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[Digestive system neoplasms originating from the autonomic nervous system. Diagnostic, therapeutic and prognostic issues].

The gastrointestinal autonomic nerve tumors (GAN tumor) are uncommon stromal tumors of the intestinal tract and retroperitoneum. The distinction of GAN tumors from other gastrointestinal stromal tumors is based on electron microscopic findings. However further study of additional cases is needed to fully characterize both their gross and microscopic features and to further characterize the natural history of such tumors. In the present study we report two cases of GAN tumor that arose from the stomach and small intestinal with different prognostic evolution in two patients of 73 and 65 years old. They were both treated by surgery, but only one case was successful. In addition patient 1 aged 73, died 11 months after surgical treatment with liver metastases on CT. scan. Patient 2, is clinically well five years after surgical treatment.

Aged↗
PubMed1997

[Heart and autonomic nervous system in connective tissue disorders].

UNLABELLED: Heart rate variability (HRV) is a suitable diagnostic tool in identifying patients with autonomic nervous system (ANS) disorders even in pre-clinical stage. We have enrolled in this study all patients with large variety of connective tissue disorders, given the possibility of an involvement of ANS in these diseases. The study population consisted in eighty-five patients (68 females and 17 males), 35 of whom affected by systemic lupus erythematosus, 16 by rheumatoid arthritis, 14 by Sjögren syndrome, 12 by progressive systemic sclerosis, 3 by Behçet syndrome and 5 by antiphospholipid antibodies syndrome. The mean age ranged between 33.7 of patients with lupus erythematosus and 51.8 of those with Sjögren syndrome. As control, we enrolled healthy subjects of different age, divided into two groups, to rule out the aging as potential source of considered parameters alteration. The autonomic function has been evaluated by 24 hours ambulatory monitoring, using a Zymed 1210 Scanner with Zymed 3.74-PC 1990 software. We have considered: in the time domain, the standard deviation of the RR intervals average (SDNN) and the percentage of RR adjacent intervals differing each other more than 50 msec (pNN50); in the frequency domain, the low (LF) and high (HF) frequencies, the LF/HF ratio, and the total power (RT). The HRV parameters resulted abnormal in every type of the connective tissue diseases considered: particularly SDNN, pNN50, LF, HF and RT (p < or = 0.01). IN CONCLUSION: the results of our study suggest that autonomic neuropathy may be present in any kind of connective tissue disorders even in preclinical stage.

Adolescent↗
PubMed1992

[Diseases of the autonomic nervous system. General aspect of symptomatology].

The human internal environment is regulated by the autonomic nervous system (ANS), endocrine glands and neuropeptides as well as the integrated activity of these three systems. The ANS is divided into thoraco-lumbar (sympathetic) and cranio-sacral (parasympathetic) divisions. They comprise two neurons: pre- and post-ganglionic fibers. The limbic system and hypothalamus are known to regulate the peripheral ANS through descending pathways in the brain stem and spinal cord. Cardinal semiologies of the ANS disorders are classified as follows: cardiovascular (orthostatic hypotension, a variety of syncopes, postprandial hypotension, Raynaud's phenomenon), pupillomotor (paralytic mydriasis, Adie's tonic pupil, Horner's syndrome), urodynamic (urinary retention and incontinence), and sexual (impotence, hyper- and hyposexuality).

Animals↗
PubMed2003

Heart rate variability in patients with rheumatoid arthritis.

Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed changes in patients with RA in comparison with the normal population. Short-term analysis of HRV was performed for time-domain frequency in 42 patients with RA and 44 matched controls. In this analysis, patients displayed lower standard deviation of the mean than healthy subjects ( P<0.0001). Patients tended to display higher pNN50 and root-mean-square of successive difference values than did healthy subjects, but these differences were not statistically significant (P >0.05). In frequency domain analysis, the spectral measures of HRV showed reduced high-frequency (HF) values and an higher low-frequency (LF) values; as a result, the ratio between low and high frequencies (LF/HF), representative of sympathovagal modulation, was significantly increased (P=0.001, P=0.012, and P=0.003, respectively). Our data suggest an increase in sympathetic control of the heart rate in patients with RA. This increased sympathetic activity could play a key role in the development of ventricular tachyarrhythmias in RA and may be related to the higher incidence of sudden death in this disorder.

Arrhythmias, Cardiac↗
PubMed1990

[The function of the autonomic nervous system in women with androgenetic alopecia].

Essential shifts in the autonomic nervous system, detectable by clinical methods and during a dynamic examination (of the autonomic reactivity and autonomic activity provision) were revealed in women suffering from androgenetic alopecia. The status of the autonomic nervous system was analyzed with consideration for the effects of psychogenic factors and the type of hair loss. The findings will help develop approaches to treatment of the condition.

Adult↗