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At least 217 records · Page 12Linked to original sources
PubMed1994

[Significance of monitoring histamine serum levels, cryoglobulins and complement titers during cold tests in patients with cold allergy and Raynaud's phenomenon].

The aim of our investigations is to evaluate blood histamine, complement titer and cryoglobulins before and after cold stimulation (extremity water immersion test) in patients with cold urticaria and Raynaud phenomenon. In our investigations patients were put into five groups according to the following diagnoses: cold urticaria (40 patients), chronic urticaria (15 patients), Urticaria-Vasculitis Syndrome (15 patients), Raynauds Disease (16 patients), and Raynauds phenomenon (15 patients). The investigations demonstrated that the test was always positive in cold urticaria and that a high percentage of patients had a rise in blood histamine. This was found in 50% of the patients while cryoglobulins were found in one third of the patients. Consequently they can be grouped in secondary cold urticarias. A number of patients with chronic urticaria and Urticaria-Vasculitis Syndrome gave a positive history of cold sensitivity. Positive tests were accompanied by a rise in histamine, although (less frequently) there was a decrease in the complement titer and the occurence of cryoglobulins. Raynauds Disease was accompanied by a positive test in 94% of the patients, while patients with Raynauds Phenomenon (whose etiology was Thoracic Outlet Syndrome) had a negative test (60% of the patients). Significant changes were not found in the remaining groups. Positive tests were accompanied by abnormal values of cryoglobulins and of complement titer as well as an increase in histamine. The rise in histamine was not significant in Raynauds Phenomenon, while one patient had a decrease in the complement titer and the appearance of cryoglobulins.

Adolescent↗
PubMed1977

[Clinical course, diagnosis and surgical treatment of Raynaud's disease].

The work is based on the experience with treatment of 86 patients with Raynaud's disease. 41 patients were treated conservatively, in 45 patients thoracic sympathectomy was performed. All 45 patients subjected to thoracic sympathectomy showed excellent and good immediate results. Late results were favourable in 20 out of 23 operated patients, examined within the terms from 5 to 15 years postoperatively. Thus, thoracic sympathectomy is an effective method of treatment for Raynaud's disease.

Adolescent↗
PubMed1991

[Local administration of cerebrolysin in Raynaud's disease in a 2-year-old child].

A case of Raynaud's disease in a 2-year-old child seen by the authors for 1.5 yr. is described. The paper treats of the basic reported data on the pathogenesis, clinical picture and treatment of Raynaud's phenomenon and disease; the child's disease history and the main clinical manifestations are described as are the results of examinations. The case is characterized by successful counteracting the main clinical manifestations of Raynaud's phenomenon by the local metameric application of cerebrolysin (neuromeric, scleromeric puncturing) employed by the authors for the first time for the disease treatment. Interpretation of the effect obtained is briefed.

Amino Acids↗
PubMed1989

Induction of vasospastic attacks despite digital nerve block in Raynaud's disease and phenomenon.

Using a combination of environmental and local cooling, we induced vasospastic attacks of Raynaud's phenomenon in nine of 11 patients with idiopathic Raynaud's disease and in eight of 10 patients with scleroderma. Attacks were defined as occurring if two of the possible three color changes (pallor, cyanosis, and rubor) occurred, and serial photographs were scored by three independent raters. Two fingers on one hand were anesthetized by local injection of lidocaine, and the effectiveness of nerve blocks was verified by plethysmography. The frequency of vasospastic attacks in nerve-blocked fingers was not significantly different from that in the corresponding intact fingers on the contralateral hand. These findings show that the vasospastic attacks of Raynaud's disease and phenomenon can occur without the involvement of efferent digital nerves and argue against the etiologic role of sympathetic hyperactivity.

Cold Temperature↗
PubMedDate not supplied

[Rheographic evaluation of the changes in blood flow after superficial electric stimulation in patients with Raynaud's disease or syndrome].

An effect of the superficial electrostimulation on skin microcirculation in the patients with both Raynaud's disease and syndrome was assessed with electro-impedance rheography. Significant increase of blood flow through the stimulated region was seen (mean value 42%). It was also shown that electro-impedance rheography is of value in both quantitative and qualitative investigation comparing Raynaud's disease and syndrome.

Adult↗
PubMed1983

[Digital capillaroscopy in idiopathic Raynaud's disease].

Nail-fold capillaroscopy is performed on 135 patients with primary Raynaud's disease. There is no significant difference between patients with long clinical story and new ones. The capillaroscopy is highly correlated with severity of vasomotor troubles. Parameters of bad prognosis are a high frequency of morphological abnormalities, venodilation, sludge phenomenon and hemorrhagies.

Adult↗
PubMed1998

Functional studies in small arteries do not support a primary role for endothelin in the pathogenesis of Raynaud's disease.

Endothelin-1 (ET-1) has been implicated in the pathogenesis of Raynaud's disease (RD). This study examined the effect of cooling on the response to ET-1 in human microvessels. Subcutaneous small arteries were dissected from gluteal fat biopsies taken from patients with RD (n = 20) and from age- and sex-matched control subjects (n = 17) and were cannulated in a small vessel arteriograph. Cumulative concentration-response curves to ET-1 (10(-12) to 3 x 10(-7) M) were obtained in vessels at 37 degrees C and 24 degrees C, with the endothelium either intact or removed (n = 6 per group). There were no significant differences in responses to ET-1 between RD patients and controls in either intact or denuded vessels, at either 37 degrees C or at 24 degrees C. There was, however, a significant endothelium-dependent interaction between the groups when the effect of temperature on the response to ET-1 was examined (p = 0.01; two-way ANOVA). Whereas cooling tended to reduce the sensitivity in RD, the opposite effect was observed in controls. Measurements of plasma ET-1 did not reveal any significant difference between patients with RD and healthy controls. These results suggest that ET-1 does not play a primary pathophysiologic role in RD. ET-1 might be responsible for mediating the prolonged vasospasm in RD, but secondary to another factor(s), such as impaired endothelium-dependent vasodilation.

Adult↗