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At least 235 records · Page 13Linked to original sources
PubMed1992

Hyperkeratosis lenticularis perstans (Flegel's disease). Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil.

Lesional and perilesional skin samples from a 57-year-old man who had hyperkeratosis lenticularis perstans (HLP) (Flegel's disease) were studied by light and electron microscopic examination. Keratohyalin granules were diminished at the center of a fully-developed lesion. In contrast, keratohyalin appeared normal and membrane-coating granules were found in reduced numbers at the edges of the HLP lesion and were easily detected in normal numbers in clinically normal, perilesional skin. The inflammatory infiltrate in the HLP lesion was composed of small lymphocytes, which often displayed nuclei with deep infoldings resembling Sézary cells, and larger histiocytic cells, many of which were in close contact with the lymphocytes. Peripheral blood mononuclear cells did not show an abnormal ultrastructural appearance. Treatment with topical 5-fluorouracil cream led to the disappearance of the HLP lesions, whereas topical tretinoin was ineffective.

Administration, Cutaneous↗
PubMed1989

[Hyperkeratosis lenticularis perstans (Flegel)].

The case of a female patient, 67 years old, with hyperkeratotic papules in the lower extremities which are characteristic of hyperkeratosis lenticularis perstans is reported. The clinical, histological and ultrastructural findings are shown. We have recorded the absence of Odland bodies in the area of the lesion, the persistence of desmosomes in the stratum corneum and lymphocytes with cerebriform nuclei within the inflammatory cell infiltrate. She was satisfactorily treated with etretinate and topical 5-fluorouracil We have reviewed the existing literature on this subject.

Aged↗
PubMed1986

Contact dermatitis. A review.

Contact dermatitis of the lower extremity is reviewed in regard to symptoms, clinical manifestations, etiologic agents, and treatment. Examples of some of the clinical manifestations are presented pictorially.

Administration, Topical↗
PubMed1979

Cryofibrinogenemia, monoclonal gammopathy, and purpura. Report of a case and review of the literature.

A patient with purpura, acral blisters, and ulcerations was evaluated and found to have cryofibrinogenemia and an IgG K light chain monoclonal gammopathy. No other systemic illness was found. The overall incidence of significant cryofibrinogenemia include neoplastic, thrombotic, infectious, and miscellaneous disorders. The patient described was not easily classified. This case is probably best considered primary or idiopathic cryofibrinogenemia.

Adult↗
PubMed1979

Porokeratosis of Mibelli. A report of two unusual cases.

2 cases are reported with unusual manifestations of porokeratosis of Mibelli. In 1 case multiple atrophic facial lesions resembled plaques of chronic discoid lupus erythematosus. The second case exhibited extensive cutaneous involvement in the form of hyperkeratotic lesions in linear configuration.

Adolescent↗
PubMed1977

Keratolytic winter erythema or 'oudtshoorn skin': a newly recognized inherited dermatosis prevalent in South Africa.

A hitherto undescribed inherited dermatosis, traceable to certain 19th-century inhabitants of Oudtshoorn, CP, has been transmitted as an autosomal dominant to a large number of their present-day descendants. The disease consists of intermittent and recurrent centrifugal peeling, with redness, of the palms and soles in particular. In more severe cases similar patches are found extending up the limbs to the buttocks and the trunk generally. The inconvenience is usually moderate, but it may be incapacitating. Some temporary relief, but so far nothing permanent, can be offered through treatment.

Adolescent↗
PubMed1995

Coccidioidomycosis: the other great imitator.

A "great imitator," like the perhaps more familiar syphilis and tuberculosis, coccidioidomycosis has a wide variety of clinical presentations. A recent dramatic surge in the incidence of this saprobe increases the likelihood that clinicians will encounter an infected patient. Although rare, the disseminated form of the disease is potentially fatal. Vigilance and familiarity with the many faces of this pathogen will permit early detection and treatment. We present two cases of disseminated coccidioidomycosis and briefly review this increasingly common fungal infection.

Adult↗
PubMed1997

Painful piezogenic pedal papules: response to local electro-acupuncture.

We report the case of a woman who had pain in both heels which was exacerbated by long periods of exercise. On examination, there were small flesh-coloured papules which appeared over the medial and lateral aspects of the heels only on weight bearing. Coincidentally, she was noted to have larger flesh-coloured papules over the anterior surface of the shins. The diagnoses of painful piezogenic pedal papules and bilateral tibialis anterior muscle herniation, respectively, were made. After many attempts to control the pain, a course of electro-acupuncture was commenced. A good subjective clinical response was achieved which has been maintained by fortnightly treatments. We discuss the prevalence, pathogenesis and treatment of painful piezogenic pedal papules. We believe that our patient is the first to have 'herniations' at both heel and shin sites and the first to have successful sustained pain relief for painful piezogenic pedal papules.

Acupuncture Analgesia↗