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PubMed1988

Irritant contact dermatitis due to a Chinese herbal medicine lu-shen-wan.

A Chinese herbal medicine Lu-Shen-Wan, which contains 6 ingredients, is sometimes applied topically to treat boils, carbuncles and other skin infections. 2 elderly women developed a rash after applying Lu-Shen-Wan. Patch tests showed positive reactions to Lu-Shen-Wan and to one of its 6 ingredients, Venenum Bufonis. A study in 15 control patients showed that 13 had positive reactions to 50% Lu-Shen-Wan and 50% Venenum Bufonis but that only 2 showed mild reactions when the concentration of the latter was reduced to 5%. The results suggest that Venenum Bufonis in Lu-Shen-Wan can cause irritant contact dermatitis. The present paper demonstrates that a Western dermatological investigative method, the patch test, is applicable to traditional medicine in confirming the cause of contact dermatitis from a Chinese herbal preparation and in identifying the causative ingredient. Such knowledge is very useful for the improvement of the preparation by reducing the concentration of the irritant, by removing it or by substituting it with an alternative non-irritant substance.

Administration, Cutaneous↗

PubMed1989

The effects of vandellia cordifolia on renal functions and arterial blood pressure.

Vandellia cordifolia (COLSM) G. DON of Scrophulariaceae (V. cordifolia) is an annual wild herb indigenous to Taiwan. It can be found in plains, low altitudes, swampy places, and paddy fields. Taiwanese folk physicians use it in "nephritis, uremia, furnucle, carbuncle." The LD50 (95% confidence limit) of the crude extract of V. codifolia given by the oral route was more than 10 g/kg in rats. By the intraperitoneal route, it was 4.6 g/kg (4.35-4.93). The extraction rate was 16.6%. We studied its effects on renal functions and blood pressure and found that (1) it had diuretic effect on normal rats, (2) it decreased glomerular filtration rate and renal blood flow on normal kidneys in rabbits, (3) it had no effects on glomerular filtration rate and renal blood flow on glycerin-induced insufficient kidneys in rabbits, (4) it had diuretic effects on both normal and glycerin-induced insufficient kidneys in rabbits, (5) it could inhibit Na+ and K+ reabsorption on normal and glycerin-induced insufficient kidneys in rabbits, (6) it had hypertensive effect and this effect could be blocked by phenoxybenzamine. From the above facts, we conclude that V. cordifolia has diuretic effect and it may act on renal tubules to inhibit Na+ and K+ reabsorption.

Animals↗

PubMed1976

Treatment of skin and soft tissue infections with cefadroxil, a new oral cephalosporin.

Oral cefadroxil in doses of 0-6-1-8 g per day given on twice or three times daily schedules was effective in the treatment of thirty-six patients with infections such as abscesses, carbuncles, cellulitis, furunculosis and impetigo. Staphylococcus aureus strains and beta-haemolytic streptococci, alone or in combination, were cultured from lesions before treatment. In vitro studies with test discs showed that all the organisms were sensitive to cefadroxil, but twenty-three of twenty-nine S aureus strains and one of the seven streptococci strains were resistant to penicillin G. Pre- and post-treatment laboratory tests of renal, hepatic and haematopoietic functions produced no evidence of drug toxicity. The cefadroxil dosage effective in this study is lower than that recommended for currently available oral cephalosporins, which must be given on a four times daily schedule.

Adolescent↗

PubMed2004

Treatment of staphylococcal scalded skin syndrome.

Humans are a natural reservoir for Staphylococcal aureus. Colonization begins soon after birth and predisposes to infection. S. aureus is one of the most common causes of skin infection, giving rise to folliculitis, furunculosis, carbuncles, ecthyma, impetigo, cellulitis and abscesses. In addition, S. aureus may cause a number of toxin-mediated life-threatening diseases, including staphylococcal scalded skin syndrome (SSSS). Epidermolytic toxins released by certain S. aureus strains cause SSSS by cleaving the epidermal cell adhesion molecule, desmogelin-1, resulting in superficial skin erosion. Recent experiments have revealed similarities in the pathophysiology of SSSS and pemphigus foliaceus, an autoimmune disorder that is characterized by antibodies targeting the same epidermal attachment protein. SSSS typically affects neonates and infants but may also occur in predisposed adults. It is painful and distressing for the patient and parents, although most cases respond to antibiotic treatment. Mortality is low in infants but can be as high as 67% in adults, and is dependent on the extent of skin involvement and the comorbid state. Thus, the management of adults who develop SSSS remains a major therapeutic challenge. The antibody response against the toxins neutralizes their effect and prevents recurrence or limits the effects to the area of infection, which is known as bullous impetigo.

Animals↗

PubMed2005

Bacterial diseases of the skin.

When considering common bacterial diseases of the skin, rather distinct clinical responses to a variety of bacterial infections have been identified. In these cases, it is the specific site of infection and the attendant inflammatory responses that provide the characteristic clinical picture. When the pyoderma extends just below the stratum corneum, it is called impetigo. Nonbullous impetigo is the most common pediatric skin infection. It usually starts in a traumatized area. The typical lesion begins as an erythematous papule, after which it becomes a unilocular vesicle. When the subcorneal vesicle becomes pustular, it ruptures and eventually becomes a yellow, golden crust that is a hallmark of the disease process. Bullous impetigo is a less common form of impetigo, accounting for fewer than 30% of all impetigo cases. It occurs in infants and is characterized by rapid progression of vesicles to the formation of bullae measuring larger than 5 mm in diameter in previously untraumatized skin. Treatment of nonbullous impetigo must include intervention against the pathogen as well as improvements in the hygiene and living conditions of the patient. A fundamental tenet is to debride the crust (scab) from the wound surface using poloxamer 188. If the lesions are not widespread, topical mupirocin is the treatment of choice. Treatment of bullous impetigo is similar, except that the local cleansing and topical antibiotic must be complemented by systemic antibiotics if there is evidence of disseminating infections. Ecthyma is usually a consequence of failure to treat effectively impetigo. The untreated infection extends deep into the tissue in shallow ulcerations that often heal without scar. Treatment for ecthyma usually requires systemic antibiotics against either staphylococcus or streptococcus. Folliculitis is a pyoderma located within a hair follicle, secondary to follicular occlusion by keratin, overhydration, or either bacterial or fungal infection. Folliculitis may be divided into either a deep or a superficial type. In the superficial type, the pustule is located at the opening of the hair follicle. In the deep form, the infection may extend beyond the confines of the hair follicle, becoming a furuncle or boil. Carbuncles are aggregates of interconnected furuncles that drain through multiple openings of the skin. Treatment of folliculitis must include searching for and avoiding any factors predisposing to infection. If topical antibiotic therapy is ineffective in controlling the infection, surgical drainage of the infected skin abscess will be necessary. Paronychia is the most common bacterial infection of the hand, which often requires surgical incisional drainage. Similarly, a felon that is an infection of the distal pulp of a finger usually requires surgical drainage. Finally, cellulitis is an acute inflammatory reaction involving the skin and underlying subcutaneous tissue. It usually starts as erysipelas and may advance to lymphangitis, lymphadenitis, or gangrene,which will respond to life-saving interventions in the hospital that usually include systemic antibiotic treatment as well as surgical intervention.

Anti-Bacterial Agents↗

PubMed2001

Cefpodoxime proxetil: a review of its use in the management of bacterial infections in paediatric patients.

UNLABELLED: Cefpodoxime proxetil is an oral third generation cephalosporin with a broad spectrum of antibacterial activity. The drug has in vitro activity against many common Gram-positive and Gram-negative pathogens associated with common paediatric infections, making the drug a useful option for empirical therapy. In randomised controlled trials conducted in children with acute otitis media, oral cefpodoxime proxetil 8 to 10 mg/kg/day (usually administered in 2 divided doses) for 5 to 10 days was at least as effective as standard regimens of amoxicillin/ clavulanic acid, cefixime, cefuroxime axetil or cefaclor as assessed by either clinical or bacteriological criteria. Cefpodoxime 8 to 10 mg/kg/day (administered in 2 divided doses) for 5 to 10 days was at least as effective as standard 10-day regimens of penicillin V in the treatment of children with pharyngitis and/or tonsillitis. Significant differences in favour of cefpodoxime proxetil were demonstrated in terms of clinical (1 study) and bacteriological (2 studies) criteria. The clinical efficacy of 5 days of treatment with cefpodoxime proxetil is similar to that of 10 days of treatment with penicillin V. In children with lower respiratory tract infections (primarily pneumonia), clinical and bacteriological efficacy rates achieved with cefpodoxime proxetil treatment were similar to those produced by cefuroxime axetil or amoxicillin/clavulanic acid in randomised controlled trials. Cefpodoxime proxetil also demonstrated clinical efficacy in paediatric patients with skin and soft tissue infections. In randomised studies that included both adults and children with a variety of infections (e.g. abscess, atheroma, furuncle and carbuncle, infected wounds, cellulitis), cefpodoxime proxetil showed efficacy similar to that of cefuroxime axetil or cefaclor. Cefpodoxime proxetil is well tolerated by paediatric patients, with adverse events (primarily gastrointestinal tract disturbances and skin rashes) that are consistent with those reported for other oral cephalosporins. CONCLUSION: Cefpodoxime proxetil is a third generation cephalosporin with a broad spectrum of antibacterial activity and a favourable pharmacokinetic profile which allows twice-daily administration. It is generally well tolerated and demonstrates good bacteriological and clinical efficacy in paediatric patients with various infectious diseases, including acute otitis media, tonsillitis and/or pharyngitis. Based on these characteristics, cefpodoxime proxetil is a suitable option for the treatment of paediatric patients with various common bacterial infections.

Acute Disease↗

PubMed1999

[Clinico-laboratory effectiveness of modern ointments with a polyethylene glycol base in the treatment of purulent wounds].

The 25-year experience with the underbandage treatment of soft tissue purulent wounds of various location and genesis with modern ointments with polyethylene glycol as the basis was analyzed. Levocin, levomecole, dioxycole, 5-percent dioxydinic, 1-percent iodopyronic, 0.5-percent quinifuryl and furagel ointments proved to preserve their high activity against aerobic grampositive and gramnegative flora. 10-percent mafenide acetate ointment had a high selective effect on Pseudomonas aeruginosa. The new ointments nitacid and streptonitole containing nitazole and white streptocide were highly active against both aerobic and anaerobic infections. The use of the ointments with the polyethylene glycol as the basis made it possible to decrease 2 times the period of the patient hospitalization in surgical units and to shorten the terms of the systemic antibacterial therapy. The marked therapeutic effect of such ointments due to their high dehydrating capacity and broad antibacterial spectrum enabled to consider them as the drugs of choice in the local treatment of purulent wounds during the 1st phase of the wound process, trophic and decubic ulcers, infected burns, diabetic and atherosclerotic gangrene, furuncles, carbuncles, mastitis, etc. The ointments in the water soluble vehicle can be as well used with success for the prophylactic treatment of infected wounds after the suture. The multitarget effect of the ointments in the water soluble vehicle and their ability to prevent severe purulent complications permitted to consider them as the 1st order drugs in cases of emergency.

Anti-Bacterial Agents↗

PubMed2000

[Characteristics of the diagnosis of purulent pyelonephritis].

Results of diagnosing pyelonephritis in 106 patients using ultrasonography, CT and thermovision were analyzed. Purulent pyelonephritis (PP) was diagnosed in 57 patients, serous pyelonephritis--in 49 patients. The sensitivity of ultrasonography in the diagnosing of PP was more than 80%, that of CT--90%. The methods used allowed the 100% improvement of the differential diagnosis of renal abscess, apostematous nephritis and pyonephrosis. The greatest problems were met in the diagnosis of renal carbuncle which was detected in 50% of cases by ultrasonography and in 54% of patients by CT. The minimum sizes of the destruction focus when the diagnosis could be reliable were 2 cm for ultrasonography and 1.5 cm for CT. Only using the findings of CT could diagnose emphysematous pyelonephritis. Thermovision could not find any definite criteria of PP. The timely diagnosis of PP allowed the organ-saving operations to be fulfilled in the overwhelming amount of the patients. Positive results of the treatment using the above mentioned diagnostic methods were obtained in 98.8% of the patients.

Adolescent↗

PubMed2001

[Cervical necrotizing cellulitis caused by spider bite].

Foremost causes of originating shallow painful inflammations on the neck are: boils, carbuncle or infected dermoid cysts and atheroma. When remembering other possible inflammatory sources in this site we cont with insects bites through scarces in our environment. We report one case of spider's bite (Loxoceles rufecens) originating a necrotic neck cellulitis and remind also the several clinical symptoms of arachnid bites scarce in our environment.

Cellulitis↗

PubMed2000

[Effective case records of Luo Tianyi in the army as recorded in Wei Sheng Bao Jian (hygienic precious minor)].

During his life in the army in 1252 - 1261, Luo Tianyi wrote down case records taken from his patients, including soldiers, military officials and their relatives. In addition to infectious diseases such as malaria, dysentery, vomiting and diarrhea and seasonal epidemics, he also treated psychosis, digestive disorders, cold damage, beriberi, coughing and cold in the legs and external diseases such as eye diseases, boils and carbuncles, hernia. The therapeutics he applied included recipes, pills, powders, pastes as well as acu - moxibustion.

China↗

PubMed2002

Subdural block--from a spinal? A case report.

INTRODUCTION: Multicompartmental blocks are commonly described in epidurals but not spinals. We describe a case of subarachnoid block performed in an obese patient which resulted in a clinical presentation resembling that of a subdural block. CLINICAL PICTURE: A 29-year-old woman, scheduled for saucerisation of thigh carbuncle, was administered 2.1 mL of hyperbaric bupivacaine. The spinal resulted in a late onset of sensory block that extended to the neck and upper limbs. There was no sympathetic or motor blockade. TREATMENT/OUTCOME: The block receded spontaneously without causing any cardiovascular or respiratory compromise. CONCLUSIONS: The diagnosis of subdural block must be considered in patients with unusual presentations after a spinal anaesthetic. Factors affecting spread of hyperbaric bupivacaine are also highlighted.

Adult↗

PubMed2003

[Treatment of inflammatory pyodestructive processes of the oral cavity, maxillofacial area, and neck by laser and magnetic-laser exposure of the carotid sinus using the Optodan laser apparatus].

This paper presents the priority original methods (patent No. 2101046, Russia) for the treatment of inflammatory pyodestructive processes in the oral cavity, maxillofacial area, and neck (odontogenic abscesses and phlegmons including those complicated by mediastinitis and sepsis), sinusitis, carbuncles and furuncles of face and neck skin, parotitis, sialadenitis, adenophlegmons, lymphadenitis, periotitis, alveolitis, arthritis, arthrosis of the temporomandibular joint, odontogenic and traumatic osteomyelitis, infected purulent traumas (including gunshot ones), fractures of the jaws, etc. making use of Optodan laser (patent No. 2014107, Russia) for laser and magnetic-laser therapy.

Carotid Sinus↗

PubMed1965

LINCOMYCIN IN DERMATOLOGIC PRACTICE.

In clinical studies with a new oral antibiotic, lincomycin, excellent results were obtained in the treatment of carbuncles, furuncles, folliculitis, cellulitis, lymphangitis, lymphadenitis, pyonychias and dermatitis infectiosa eczematoides due to coagulase-positive Staphylococcus aureus and to Streptococcus hemolyticus Type A. Encouraging results were noted in a small series of acne conglobata (cystic acne). Loose stools and diarrhea were frequently encountered but these symptoms abated when the dosage was reduced.

Acne Vulgaris↗

PubMed1992

[The combined treatment of acute suppurative diseases of the fingers and hand using decamethoxin].

The authors discuss the results of complex treatment of 286 patients with acute pyoinflammatory diseases of the fingers and hand with the use of a new Soviet-produced antiseptic decametoxin. Panaris was diagnosed in 196 (68.5%), phlegmons and abscesses in 82 (29.7%), furuncle in 6 (2.1%) and carbuncle in 2 (0.7%) patients. 224 (78.4%) patients received out-patient and 62 (21.6%) in-patient treatment. The authors established that as the result of the applied complex treatment with the use of various antiseptic compositions containing decametoxin the mean duration of treatment was 7.8 days. The article discusses the causes of the disease, the methods of operative treatment, and management of patients in the postoperative period.

Abscess↗

PubMedDate not supplied

[Radiodiagnosis of kidney diseases in a municipal hospital].

Ultrasonic (US) examinations of the urinary tract of 2384 patients have revealed pathologic shifts in 725 cases; x-ray examinations had to be carried out in 632 of these to specify the diagnosis. X-Ray and US-based radiodiagnosis of a wide spectrum of renal diseases, carried out at a common municipal hospital, promotes a better diagnosis. Employment of US examinations as a screening method helps recognize renal hypoplasia, cystic diseases, and an acute inflammatory process, renal carbuncle, fairly well. The diagnosis of other renal abnormalities, urolithiasis, hydronephrotic transformations, tumors and injuries still has to be specified by routine x-ray methods.

Female↗

PubMed2000

[Dermatological diseases and treatment described in the Turkish manuscripts (XIV-XVth centuries) (part I)].

This study deals with skin diseases described in the earliest compiled or translated Turkish medical manuscripts of the 14th and 15th centuries in Anatolia. The manuscripts studied are: Müntehab-i Sifa, Edviye-i Müfrede, Tervihü'l-Ervah, Yadigâr, Cerrahiyyetü'l-Haniyye, Kamilü's-Sinaatü't-Tibbiye Tercü-mesi, Kitab-i Müntehab-i fi't-Tibb, Haza'inü's-Sa'adat, Akrabadin Tercümesi, Mücerrebname, Müfredât-i Ibn-i Baytar Tercümesi, Tuhfe-i Mübarizi, Tuhfe-i Muradi. The skin diseases known at that time are studied under the following topics: Cüderi (Ciçek, Variola, Small-pox); Hasbe (Kizamik, Rubeola, Measles); Cüzzam (Lepra, Leprosy, Hansen's disease); Demregü (Temriye, Dermatophtosis, Tinea corporis); Behak (There are two types: the white and the black; the black is Addison's disease); Baras (Ala, Vitilio); Nemle (Isirga, Makül); Ateş paresi (Nar-l farisi, frunculosis); Cemre (Kara kabarcik, Sirpençe, Karbonkül, Carbuncle); Caversiye (Kabarcik hastaliği, blisters disease); Sivilceler (Various types of pimples; Humre: Yilancik, Erizipel, Erysipelas, St. Anthony's fire; Başbert: Ciban, Fronkül, Boil, Fruncle; Dümmel: Kan çibani, Abse, Abscess); Abile (Kabarcik, Bule); Seretan (kanser, Cancer); Hanazir (Siraca, Scrofuloderma); Akile (Yinürbaş, Gangren); Kurdeşen (Urtiker, Urticeria); Uyuz (Gale, Scabies); Giciyik (Kaşinti, Pruritus); Sa'fe (Konak, Seboreik dermatit, Scurf); Kel (Alopesi, Favus); Evram (Sişler, Urlar, Tumours); Yara (Karha, Cerahat, Wound). The terminology and symptoms of these diseases are studied and tried to find their equivalents of today. The causes and the treatment of the skin diseases known then are presented.

History, 15th Century↗

PubMed2001

[Dermatological diseases and treatment described in the Turkish manuscripts (XIV-XVth centuries) (part II)].

This study deals with skin diseases described in the earliest compiled or translated Turkish medical manuscripts of the 14th and 15th centuries in Anatolia. The manuscripts studied are: Müntehab-i Sifa, Edviye-i Müfrede, Tervihü'l-Ervah, Yadigâr, Cerrahiyyetü'l-Haniyye, Kamilü's-Sinaatü't-Tibbiye Tercü-mesi, Kitab-i Müntehab-i fi't-Tibb, Haza'inü's-Sa'adat, Akrabadin Tercümesi, Mücerrebname, Müfredât-i Ibn-i Baytar Tercümesi, Tuhfe-i Mübarizi and Tuhfe-i Muradi. The skin diseases known at that time are studied under the following topics: Cüderi (Ciçek, Variola, Small-pox); Hasbe (Kizamik, Rubeola, Measles); Cüzzam (Lepra, Leprosy, Hansen's disease); Demregü (Temriye, Dermatophtosis, Tinea corporis); Behak (There are two types: the white and the black; the black is Addison's disease); Baras (Ala, Vitilio); Nemle (Isirga, Makül); Ateş paresi (Nar-i farisi, frunculosis); Cemre (Kara kabarcik, Sirpençe, Karbonkül, Carbuncle); Caversiye (Kabarcik hastaliği, blisters disease); Sivilceler (Various types of pimples; Humre: Yilancik, Erizipel, Erysipelas, St. Anthony's fire; Başbert: Ciban, Fronkül, Boil, Fruncle; Dümmel: Kan çibani, Abse, Abscess); Abile (Kabarcik, Bule); Seretan (Kanser, Cancer); Hanazir (Siraca, Scrofuloderma); Akile (Yinürbaş, Gangren); Kurdeşen (Urtiker, Urticeria); Uyuz (Gale, Scabies); Giciyik (Kaşinti, Pruritus); Sa'fe (Konak, Seboreik dermatit, Scurf; Kel (Alopesi, Favus); Evram (Sişler, Urlar, Tumours); Yara (Karha, Cerahat, Wound). The terminology and symptoms of these diseases are studied and tried to find their equivalents of today. The causes and the treatment of the skin diseases known then are presented. The second part of Tokaç's article continues to deal with the etiology, symptoms and treatment of dermatological diseases.

History, 15th Century↗

PubMed2003

Acute bacterial skin infections in pediatric medicine: current issues in presentation and treatment.

Bacterial skin and skin structure infections commonly encountered in children include impetigo, folliculitis, furunculosis, carbuncles, wound infections, abscesses, cellulitis, erysipelas, scarlet fever, acute paronychia, and staphylococcal scalded skin syndrome. If diagnosed early and treated appropriately, these infections are almost always curable, but some have the potential to cause serious complications such as septicemia, nephritis, carditis and arthritis if diagnosis is delayed and/or treatment is inadequate. During the initial evaluation, it is important to determine whether the infection is superficial or deep, and whether it is localized or spreading. Prompt treatment is essential if the infection appears to be spreading, as the sequelae can be life threatening. Once the proper diagnosis is made, the next important step is selecting the most appropriate therapy. In children presenting with mild or moderately severe bacterial skin and skin structure infections and not requiring inpatient management or urgent operative débridement, prompt provision of oral antimicrobial therapy avoids the risk of worsening infection or hospitalization. Empiric antimicrobial therapy should be directed at the most likely pathogens, (e.g. Staphylococcus aureus or Streptococcus pyogenes), although some infections (e.g. subcutaneous abscesses and cellulitis following animal or human bites) may have a polymicrobial origin. In choosing the appropriate antimicrobial therapy, one must take into account the resistance profile of the target pathogen, the agent's antibacterial profile and intrinsic activity against the target pathogen, and its pharmacokinetic properties (including absorption, elimination, and extent of tissue penetration). Other factors to consider include tolerability of the drug, convenience of the dosing regimen, and acceptability and palatability of the oral formulation administered. Any treatment plan for bacterial skin and skin structure infections should aim to minimize the emergence of resistant organisms so that the risk of their dissemination to others in the community is reduced. Oral antimicrobial agents currently available that may be considered include: beta-lactamase-stable penicillins (e.g. cloxacillin, dicloxacillin, and amoxicillin-clavulanate potassium), the macrolides (e.g. erythromycin, clarithromycin, and azithromycin), and the cephalosporins. Cephalosporins are now the most commonly used class, particularly because of increasing resistance among strains of S. pyogenes to erythromycin (and by implication, the other macrolides). The second- and third-generation cephalosporins have many advantages, with their extended spectra of antimicrobial activity, favorable pharmacokinetic and tolerability profiles, and convenient dosage schedules. The third-generation agent, cefdinir, has good activity against a broad range of likely pathogens, including staphylococci, a twice-daily administration schedule, a favorable efficacy and tolerability profile, is well accepted by young children when administered as an oral suspension, and may be an attractive alternative in the pediatric setting.

Acute Disease↗