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At least 217 records · Page 12Linked to original sources

Papillary muscle hypertrophy in chronic rheumatic mitral valve stenosis. A clinicopathologic study.

A quantitative pathologic study was performed on papillary muscles in 15 cases of chronic rheumatic mitral stenosis. The papillary muscles were grossly hypertrophied as compared with papillary muscles in 10 normal specimens. Hypertrophy of papillary muscles was associated with pronounced fibrosis. Angiographically, these hearts were remarkable in small left ventricular cavity with almost complete cavity elimination at end systole. Left ventricular wall dyskinesia was also present. It is probable that derangement of the mitral valve structure due to rheumatic process leads to more stress on the supporting elements, thus resulting in papillary muscle hypertrophy.

Adolescent↗

[Immediate results of closed correction of recurrent mitral valve stenosis in the late stages of the disease].

Immediate results of closed surgical correction of recurrence of mitral stenosis in 127 patients at late stages of the disease performed in 1957-1986 are described. Closed re-commissurotomy proved to be possible in 98.5% and was effective in 80% of the patients operated upon. The complications were related with hemorrhage, acute cardiac failure. The intrahospital lethality was 11.8%. Immediate improvement was obtained in 70.1% of the patients after operation. A conclusion was made that closed commissurotomy could be used with sufficient effects in cases where the artificial circulation was impossible.

Adult↗

[Evaluation and management of patients with mitral valve stenosis].

A review of the guidelines of the American College of Cardiology and the American Heart Association for the management of patients with valvular heart disease, published in 1998, is presented. The therapeutical advances introduced during the past decade, percutaneous mitral balloon valvotomy and surgical ablation of atrial fibrillation, have modified the therapeutical approach to patients with mitral stenosis. In this article some controversial aspects are examined with a review of the recent literature. The definition of "valve morphology favorable for percutaneous balloon valvotomy", which is based on echocardiographic examination, is still debatable. Different echocardiographic scores published until now are reported. Some patients, who have no or mild symptoms, develop irreversible pulmonary hypertension: in order to avoid this complication early interventional procedure is suggested, but only in those patients at low post-procedural risk. In symptomatic patients, NYHA class II/III, with atrial fibrillation it is possible to consider a conservative surgical approach combined to crioablation of atrial fibrillation. The possibility of maintaining sinus rhythm and avoiding anticoagulation leads to a revaluation of surgical repair as option to valve replacement and percutaneous mitral balloon valvotomy.

Atrial Fibrillation↗

[Activity of enzymes of pentosephosphate pathway in the erythrocytes, myocardium and intercostal muscle of patients with mitral valve stenosis].

Decrease in activities of glucose-6-phosphate dehydrogenase and transketolase was observed in erythrocytes of patients with mitral stenosis. Development of the disease was accompanied by a further decrease in the enzymatic activity. The activity of the enzymes was increased in myocardium of atrium sinistrum at the IV stadium as compared with the III stadium of the disease. The glucose-6-phosphate dehydrogenase activity was decreased and the transketolase activity was unaltered in intercostal muscle of the patients.

Erythrocytes↗

[Doppler echocardiography in the functional evaluation of patients with pure mitral valve stenosis].

To evaluate the utility of echo-Doppler (ED; PW, CW and color), 67 patients affected by pure mitral stenosis (20 M, 47 F, mean age 52 years) were submitted to ED examination. Right and left cardiac catheterization were performed in 20 patients within 24 hours before ED. Mitral area obtained by Doppler method (Hatle's formula) correlated highly with both echo-2 dimensional and hemodynamic area (r = 0.93, p less than 0.001; r = 0.95, p less than 0.001 respectively). It was possible to calculate systolic pulmonary pressure, in patients with tricuspid incompetence, (43.9 +/- 14.9 mmHg, range 25-80) which correlated significantly (r = 0.95, p less than 0.001) with hemodynamic data (40.2 +/- 12.7 mmHg, range 20-70). The left atrial-left ventricular pressure gradient was 15.6 +/- 6.9 mmHg, range 6-32; the mean pressure gradient was 8.4 +/- 3.7 mmHg, range 3-17; the pressure half time 170.2 +/- 62.3 ms, range 83-330. We observed different types of direction of transmitral jets: centrally directed (n = 34); forward antero-lateral wall (n = 28); toward interventricular septum (n = 5). The transmitral jets presented 4 different appearances: scimitar-shaped (n = 28); candle flame (n = 24); mushroom (n = 9); double-jets (n = 6). No correlation was observed between the different types of transmitral jets (direction and appearance) and the parameters obtained by Doppler (PW and CW): velocities, pressure half-time, gradients. Thus, Doppler echocardiography permits a complete anatomic and functional evaluation of patients with pure mitral stenosis. We have not observed any correlation between the hemodynamic data and the different types of transmitral jets visualized by color Doppler.

Echocardiography, Doppler↗

[Echocardiography evaluation of left ventricular function in mitral valve stenosis].

It is reported on results of echocardiographic investigations concerning the left ventricular function in 60 patients with mitral stenosis (30 patients in stage II, 30 patients in stage III of the classification after NYHA) and the results are compared with those of 30 normal persons. The echocardiographic parameters 'systolic shortening fraction of the left ventricle' (FS), mean circumferential shortening speed of the fibre (mVCF) and the ejection fraction (EF) are suitable for the assessment of the functional condition of the left ventricle. On the basis of these parameters a determination of the degree of severity of the mitral stenosis is not possible, since there are no significant differences between the degrees of severity. The clear restriction of the left ventricular function in mitral stenoses which is partly described in the literature cannot be confirmed. In the two stages the parameters investigated lie widely within the norm. Significant differences in comparison to normal persons can be realized only in the determination of the early diagnostic filling speed of the left ventricle in the two stages.

Adult↗

Percutaneous balloon dilatation of mitral valve stenosis and aortic coarctation.

We describe the percutaneous management of a 19-year-old woman with juvenile rheumatic mitral stenosis, associated with aortic coarctation. The dilemmas were both diagnostic and therapeutic, i.e., the association of juvenile rheumatic mitral stenosis with aortic coarctation and the difficult surgical approach of managing both lesions in the same intervention. We performed the balloon dilatation of these lesions during the same procedure, with good short- and long-term results.

Adult↗