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At least 217 records · Page 12Linked to original sources

[Effect of novelty and behavioral stereotype on development of amnesia in mice].

The research was aimed at analysis of interaction of basic behavioural strategy, extinction of information novelty and efficiency of amnesic influence. It is shown that preliminary habituation to the task apparatus prevented development of amnesia, induced detention of the animal in a dangerous compartment in submissive rather than aggressive mice C57BL/6J. The findings suggest that revealed distinctions in effects of pre-exposure on development of amnesia are essentially predetermined by selectivity of extinction of the information novelty specific to a stereotype of behaviour.

Aggression↗

[Different role of various regions of the caudate nucleus in phenamine-induced stereotyped behavior in cats].

Electrolytic ablation of the ventral parts of the cat caudate nucleus head results in an increase of frequency and disorganization of the pattern of the stereotype head turnings, induced by large doses of amphetamine. Lesion of the dorsal parts, on the other hand, is attended with a decreased number and limited manifestation of stereotype movements. A similar effect appears following a low frequency electrical stimulation of the nucleus ventral part. The disrupting action of neuroleptic haloperidol on the amphetamine-induced stereotype is weakened in animals with ventral lesions and enhanced in those with dorsal lesions. Due to dopaminergic activity, the amphetamine, apparently, produces a functional unbalance between different zones of the caudate nucleus, which underlies stereotype behaviour.

Amphetamine↗

[The effect of the deprivation of paradoxical sleep on the rotational and stereotyped behavior induced by selective agonists of the dopamine receptors].

The ability of selective D1 and D2 agonists of dopamine (DA) receptors SKE-38393 and Ly-171555 to induce rotational and stereotypes behaviour were studied in rats with unilateral striatal kainic acid lesion before and after procedure of REM sleep deprivation (REMSD) lasting for 5 days. It was found that REMSD SKF-38393 given along induced the ipsilateral rotation. REMSD increased the circling and decreased an oral stereotype simultaneously when SKF-38393 and Ly-171555 were given together. The depletion of brain DA in part with alpha-methyl-p-tyrosine (AMPT) in nondeprived rats fails to influence the rotational behaviour and stereotype when SKF 38393 was injected 30 min following Ly-171555. After REMSD the AMPT pretreatment prevents the rotational behaviour caused by Ly-171555 which restores SKF-38393. The results suggest that prolonged REMSD may induce nonidentical changes in the sensitivity of the postsynaptic D1 and D2 receptors.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗

Effects of vestibular stimulation on motor development and stereotyped behavior of developmentally delayed children.

Four developmentally delayed babies were given semicircular canal stimulation in an effort to facilitate their motor and reflex development. Each of the children also exhibited abnormal stereotyped movements. The theory was advanced that these movements are related to motor development and that significant improvements in motor abilities will produce changes in the intensity and/or form of stereotypic responding. Semicircular canal stimulation was provided by rotating the children in a motor-driven chair at a velocity of about 17 rpm for 10 minutes daily over a period of 2 weeks. Standard motor and reflex measures were taken before, during, and after the rotation treatment period. Daily observations were made of the children's stereotyped movements. Over the course of the study all of the children showed motor and/or reflex changes that were attributable to the vestibular stimulation. In addition, some evidence was obtained linking changes in stereotypic responding to the vestibular stimulation.

Arousal↗

[Laterality in institutionalized patients with moderate, severe and very severe mental retardation and stereotyped behavior].

A total of 54 moderately (n = 13), more severely (n = 27) and severely (n = 14) mentally retarded persons living in institutions were dealt with in this paper. Qualities of their stereotyped actions were analysed and compared in respect to the used lateralization according to Cordić-Bojanin's modified scale and to Berg's scale for used lateralization. Results obtained pointed to the differences among stereotypes themselves in respect to the influence of social environment and the degree of retardation. Therefore, twisting of the body was regarded as the "mildest" form of retardation and passivity, while the motions of hands only were associated with the most severe ones. Used lateralization in the form of dextrality occurred in 62.96%, in the ambidextrality in 14.8% while sinistrality accounted for 22.2%. Right-handed persons most frequently showed stereotyped behaviour which was manifested by the forward-backward motion of the body, while left-handed persons showed stereotypes connected with hands. It was believed that the tonus which represented the termination of the voluntary action and the basis of the development of lateralization would be regarded as the connection between lateralization and stereotypes.

Adolescent↗

Stereotypic behavior, endogenous opioids, and postfeeding hypoalgesia in pigs.

Tethered sows, some of which performed marked behavioral stereotypies after feeding, were injected IM with 1 mg/kg of naloxone 30 min before feeding (with 2 saline control days). Tail-flick latencies on a pain-sensitivity test were recorded before and after feeding. On control days, tail-flick latencies after feeding were longer than those before feeding, and this effect was abolished by naloxone pretreatment. Thus, there is an opioid-based hypoalgesia after feeding. However, sows with marked behavioral stereotypies had shorter tail-flick latencies after feeding. Thus, we have no evidence that performance of behavioral stereotypies results in increased opioid activity. Naloxone reduced the time spent in behavioral stereotypies by approximately 30% but this may be due to a reduction in time spent active. Naloxone increased the frequency and reduced the mean duration of bouts of chain manipulating, operating the drinker and rooting. We suggest that endogenous opioids are involved in the positive feedback that maintains the persistence of behavior and inhibits switching between different activities.

Animals↗

Growth differences associated with compulsive and stereotyped behavior disorders in adults with mental retardation.

We have recently observed that compulsive behaviors in mentally retarded patients appear to be quite prevalent, can be reliably assessed, and have a high rate of co-occurrence with stereotyped and self-injurious behaviors in this population. As abnormal growth rate has been observed in obsessive-compulsive disorder (OCD) patients, we examined physical stature in adults with mental retardation who display repetitive movement disorders. Identification of cases with stereotypic movement disorder, and cases with compulsive behaviors was done using a symptom checklist and direct observation. Subjects with repetitive movement disorders were smaller in stature than control subjects, with gender differences observed across repetitive behavior disorders. Specifically, female subjects with compulsive behavior disorder, but not stereotypic movement disorder, were significantly shorter and weighted significantly less than same sex-matched controls. Conversely, male subjects with stereotypic movement disorder, but not compulsive disorder, were significantly shorter and weighed significantly less than same sex controls. These findings may point to a neuroendocrine abnormality associated with repetitive movement disorders.

Adolescent↗