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At least 217 records · Page 12Linked to original sources
PubMed2001

Skin allograft maintenance in a new synchimeric model system of tolerance.

Treatment of mice with a single donor-specific transfusion plus a brief course of anti-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion of alloreactive CD8+ T cells. Survival of islet allografts in treated mice is permanent, but skin grafts eventually fail unless recipients are thymectomized. To analyze the mechanisms underlying tolerance induction, maintenance, and failure in euthymic mice we created a new analytical system based on allo-TCR-transgenic hemopoietic chimeric graft recipients. Chimeras were CBA (H-2(k)) mice engrafted with small numbers of syngeneic TCR-transgenic KB5 bone marrow cells. These mice subsequently circulated a self-renewing trace population of anti-H-2(b)-alloreactive CD8+ T cells maturing in a normal microenvironment. With this system, we studied the maintenance of H-2(b) allografts in tolerized mice. We documented that alloreactive CD8+ T cells deleted during tolerance induction slowly returned toward pretreatment levels. Skin allograft rejection in this system occurred in the context of 1) increasing numbers of alloreactive CD8+ cells; 2) a decline in anti-CD154 mAb concentration to levels too low to inhibit costimulatory functions; and 3) activation of the alloreactive CD8+ T cells during graft rejection following deliberate depletion of regulatory CD4+ T cells. Rejection of healed-in allografts in tolerized mice appears to be a dynamic process dependent on the level of residual costimulation blockade, CD4+ regulatory cells, and activated alloreactive CD8+ thymic emigrants that have repopulated the periphery after tolerization.

Animals↗
PubMed1999

[The research of evaluation the compatibility of biotic material in cell-culturing method].

It is quick convienent good-repeating and cheap that examining the biotic material's compatibility through cell-culturing method, and it is more and more important in evaluating the compatibility of biotic material. The new material appearing continously complicating of the part and aim material be planted in the intensity of material's toxic effect the reaction's complication of material and biotic body, all of these decide the variety of experiment method and cells in cell toxicity experiment. It is very important that choices the right experiment method and cells according to the material's character the part and aim the material be planted in. The evaluation of biotic material's compatibility stressed on the changing of cell's form and quantity before. In recent years, more and more reports appear about material influences the growth. Adhesion proliferation and metabolizing of cell, and presents the point that the evaluation standard of biotic material's compatibility should be set according to the active cell's quantity and their growth. Combining many subject's technological development, such as immunology, chemistry, radiation and shadowgraphy, thoroughly inquires the changing relation of cell's structure and function, furtherly clarifes the material's effect on cell. It is the developing direction in the future that evaluates the biotic material's compatibility in cell-culturing method.

Cell Culture Techniques↗