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PubMed1987

Differences in drinking behavior between normal and laryngectomized man.

The properties of drinking in normal and laryngectomized groups were examined. Drinking associated with meals was more frequent in the 76 young and 37 older normal subjects than the 25 laryngectomized persons. The laryngectomized group preferred tea and coffee to water to alleviate thirst sensation, while such a preference was hardly seen in either normal group. Results suggest that the larynx may contribute not only to thirst sensation but may be associated with preference in drinking.

Adult↗
PubMedDate not supplied

Naturalistic follow-up of drinking behavior following participation in an alcohol administration study.

Administration of alcohol to alcohol-dependent individuals for research purposes, while contributing significantly to the fund of knowledge on etiology and treatment of alcohol dependence, has often raised clinical and ethical concerns that such exposure may adversely affect the individual's motivation to reduce drinking or abstain from drinking. In an attempt to evaluate these concerns, we conducted a naturalistic follow-up of subsequent drinking among individuals who participated in an alcohol self-administration study and also received a brief motivational intervention. Twenty-one non-treatment-seeking alcoholics participated in a study examining the effects of naltrexone on alcohol self-administration. Assessment of drinking during the 3 months following the laboratory study indicated that participants had significantly reduced the total number of drinking days and the number of drinks consumed per occasion, as compared to baseline levels. The findings suggest that participation in alcohol administration research does not adversely influence the subsequent drinking of alcohol-dependent individuals. Further, when the alcohol administration research is conducted carefully, with specific attention to the clinical needs of the participants, the risks of adverse effects on participants' drinking behavior is minimal, and, in fact, there is scientific benefit to society and clinical benefit to the participants with regard to their alcoholism.

Adult↗
PubMed2001

Positive alcohol expectancies and drinking behavior: the influence of expectancy strength and memory accessibility.

College student drinkers (N = 314) participated in a health survey in which they (a) completed an alcohol-related memory association task (expectancy accessibility measure), (b) rated their positive expectancies about alcohol use (expectancy strength measure), and (c) reported their level of alcohol involvement. Hierarchical regression analyses showed that both expectancy accessibility and expectancy strength predicted frequency of alcohol use and alcohol-related problems. Moreover, moderational analyses showed that the association between expectancy strength and frequency of alcohol use was greater for those who generated more alcohol responses on the expectancy association task. These findings suggest that the outcome association measure and Likert scale ratings of expectancies may assess distinct properties of expectancy representations, which may have independent and interactive effects on different aspects of drinking behavior.

Adult↗
PubMed2006

Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample.

BACKGROUND: A wealth of literature supports the role of gamma-aminobutyric acid (GABA) in neurobiological pathways contributing to alcohol dependence and related phenotypes. Animal studies have consistently tied rodent homologs of the GABAA receptor genes on human chromosome 5q to alcohol-related behaviors; however, human studies have produced mixed results. Family-based association analyses previously conducted in the Collaborative Study on the Genetics of Alcoholism (COGA) sample yielded no evidence of association with Diagnostic and Statistical Manual of Mental Disorder-fourth edition (DSM-IV) alcohol dependence and these genes. As a follow-up to that study, we examined several alcohol-related behaviors in the COGA sample as follows: (1) a broader definition of alcohol dependence, including DSM-III-R symptoms and Feighner criteria (referred to as COGA alcohol dependence); (2) withdrawal; (3) history of alcohol-induced blackouts; (4) level of response to alcohol; (5) age of onset of regular drinking; and (6) age at first drunkenness. METHODS: Family-based association tests were conducted, using multiple single-nucleotide polymorphisms (SNPs) in each of the 4 GABAA receptor genes on chromosome 5q. RESULTS: In GABRA1, we found evidence of association with several of the drinking behavior phenotypes, including COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol. We did not find consistent evidence of association with the remaining genes and any of the phenotypes. CONCLUSIONS: We found evidence for association between GABRA1 and COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol. These analyses suggest that efforts to characterize genetic contributions to alcohol dependence may benefit by examining alcohol-related behaviors in addition to clinical alcohol dependence diagnoses.

Age of Onset↗
PubMed2002

Educational and occupational attainment and drinking behavior: an expectancy model in young adulthood.

AIMS: The socio-economic status (SES) variables of education level and occupational functioning have been found to be correlated negatively with alcohol use. The present study examined prospectively the relationship between these functioning measures, alcohol expectancies and alcohol involvement. We propose that expectancies function as a mediator of the relationship between educational/occupational attainment and drinking behavior. We hypothesized that changes in young adult functioning are linked to changes in social context and/or the availability of non-alcohol reinforcers, which in turn affect the reinforcement expected from alcohol. PARTICIPANTS AND DESIGN: Participants were 172 young adults from an ongoing longitudinal study of long-term clinical course of adolescent substance use treatment. Data from 6- and 8-year follow-ups were used in the present analyses. The treated sample (n=100) was recruited from in-patient substance abuse treatment programs for adolescents. A community sample (n=72) was matched on family history of substance abuse and SES at intake. FINDINGS: A cross-lag panel analysis indicated that education had a unique longitudinal relationship with expectancy for both the treated and community sample, over and above previous alcohol use and expectancy. Occupational variables did not have a longitudinal relationship with alcohol use and expectancy for either sample. Expectancies mediated the education/drinking relationship for the treated sample only. CONCLUSIONS: These results suggest one means through which changes in functioning may alter alcohol involvement over time: alteration of the reinforcement expected from alcohol.

Adult↗
PubMed1980

Neuropsychological consequences of posttreatment drinking behavior in male alcoholics.

A prospective study was designed to determine the neuropsychological consequences of continued alcohol consumption after treatment for alcoholism. Performance on 24 commonly used clinical neuropsychological tests was examined in 56 male alcoholics approximately 7 months after completion of an inpatient alcoholism treatment program. Abstainers (n = 17) performed better than those who resumed alcohol consumption. Although there was a significant decrease in alcohol consumption, posttreatment drinking behavior still predicted cognitive performance, with increased frequency and quantity per occasion having more deleterious consequences even at consumption levels that are deemed by some to be socially acceptable. It is concluded that alcohol consumption by former alcoholics might serve to maintain cognitive performance at reduced levels, and that this possibility should be considered in determining appropriate treatment goals for alcoholic patients.

Adult↗
PubMed1995

Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai.

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), the principal enzymes responsible for oxidative metabolism of ethanol, exist in multiple, genetically determined molecular forms. Widely different kinetic properties in some of these isozymes account for the individual differences in alcohol sensitivity. In this study we used the polymerase chain reaction/restriction fragment length polymorphism method to determine the genotypes of the ADH2 and ALDH2 loci of alcoholic and nonalcoholic Chinese living in Shanghai. We also investigated the subjects' drinking patterns by means of semistructured interviews. The alcoholics had significantly lower frequencies of the ADH2(2) and ALDH2(2) alleles than did the nonalcoholics, suggesting the inhibitory effects of these alleles for the development of alcoholism. In the nonalcoholic subjects, ADH2(2) had little, if any, effect, despite the significant effect of the ALDH2(2) allele in decreasing the alcohol consumption of the individual. Taken together, these results fit the proposed hypothesis for the development of alcoholism, i.e., drinking behavior is greatly influenced by the individual's genotypes of alcohol-metabolizing enzymes, and the risk of becoming alcoholic is proportionate with the ethanol consumption of the individual.

Adult↗
PubMed1994

Anxiety and drinking behavior: moderating effects of tension-reduction alcohol outcome expectancies.

We evaluated whether alcohol outcome expectancies moderate the association between measures of anxiety and alcohol use. Student subjects completed questionnaires related to their level of anxiety, recent alcohol-use patterns, and outcome expectancies for alcohol to be tension reducing. Interviews were used to determine the presence or absence of alcohol dependence in subjects and in their first- and second-degree relatives. Consistent with predictions, male subjects with high tension-reduction alcohol outcome expectancies showed a stronger positive correlation between measures of anxiety and drinking behavior than did male subjects with low tension-reduction outcome expectancies. However, this effect was not found for female subjects. We note past studies showing similar gender effects, and relate the overall study findings to the tension-reduction hypothesis of stress-induced drinking.

Adaptation, Psychological↗
PubMed2003

Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers.

Alcohol abuse is a serious health problem, leading to life-threatening damage to most of the important organ systems. Genotoxic damage is used as an early effect indicator in the surveillance of human exposure to genotoxic substances. Intra- and inter-individual variations of baseline frequencies of micronuclei (MN) in peripheral blood lymphocytes of human populations have been reported previously. Polymorphisms in a few metabolic enzyme genes seem to account for a proportion of this variability, but the impact of specific genetic variants on MN frequencies has not yet been clarified. In 42 healthy Japanese non-smoking men, we investigated the relationship between the MN frequency levels and genetic polymorphisms in three different genes: aldehyde dehydrogenase 2 (ALDH2), X-ray repair cross-complementing group 1 (XRCC1) and excision repair cross-complementing group 2 (ERCC2). Genotyping was performed by PCR-RFLP analysis. The ALDH2 variant (deficient-type) was significantly associated with increased MN frequency levels in subjects with drinking more than three times per week, whereas the XRCC1 and ERCC2 variants seemed to be unrelated to the MN frequency. The ALDH2-deficient habitual drinkers had an average MN frequency of 5.88+/-0.58 (+/- S.E.) compared with 3.20 +/- 0.80 in the ALDH2-proficient habitual drinkers (P<0.05). The ALDH2-proficient non-habitual drinkers had the lowest MN frequency (1.56 +/- 0.41). Furthermore, subjects with highest levels of mean MN frequency, who consumed more than 100g of alcohol per week and more than three times per week, had A2 genotype of ALDH2. A significant odds ratio (12.25, P<0.05) for the MN frequency levels above the 50th percentile value was observed for the ALDH2-deficient individuals versus the ALDH2-proficient individuals after adjustment for several confounders. These results strongly suggest that human early genotoxic effect studies based on the cytogenetic markers of MN should take into account both the individual ALDH2 polymorphism and the potential confounding effect of the drinking behavior.

Adult↗
PubMedDate not supplied

Athletic status and drinking behavior in college students: the influence of gender and coping styles.

College students' alcohol use as well documented, and published studies have indicated that athletes drink more frequently and more often to the stage of intoxication than do nonathletes. Some researchers have cited sociological factors to explain these behaviors, but neither the underlying emotional factors that drive students' alcohol use nor the interaction of gender and athletic status have been examined. The authors' twofold purpose in conducting this study was (1) to examine the influence of the interaction of gender and athletic status on the drinking behaviors of college students, and (2) to examine whether differences in male and female athletes' and nonathletes' coping styles influenced their drinking behaviors.

Adaptation, Psychological↗
PubMed1988

Disruption of light-dark cycle of feeding and drinking behavior, and ambulatory activity induced by development of obesity in the Zucker rat.

To clarify the contribution of abnormalities and disruption of the light-dark cycle of feeding behavior during obesity progression in Zucker rats, feeding, drinking and ambulation were measured at four different stages of obesity. In the obese rats, the nocturnal pattern of feeding, drinking and ambulation shifted gradually into the light period with the progression of obesity. The lean rats however were unaffected. In the analysis of meal parameters, nocturnal dominance of meal size in the obese disappeared by 12 weeks of age and that of meal frequency was lost by 30 weeks of age. This disruption of the light-dark cycle in meal parameters appeared uneven at different stages indicating that synergistic impairment of meal size and meal frequency might contribute to the impairment of the nocturnal feeding pattern, which leads, in part, to the development of obesity.

Age Factors↗
PubMed1984

Drinking behavior is modulated by CNS administration of opioids in the rat.

While opiate antagonists have been shown to reliably attenuate drinking following both central and peripheral administration, relatively few data exist on the effects of agonist agents on this behavior. To address this issue, two opiate agonists, morphine sulfate, a mu agonist, and [D-ala2, D-leu5]-enkephalin (DADLE), a semi-synthetic delta analog of a delta agonist, were administered into several CNS sites in rats. There was a dose-related, naloxone-reversible reduction of water intake following morphine injections into the lateral hypothalamus (LH) and preoptic area (POA). In addition, injections of DADLE also attenuated drinking when injected into LH and POA, but not following the ventral tegmental area or zona incerta administration. These data are discussed in view of a role for the endogenous opioid peptides in the regulation of drinking behavior.

Animals↗
PubMed1990

Circulating angiotensin II and drinking behavior in rats.

This study was designed to investigate the effects on water drinking of acute and chronic increases in circulating angiotensin II (ANG II) concentrations in rats. Experiments were conducted in male Sprague-Dawley rats chronically instrumented with femoral arterial and venous catheters and permanently housed in metal metabolism cages. ANG II was infused intravenously either acutely (30 min-2 h) or chronically (3 days) in a dose range of 10-60 ng/min. In no instance did such infusions cause a statistically significant increase in water intake. Other experiments examined the influence of ANG II (10 ng/min iv) on drinking elicited by infusion of hypertonic sodium chloride (1.5 M at 3.5 microliters/min). ANG II administration did not increase drinking to a hypertonic saline stimulus or lower the osmotic threshold for drinking. Nitroprusside (12 micrograms/min) was infused for 30 min to produce hypotension and drinking. Water intake associated with this stimulus was not changed by blocking ANG II formation with enalapril (2 mg/kg iv) or by concomitant infusion of ANG II (10 ng/min iv). Finally, plasma ANG II concentrations were measured before and after 1-h intravenous infusion of saline or ANG II to determine the levels of circulating ANG II produced by the infusion rates used here. It is concluded that the range of circulating ANG II concentrations found under most physiological conditions in rats does not directly stimulate drinking or participate importantly in osmotic or hypotension-induced drinking.

Angiotensin II↗