Purification of a blue-green algal deoxyribonucleic acid photoreactiving enzyme. An enzyme requiring light as a physical cofactor to perform its catalytic function.
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Results for “Physical Functional Performance”
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The use of a simple Likert scale to measure quality of life in brain tumor patients.
The use of a self-administered 10-Point Likert self-assessment quality of life scale was explored in a convenience sample of patients attending a brain tumor clinic. The original scale, developed by Priestman, was modified to be more brain-tumor specific. A total of 430 patients completed the scale at 535 different points of measurement. The patients had a variety of brain tumors ranging from meningiomas to high-grade gliomas. The Total Score of the original scale and the Modified Total Score of the brain-specific version were explored in relationship to patient demographics and available clinical characteristics: age, gender, severity of tumor, location of tumor, survival rates, prior surgery, radiation, radiosurgery, and chemotherapy. We also examined the relationship between sub-scales and these variables. On a scale of 10-100, the average Total Score was 67.83, not significantly different from the Modified Score. There were no differences between bilateral, midline, or left- versus right-sided lesions. Patients with the worst prognosis in terms of tumor type were 5-6 points lower in quality of life than patients with intermediate or relatively good prognosis. In a multiple regression model, adjusted for age, the overall score was related only to tumor severity and to gender, with women having significantly poorer functional status than men by 4 points. Both the Modified and Total Scores were significantly associated with higher mortality risk, and more specifically, poor scores on well-being, mood, physical function, house/job performance, self-care, concentration, and energy all predicted higher mortality risk. We suggest that the simplicity of this instrument may make it particularly useful for longitudinal assessment of quality of life in brain tumor patients.
Activities of Daily Living↗
Comparison of health-related quality of life in three subgroups of spinal cord injury patients.
Health-related quality of life (HRQL) was evaluated in three subgroups of spinal cord injury (SCI) patients: (1) persons who had sustained a pediatric SCI (mean time from injury 20 years, age at injury 11.3 years, n = 36), (2) newly injured patients at the beginning of acute rehabilitation (mean age 35.3 years, n = 31), and (3) patients with a chronic SCI (mean time from injury 4.8 years, mean age at injury 35.2 years, n = 34). All the patients were clinically examined and structurally interviewed with a list of questions dealing with details of anamnestic information about injury, its treatment, possible complications and persons past and present psycho-social condition. HRQL was assessed by a generic fifteen-dimensional self-administered instrument (15D). The relative importance of the 15D dimensions and an overall judgement of health status were measured by a 0-100 visual analogue scale. Average importance weights of the dimensions of moving and working differed significantly in the three subgroups. Patients with pediatric SCI assigned the lowest importance for moving. The newly injured patients highly valued working capability. The HRQL scores of the patients who had sustained their injury in childhood were significantly higher than those of the newly injured patients or chronic patients. The tetraplegic patients estimated their HRQL significantly lower than patients with incomplete paraplegia. Of the three subgroups studied, those with pediatric SCI were well adjusted on the basis of anamnestic information and scored high on HRQL when compared with the other two subgroups. Patients injured in adulthood rated their overall HRQL lower and were often unable to return to work. Patients injured in childhood expressed better performance in physical functions than patients who had sustained their injury in adulthood. The subgroups did not differ in psychological functions.
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The interrelationship of weight loss, dietary intake, and quality of life in ambulatory patients with cancer of the lung, breast, and ovary.
One hundred four consecutive patients with newly diagnosed small cell lung cancer, metastatic breast cancer, and ovarian cancer in good physical functional condition (performance rating 0-1 on Eastern Cooperative Oncology Group scale) were divided into a weight-losing group (> or = 5% unintentional weight loss within 3 mo; n = 48) and a weight-stable group (n = 56). Dietary intakes in relation to fat-free mass were not different in the two groups. According to the Quality of Life index and the General Health Questionnaire, weight-losing patients had significantly lower quality of life than weight-stable patients. In patients with weight loss, daily intakes of energy and protein correlated significantly with scores on the General Health Questionnaire. This study has shown that many ambulatory cancer patients do not eat enough to maintain weight and that even a moderate weight loss is associated with psychological distress and lower quality of life.
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Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: prospective assessment with implications for enhancing compliance.
Non-compliance with therapy is a significant problem, particularly when the disease process is chronic and therapeutic regimens are employed for prolonged periods. We assessed the prevalence and variables associated with compliance with antiretroviral therapy in patients with human immunodeficiency virus infection, by means of a longitudinal observational study of 46 patients aged 23 to 68 years, with human immunodeficiency virus infection, followed at the Pittsburgh VA Medical Center. Data on demographics, medical status, physical functioning (Karnofsky performance scores), CD4 lymphocyte count, depression (Beck depression inventory), coping (inventory of coping with illness scale scores), and psychological and emotional stress (profile of mood states scale scores), were prospectively assessed on all patients at baseline and every 6 months. Compliance was assessed at 6 and 12 months: patients taking > or = 80% of antiretroviral therapy were considered compliant. Overall, 63% of patients were compliant with antiretroviral therapy. Age, education, employment, religious support, and perceived quality of life did not correlate with compliance. By univariate analysis, lack of prior intravenous drug use was significantly associated with compliance (p = 0.01). Compliant patients had significantly better adaptive coping (p = 0.03), and less depression (p = 0.04). By multivariate analysis, black race was significantly associated with non-compliance independent of intravenous drug use and educational status. History of prior opportunistic infection (which presumably heightens the perceived severity of illness) (p = 0.02), and lesser psychological disturbance scores (p = 0.02) were associated with compliance. Compliance was observed despite the greater number of prescription medications taken by compliant patients (p = 0.04). At 12 months, Karnofsky scores were better in compliant patients (p = 0.02), although mortality was not different. Besides identifying predictors of compliance, our data suggest that symptoms of depression and psychological stress be sought in patients with non-adherence.
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Acute delirium and functional decline in the hospitalized elderly patient.
BACKGROUND: Delirium is often considered a transient cognitive syndrome. Its effect on long-term physical function, however, has not been well defined. METHODS: In a prospective study of 325 hospitalized community and nursing home elderly, we analyzed the effect of in-hospital delirium on subsequent physical function. ADL performance was assessed prior to admission, and at 3 and 6 months after hospital discharge. RESULTS: There was a strong univariate (unadjusted) association between incident delirium and functional decline (p < .02). Delirious subjects lost a mean of almost one ADL, as measured 3 months after hospital discharge. Using multivariate linear regression analysis, with adjusted change in function as the dependent variable, delirium persisted as the sole predictor of loss of function (p = .009) at 3 months after discharge. The functional decline persisted at 6 months after hospital discharge. CONCLUSION: This finding of a nontransient, perhaps permanent consequence of delirium invites reexamination of the definition of delirium from that of an acute, reversible syndrome to one of acute onset with long-term sequelae.
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Body composition studies in HIV-infected individuals.
Malnutrition is common in HIV infection. Early studies demonstrated a disproportionate depletion of body cell mass compared to body weight, plus relative expansion of extracellular water volume. Neutron activation studies showed that both potassium and nitrogen were depleted in the HIV+ subjects, whereas cross-sectional imaging documented depletion of skeletal muscle mass. The etiology of malnutrition affects the composition of lost weight. Malnutrition is associated with adverse outcomes, whereas clinical stability is associated with nutritional stability. Increasingly, body composition studies are being incorporated into clinical trials. Hypercaloric feeding promotes gains in weight and body fat, but not in lean mass. Adjunctive therapies include anabolic agents, both steroids and recombinant human growth hormone (rhGH), cytokine inhibitors, and resistance training exercise. In addition to increasing fat-free mass, these therapies also have benefits in quality of life, notably functional performance, as well as physical function. Current research on alterations in body composition in HIV have noted a redistribution of fat, with visceral obesity in patients receiving highly active antiretroviral therapies.
Acquired Immunodeficiency Syndrome↗
Effect of treadmill and overground walking on function and attitudes in older adults.
PURPOSE: The purpose of this study was to determine whether treadmill walking, as a mode of physical activity for older adults, was comparable with overground walking when considering 1) spatiotemporal gait characteristics (walking velocity, stride length, and stride rate) at a preferred velocity and a prescribed intensity typical of many exercise prescriptions (i.e., RPE of 13); and 2) the effects on physical function (short physical performance battery (SPPB), lateral mobility, 400-m walk) and participants' attitude towards training and level of enjoyment. METHODS: Gait characteristics were measured at each participant's preferred and RPE 13 velocity during treadmill and overground walking (N=23, 74+/-4 yr). Participants were then randomized to either a treadmill or overground progressive intensity and duration walking program of 18 sessions. RESULTS: Both the preferred and RPE 13 walking velocities were significantly slower on the treadmill compared with overground (t(22)=-10.87, P<0.001 and t(22)=-8.54, P<0.001, respectively), as a result of significantly shorter stride lengths and slower stride rates. After training, there were no differences between the groups for RPE 13 velocity, SPPB or lateral mobility. However, following the intervention, the overground group completed the 400-m walk faster (F(1,15)=6.06, P<0.05), had a more favorable attitude towards training, and expressed a more favorable level of enjoyment about the training program than the treadmill group (F(1,16)=7.5; P<0.05). CONCLUSION: An overground walking program appears to offer some advantages over a treadmill walking program in older adults. Using RPE alone to regulate intensity may reduce the benefits of a treadmill walking program in older adults.
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Glycemic carbohydrate and health: background and synopsis of the symposium.
Carbohydrates are global foodstuffs and important energy sources. They also influence many physiologic functions, including brain function and physical performance and are ultimately related to human health. In 1998, ILSI Japan formed a team to conduct research on "The Medical and Nutritional Aspects of Sugars." The research included studies of several new aspects of the metabolic characteristics and physiologic effects of sugars. This paper presents some highlights of our research, including the background of the project, the metabolic characteristics of sugars, and the effect of sugars on glycemic response, memory, and appetite and food intake in humans, etc.
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Outcomes of total hip arthroplasty: a study of patients one year postsurgery.
STUDY DESIGN: Ex post facto research using prospective analysis of differences between the involved hip and uninvolved hip. OBJECTIVES: To assess outcomes of total hip arthroplasty (THA) by comparing range of motion (ROM), muscle strength, and postural stability in the surgical hip to those of the uninvolved hip 1 year postsurgery. An additional objective was to assess degree of relationship among ROM, strength, and postural stability impairments to a measure of self-assessed function. BACKGROUND: Most patients who have THA receive physical therapy that consists mainly of self-care instructions and an exercise protocol that emphasizes mobility during the acute phase of recovery. But, outcomes of THA 1 year postsurgery indicate that current physical therapy programs used during the acute phase of recovery do not effectively restore physical and functional performance. METHODS AND MEASURES: Subjects consisted of 11 women and 4 men (mean age +/- standard deviation = 62 +/- 8 years) with unilateral THA performed 1 year prior to data collection. Assessment variables consisted of self-assessment of function and measures of postural stability, muscle strength, and hip ROM. The 12-Item Hip Questionnaire was used for self-assessment of function. Three separate repeated measures MANOVA were used to compare the involved side to the uninvolved side in measures of postural stability, strength, and ROM. The Spearman's rho was used to assess degree of association between the subjects' score of self-assessed function and impairments in strength and postural stability. RESULTS: Measures of postural stability were significantly lower (P < or = 0.01) on the side of the replaced hip. Differences in strength values between the involved and uninvolved sides were not statistically significant. Correlations between scores of self-assessed function and hip abductor and knee extensor strength were statistically significant (r = 0.56, P < or = 0.03). Self-assessed function was not significantly correlated to postural stability impairments. CONCLUSION: The brief postsurgical rehabilitation program received by patients with THA may not be sufficient. A second phase of rehabilitation implemented 4 months or more after surgery that emphasizes weight bearing and postural stability may be advisable.
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Effects of intensity of treatment and length of stay on rehabilitation outcomes.
The combined effects of intensity of treatment and length of stay during inpatient rehabilitation hospitalization on the outcomes of 95 traumatic brain injury patients were examined. Outcome was assessed using the Rancho Scale and three measures of functional status--physical performance, higher-level cognitive skills, and cognitively mediated physical skills. The effects of intensity of treatment and length of stay were assessed using 2 x 2 analyses of variance with repeated measures. The results showed clearly that both length of stay and intensity of treatment affect outcomes. Patients in the long length of stay group consistently made more progress across all outcome variables than patients in the short length of stay group. However, the greater progress of the long length of stay patients was from a point significantly more disabled than that of the short length of stay patients, with improvement at discharge to the point at which the groups were now equal. The effect of intensity of treatment was significant or closely approached significance for higher-level cognitive skills and Rancho Level. In the long length of stay group, the two intensity groups were initially equivalent, but at discharge the high-intensity group surpassed the low-intensity group. The practical implications of the results are discussed.
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Incidence of upper extremity discomfort among piano students.
The purpose of this study was to determine the incidence of upper extremity discomfort among piano majors at seven Philadelphia-area music schools. A questionnaire was distributed to 232 students, and a 31% return rate was obtained. Thirty (42%) of the 71 respondents reported experiencing discomfort that lasted more than 1 week, and 41 (58%) of the respondents reported experiencing little or no discomfort. Twenty-six (87%) of the students with discomfort suspended practice for a period of time or made adjustments at the piano. Pain/aching was the predominant discomfort reported among students. Students experienced their discomforts most frequently in the band (49% of respondents), the forearm (19% of respondents), and the wrist (16% of respondents). The majority of students reported an impaired ability to play the piano that lasted for 6 months or less. Further research is needed to verify the scope of the problem among student pianists and to substantiate the numerous causes of discomfort that were uncovered in this study. This occupational group could benefit from the knowledge and skills of occupational therapists in the area of occupational performance and physical function.
Adult↗
[Consequences of osteoporotic fractures--epidemiological review].
Most fractures among the elderly is a common consequence of osteoporosis and occurs very frequently in older people. Osteoporotic fractures are associated with diminished physical and functional performance, difficulties in performing activities of daily living (ADL), and a decline in several aspects of well-being or quality of life (QOL). In this article, consequence of osteoporotic fractures are reviewed based on the recent population-based epidemiological studies.
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[Quality of life following anterior skull base surgery].
Surgery for craniofacial resections is continuously improving, enabling the extirpation of tumors once considered unresectable. Nevertheless, the physical and psychological sequelae of these procedures and their affect on patients' everyday lives have not been systematically evaluated. The purpose of this study was to estimate the impact of anterior skull base surgery on the long-term quality of life (QOL) and on the family relations of patients with anterior skull base tumors. Demographic, medical and outcome data on 69 patients undergoing subcranial surgery for extirpation of tumors were retrospectively analyzed. Within this group, 35 patients and their lay caregiver successfully completed a disease-specific questionnaire. We did not find significant differences in QOL estimation between patients and their caregivers. Malignancy had the most significant impact on QOL, leading to a significant decrease in the overall score. Radiotherapy significantly decreased the scores in the specific symptoms and influence upon emotions domains. Age and comorbidity reduced the scores in the role of performance and physical function domains. A better correlation was found between the scores of married couples than between patients and lay caregivers who weren't married. Eighty three percent of the married couple's replies noted that the disease and surgery did not influence their relations. We conclude that malignancy, radiotherapy, comorbidity and age over 60, significantly impair quality of life in patients undergoing anterior skull base surgery. We suggest that a rehabilitation program should be implemented in these patients in order to improve their overall QOL.
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Racial analyses of longer-stay nursing home residents with multiple sclerosis.
OBJECTIVES: Compare profiles of African Americans with multiple sclerosis (MS) to White residents with MS one year after admission to a nursing facility. METHODS: We used all admission assessments recorded in the national Minimum Data Set (MDS) from 1999 to 2001 as well as all MDS annual assessments recorded from 2000 to 2002. We matched admission assessments with first annual assessment for 3632 White residents with MS and 461 African-American residents with MS. RESULTS: African Americans with MS were admitted at a significantly younger age and with more aid to daily living (ADL) dependence and cognitive dysfunction than Whites with MS one year after admission. Despite significantly poorer physical performance, cognitive function, and more medical comorbidities, African Americans with MS did not receive significantly more therapies or medications than White residents with MS after one year in the facility. CONCLUSIONS: Basic differences in MS expression and progression in African Americans appear to have to do with both genetic and environmental factors. Further study will help to clarify the reasons for these differences.
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Quadriceps activation failure as a moderator of the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis.
OBJECTIVE: To determine if quadriceps activation failure (QAF) moderates the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis (OA). METHODS: Quadriceps strength and QAF were measured in 105 subjects (80 females) with radiographically confirmed knee OA using a burst-superimposition maximum voluntary isometric quadriceps torque test procedure. Subjects performed the Get Up and Go test as a physical performance measure of function and completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a self-report measure of function. A principal component analysis was performed to combine the Get Up and Go score and the WOMAC subscores into a single function score. Hierarchical regression analysis was performed to examine the ability of 3 models to predict physical function (strength = function; strength + QAF = function; strength + QAF + [strength x QAF] = function). Partial F tests were used to compare differences in R(2) values between each model. RESULTS: Each model independently predicted the principal component score for function. Adding the strength x QAF interaction term with strength to the model resulted in the highest prediction of function. The strength x QAF interaction indicated that subjects with lower levels of quadriceps strength and higher levels of QAF had lower levels of function than those with comparable levels of weakness but low levels of QAF. CONCLUSION: The magnitude of QAF serves to moderate the relationship between quadriceps strength and physical function. Physical function may be more severely affected by weakness of the quadriceps muscles in individuals with knee OA who have higher degrees of QAF than those who may have quadriceps weakness, but do not have QAF.
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Physical performance measures in aging research.
Evaluation of physical functioning plays a valuable role in clinical geriatrics as well as in aging research. Physical functioning has generally been assessed through self- or proxy-report. An important addition to this form of assessment is the use of performance measures of physical function, in which individuals are asked to actually perform specific tasks and are evaluated using standardized criteria. Although there has been limited methodological work on physical performance instruments, this approach offers a number of potential advantages. Several performance assessments have been developed that correlate highly with other measures of health status and predict need for long-term care and mortality. It is suggested that more widespread use be made of physical performance assessments and that they be evaluated as measures of functioning in cross-national studies, as indicators of change in functioning over time, as endpoints in intervention studies, as tools for identifying persons functioning at high levels, and as sources of relevant information for the clinician.
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Natural history of physical function in older men with intermittent claudication.
PURPOSE: This study was undertaken to determine the natural history of physical function in older men limited by intermittent claudication. METHODS: Forty-three men limited by intermittent claudication (mean age, 69 +/- 7 years) were recruited and followed up for 18 months. At baseline the patients reported a history of intermittent claudication for 6.1 +/- 6.1 years, and were able to walk for 1.9 +/- 1.6 blocks before experiencing claudication pain. Measurements during the 18-month study included ankle-brachial index (ABI), calf blood flow, 6-minute walk performance, monitored and self-reported physical activity, self-reported stability while walking, and summary performance score of physical function determined from a 4-m walk test, a chair stand test, and a tandem stand test. RESULTS: Pain-free walking distance during the 6-minute walk test decreased by 22% (P <.05) from baseline (185 +/- 96 m) to follow-up (144 +/- 93 m), and the total 6-minute walk distance decreased by 9% (P <.05), from 368 +/- 106 m to 334 +/- 90 m. Furthermore, monitored physical activity decreased by 31% (P <.05), from 159 +/- 151 kcal/d to 110 +/- 137 kcal/d; self-reported physical activity declined by 27% (P <.05), from 1.5 +/- 1.0 units to 1.1 +/- 0.8 units; tandem stance time declined by 14% (P <.05), from 9.46 +/- 1.83 seconds to 8.12 +/- 2.10 seconds; summary performance score of physical function decreased by 12% (P <.05), from 6.8 +/- 2.4 units to 6.0 +/- 2.4 units; and the percentage of patients reporting ambulatory unsteadiness and stumbling increased from 28% to 43% (P <.05). Calf blood flow measured at rest declined by 18% (P <.05), from 3.72 +/- 1.81 (mL/100 mL(-1)/min(-1)) to 3.04 +/- 1.43 mL/100 mL(-1)/min(-1), whereas ABI did not change (P >.05). CONCLUSION: Older men limited by intermittent claudication experienced decline in ambulatory function, physical activity, physical function, stability, and calf blood flow over 18 months of follow-up, despite no change in ABI.
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