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At least 217 records · Page 12Linked to original sources
PubMed1984

Myoglobin content of granular cell tumor of the tongue. An immunoperoxidase study.

Myoglobin is a protein with a molecular weight of 16,900 daltons that is normally found in adult and fetal striated and cardiac muscle cells. Its synthesis relates to the total ATP requirements of the muscle cell. The histogenesis of the granular cell tumor is controversial, but an origin from striated muscle has been postulated. Seven cases of tongue GCT were evaluated for the presence of myoglobin using the unlabeled antibody (PAP) technique. Normal human striated muscle was used for both positive and negative controls. None of the tumors showed positive staining of the granular cells. Positive controls showed specificity of staining for skeletal muscle. The negative controls did not stain. Granular cell tumors of the tongue do not appear to contain myoglobin. This suggests that either the GCT is not of muscle origin or that, if it is, there may be a metabolic change in the granular cells so that myoglobin is not synthesized. It may be possible that a change in the antigenic determinant has occurred.

Adult↗
PubMedDate not supplied

Granular cell tumor of the orbit and ocular adnexae.

Although granular cell tumor (GCT) has been a distinct pathological entity since 1926, confusion and controversy have long existed regarding the nature and histogenesis of the tumor. Twenty-five cases of granular cell tumor involving the orbit and ocular adnexae previously reported in the ophthalmic literature, are reviewed and six additional cases are reported. The histopathological and immunohistochemical characteristics of granular cell tumors in this uncommon location are discussed and their probable origin from Schwann cells is also considered.

Eyelid Neoplasms↗
PubMed1990

A pilot study investigating intraoperative electron beam irradiation in the treatment of ovarian malignancies.

Intraoperative electron beam radiation therapy (IOEBRT) in the treatment of ovarian malignancies was investigated at the Clement O. Miniger Radiation Oncology Center (COMROC). Nine patients were operated in the COMROC IOEBRT operating amphitheater and five were found to have disease sufficiently limited to allow for IOEBRT. The patients' ages ranged from 13 to 80 (median 53) years. Five patients had serous cystadenocarcinoma, one papillary adenocarcinoma, one mixed germ cell tumor, one squamous cell carcinoma, and one granular cell tumor of the ovary. The median survival of the non-IOEBRT group was 13 (range 12-29) months, while the IOEBRT group's median survival was 14 (range 18-46) months. All of the patients tolerated IOEBRT well without addition to the surgical morbidity.

Adenocarcinoma, Papillary↗
PubMed1981

Respiratory obstruction caused by a multicentric granular cell tumor of the laryngotracheobronchial tree.

An unusual case of acute respiratory obstruction caused by multicentric granular cell tumors of the laryngotracheobronchial tree is presented. The patient also had granular cell tumors in the tongue, vulva, and chest wall. Multiplicity of the lesions in the left lung and recurrent episodes of intercurrent pulmonary infections necessitated left pneumonectomy. The extreme rarity of such a clinical circumstance is illustrated by a review of the literature. Salient clinical and pathological features of the tumor are briefly discussed.

Adult↗
PubMed1987

Multiple granular cell tumors of the palate.

A report of a case of bilateral granular cell tumors of the soft palate is presented. This is an unusual location for the tumor and is the first report of bilateral tumors at this site.

Adult↗