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Results for “GINGIVAL HYPERPLASIA”

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PubMed2005

[Histopathologic investigations of nifedipine-induced gingival hyperplasia in Wistar rats].

BACKGROUND: Nifedipine, a calcium channel blocker, used in the therapy of cardiovascular diseases, can induce gingival overgrowth. The aim of the study was to assess the influence of nifedipine on the deeper periodontal tissues of the experimental animals concerning connective tissue and blood vessels proliferation. METHODS: The research was performed on Wistar rats, and they received the precise doses of nifedipine water suspension while the changes were followed up in pre-determined time intervals. The analyses of samples of tissues were done on the cross-sections of papilla from the top to the bottom on five levels. RESULTS: Considerable level of changes was observed in the area of dental alveolar edge and in the gingivo-dental interspace. Epithelial hyperplasia and inflammatory subepithelial infiltration of lymphoplasmocyte type were also present. Alveolar bone destruction, the increased number of osteoclasts and periodontal destruction were found, as well. CONCLUSION: The results of this study showed a significant gingival hyperplasia in the experimental animals which received high doses of drug during extended period of time.

Animals↗
PubMedDate not supplied

Nifedipine-induced gingival hyperplasia: non-surgical management of a patient.

A clinical report of nifedipine-induced gingivitis in a medically compromised patient is presented. This case history also describes the challenges faced by the oral health practitioner to develop an appropriate regimen of treatment for a patient in whom neither withdrawal of the drug nor substituting for it was feasible, and periodontal surgery was contra-indicated.

Adult↗