Proceedings of the VI International Symposium on Occupational Health in the Production of Artificial Organic Fibres. Mannheim (Federal Republic of Germany), September 12-15, 1983.
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In organ replacement therapy, there are lessons to be learned from the biological, clinical, social, and educational implications of renal replacement therapy, the kidney being first among other organs in the quality and quantity of therapy. In the light of the teaching potential of these lessons, no pre- or postgraduate educational reforms can afford to ignore the fruit of 20 years of renal replacement therapy.
Current organ shortage is estimated to keep outpacing demand for years to come. Among the advocated strategies, artificial and bioartificial devices may prove beneficial to a wide category of patients on transplant waiting lists. Bionic organ science allows to reproduce organ architecture and function through a complex interplay of cellular and mechanical elements. Some bioartificial organs may well be used to replace anatomical defects, while others allow to compensate for failing organ functions and to bridge patients to transplantation. Among these latter, bioartificial liver (BAL) systems bear the highest potential for clinical application, even if their use is raising several controversial issues. These latter regard the identification and stratification of patients fit for transplantation, timing and type of transplantation after recovery, appropriateness of double-blind, randomized clinical trials and safety of animal and/or human cell lines. Nonetheless, bionic organ science needs to be regarded as a useful adjunct in the armamentarium of organ replacement therapies for the third millennium.
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