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Results for “Polypharmacy”

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At least 217 records · Page 12Linked to original sources
PubMed2000

Rational antipsychotic polypharmacy.

The use of two antipsychotics for the treatment of individuals with psychiatric disorders is not uncommon in clinical practice but is rarely documented in the literature. The present article suggests an alternative method of treating individuals who show a partial but inadequate response to antipsychotic monotherapy. A rational strategy for augmenting one antipsychotic with a second, based on pharmacodynamic and pharmacokinetic principles, is provided. The present approach considers the 5-hydroxytryptamine2 to dopamine2 ratio, other complementary receptor affinities and drug-drug interactions involving the cytochrome P450 isoenzymes. The present article presents a rationale for augmenting haloperidol in patients who are partially responsive to clozapine.

Antipsychotic Agents↗
PubMed2001

Polypharmacy.

In today's managed healthcare environment two issues are at the forefront of concern: patient safety and patient confidentiality. Both of these share a common element in their relationship with medical and pharmaceutical health data. Patient safety depends upon access to this information, and yet ironically, medical and pharmaceutical records are now more difficult to access. This article looks at a case study of patients in Appalachia and how various issues influence patient safety, information that is needed and how to use these resources to reduce medical risk, especially in pharmaceutical therapies of the elderly.

Access to Information↗
PubMed2002

[Severe parkinsonism due to metoclopramide in a patient with polypharmacy].

A 73-year-old woman, with tuberculosis of the large intestine, developed nausea as a side effect of the antituberculosis drugs. The nausea was treated with metoclopramide. Subsequently she developed severe medication-induced parkinsonism. As her symptoms initially mimicked a depressive disorder, drug-induced parkinsonism was only considered at a later stage. Due to drug-induced impaired function of the liver and kidney the patient had received a toxic dose of metoclopramide. Treatment with biperiden and withdrawal of the metoclopramide resulted in a reduction of the complaints within 3 months, after which the anti-tuberculosis medication could be reintroduced. Adjusting the dose of metoclopramide could possibly have prevented this severe side effect.

Aged↗