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PubMed1990

[Results of multiphasic oncology screening of the population in the community of Beĕj 1986-1987. II. Questionnaire screening].

In the framework of the multiphase oncologic population screening in the community of Becej in the period from 1986-1987, the inquiry screening comprised 16,895 persons, whereby the following results were obtained: two malignant breast neoplasms, one uterine corpus neoplasm, one carcinoma of the larynx, and out of the non-target locations, not included in the specific questionnaire, there was one carcinoma of the lower lip and one malignant neoplasm of the salivary gland. Besides, 10 benign breast neoplasms and 12 benign uterine neoplasms were also detected. These specific results lagged behind the expected ones on the basis of the known average incidence and mortality in locations of Vojvodina included by this questionnaire. The elucidation of all possible causes leading to this disaccordance, was the task of specific studies intended for the improvement of this questionnaire as a method for the early detection of malignant and premalignant lesions. Other numerous mass pathological states were detected during the screening of either the characteristic signs of specific malignant neoplasm locations, or of risk factors of particular importance for the appearances of these malignant neoplasms. These health problems with clarified epidemiological dimensions in the population studied, necessitated planned solution according to the accepted doctrinary principals (protocols). Data on these diseases gave new dimensions to the inquiry (and the overall multiphase) oncologic population screening. The target-health educational effect of this inquiry which reached every man over 40 years of age in the population studied should not be neglected, either.

Female↗
PubMed1975

The effect of multiphasic biochemical screening on the diagnosis of primary hyperparathyroidism.

Experience of primary hyperparathyroidism (PHPT) at the Royal Brisbane Hospital was reviewed to determine the effect of multiphasic biochemical screening, introduced during 1970, on the rate of diagnosis of this disease. In the period 1959-1970, there were 28 proved cases and, in the period 1971-1974, 41 cases, an increase from 2.5 to 11.7 cases per annum. The main factor contributing to this increase was the inclusion of plasma calcium in the multiphasic screening programme, together with correction of the plasma calcium for the total protein concentration in the same blood sample.

Blood Proteins↗
PubMed1998

Plasma B-type natriuretic peptide measurement in a multiphasic health screening program.

The aim of this study was to determine whether measurement of plasma levels of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) is an efficacious method to predict patients with heart disease irrespective of left ventricular function in a multiphasic health screening program. We have examined whether patients with various heart disease selected by physical examination, ECG, and chest X-rays can be identified by plasma levels of ANP and BNP. We examined 481 consecutive subjects who visited our checkup clinic for a multiphasic health screening test. By routine methods, among the 481 subjects, 13 were found to have some form of heart disease (old myocardial infarction, 2; cardiomyopathy, 2; valvular heart disease, 2; hypertensive heart disease, 5, and lone atrial fibrillation, 2). Sensitivity, specificity, and quintile analysis for identification of the patients with heart disease were determined by various cutoff levels of plasma ANP and BNP. Receiver operating characteristic (ROC) curves were constructed for the identification of these patients. A plasma BNP level of 40 pg/ml had a sensitivity of 85% and a specificity of 92% for heart disease detection. The area under the ROC curve for BNP was significantly greater than that for ANP (0.94 vs. 0.81; p < 0.001). A plasma BNP level of 13 pg/ml or less gave a 100% negative prediction value for heart disease. Plasma BNP concentration is a useful biochemical marker for the screening of asymptomatic patients with heart disease due to various etiologies from large population samples.

Adult↗
PubMed1997

What is the long term value of multiphasic health screening and the initial judgement of benefit?

The long term effects of multiphasic health screening (MHS) are rarely studied. In 1964 a random sample of 546 women and 544 men born 1899, 1904, 1909, 1914 or 1919 equally distributed on cohorts from the Swedish town Eskilstuna were invited to examination. For several reasons 167 persons (15%) did not participate in the study. In 1969 the whole sample was invited to a second MHS together with a control group that had not been exposed to MHS. Furthermore, 79 of those alive 1989 born 1899 or 1904 and examined 1964 and 1969 were reexamined. Over all survival rate 1989 for those examined 1964 was for males 18% and for females 35%. Screening instruments 1964 and 1969 were questionnaires, laboratory tests, antropometric measurements, ECG, measurement of blood pressure, chest radiography, peak expiratory flow (PEF), tonometry and fundoscopy of the eyes, audiometric screening, dental, gynecological and general clinical examination. Systolic hypertension for both sexes, low PEF and smoking, low cholesterol in women were negatively related to survival. Of 18 diabetics only one was alive at follow-up. No association was found between BMI and mortality for men, but some (1964 p < 0.01; 1969 p < 0.05) for women. Altogether 87 individuals were 1969 judged to have had some benefit of the MHS in 1964, 40 of them substantial. This was, however, not statistically significantly associated with improved survival. Of the reexamined survivors 86% reported to be generally satisfied with their life situation. The prognostic value of graded benefit was analysed in some detail. The survival to age 85 in the group allotted any benefit was somewhat less good (37%) than in the group with no benefit (44%). The difference did not reach statistical significance.

Aged↗