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At least 235 records · Page 13Linked to original sources

PubMed2002

Indoor dampness and molds and development of adult-onset asthma: a population-based incident case-control study.

Previous cross-sectional and prevalent case-control studies have suggested increased risk of asthma in adults related to dampness problems and molds in homes. We conducted a population-based incident case-control study to assess the effects of indoor dampness problems and molds at work and at home on development of asthma in adults. We recruited systematically all new cases of asthma during a 2.5-year study period (1997-2000) and randomly selected controls from a source population consisting of adults 21-63 years old living in the Pirkanmaa Hospital district, South Finland. The clinically diagnosed case series consisted of 521 adults with newly diagnosed asthma and the control series of 932 controls, after we excluded 76 (7.5%) controls with a history of asthma. In logistic regression analysis adjusting for confounders, the risk of asthma was related to the presence of visible mold and/or mold odor in the workplace (odds ratio, 1.54; 95% confidence interval, 1.01-2.32) but not to water damage or damp stains alone. We estimated the fraction of asthma attributable to workplace mold exposure to be 35.1% (95% confidence interval, 1.0-56.9%) among the exposed. Present results provide new evidence of the relation between workplace exposure to indoor molds and adult-onset asthma.

Adult↗

PubMed2026

Integrated analysis of plasma metabolomics and proteomics reveals the biological characteristics of damp-heat and stasis-toxin syndrome in colorectal cancer.

OBJECTIVE: To investigate the biological attributes of core syndromes in colorectal cancer, namely, the damp-heat and stasis-toxin syndrome (SRYD). METHODS: Between October 2021 and October 2022, a cohort comprising 40 patients with colorectal cancer (CRC) diagnosed with damp-heat and stasis-toxin syndrome (SRYD group), 40 patients with CRC without this syndrome (non-SRYD group), and 40 healthy controls (Normal group) was recruited at Jiangsu Province Hospital of Chinese Medicine. Untargeted metabolomics analysis was conducted on plasma samples from all 120 participants, while differential protein analysis using four-dimensional data-independent acquisition proteomics was performed on 20 randomly selected samples per group. A combined analysis of proteomics and metabolomics data followed, and the identified potential diagnostic biomarkers were subsequently used to train and validate multiple machine learning models. RESULTS: Proteomic analysis revealed 130 differential proteins in the colorectal cancer with damp-heat and stasis-toxin syndrome (CRC-SRYD) group, enriched in pathways including complement and coagulation cascades, as well as nuclear factor kappa-B (NF-κB) signaling. Metabolomic analysis identified 584 differential metabolites within the same group, showing enrichment in pathways such as primary bile acid biosynthesis, central carbon metabolism in cancer, and glucagon signaling. Integrated pathway analysis indicated heightened activity of the NF-κB signaling pathway in the CRC-SRYD group. A biomarker panel, comprising 6 proteins and 9 metabolites selected through the ReliefF algorithm, was used to construct a diagnostic model with random forest, achieving an accuracy of 93.33%, sensitivity of 80.00%, and specificity of 100%. CONCLUSION: This study systematically elucidates plasma metabolomic and proteomic alterations in patients with CRC, establishing a robust diagnostic model for CRC syndrome (CRC-SRYD). Further investigation is warranted to clarify the underlying molecular mechanisms and biological foundations.

Humans↗

PubMed2007

[A rabbit model of cervical spondylosis established by stimulation of wind, cold and dampness].

OBJECTIVE: To make an animal model of cervical spondylosis (arthralgia syndrome type) with stimulation of wind, cold, and dampness. METHODS: Twenty-four 8 months old male New Zealand white rabbits were randomly allocated into four groups: normal control group, light stimulation group, moderate stimulation group and severe stimulation group. The wind speed was 10.8-13.8 m/s, the temperature was (5+/-0.5)degrees centigrade, and the humidity was 100%. The rabbits of light, moderate, and severe stimulation groups were kept in the above-mentioned environments for 4 hours everyday, and for a total of 32, 64, and 128 hours, respectively. The intervertebral discs were stained with HE method, and observed with a light microscope. Prostaglandin E(2) (PGE(2)), 6-ketone-prostaglandin F1alpha (6-K-PGF(1alpha)) and thromboxane B(2) (TXB(2)) contents were measured by ELISA. Fas and Bcl-2 expressions were examined by immunohistochemical avidin-biotin peroxidose complex technique. Interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and transforming growth factor beta (TGF-beta) mRNA expressions were examined by reverse transcription-polymerase chain reaction. RESULTS: The nucleus pulposus of rabbits in the light and moderate stimulation groups shrunken, and in the severe stimulation group, the anulus fibrosus loosed or ruptured, and the cartilage end-plate became proliferated. Compared with rabbits in the normal control group, the PGE(2) content rose in the light stimulation group, the contents of PGE(2), 6-K-PGF(1alpha), and TXB(2) increased, the expressions of IL-1beta and TNF-alpha mRNAs and Fas were up-regulated, and the expressions of TGF-beta mRNA and Bcl-2 were down-regulated in the moderate and severe stimulation groups. The expression of Fas was up-regulated mostly and Bcl-2 was down-regulated mostly in the severe group. CONCLUSION: Moderate and severe stimulations of wind, cold and dampness can lead to degeneration of cervical intervertebral discs of rabbits. The model corresponds to the theory of traditional Chinese medicine about arthralgia syndrome caused by wind, cold and dampness.

Animals↗

PubMed1994

[Fundamental study on effects of different form of mouthguards on modal shape and damping ratio of human dry mandible].

Effect of 6 types of mouthguards on the vibratory characteristics of the human dry mandible was investigated by means of modal analysis with the impact test method. In this study, 20 test points were established on the mandible and the modal shape and damping ratio of the vibration of the mandible itself and the mandible each attached with a mouthguard were analyzed by using the FFT analyzer (CF-6400) and personal computer (PC-9801FA) with a modal analyzing software (VIBRANT-PC). The results were as follows: 1. With regard to the modal shape, there was almost no difference among the mandibles and each mandible with 6 types of mouthguard. 2. With regard to the damping ratio, there was a significant difference between the mandible itself and mandible with each mouthguard. And the effect of the mandible with each mouthguard on the damping ratio was different.

Biomechanical Phenomena↗

PubMed2001

[Clinical study on treatment 82 cases of chronic primary glomerulopathy with deficiency of yin with damp-heat symptom with dan shao tang].

OBJECTIVE: To investigate the treatment effect of Dan Shao Tang on chronic primary glomerulopathy with deficiency of Yin with damp-heat symptom. METHODS: 132 cases of chronic glomerulopathy with deficiency of Yin with damp-heat symptom, which divided into two groups at random, the 82 cases which were the therapy group using Dan Shao Tang and west medicine, and the other 50 cases which treated only by west medicine. We observed the effect and indexes change including renal function, proteinuria, hematuria. RESULTS: The effective rate of the therapy group is 90.24%, and the effective rate of the control group is 66% (P < 0.05), The therapy group is superior to the control group in improving renal function, decreasing proteinuria and hematuria in evidence(P < 0.05). CONCLUSION: Dan Shao Tang is effective to treatment on chronic primary glomerulopathy with deficiency of Yin with damp-heat symptom.

Adult↗

PubMed2002

[Attention deficit disorder, hyperkinetic disorder and DAMP in children. Diagnosis and differential diagnosis].

INTRODUCTION: The aim was to evaluate the diagnostic methods and differential diagnostic spectrum in children admitted for ADHD (attention-deficit hyperactivity disorder), hyperkinetic disorder, or DAMP (deficit in attention, motor control and perception), including evaluation of the factors that are of greatest value in making a diagnosis. MATERIAL AND METHODS: Data were recorded on admission and again after 12-15 months for all children admitted for suspected attention deficit to the children's department, Gentofte County Hospital in 1999. RESULTS: Of the 68 children admitted with the same behaviour, 27 had attention deficit (14 children with DAMP and 12 with ADHD) and 41 children had other disorders, including seven with pervasive developmental disorders, ten children who were mentally retarded, and 12 with psychosocial problems. DISCUSSION: The most important diagnostic method was a psychological investigation, if necessary in combination with a neuropsychological and/or motor examination. The Danish reference programme for children with DAMP seems the most reliable of the various diagnostic systems that exist today.

Attention Deficit Disorder with Hyperactivity↗

PubMed2001

[Study on effect of spleen invigorating, qi benefiting and dampness removing Chinese drugs and Western medicine on serum epidermal growth factor in chronic atrophic gastritis patients].

OBJECTIVE: To investigate the effect of various combinations of Spleen invigorating and Dampness removing recipes and western medicine on level of serum epidermal growth factor (sEGF) in patients of chronic atrophic gastritis (CAG). METHODS: By means of Syndrome Differentiation three groups were divided as (1) Spleen invigorating I group (SI-I); (2) Spleen invigorating II group (SI-II); (3) Dampness removing group (DR); (4) western medicine group (WM); (5) healthy volunteers served as normal control group. The changes of symptoms and sEGF level were determined and compared between groups as well as before and after treatment. RESULTS: The sEGF in various groups of CAG were higher than that in the normal control (P < 0.01). In patients of SI-I and II groups, symptoms and pathological manifestations were improved significantly (P < 0.01), and sEGF dropped markedly after treatment (P < 0.01 and P < 0.05). The level of sEGF in DR raised after treatment (P < 0.05), but the level of sEGF in WM group lowered insignificantly. CONCLUSION: Inflammation of gastric mucosa could cause responsive elevation of sEGF in CAG patients. After treated with Spleen invigorating and Dampness removing Chinese drugs, the symptoms of CAG improved, simultaneously with the restoration of sEGF. sEGF could be taken as a sensitive index of the prognosis of CAG.

Adult↗

PubMed2003

[Principles and experimental analysis of a measuring system for measuring spacesuit joint's damping parameters].

OBJECTIVE: To measure the damping parameters of the spacesuit joint. METHOD: The principles of the passive robot system for measuring spacesuit joint's damping parameters were presented. Basing on its special mechanical structure, a 3 DOF model of the flexible IVA (intra-vehicular activity) spacesuit's sleeve was built. The optimal approximation of inverse calculation based on 6 dimension space interval was described. The damping parameters of an actual IVA spacesuit's sleeve were measured on the actual testbed. Also, the potential application of the measuring system was discussed. RESULT: The model of spacesuit sleeve and the forward/inverse kinematics were proved by experimental measurements and real time 3D simulation. CONCLUSION: The principles and the proposed method of the measurement were testified.

Computer Simulation↗

PubMed2003

[Clinical study on dan shao tang in treating IgA nephropathy of deficiency of yin with damp-heat symptom].

OBJECTIVE: To explore the effect of Dan Shao Tang(DST) in treating IgA nephropathy(IgAN) of deficiency of Yin with damp-heat symptom. METHODS: 90 patients with IgAN of deficiency of Yin with damp-heat symptom were randomly divided into two groups. 50 patients in treatment group were treated with DST and western medicine and 40 patients in control group were treated only with western medicine. The effects and changes of the indexes including renal function, hematuria, proteinuria, blood IgA before and after treatment were observed. RESULTS: After six months treatment, the general effective rate in treatment group was 70.00%, which was markedly higher than that in control group(37.50%, P < 0.01). Treatment group is obviously better than control group on decreasing hematuria, proteinuria, blood IgA and improving renal function(P < 0.05). CONCLUSION: DST is effective on IgAN of deficiency of Yin with damp-heat symptom.

Adjuvants, Immunologic↗

PubMed2004

[Clinical observation of "dan shao tang" in treating mesangial proliferative glomerulonephritis of deficiency of yin with damp-heat symptom].

OBJECTIVE: To explore the effect of "Dan Shao Tang" (DST) on mesangial proliferative glomerulonephritis (MsPGN) of deficiency of Yin with damp-heat symptom. METHODS: 90 patients with MsPGN of deficiency of Yin with damp-heat symptom were randomly divided into two groups. 54 patients in treatment group were treated with DST and western medicine, and 36 patients in control group were treated only with western medicine. We observed the effect and indexes change including renal function, proteinuria, hematuria, lipid before and after treatment. RESULTS: After three months treatment, the general effective rate in treatment group was 75.93%, which was markedly higher than that in control group (47.22%, P < 0.01). Treatment group is obviously better than control group on decreasing proteinuria and hematuria, improving renal function, ameliorating lipid metabolism (P < 0.05). CONCLUSION: DST is effective on MsPGN of deficiency of Yin with damp-heat symptom.

Adjuvants, Immunologic↗

PubMed2004

Simulating periodontal effects in dental osseointegrated implants: effect of an intramobile damping element on the fatigue strength of dental implants--an in vitro test method.

OBJECTIVE: The purpose of this study was to develop and adapt a new method for testing dental implant systems and to apply it to existing systems with and without dampers. The parameters examined were the fatigue strength of the superstructure-retaining titanium screw, the deformation of the damper, and the effect on the supporting, bone-stimulating, and embedding material. METHOD AND MATERIALS: Ten pairs of implant specimens were prepared according to standard laboratory procedure and embedded in transparent polymethylmethacrylate (PMMA). Five pairs were provided with polyoxymethylene dampers and five with nondamping titanium connectors. Each pair was connected with a metal beam, and cyclic loads were applied with a pneumatic-driven machine at a frequency of 2 Hz. Chewing forces of 150 to 450 N were transmitted by springs individual to each specimen. For each of the 2 x 10(5) cycles, there was a control of the retaining screw and bonding between the fixture and embedding material by registration of gap propagation in the implant-PMMA interface. RESULTS: A significant damping effect was noticed on the implant--embedding material interface. Damping did affect the superstructure, since the retaining screws were plastically deformed. The screws were unscrewed when the applied load exceeded 300 N, while the undamped system was seemingly unaffected. CONCLUSION: The study method made it possible to evaluate damping effects on different levels of implant systems, while satisfying the requirements for testing in a "clinical-like" way. PMMA was comparable to bone in supporting implants during fatigue testing.

Alveolar Process↗

PubMed2002

[The clinical study on Dan Shao Tang in treating simple hematuria of masked nephritis of deficiency of Yin with damp-heat symptom].

OBJECTIVE: To explore the effect of Dan Shao Tang (DST) in treating simple hematuria of masked nephritis of deficiency of Yin with damp-heat symptom. METHODS: Sixty patients of simple hematuria of masked nephritis of deficiency of Yin with damp-heat symptom were divided into two groups in random, 35 patients in treatment group were treated with Dan Shao Tang and westen medicine, and 25 patients in control group were treated only with western medicine. The effect, change of hematuria and immunity index of the two groups were observed three months later. RESULTS: The total efficiency of treatment group (65.71%) is better than that of control group (36%). Treatment group is obviously better than control group on decreasing hematuria and improving immune function. CONCLUSION: Dan Shao Tang is effective to treatment on simple hematuria of masked nephritis of dificiency of Yin with damp-heat symptom effectively.

Adjuvants, Immunologic↗

PubMed2006

Bounds for damping that guarantee stability in mass-spring systems.

Mass-spring systems are often used to model anatomical structures in medical simulation. They can produce plausible deformations in soft tissue, and are computationally efficient. Determining damping values for a stable mass-spring system can be difficult. Previously stable models can become unstable with topology changes, such as during cutting. In this paper, we derive bounds for the damping coefficient in a mass-spring system. Our formulation can be used to evaluate the stability for user specified damping values, or to compute values that are unconditionally stable.

Algorithms↗

PubMed2006

[Clinical observation on pricking blood therapy with three-edged-needle plus cupping on Bi-syndrome of wind-dampness type in yemenia].

OBJECTIVE: To observe clinical therapeutic effect of pricking blood therapy with three-edged-needle plus cupping on Bi-syndrome of wind-dampness type in Yemenia and compare with "Heigama", a traditional Arabic therapy. Methods Forty cases of Bi-syndrome of wind-dampness type were treated with pricking blood therapy with three edged needle plus cupping and 40 cases with "Heigama" for 3 weeks, once each week. RESULTS: The total effective rate in the two groups was 82.5% and 80.0% respectively, with no significant difference between the two groups (P > 0.05). CONCLUSION: Pricking blood therapy with three-edged-needle plus cupping of TCM has obvious therapeutic effect on Bi-syndrome of wind-dampness type in Yemenia, with more convenience than Arabic "Heigama".

Acupuncture Points↗

PubMed2006

[Clinical observation on needle-sticking method for treatment of rheumatoid arthritis of wind-cold-damp retention type].

OBJECTIVE: To observe clinical therapeutic effect of needle-sticking method on rheumatoid arthritis (RA) of wind-cold-damp retention type. METHODS: Fifty cases of such disease were divided into 2 groups in order of visiting. The treatment group (n = 30) were treated with needle-sticking method, and the control group (n = 20) with routine filiform needle therapy for 2 therapeutic courses. Total cumulative scores, numbers of both the pressure-pain joint and the swollen-distention joint, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C reaction protein (CRP) before and after treatment were investigated. RESULTS: Both the needle-sticking method and the filiform needle therapy had an apparent therapeutic effect on RA of wind-cold-damp retention type, and the therapeutic effect for the clinical indexes in the treatment group was better than the control group, with a very significant difference in improvement of RF, the number of pressure-pain joints and the total cumulative scores as the treatment group compared with the control group (P < 0.01). CONCLUSION: Needle-sticking method has definite therapeutic effect on RA of wind-cold-damp retention type with obvious superiority.

Acupuncture Points↗

PubMed2006

[Clinical study on Dan Shao Tang in treating diabetic nephropathy of deficiency of Yin with damp-heat symptom].

OBJECTIVE: To explore the effect of Dan Shao Tang (DST) in treating diabetic nephropathy (DN) of deficiency of Yin with damp-heat symptom. METHODS: The 72 patients with DN of deficieny of Yin with damp-heat symptom were randomly divided into two groups. Among them, the 42 patients in treatment group were treated with DST and western medicine and the 30 patients in control group were treated only with western medicine. Before and after treatment, the effect and indexes change including blood glucose, renal function, proteinuria, microproteins, lipid metabolism and hyperviscosity were observed. RESULTS: After three months treatment, the general effective rate in treatment group was 76.19%, which was markedly higher than that in control group (50.00%, P < 0.01). Moreover, treatment group was obviously better than control group on decreasing blood glucose proteinuria and microproteins, improving renal function, ameliorating lipuid metabolism and hyperviscosity (P < 0.01 or P < 0.05). CONCLUSION: DST is effective ton treatment on DN of deficiency of Yin with damp-heat symptom.

Adult↗

PubMed1990

[Effect of various fixation agents on ultrasound damping in normal and pathological testicular tissues].

In normal and pathological testicular tissue the influence of various fixing agents (Formalin solution, Bouins solution, Hellys solution, Carnoys solution) concerning the acoustical properties of testicular tissue was examined. By means of an ultrasound spectroscopic measurement technique the ultrasound damping was registered by calculation of the ultrasound damping coefficient alpha. The results show that the most lower alpha values were obtained by fixation with formalin solution as well in normal as in altered testicular tissue. The results of fixation according to Helly, Carnoy and Bouin did show markedly differences. Therefore, the fixation of testicular tissue using formalin solution is the best way for experimental examinations of the ultrasound damping behaviour.

Dysgerminoma↗

PubMed1987

Comparison of the efficacy of defibrillation with the damped sine and constant-tilt current waveforms in the intact animal.

The efficacy of defibrillation using the damped sine and constant-tile (60%) truncated exponential waveforms was determined in each of nine dogs. Two measures of efficacy were used to compare the two waveforms: 1) threshold defibrillation current and 2) percent successful defibrillation. For both measures of efficacy, shock strength was expressed in terms of delivered energy. Mean threshold energy was 0.98 J/kg for the damped sine wave and it was 1.24 J/kg for the truncated exponential waveform. Percent successful defibrillation versus energy/kg curves were constructed for each of the waveforms and were found to be essentially the same. Percent successful defibrillation increased with increasing shock intensity. For 50% success, the energy for the damped sine wave was 1.16 J/kg; for the truncated exponential wave, the corresponding value was 1.15 J/kg. A shock of threshold intensity successfully defibrillated in approximately 50% of the defibrillation attempts, i.e., defibrillation threshold corresponds to about 50% successful defibrillation.

Animals↗