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At least 217 records · Page 12Linked to original sources
PubMed2002

Hearing loss and tinnitus in Meniere's disease.

OBJECTIVES: To characterize hearing loss, tinnitus and associative factors in Meniere's disease. METHODS: From our vertigo database consisting of 1356 patients, we retrieved 243 patients with Meniere's disease (MD). RESULTS: Hearing loss was the initial symptom in 13% of cases. Altogether 64% (n=133) of the patients stated that their hearing was reduced during the vertigo attack. The hearing deteriorated more likely during the vertigo attack if the vertigo attack was very intense [r(206)=0.19]. Tinnitus was the initial symptom in 5% of cases. The tinnitus was mild in 38% (n=90), moderate in 32% (n=76) and severe in 30% (n=72) of patients. The intensity of tinnitus correlated with the occurrence of drop attacks [r(237)=0.29], vertigo provoked by head positioning [r(235)=0.25], by physical activity [r(230)=0.33], or by pressure changes [r(239)=0.27]. CONCLUSION: Prolonged disease causes deterioration of hearing. Intense tinnitus is common in MD and is more often seen in late stage of the disease.

Adolescent↗
PubMed2000

Prevalence of allergy in Meniere's disease.

OBJECTIVES: The goal of this study was to determine the prevalence of allergy in a population of patients with Meniere's disease. METHODS: A survey was mailed to all patients with Meniere's disease seen at our institution from 1994 to July 1998 (n = 1490). As a control group, 172 patients with otologic problems other than Meniere's disease completed the same survey. RESULTS: Of 734 respondents with Meniere's disease, 59.2% reported possible airborne allergy, 40.3% had or suspected food allergies, and 37% had had confirmatory skin or in vitro tests for allergy. These prevalence rates were significantly higher than those found in the control group, of which 42.7% reported having or suspecting airborne allergies and 25% had or suspected food allergies (differences all significant at P< or =0.005). CONCLUSION: The prevalence of allergy appears to be much higher in patients with Meniere's disease than in the general population or the population of patients visiting an otologic clinic for other symptoms.

Adolescent↗
PubMed2006

Transtympanic gentamicin treatment in Meniere's disease: a preliminary report.

OBJECTIVE: To evaluate the effectiveness of transtympanic gentamicin treatment in Meniere's disease. MATERIAL AND METHOD: The present study is a prospective study of 8 patients in Ramathibodi Hospital who had transtympanic gentamicin treatment of Meniere's disease by fixed dose regimen of 12 injections during a period of 4 days. The committee on hearing and equilibrium guidelines for reporting treatment results in Meniere's disease of the American Academy of Otolaryngology and Head & Neck Surgery (1995) were used. Paired t-test or Wilcoxon Signed Ranks Test was used for statistical comparisons. RESULTS: Among 8 patients, there were 2 males and 6 females. All patients (100%) had either complete (37.5%) or substantial (62.5%) control of vertigo. Disability was also improved in all of the subjects (100%). Tinnitus was improved in 62.5%. Their tinnitus score and functional level scale were much improved with statistical significance (p = 0.001, p < 0.005, respectively). Hearing was unchanged in 87.5% and slightly worse in 12.5%. This was not significant. CONCLUSION: Transtympanic gentamicin treatment was found to be an effective treatment option for patients with disabling or intractable Meniere's disease, with a low incidence of hearing loss. The use of this method appears to be practical and may replace the vestibular surgery.

Adult↗
PubMed1997

Imaging of Meniere's disease.

The role of CT and MR studies in the evaluation of patients with Meniere's disease is to exclude other pathologic conditions that could masquerade as Meniere's disease clinically. This article is divided into three sections corresponding to the three major symptoms of Meniere's disease. Each section presents examples of CT and MR pathologic conditions that could mimic these clinical findings: "sensorineural hearing loss" covers acoustic neuromas and other cerebellopontine angle tumors, inner ear anomalies, otosclerosis, and more; "vertigo" includes examples of labyrinthitis, endolymphatic sac tumor, cholesteatomatous fistula, and brain metastasis; and "tinnitus" emphasizes causes of nonpulsatile tinnitus and briefly mentions pulsatile tinnitus. Each section also discusses which imaging study best addresses these specific clinical questions.

Hearing Loss, Sensorineural↗
PubMed1980

The cochlear nerve in Meniere's disease.

Cochlear nerves of 11 patients with advanced Meniere's disease were studied by light and electron microscopy. All the nerves appeared normal on light microscopy. In cross sections, the density of myelinated nerve fibers was approximately 20,000 fibers per square millimeter in most cases. In two cases, the density was reduced, about 14,000/sq mm. No correlation was found between the age of patients or the duration of the disease and the density of myelinated nerve fibers. On electron microscopy, there were several features that suggested primary axonal degeneration or segmental demyelination in the cochlear nerve.

Age Factors↗
PubMed1985

Unilateral Meniere's disease: is the contralateral ear normal?

Certain investigations in patients with unilateral Meniere's disease may on occasion show abnormalities in the completely symptomless contralateral ear. These tests include transtympanic electrocochleography, the acetazolamide cochlear hydration test, vestibular aqueduct tomography, and caloric testing. Eventually these ears may well become symptomatic. Previous studies have shown that otoadmittance changes are a sensitive indicator of glycerol-induced intracochlear pressure alterations in hydropic ears, but do not occur in patients without Meniere's disease. Otoadmittance parameters were evaluated in the asymptomatic ears of 73 consecutive patients with unilateral Meniere's disease. Satisfactory traces and adequate dehydration were achieved in fifty-nine. A significant change in the maximum conductance, similar to that often seen in symptomatic hydropic ears, was found in twenty-four cases (40.7%). The presence of functional abnormalities in well over one-third of asymptomatic ears means that they cannot be used as controls in clinical research studies. Furthermore, recognition of contralateral latent hydrops at the initial otologic assessment may modify the subsequent treatment strategy.

Acoustic Impedance Tests↗
PubMed1982

Hyperosmotic solutions and hearing Meniere's disease.

Hearing was studied in nineteen patients with Meniere's disease before and after administration of three different hyperosmolar solutions-glycerol, ethanol, and Mannitol. Ethanol and Mannitol were found to be much less effective than glycerol in producing hearing gain. Alternative mechanisms underlying the observed differences are discussed.

Drug Therapy, Combination↗
PubMed1984

Use of streptomycin sulfate in the treatment of Meniere's disease.

Streptomycin sulfate has been known to be ototoxic since its use in the treatment of tuberculosis. This report describes 10 years of experience in the treatment of Meniere's disease with streptomycin. Streptomycin has been used in classical Schuknecht ablation of the vestibular system in bilateral Meniere's disease; classical Schuknecht ablation of the vestibular system in unilateral Meniere's disease in the only hearing ear; intratympanic streptomycin in the treatment of unilateral Meniere's disease; and low-dose intramuscular streptomycin as outpatient treatment in unilateral Meniere's disease. The results of bilateral vestibular ablation were similar to Schuknecht's and others. Patients developed profound ataxia with a wide-based gait and oscillopsia, which improved rapidly over a period of months. Approximately 30% experienced significant improvement in hearing, which usually deteriorated again after several months. All patients were relieved of vertigo. Patients with unilateral Meniere's disease in the only hearing ear responded as did the bilateral cases. Hearing in the only hearing ear was preserved in all cases. Low-dose subototoxic streptomycin as outpatient treatment offers promise in some cases for relieving attacks of Meniere's disease while improving hearing without producing the temporary disabling effects of ataxia and oscillopsia. Streptomycin and similar drugs that may reduce the production of endolymph may eventually be the treatment of choice in Meniere's disease.

Ataxia↗
PubMed1975

Endolymphatic sac drainage in Meniere's disease.

Endolymphatic sac drainage was applied in 7 cases of severe Meniere's disease. The results were favorable in 4 patients, while 3 patients had insufficient relief. The management of Meniere's disease is discussed in relation to surgery.

Drainage↗
PubMed1998

[Laser destruction of the labyrinth in Meniere's disease: rationale and results].

The authors suggest that Meniere's disease may arise as a psychovegetative syndrome with impairment of labyrinthine homeostasis. It is thought valid to distruct the cupular receptor of the horizontal bony semicircular canal by means of impulse neodymium laser radiation brought to the ampullare bone wall via quartz light guide. Short- and long-term effects of such laser treatment are available. This technique of laser destruction is symptomatic, aimed at relief of severe episodes of vertigo.

Ear, Inner↗
PubMed2005

[Management of the patient with Meniere's disease. Clear diagnosis but vertigo-provoking perspective].

Meniere's disease is characterised by recurrent attacks of vertigo, sensory hearing loss and tinnitus. Meniere's attacks can lead to additional bouts of dizziness. While diagnosis in recurrent spells is easily secured, managing the patients is as difficult as the often unclear development of this -- mostly -- progressive disease. The underlying principle for therapy of this frequently changing disease is a reliable patient-physician relation, which should be based on extensive knowledge of the disease and not only include ENT findings but also broad medical counselling.

Directive Counseling↗
PubMedDate not supplied

Autonomic dysfunction on the affected side in Meniere's disease.

For ascertaining the existence of autonomic dysfunction on the affected side as being the cause of Meniere's disease, the mecholyl tests were conducted by means of conjunctival instillation in normal subjects as well as in patients with Meniere's disease, labyrinthitis and vestibular neuritis. The rate at which significant miosis (more than 10%) appeared in the mecholyl test was 3.1% among normal subjects, whereas the rate among Meniere's disease patients on the affected side was significantly higher during the attack, quasi-attack and interval stages. The appearance rate among Meniere's disease patients on the unaffected side was not different from that in normal subjects during any of the three stages. None of the patients with labyrinthitis or vestibular neuritis showed significant miosis on the affected side alone in the mecholyl test. This indicates that abnormality of vestibular-autonomic reflex in itself does not cause a positive reaction in the mecholyl test. Hence it can be concluded that the cause of Meniere's disease is related to the existence of autonomic dysfunction on the affected side.

Adult↗