PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ADRENAL GLAND HYPOFUNCTION”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 235 records · Page 13Linked to original sources
PubMed1993

Glucocorticoid receptor quantification under low glucocorticoid level conditions.

Disturbances in the glucocorticoid hormone serum level lead to dramatic, frequently lethal changes in mammalian organism (Addison's disease, Cushing's syndrome). Hypofunction of adrenal glands (hypocorticism) was simulated by bilateral adrenalectomy of male Wistar rats. Changes in the liver cell glucocorticoid receptor (GR) content were followed throughout 2 hrs to 8 days in the postoperative period, by the quantitative Western blot method and by the synthetic steroid equilibrium binding method of Scatchard. The results of our measurements showed: 1, 1.5 to 2 fold increase in the rat liver GR protein of adrenalectomized animals in respect to the appropriate controls. 2. the increase in the GR protein occurs already 2 hours after the operation and remains at the increased, plateau values throughout the time period studied. It is suggested that the liver GR level may be regulated by the negative feed back mechanism. The raised GR level in adrenalectomy may be a functional adaptation to the low hormone conditions.

Adrenal Insufficiency↗
PubMed1990

[The effect of dry standing time in cows with the obesity syndrome on selected indicators of metabolism and the state of their calves].

Differences in the composition of the blood (plasma) and urine of cows were evaluated in groups (n = 8) with a normal time of dry standing (50-60 days) and in cows standing dry for 80 to 124 days. Two approaches were used: repeated examination of the same animals two to three weeks before parturition and six to eight weeks after parturition, and single examination of the cows being in the same stage of reproduction cycle. A number of changes were recorded, testifying to a reduction of the function of the adrenal glands and to a decrease in the activity of the liver in the cows left to stand dry for a longer time. The calves of these cows had changes in their blood (plasma), indicating a hypofunction of the adrenal glands and a reduced phagocytic activity of the leucocytes, one of the parameters of the immunity system.

Animals↗
PubMed1982

[Current status of knowledge on the changes in the hypothalamo-hypophyseo-adrenal cortex system and their effects in chronic alcohol use and withdrawal].

The results of investigations into the changes in the function of the hypothalamus-hypophysis-renal gland system in chronic alcoholics are collated. The review shows that the activity of the hypothalamus-hypophysis-renal gland system is below-normal in at least some alcoholics, but due to conflicting results, it is not possible to decide whether the hypofunction of the adrenal gland is a primary of a secondary effect. The interrelationship between glucocorticosteroids and catecholamines is described and its importance for the adaptability of the organism is stressed. On the basis of the review it may seem advisable to introduce corticosteroid treatment into the therapeutic schema for delerious alcoholic patients and also to apply it on patients with the alcohol withdrawal syndrome if tests show that the function of their hypothalamus-hypophysis-renal gland systems is impaired.

Adrenal Cortex↗
PubMed1990

[Massive bilateral non-Hodgkin's lymphoma of the adrenal glands].

The patient was a 47-year-old male who attended our hospital complaining of back pain. Masses in the bilateral adrenal glands were noted on abdominal ultrasonography and the patient was admitted to the hospital on August 9, 1988. Upon test laparotomy, non-Hodgkin's lymphoma (diffuse small-cell type, B-cell type) was diagnosed, and endocrinological examination revealed hypofunction of the adrenal gland. The results of various tests showed absence of distance metastasis except for that to the bilateral adrenal glands. Since complete remission was attained after 2 courses of COP-BLAM III therapy, and adrenal function also became normal, the patient was discharged on January 9, 1989. Malignant lymphoma originating from the adrenal gland seems to be a rare condition, and only 16 cases have been reported to this date.

Adrenal Gland Neoplasms↗