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Patients with suspected Lassa fever in London during 1984: problems in their management at St Thomas's Hospital.

During 1984, 23 patients in whom a diagnosis of viral haemorrhagic fever was considered presented to the accident and emergency department at St Thomas's Hospital. There were no confirmed cases of viral haemorrhagic fever. Nine patients were transferred to Coppett's Wood Hospital, the nearest specially designated high security isolation unit. Malaria was the final diagnosis in 14, and in six this diagnosis was confirmed only after examining repeated smears at Coppett's Wood Hospital. Transferral of patients to such units is time consuming, expensive, and often unnecessary. Specially designated isolation units in district general hospitals and all teaching hospitals would simplify and improve the care not only of patients with a possible viral haemorrhagic fever but also patients with tuberculosis, multiply resistant staphylococcal infections, and viral infections that may be hazardous if transmitted to immunocompromised patients.

Diagnosis, Differential↗

Lassa fever.

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Adult↗

Lassa fever.

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Adult↗

Indirect immunofluorescence for the diagnosis of Lassa fever infection.

The indirect immunofluorescent technique is a rapid method for identification of Lassa virus and Lassa virus antibody. In the study reported here, Lassa virus antigen was detected by this method in Vero cell cultures within 24 hours of their inoculation with an infected human blood specimen. A diagnosis could be made from field-collected specimens within 3 days of their receipt.Fluorescent antibodies against Lassa virus were detected in human serum as early as 7 to 10 days after onset of illness, and were detected as long as 61 months after infection. Complement fixing antibodies were not as long lasting.No antigenic differences were noted by the indirect immunofluorescence technique between several Lassa virus strains isolated from Nigeria, Liberia, and Sierra Leone over a 6-year period.

Animals↗

[Lassa fever].

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Lassa virus↗

Lassa fever.

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Africa, Western↗

[Lassa fever].

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Africa, Western↗