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PubMed1983

[Effect of antidepressive agents on serotonin secretion and membrane potential changes in thrombocytes].

Antidepressants (Amitriptylin, Imipramine, Ludiomil, Alival) at the concentrations present in the blood during treatment do not inhibit serotonin secretion by human blood platelets. This also applies for the concentrations at which they are present in the blood during therapy. The same antidepressants do inhibit the changes in membrane potential accompanying serotonin secretion. This suggests that there is a weak interaction between the antidepressants and the secretion mechanism.

Antidepressive Agents↗
PubMed1980

Relationship between blood and cerebrospinal levels of the antidepressant agent viloxazine.

Viloxazine levels in blood and CSF have been measured following acute and chronic dosing in depressed patients. Blood profiles confirm previous findings that viloxazine is rapidly absorbed and eliminated with a half-life of 4.5 h. Viloxazine crosses the blood-brain barrier and concentrations in CSF remain virtually unchanged over a ten hour period post administration. Viloxazine does not accumulate in CSF on chronic administration. The fact that CSF levels do not reflect concentrations in blood has significant implications on any attempt to correlate the clinical efficacy and the pharmacokinetic behaviour of an antidepressant agent.

Adult↗