stabilization. Exposition of the rat normal tissues and cells to the cytostatic caused the alteration in the urinary polyamine excretion. These data suggests that the polyamine test may be useful to evaluate the efficiency of the anticancer treatment soon after its beginning.

Animals↗

PubMed1987

Use of viable-cell ELISA for detection of monoclonal antibodies recognizing tumor-associated antigens on bovine lymphosarcoma cells.

An ELISA, using viable bovine lymphosarcoma cells, was developed to detect tumor-associated antigens (TAA) expressed on lymphosarcoma cells from cows with enzootic bovine leukosis (EBL). Monoclonal antibodies (MAB) against TAA were used. Using viable-cell ELISA, MAB reacted with tumor cells from 9 cows with EBL, but not with peripheral blood lymphocytes from 10 clinically normal cows. Titers of MAB against tumor cells from 1 cow with EBL were 2,048 (direct immunofluorescence assay), 8,192 (flow cytometry), 2,048 (fixed-cell ELISA), and 16,384 (viable-cell ELISA). Viable-cell ELISA was the most sensitive method for detection of TAA. Reactivities of 7 MAB to tumor cells from cows with EBL were compared between viable-cell ELISA and a complement-dependent antibody cytotoxicity test. Of 5 MAB with no cytotoxic activity against tumor cells, 3 were reactive against tumor cells from the same cow, as determined by viable-cell ELISA, with titers ranging from 128 to 2,048.

Animals↗

PubMed1988

Ultrasonographic features of splenic lymphosarcoma in dogs: 12 cases (1980-1986).

The ultrasonographic appearance of the spleen and adjacent organs in 12 dogs with splenic lymphosarcoma was reviewed. Poorly marginated hypoechoic to anechoic nodules (4 mm to 3 cm in diameter) were found in all dogs. The anechoic nodules did not result in reflective shadowing or acoustic enhancement of the underlying tissues. The remainder of the splenic parenchyma appeared relatively hypoechoic when compared with the liver or renal cortices in 9 dogs. Recognition of this ultrasonographic pattern appears to be a useful diagnostic tool. Needle aspiration guided ultrasonographically will then enable histologic confirmation of lymphosarcoma.

Animals↗

PubMed1986

Alterations in microsomal drug metabolism and heme oxygenase activity in isolated hepatic parenchymal and sinusoidal cells in Murphy-Sturm lymphosarcoma-bearing rats.

Previous studies have demonstrated that Murphy-Sturm lymphosarcoma-bearing rats have significantly decreased hepatic microsomal cytochrome P-450 and NADPH-cytochrome c reductase activity, a consequent decreased capacity for oxidative microsomal drug metabolism, and increased microsomal heme oxygenase activity. Splenic microsomes obtained from tumor-bearing rats did not display similar changes. To define the cellular locus of these changes, preparations of hepatic parenchymal and hepatic sinusoidal cells were obtained from control and Murphy-Sturm lymphosarcoma-bearing rats and examined for alterations in microsomal parameters of drug metabolism and heme oxygenase. In hepatic parenchymal cell populations, heme oxygenase activity was significantly increased in tumor-bearing rats (0.046 nmol/mg/min vs. 0.019 nmol/mg/min, control, p less than 0.01) while other microsomal parameters were all significantly decreased in activity (cytochrome P-450, 0.25 nmol/mg vs 0.70 nmol/mg, control, p less than 0.001; NADPH-cytochrome c reductase, 24.4 nmol/mg/min vs 42.6 nmol/mg/min, control, p less than 0.005; benzo(a) pyrene hydroxylase, 0.230 nmol/mg/min vs. 0.518 nmol/mg/min, control, p less than 0.001). These results are similar to those obtained with microsomes from whole liver. Conversely, while hepatic sinusoidal cell preparations also demonstrated increased heme oxygenase activity (0.134 nmol/mg/min vs 0.079 nmol/mg/min, control, p less than 0.01), all other hepatic sinusoidal cell microsomal parameters were not appreciably altered in tumor-bearing animals. The results indicate that the major effect of the tumor-bearing state on hepatic microsomal heme and drug metabolism is on the parenchymal cell, and not the sinusoidal cell population.

Animals↗

PubMed1988

[Treatment and prognosis of recurrences of lymphosarcoma].

Short- and long-term results of various methods of chemotherapy of 547 adult lymphosarcoma patients with tumor recurrences were analyzed. Therapeutic tactics and prognosis were determined mainly by a morphological type of lymphosarcomas.

Adolescent↗

PubMed1986

[Morphologic and cytochemical characteristics of lymphosarcoma in children with various immunologic subtypes of the disease].

Detailed immunological and cytochemical studies of tumour lymphoblasts in 44 children with lymphosarcoma involved a broad panel of monoclonal antibodies and xenogenic antisera allowed detecting cytomorphological differences between immunological subtypes of the disease. Most homogenic groups represented by T1 and T2 subtypes (L1 type) sharply differed from B-cellular lymphosarcoma (L2, L3, immunoblastic) while T3 and "zero" subtypes were more heterogenic.

B-Lymphocytes↗

PubMed1986

[Diagnosis of reactive lymphadenopathies and the stage of lymphosarcoma leukemization using the simplest methods of immunologic phenotyping].

The authors have summarized the research data on lymphoid cells of the lymph nodes and peripheral blood of normal donors, patients with hematological nonlymphoproliferative diseases, reactive lymphadenopathies and malignant lymphoproliferative diseases (Hodgkin's disease, chronic lympholeukemia and lymphosarcomas). The data indicate that the use of the panel of the simplest tests of immunological phenotyping provides in many cases sufficient information for differential diagnosis of reactive lymphadenopathies and malignant lymphoproliferative diseases as well as for diagnosing the early stage of lymphosarcoma leukemization.

B-Lymphocytes↗

PubMed1987

Organ distribution of fibrinogen-bound methotrexate in mice with Gardner lymphosarcoma.

The distribution of fibrinogen-bound 3H methotrexate was investigated in Gardner lymphosarcoma bearing mice. 3H labeled methotrexate (3H MTX) was covalently bound by means of aminopropyl carbodiimide to bovine and mouse fibrinogen (FBG). The preparations as well as the free 3H MTX were applied i.v. in a single dose to three groups of C3H mice on day 6 after the inoculation of Gardner lymphosarcoma. 3H MTX level was determined in the blood, spleen, tumor and liver. Sufficient amounts of MTX were released by proteolysis of FBG-MTX derivatives to induce chemotherapeutical effects. Protracted accumulation of MTX applied in the form of FBG-MTX derivatives was found in the spleen and in the liver, in contradistinction to free drug application, suggesting the proteolytic degradation as a directing step responsible for the prolonged persistence of FBG-MTX derivatives in the organs. In the tumor the highest amount of MTX was released from mouse FBG supporting the view of ready uptake of homologous FBG by tumors.

Animals↗

PubMed1986

[Results of treatment of lymphosarcomas with primary involvement of the peritoneal and mesenteric lymph nodes].

A total of 105 lymphosarcoma patients with primary involvement of retroperitoneal and mesenterial lymph nodes (aged 17 to 77) were examined. Diagnosis was verified on morphology. Chemo- and radiotherapy was administered to 35 (33.3%) patients, chemotherapy alone to 34 (32.3%), combined therapy (surgery combined with radio- and drug therapy) to 20 (19%) patients, gamma-beam therapy to 16 (15.2%) patients. Remissions were achieved in 85.7% of the patients, of them complete remissions in 51.4% of the patients. Seventy patients were followed up prior to recurrences. In 54.2% of the patients recurrences manifested themselves in the generalization of tumor process with involvement of distant peripheral lymph nodes as well as extranodal organs within 1 year of remission irrespective of therapeutic methods. Local recurrences were noted in 73.9% of the patients on chemotherapy. Lymphosarcoma generalization was found in 63.6% of the patients receiving chemotherapy. A 5-year recurrence-free period was noted in 28.5% of the patients receiving combined therapy.

Adolescent↗

PubMed1986

[Effect of methylglyoxal bis(guanylhydrazone) in combination with antifolic acid preparations on the biochemical indices and growth of Pliss lymphosarcoma in rats].

It was shown in experiments with Pliss' lymphosarcoma in rats that antifolates--cis-2,5-bis (aminohydroxymethyl)-piperazine-3,6-dione and methotrexate--cause tumor cell spermidine level to drop. Also, treatment with antifolates prevented the undesirable accumulation of S-adenosylmethionine in tumor cells induced by methyl-glyoxal-bis (guanylhydrazone) which inhibits polyamine biosynthesis. In chemotherapeutic experiments with rat lymphosarcoma, antifolates markedly potentiated the antitumor effect of methylglyoxal-bis (guanylhydrazone). The data suggest that the combination of polyamine biosynthesis inhibitors such as methylglyoxal-bis (guanylhydrazone) and alpha-difluoromethylornithine and antifolates may be useful in tumor chemotherapy.

Adenosylmethionine Decarboxylase↗

PubMed1986

[Clinical picture and treatment of lesions of the epidural space in lymphosarcoma].

The article presents the results of the examination and treatment of 10 lymphosarcoma patients with damage to the epidural space. The neurological symptomatology was due to the compression of the spinal cord or the vessels supplying it. The results of the treatment depended on the sensitivity of the lymphosarcoma to cytostatic therapy and on how early the treatment was initiated.

Adolescent↗

PubMed1979

[Intercellular information transfer in the process of immunogenesis. VI. The induction of antiphage antibody synthesis in the cells of rat transplantable lymphosarcoma under the influence of splenic RNA from rats and mice immunized with phage T2].

It has been proved that nuclear and cytoplasmic RNAs, isolated from spleens of T2 phage immunized rats and mice, can induce T2 phage antibodies in cells of the transplantable rat lymphosarcoma. With the nuclear RNA from rat spleens, the effect is persisting in a number of subsequent cell generations. The data presented are principally in accord with results of the authors' previous studies in which lymphosarcoma cells were treated with RNA extracted from spleens of rat immunized with sheep red cells. These results well compare with the authors' earlier advanced hypothesis suggesting a possible involvement of RNA in deblockation of genes responsible for the synthesis of the antibodies in question.

Animals↗

PubMed1985

[Prognostic value of the initial remission during chemotherapy of patients with lymphosarcoma].

A study of the results of the first course of chemotherapy of 443 previously untreated patients with lymphosarcoma pointed to the predictive value of the extent and duration of the first remission, particularly in cases of blastic forms of lymphosarcoma. It was found that no significant increase in survival time can be obtained unless remission is complete. No significant difference in survival time was observed in cases of partial remission or ineffective primary therapy.

Adolescent↗

PubMed1975

[Cells of rat lymphosarcoma in chambers for intravital microscopy].

In a chamber for intra vital microscopy, implanted subcutaneously in a rat, stained rat lymphosarcoma cells were applied into a preliminary formed connective tissue layer. The process of intracellular transformation of a dye and its elimination from the cytoplasm was observed. Following elimination of the dye a duplication of lymphosarcoma cells would proceed. This is a very intensive process, and after 5-7 days the connective tissue is completely substituted by tumor cells.

Animals↗