SEARCH · PubMed Health
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Epidural lipomatosis is most frequently seen in patients on chronic steroid treatment. Only fourteen cases of idiopathic spinal epidural lipomatosis have been described. In this report we present an additional case of this condition in a 38 year-old man.
INTRODUCTION: Lipomatosis of the tongue is rarely observed. CASE REPORT: An 85-year-old man with chronic alcoholism presented several symmetrical lipomas of the tongue with no other clinical manifestations. There was no capsule at the histology examination. DISCUSSION: The multiple and symmetrical nature of the lesion without a capsule led to the diagnosis of benign symmetrical lipomatosis of the tongue, the fourth case reported in the literature.
A case of benign symmetric lipomatosis is reported in conjunction with a review of the literature. The association with metabolic disorders such as gout and hyperlipemia, as reported by others, is fortuitous and not statistically significant. The etiology of this rare type of lipomatosis is unknown; its treatment is surgical and should be confined to cases with symptoms of compression or extremely disturbing appearance.
Five adult female Eld's deer died acutely or were euthanatized because of clinical signs including anorexia, signs of depression, and uremia. On necropsy, these deer had large masses of necrotic abdominal fat constricting the ureters, causing hydroureter and hydronephrosis. The herd from which these deer originated was maintained on pastures consisting primarily of tall fescue, samples from which were subsequently confirmed to be infected with an endophytic fungus that is known to cause similar lesions in cattle. A retrospective study of deaths in this herd revealed a sharp increase in incidence of abdominal lipomatosis since 1994. Physical examinations on the herd revealed > 90% of females to be affected. Endophyte-infected tall fescue forage was concluded to be a major factor in the development of lipomatosis in these deer. Other contributing factors were considered. Lesions caused by endophyte-infected fescue can be severe, and this disease can develop in nondomestic species.
We describe a further case of cauda equina compression secondary to steroid-induced epidural lipomatosis in a patient treated for IBD. The diagnosis was rapidly confirmed by MRI allowing conservative management by corticosteroid withdrawal as well as use of hygiene and dietary measures. Therapeutic efficacy was noted on a clinical basis and confirmed by repeated follow-up MRI exams which showed regression of fat accumulation. Symptomatic epidural lipomatosis is probably underestimated because physicians concerned by steroid treatment are not fully informed about this potentially severe and usually iatrogenic disease. Also, proper medical attention to the first neurological symptom in these patients might help limit therapeutic management to a medical measurer, before requiring surgical decompressive surgery.
Spinal epidural lipomatosis is the result of deposition of unencapsulated fat in the extradural space of the spinal canal. Most commonly, this rare condition is a complication secondary to corticosteroid treatment. We describe a 49-year-old patient with ulcerative colitis who developed paraparesis due to overgrowth of epidural fat tissue. This is the second patient with ulcerative colitis described in the literature who developed symptomatic epidural lipomatosis secondary to corticosteroid treatment. All internists tending patients with chronic diseases that require corticosteroid treatment should be aware of this rare clinical entity.
Lipomatosis of the parotid gland is a very rare tumour and its discovery in a child is exceptional. These tumours are not generally considered in the preoperative differential diagnosis of parotid region neoplasms because of their rarity. The treatment of choice is surgical excision, with a superficial or total parotidectomy, preserving the facial nerve. Long-term follow-up is advised due to possible microscopic infiltration. A case of lipomatosis of the parotid gland in a 4-month-old child is reported.
Encephalocraniocutaneous lipomatosis is a rare neurocutaneous syndrome characterized by lipomatous hamartomas ranging in size from a few millimeters to several centimeters and affecting the head. Ocular anomalies and a variable degree of mental retardation with or without convulsions are usually observed. This disorder should be distinguished from other mosaic neurocutaneous phenotypes such as Proteus syndrome, oculocerebrocutaneous syndrome, and nevus sebaceous syndrome. We report the clinicopathologic findings of a 4-year-old Brazilian girl affected by this syndrome and review the literature. To our best knowledge, this is the first documented case of encephalocraniocutaneous lipomatosis occurring sporadically in South America.
We present the results of surgical treatment of idiopathic epidural lipomatosis in a 38 year-old man. Our results were evaluated 3 years; after operation. This is the third case of idiopathic epidural lipomatosis in literature in which a very good result of treatment was obtained and patient returned to previous work.
The authors describe a case of mediastino-abdominal lipomatosis. The patient, who is 70 years old, was kept under observation, because of her recent state of illness. This state of illness was initially interpreted as angor attacks and a left ventricular failure. Only after the results of a CT examination showing a characteristic disproportion between the endothoracic-endoabdominal adipose tissue and the subcutaneous tissue, a correct interpretation was given. As a result the patient's state of illness was attributed to a compression of the adipose tissue growth in the abdominal and thoracic cavity. The etiology of mediastino-abdominal lipomatosis is still unknown. Therapy consists in removing the lipomas surgically when they cause a compression of the trachea and the upper vena cava.
Madelung's disease, benign symmetric lipomatosis, is a rare disease of undetermined cause characterized by symmetric deposits of diffuse adipose tissue on the cheeks, the neck, and the upper trunk. This article outlines our experience with four patients and presents a case report of a specifically remarkable affectation that agrees with previous data linking male alcoholics with this disease. The treatment in all cases was palliative surgical removal of excess fat from the neck and paracervical regions.
Multiple symmetric lipomatosis is a fascinating disease of uncertain etiology that manifests as massive lipomatous deposits in specific areas of the body. The clinical syndrome and possible pathogenesis are discussed. Classic surgical lipectomy has been the only treatment thus far reported; we report a patient successfully treated with liposuction.
With increasing age, peripheral neuropathy becomes more common in multiple symmetric lipomatosis (MSL) and the principal cause of severe disability. High alcohol consumption is frequently associated and the peripheral neuropathy of MSL is often attributed to alcoholism. In this study, sural nerve biopsies from MSL patients revealed an absence of acute axonal degeneration, a significant shift to the left of myelinated fibre diameter distributions, reduced indices of axonal and nerve fibre circularity, and an increase in myelin periodicity. This pathology supports the view that the neuropathy of MSL is not alcohol-induced but that a chronic distal axonopathy is an integral part of the MSL syndrome. Biochemical observations suggest a defect in catecholamine-stimulated lipolysis in MSL at a membrane level, possibly in the amount or function of Gs membrane protein or in the catalytic unit of adenylate cyclase. Evidence is presented that the frequent association of MSL with alcoholism is on the basis of an additional ethanol-induced membrane lesion involving beta-adrenergic receptors.
Benign symmetrical lipomatosis is an unusual disorder of fat metabolism that results in a characteristic accumulation of adipose tissue around the head and neck. Surgical extirpation is the only known effective therapy. Physical examination does not provide a comprehensive delineation of tumor extent. We present the first reported use of CT scanning to investigate the anatomic limits of BSL and to plan the operative approach.
Non-encapsulated lipomatosis of symmetrical distribution may be acquired in middle age. A case is described in which the hands are affected.
A 65-year-old Kenyan Asian developed rapidly progressive multiple symmetrical lipomatosis over 8 years. Noradrenaline infusion showed a normal response of plasma free fatty acids. In-vitro studies of the lipomatous tissue demonstrated intact lipolytic activities with a normal rate of free fatty acids release and cyclic AMP accumulation with or without isoprenaline and fenoterol stimulation. A clinical trial of oral salbutamol, a beta 2-agonist, was performed with significant therapeutic effect. The body fat mass showed a reversal of the rapid progression while on the treatment, associated with an increase in the resting metabolic rate.
Multiple symmetric lipomatosis (MSL) is an extremely uncommon disorder. In the medical literatures about 200 cases have been reported. MSL is not associated with other generalized lipomatous disorders, nor are these patient to be necessarily obese. The cause of MSL is unknown. The disorder usually occurs in middle-aged males and there is frequently a history of alcoholism. Some instances of familial occurrence have been reported, but the majority of cases are sporadic. Two cases of MSL are presented.
A case of benign symmetrical lipomatosis (Madelung-Launois-Bensaude syndrome) is described. The characteristic clinical features and the association with chronic alcoholism are reported.