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At least 217 records · Page 12Linked to original sources
PubMed1977

[Clinical picture of recurring aphthae in the mouth mucosa].

Various classifications of recurrent aphthous ulcers, their differential diagnosis, especially the herpetic ulcers of the oral mucous membranes, are discussed. The clinical and histological pictures show three variants, the minor form, the major form or periadenitis mucosa necrotica recurrens (Sutton), and the herpetiforme aphthous ulcers. Recent investigations discussing the etiology of these ulcers assume that an auto-antigen might be responsible for the immuno-pathological mechanism. This auto-antigen is supposed to be formed by the contamination of the oral mucosa with microorganisms, particularly streptococci.

Adult↗
PubMed2001

[Detection of p53 mutation in mouth mucosa smears of patients with oral squamous epithelial carcinoma].

Tumour-suppressor gene p53 encodes for an important cell-cycle regulatory protein and is therefore probably important for the development of many malignant diseases, e.g. squamous cell carcinoma of the mouth. This gene has mutated most frequently in connection with the development of cancer, so it has been well explored. Hence we chose it to find out whether swabs of the oral mucosa are suitable for supplying material for the detection of mutations in a gene that is connected with the development of oral squamous cell carcinomas, because swabs are easier to obtain than biopsies. We examined biopsies, swabs from the tumour, and swabs from mucosa that appeared healthy from 32 patients with oral squamous cell carcinoma and mucosal swabs from 35 healthy persons with polymerase chain reaction (PCR) and temperature gradient gel electrophoresis (TGGE). Fourteen of the 32 patients with a tumour showed mutations of p53, and in all cases the mutation could be demonstrated both in the biopsy and in the tumour swab. In four cases the mutation was also found in the swab of normal mucosa. Our investigations revealed that swabs are a suitable method for obtaining material for the detection of gene mutations in oral squamous cell carcinomas.

Adult↗
PubMed1983

[Phenylhydrargyrum boricum in glycerin (Glycero-Merfen) in young children: undesirable mercury resorption in mouth mucosa even when free of lesions].

The formulation of phenylhydrargyrum boricum in glycerine (Glycero-Merfen) being frequently used in infants and young children, attention is drawn to the potentially symptomatic mercury absorption associated with its topical administration in that age group. This finding applies to both inflamed and normal oral mucosa. The use of this drug formulation in pediatric patients should be avoided.

Absorption↗
PubMed1999

[Treatment of severe scrotal hypospadias with onlay-type urethroplasty using mouth mucosa].

Failure in repairing severe hypospadias complicated with fistula and cutaneous retraction is often associated with lack of subcutaneous tissue and skin providing protection to the neourethra. We report the results of treatment in 6 patients with scrotal hypospadias with severe deviation and scarce dorsal prepuce. A neourethra was created by the onlay technique applying an oral mucosa graft and preserving in all cases the dorsal preputial skin for the island cutaneous flap. All patients had hypospadias without previous repairs excepting one of them, who had had one first time hypospadias repair in other hospital. Patients age ranged between 2 years and 3 months, and 4 years (mean: 2 years and 9 months). In all cases, hypospadias was scrotal type with severe deviation and scarce dorsal prepuce. All patients had prior hormone stimulation with dehydrotestosterone 3%. Surgical repair was performed in one-stage. Urethroplasty included preservation of the urethral plate, oral mucosa graft to provide ventral coverage, and island cutaneous flap with the dorsal preputial skin. In all cases, the chord was dissected behind the urethral plate. In 3 patients a dorsal Nesbit plication was necessary to obtain a complete straighten penis. Results in all 6 cases were satisfactory. Only one patient had a small leakage at the previous neomeatus. The other five patients are asymptomatic. Follow-up ranges from 6 months to 2 years. We conclude that urethroplasty in association with a well vascularized island flap of dorsal preputial skin decrease the incidence of fistulae. In patients with severe hypospadias with scarce dorsal prepuce urethroplasty should be completed with oral mucosa grafts preserving dorsal preputial skin for the ventral cutaneous plasty.

Child, Preschool↗
PubMedDate not supplied

[Connection between changes in the nasal and mouth mucosa with immune status under the effect of environmental factors].

The paper summarizes the results of determination of the cytological status of nasal and oral mucosae in 789 preschool and school children from different cities and towns of the Russian Federation: Moscow, Klimovsk, Yaroslavl. A relationship between the mucosae, immunity, and morbidity, and environmental pollution is shown in the town of Klimovsk as an example.

Environmental Illness↗
PubMed1992

[Mercury concentration in the mouth mucosa of patients with amalgam fillings].

Mercury concentrations were measured in specimens of oral mucosa taken during oral surgery from 90 patients (53 men, 37 women, mean age 42 +/- 16 years); 30 of the patients had no amalgam fillings. All the mucosal specimens extended for at least 2-3 mm from the epithelium of the gingival margin and were clinically and radiologically normal. Thirteen patients without metallic fillings of any kind had mercury concentrations of 118.4 +/- 83.7 ng/g tissue, and in 17 patients with precious metal fillings but no amalgam the mean mercury concentrations were 144 +/- 290 ng/g tissue. Seventeen patients with 1-3 amalgam fillings had an average of 1975 +/- 4300 ng/g tissue and in 26 patients with 3-6 amalgam fillings the average concentration was 1158 +/- 2500 ng/g tissue. In 17 patients with more than six amalgam fillings the mean mercury concentration was 2302 +/- 5600 ng/g tissue. Although these results demonstrate a considerable degree of transfer of mercury from the amalgam fillings to the oral mucosa, it had not resulted in any clinically detectable mucosal lesions.

Adult↗
PubMed1995

[Fordyce spots. A little regarded finding in the area of lip pigmentation and mouth mucosa].

Sebaceous glands on the vermilion border of the lips and the oral mucosa are common in adults. Only pathologic sebaceous glands visible through the epithelium should be regarded as Fordyce's granules. The incidence of Fordyce's granules increases from childhood to adulthood, and is slightly higher in men. The most prevalent sites are the vermilion border of the lips and the buccal mucosa. Fordyce's granules usually have the same histological features as cutaneous sebaceous glands. Pathologic alterations are rare. There is no significant correlation between Fordyce's granules and systemic diseases.

Adolescent↗