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At least 217 records · Page 12Linked to original sources

PubMed1986

Malignancy grading in oral squamous cell carcinoma. I. Squamous cell carcinoma of the tongue and floor of mouth: histologic grading in the clinical evaluation.

In a retrospective histological and clinical study, a multifactorial grading system was used for histological classification and grading of malignancy in 51 cases of squamous cell carcinoma of the tongue and floor of mouth. The results indicated that the use of such a multifactorial grading system, consisting of 7 morphological parameters, including an evaluation of both the tumor cell population itself and the tumor-host relationship, can serve as an important supplement to clinical judgement in determining the outcome of the oral tumor.

Adult↗

PubMed1988

Squamous cell carcinoma antigen as a marker for squamous cell carcinoma of the anal canal.

Twenty-one patients with documented squamous cell carcinoma (SCC) of the anal canal underwent prospective serial collection of 101 serum samples for radioimmunoassay of SCC antigen to evaluate regression or progression of disease. Eighteen presented with primary SCC of the anal canal, two with metastatic disease, and one with a recurrence in the perineum. Median follow-up was 18 months. Thirteen of 22 serum samples were true-positives, and nine of 22 were false-negatives. Four of 79 serum samples were false-positives and 75 of 79 were true-negatives. The sensitivity of this test is 59% and the specificity is 95%, with the accuracy of a positive test being 76%.

Adult↗

PubMed1997

Flow cytometric DNA content analysis of ultraviolet light-induced squamous cell carcinomas: a comparative study of squamous cell carcinomas of the lip and those arising from other sites of sun-damaged skin.

The development of squamous cell carcinoma (SCC) of the lip is considered to be mainly related to excessive sun exposure. However, its higher metastatic rate is distinct from that of SCCs arising from other sites of sun-damaged skin. Flow cytometric DNA content analysis, using paraffin-embedded specimens, was performed on 15 SCCs of the lip and 32 SCCs arising from other sites of sun-damaged skin. A significantly lower incidence of DNA-aneuploidy was observed in SCCs of the lip (2/15) than in those of sun-damaged skin (15/32) (p < 0.05). The mean age of patients with SCC of the lip (66.7 +/- 11.6 years; mean +/- SD) was significantly lower than that of the other patients (78.1 +/- 11.1 years) (p < 0.01). There was no significant difference between the mean diameter size of tumors on the lip (19.5 +/- 5.7 mm) and that of tumors on other sites of sun-damaged skin (30.7 +/- 20.5 mm). These results suggest that additional carcinogenic factors besides ultraviolet light may be involved in the development of SCC of the lip.

Adult↗

PubMed2000

[Squamous cell carcinoma antigen (Scc-Ag): diagnostic utility in squamous cell carcinoma antigen of the head and neck with metastasis to lymph nodes].

Aim of the work was estimation of squamous cell carcinoma antigen (SCC) concentrations in serum and qualification its diagnostic value in patients with malignant neoplasm of head and neck in dependence from presence of metastasis to lymphatic glands. The study comprised the group of 146 persons (108 with head and neck malignant neoplasm, 38 of persons determined group supervisory). At 35 ill one ascertained metastasis to lymph nodes. In presented work sensitivity of SCC in initial investigation was (52.8%), specificity (97.4%), positive predicting value (PV+ = 94.2%) and negative predicting value (PV- = 64.0%). We observed not characteristic statistical dependence of concentrations SCC from presence of metastasis to lymph nodes. There was characteristic correlation between concentration of SCC and presence of metastasis to regional lymphatic glands using of correlation R-Spearman.

Adolescent↗

PubMed2004

Distinction of low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions based on quantitative analysis of proliferative activity.

The management of cervical dysplasia is determined by the grade of SIL (LSIL, conservative management; HSIL, ablative/excisional therapy). The grading, however, is subjective and its reproducibility is low. This study evaluates if quantitative differences in mitotic activity and MIB-1 expression (ME) in LSIL and HSIL are helpful in their discrimination. Twenty-seven cervical biopsies with LSIL and 16 with HSIL were immunostained for MIB-1. ME was evaluated in 100 contiguous cells of lesional squamous epithelium in basal layer, lower-third, middle-third, and upper-third, in areas with highest staining. Mitoses were counted in 10 contiguous high power fields in areas with the highest mitotic activity (mitotic index, MI). MI was significantly increased in HSIL (mean 27.5) as compared to LSIL (mean 14.3). MI at cut-off values < or =10 and > or =25, favored a diagnosis of LSIL, and HSIL, respectively. ME, in all four layers, was significantly greater in HSIL vs. LSIL. ME in the basal and the upper-third layer proved useful in grading SIL with equivocal MI: all LSIL cases with MI >10 had <30% of ME in the basal layer; and all, except one, had <30% of ME in the upper-third; all, except one HSIL cases with MI <25 had >30% of ME in either the basal or the upper-third layer. MI and ME (percentage) appear helpful in grading equivocal SIL cases.

Biopsy↗

PubMed1993

The binucleate squamous cell: histologic spectrum and relationship to low-grade squamous intraepithelial lesions.

The consistent histologic distinction of HPV-related precursor lesions from nonspecific epithelial changes is hampered by the fact that the scoring of nuclear atypia is subjective and nuclear alterations or cytoplasmic halos may occur with both HPV and non-HPV-related changes. To determine the potential role of another parameter--bi- or multinucleated cells--in the diagnosis of HPV-related lesions, we analyzed a series of epithelial alterations for anisokaryosis, hyperchromasia, and cytoplasmic halos and correlated their presence with the maximum of binucleate cells per high-power field (hpf) and the detection of HPV DNA. A positive correlation was seen between the presence of both anisokaryosis and hyperchromasia and the number of binucleate cells/hpf (p = 0.011) and the presence of HPV nucleic acids by in situ hybridization (p = 0.005). Only one of 23 (5.3%) known HPV-positive lesions did not exhibit any binucleate cells. These findings indicate that, although binucleation may be associated with a spectrum of both HPV and non-HPV related changes, it is most conspicuous and virtually always present in association with HPV-positive low-grade precursor lesions. Thus, this parameter may be useful to confirm the presence when other parameters suggest the diagnosis of a low-grade squamous intraepithelial lesion.

Carcinoma, Squamous Cell↗

PubMed1993

Proliferation characteristics of cutaneous squamous cell carcinomas developing in organ graft recipients. Comparison with squamous cell carcinomas of nonimmunocompromised hosts by counting argyrophilic proteins associated with nucleolar organizer regions.

BACKGROUND AND DESIGN: Cutaneous squamous cell carcinomas (SCCs) are a frequent complication in organ graft recipients (OGRs). The clinical evolution of these lesions has been a matter of controversy. We studied, by the technique of counting argyrophilic proteins associated with nucleolar organizing regions, the proliferative profile of 11 SCCs developing in six OGRs and compared it with the profile in a group of 18 nonimmunocompromised patients with SCCs. The density of the inflammatory cellular peritumoral infiltrate was also assessed semiquantitatively. RESULTS: The SCCs in OGRs and controls contained similar numbers of argyrophilic proteins associated with nucleolar organizing regions; however, the density of the inflammatory cellular peritumoral infiltrate was much lower in OGRs than in controls (2.00 +/- 0.77 vs 3.17 +/- 0.79). CONCLUSIONS: The proliferative potential of SCCs developing in the setting of iatrogenic immunosuppression does not seem to be different from that of SCC in nonimmunocompromised hosts; however, since metastatic SCCs are known to have a reduced density of the inflammatory cellular peritumoral infiltrate as compared with nonmetastatic cases, SCCs in OGRs could have a higher metastatic potential than similar lesions developing in a control population.

Adult↗

PubMedDate not supplied

Squamous cell carcinoma-like and pox lesions occurring simultaneously in chorioallantoic membranes of chicken embryos inoculated with materials from squamous cell carcinoma and pox lesions in broiler chickens.

The finding of closely associated squamous cell carcinoma (SCC)-like lesions and pox lesions in chorioallantoic membranes (CAMs) inoculated with skin and palate samples taken from broilers is described. The samples were obtained from two broilers coming from different flocks that were not vaccinated against fowl pox. Both birds presented skin lesions, which were diagnosed in one bird as fowl pox, and in the other as SCC. After inoculation of CAMs with fresh tissues from both birds, histologic examination revealed, in all CAMs, lesions that were characteristic of fowl pox together with lesions consistent with those seen in the skin of broilers affected with SCC. This finding was unexpected and may shed some light on the etiology of SCC.

Allantois↗

PubMed1998

Assessment of cytologic follow-up as the recommended management for patients with atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions.

BACKGROUND: The optimal management of low grade Papanicolaou (Pap) smear abnormalities remains controversial. This center's experience with recommending cytologic follow-up for women with atypical cells of undetermined significance (ASCUS) or low grade squamous intraepithelial lesions (LSIL) was reviewed to determine outcome and patient/physician compliance. METHODS: The records were reviewed on women with Pap smears reported as either ASCUS (320) or LSIL (112) who did not have a history of dysplasia. The cytologic and colposcopic follow-up for a 2-year period was obtained from the laboratory data base that includes the colposcopy and cancer referrals for this region. Repeat Pap smear in 6 months was recommended. If patients subsequently demonstrated high grade SIL (HSIL) or persistent ASCUS or LSIL over three time intervals, colposcopic evaluation was recommended. RESULTS: The outcome was determined by the most significant diagnosis among the follow-up Pap smears or colposcopic biopsies. 29% of patients were lost to follow-up. Of the remaining patients, 70.5% reverted to normal or benign cellular changes, 25.3% persisted as ASCUS or LSIL, and 5.2% progressed to HSIL. The majority of patients (68%) were referred for colposcopy for persistent mildly abnormal Pap smears. The timing of referral ranged from 3-30 months. CONCLUSIONS: These results suggest that cytologic follow-up of women with low grade Pap smear abnormalities will identify a large number whose smears will regress to normal. A small but significant proportion of women showed subsequent HSIL. Most HSIL was detected within 1 year of the initial abnormal Pap smear and the majority of intervening Pap smears also were abnormal. Approximately one third of patients did not have follow-up within the study system and their outcome was uncertain. Although the recommendations are standard, patterns of follow-up and referral to colposcopy varied widely, suggesting that the guidelines need to be reinforced to both patients and physicians. [See editorial on pages 1-4, this issue.]

Carcinoma, Squamous Cell↗

PubMed1989

The association of lichen planus of the penis with squamous cell carcinoma in situ and with verrucous squamous carcinoma.

Two cases of squamous cell carcinoma (SCC) of the penis, one verrucous type and one in situ, arising in association with an inflammatory dermatosis most consistent with lichen planus, are described. Although SCC has previously been reported to have arisen from lichen planus of the oral mucosa, these are the first reported cases of the coexistence of these processes on the penis.

Adult↗

PubMed2001

High prevalence of high grade squamous intraepithelial lesions and microinvasive carcinoma in women with a cytologic diagnosis of low grade squamous intraepithelial lesions.

OBJECTIVE: To evaluate the histologic nature of low grade intraepithelial lesion (LSIL) in a region with a high prevalence of invasive cervical carcinoma and to propose a management protocol. STUDY DESIGN: Comparing the follow-up of 877 women with LSIL during a 43-month period, taking into consideration the histologic nature determined by colposcopic biopsy, endocervical curettage, conization or hysterectomy as the final pathologic diagnosis. RESULTS: During the study period, from July 1994 to February 1998, a total of 128,925 Pap smears were performed at our institute, with 877 (0.68%) diagnosed as LSIL. Among these, 722 women with CIN1-SIL and 32 with human papillomavirus-related changes (HPV-SIL) were enrolled in the study. Of the 543 women with CIN 1/squamous intraepithelial lesion, 145 (27%) cases of high grade squamous intraepithelial lesion were disclosed histologically, as were 16 (3%) cases of microinvasion. Among those followed at an interval of three months with a Pap smear alone, the persistence rate was 46.8%, while the regression rate was 40%. Thirty-two women with HPV/SIL underwent histologic evaluation, revealing 18% CIN 2/3 with no microinvasion. CONCLUSION: A high percentage of CIN 2/3 as well as microinvasive lesions will go unnoticed in the absence of colposcopic evaluation.

Colposcopy↗

PubMed2005