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Direct and indirect interrelations between anthropometric and physiological variables in athletic and non-athletic adolescent girls: a path-analytic study.

Our previous analysis of anthropometric and exercise test data of 62 athletic and 56 non-athletic girls (age range 10.5-15.5 years) showed that the intensity of habitual exercise failed to discriminate between the group means of the studied variables. However, the patterns of intervariable correlations differed between the subgroups categorized by physical activity. The present paper studies the problem of this difference further by using exploratory multivariate regression of aerobic power (VO2max) on 10 anthropometric variables and age. The VO2(max) regression was significant (Y(nonathletic) = 0.0194x(1) + 0.004x(2) - 0.371x(3) + 0.045x(4) - 0.177x(5) + 0.070x(6) - 0.271x(7) - 0.170x(8) + 0.015x(9) - 0.0005x(10) + 0.185x(11), SEE = 0.37, R2 = 0.71, F(11.44) = 9.63; Y(athletic) = 0.029x(1) + 0.063x(2) + 0.277x(3) - 0.030x(4) - 0.069x(5) + 0.151x(6) - 0.148x(7) + 0.001x(8) + 0.018x(9) - 0.019x(10) - 0.065x(11), SEE = 0.32, R2 = 0.71, F(11.50) = 11.30), but none or only one of the independent variables had a significant partial regression coefficient. The individual VO2(max) estimates were studied in both groups by using the other group's regression formula to rule out sample dependence. Both formulae gave good approximations of the observed values in spite of the dissimilar regression coefficients. The path analysis of the respective criterion-predictor correlation coefficients confirmed that the relationship of the predictor variables with VO2(max) involved quantitatively direct and indirect effects in the non-athletic and athletic groups.

Adolescent↗

Human plasma extrinsic pathway inhibitor activity: I. Standardization of assay and evaluation of physiologic variables.

An assay was standardized to measure extrinsic pathway inhibitor (EPI) activity in human plasma. Variables that could potentially influence its measurement were systematically examined. The coefficient of variation of the assay was 6.3% for the same sample assayed on different days. The linear regression line for a plot of observed v expected values of mixtures of plasmas with different EPI levels was Y = 1.01X - 2.7%. Single samples from 21 healthy adults under 60 years of age varied between 74% and 159% of a pooled reference plasma. The plasma level of a given individual (eight subjects) did not vary on repeat sampling over weeks to months. EPI activity was significantly lower in plasma from umbilical cord blood (64.3% +/- 12.7%, n = 16) than in plasma from adults. Mean EPI activity in adults greater than or equal to 60 years of age was slightly but significantly higher (112% +/- 16.8%, n = 23) than in adults less than 60 years of age (97.2% +/- 19.0%, n = 21). EPI levels in the third trimester of pregnancy were slightly higher than in nonpregnant women. Plasma EPI levels fell slightly after surgical procedures that caused fibrinogen levels to rise, which suggests that EPI is not an acute phase reactant. Administration of 1-desamino-8-d-arginine vasopressin (DDAVP) did not alter plasma EPI levels. In two patients subjected to plasmapheresis and volume replacement with albumin and isotonic saline, plasma EPI levels returned to one-half of the levels before pheresis within about one day.

Acute-Phase Proteins↗

Effects of skating and diagonal skiing techniques on results and some physiological variables.

In this study, the effects of skating and diagonal techniques on skiing load at various speeds were compared. When skiing at the same speed, subjects' heart rates were significantly lower when using the skating technique than when using the diagonal technique (p less than 0.05). At maximal speed, skating technique gave a significantly higher speed at the same heart rate (p less than 0.001) than diagonal technique. Above the anaerobic threshold (4 mmol.L-1) blood lactic acid levels remained significantly lower (p less than 0.005) when using the skating technique than when using the diagonal technique. The results suggest that at the same speed, skating technique loads aerobic and anaerobic energy production less than diagonal technique, and that the same maximal energy production gives a significantly higher skiing speed when using the skating technique than when the diagonal technique (p less than 0.001).

Anaerobic Threshold↗

Efficaciousness of immunoglobulin G prophylaxis on mortality and physiological variables in gram-negative peritonitis in rodents.

A rapidly expanding role involving the use of immunoglobulin preparations in conditions other than the classical immunodeficiency syndromes is evident in recent years. Treatment with immunoglobulin may be especially important during infection in which specific antibody to pathogens has been consumed, degraded, or not produced and in cases in which antibiotic treatment is ineffective. Recent studies in animals and humans support this concept, although further studies are needed to fully develop it. This study was completed to explore possible beneficial effects of prophylactic treatment of rodents during severe Salmonella typhimurium peritonitis with a newly developed native immunoglobulin G preparation for intravenous use (IGIV pH 4.25). This study demonstrates that IGIV pH 4.25 increases survival time and decreases absolute mortality, prevents hypotension and acidosis, and ameliorates or prevents changes in variables indicative of organ damage during S. typhimurium bacteremia in the rat. Studies in mice indicate that protection is mediated by antibody to cell surface antigen (s) of S. typhimurium.

Acidosis↗