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PubMed1986

Kinetics of 3H-serotonin uptake by platelets in infantile autism and developmental language disorder (including five pairs of twins).

The kinetics of 5-HT uptake by platelets was studied in cases of infantile autism and developmental language disorder (DLD) and normal subjects. Two patients of the autism group were twins, and the seven patients of the DLD group were members of four pairs of twins. The Vmax values (means +/- SD) for autism and DLD were 6.46 +/- .90 pmol 5-HT/10(7) cells/min and 4.85 +/- 1.50 pmol 5-HT/10(7) cells/min, respectively. These values were both significantly higher than that of 2.25 +/- .97 pmole 5-HT/10(7) cells/min for normal children. The Km values of the three groups were not significantly different. Data on the five pairs of twins examined suggested that the elevated Vmax of 5-HT uptake by platelets was determined genetically.

Autistic Disorder↗
PubMed1996

Associations among familial sinistrality, allergies, and developmental language disorders.

Here we report the results of a study that tested what has become known as the Geschwind hypothesis (Geschwind & Galaburda, 1987). This study involved 526 people who were tested by an allergist for IgE-mediated allergies and who filled out a 12-item handedness questionnaire that also included questions about eyedness, prevalence of left-handedness in the immediate family, and familial developmental language problems. A series of log-linear analyses revealed that if the definition of "anomalous" included left-handedness and having a first-order left-handed relative, one was indeed more likely to be allergic than were those not so classified. When the definition of anomalous simply included those classified as left-handed, the results were not significant. Parallel findings resulted when the criterion variable was the presence of developmental language disorders. No evidence was found for relations between allergies and developmental language problems.

Adolescent↗
PubMed2001

Language disorders as a window on universal grammar: an abstract theory of agreement for IP, DP, and V-PP.

A new concept of Agreement (AGR) has been represented as a Formal Feature that can appear in a wide range of different configurations (Chomsky, 1998). A case study from language disorders supports and extends this abstract concept. The child shows no agreement in Inflectional Phrase me can and Determiner Phrase them eyes. We then extend the notion of AGR to include verb-Prepositional Phrase relations, where the child also systematically avoids certain prepositions (go beach). The analysis is supported by intuitional data from compounds (sweep with broom --> broom-swept). We also define a systematic notion of Possible deficit as a premature fixation of functional items which normally require additional Phi-features. The notion of Maximization of Formal Features then emerges as a significant feature of learnability from both a normal and disordered perspective.

Child↗
PubMed1981

[Aphasic-type language disorders associated with lesions of the putamen and caudate nucleus: clinicopathological findings in one case (author's transl)].

Language disorders developed in a patient following a subcortical infarct involving the left putamen and caudate nucleus. Language was abundant and fluent, with many perseverations, semantic and ideation incoherences, and all activities concerned with verbal or non-verbal expression were affected. Lesions were present in the head and body of the caudate nucleus, the whole of the putamen, the anterior nucleus of the thalamus and the superior part of the internal capsule. The disorder was unique in relation to disturbances of the aphasic type observed in extensive thalamic lesions, or in transcortical sensorial aphasia. Physiopathological interpretation is based on the functional role of the putamen-caudate system in the regulation of many types of behaviour: animal experiments and results of applying stimuli in humans suggests a release of the inhibition exerted by the caudate nucleus on the frontal cortex. Lack of comparable clinicopathological data implies that other similar cases must be reported before the specificity of the disorder can be confirmed.

Aphasia↗
PubMed1992

Research in child language disorders: what do we know and where are we going?

Advances in understanding the nature of language impairment in children over the past decade have been abundant. In this paper, several recurring hypotheses about the nature of the clinical disorder of language impairment in children and underlying etiologies are explored and the ways in which we are moving forward in our understanding of them are considered. Specifically, in the first part, the recent thinking on the nature of specific language impairment as a clinical concept is examined. Characteristics of the population are reviewed and the search for causation is considered. Literature on the relations between language and cognition and between language and social cognition is probed for contributions to our understanding of developmental disorders of language. Two areas in which we have seen marked progress and which hold promise for development in the coming decade are the focus of the second part of the paper. The focal areas are: computer-assisted language sample analyses and neurophysiological contribution to understanding language impairment in children. Thoughts about future directions for work in the area of developmental disorders of language are offered in conclusion.

Adolescent↗
PubMed2004

Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis.

We report a whole-brain MRI morphometric survey of asymmetry in children with high-functioning autism and with developmental language disorder (DLD). Subjects included 46 boys of normal intelligence aged 5.7-11.3 years (16 autistic, 15 DLD, 15 controls). Imaging analysis included grey-white segmentation and cortical parcellation. Asymmetry was assessed at a series of nested levels. We found that asymmetries were masked with larger units of analysis but progressively more apparent with smaller units, and that within the cerebral cortex the differences were greatest in higher-order association cortex. The larger units of analysis, including the cerebral hemispheres, the major grey and white matter structures and the cortical lobes, showed no asymmetries in autism or DLD and few asymmetries in controls. However, at the level of cortical parcellation units, autism and DLD showed more asymmetry than controls. They had a greater aggregate volume of significantly asymmetrical cortical parcellation units (leftward plus rightward), as well as a substantially larger aggregate volume of right-asymmetrical cortex in DLD and autism than in controls; this rightward bias was more pronounced in autism than in DLD. DLD, but not autism, showed a small but significant loss of leftward asymmetry compared with controls. Right : left ratios were reversed, autism and DLD having twice as much right- as left-asymmetrical cortex, while the reverse was found in the control sample. Asymmetry differences between groups were most significant in the higher-order association areas. Autism and DLD were much more similar to each other in patterns of asymmetry throughout the cerebral cortex than either was to controls; this similarity suggests systematic and related alterations rather than random neural systems alterations. We review these findings in relation to previously reported volumetric features in these two samples of brains, including increased total brain and white matter volumes and lack of increase in the size of the corpus callosum. Larger brain volume has previously been associated with increased lateralization. The sizeable right-asymmetry increase reported here may be a consequence of early abnormal brain growth trajectories in these disorders, while higher-order association areas may be most vulnerable to connectivity abnormalities associated with white matter increases.

Autistic Disorder↗
PubMed1994

[Habilitation for handicapped children, mainly for children with visual and hearing impairment, speech-language disorder, and hyperkinetic disorder].

This symposium was focused on habilitation for children with visual and hearing impairment, speech-language disorder, and hyperkinetic disorder. New and variable approaches were reported in topics of habilitation for these handicapped children by an ophthalmologist, an otorhinolaryngologist, a child neurologist, a speech therapist and an educational psychologist. Many points of these approaches were then discussed.

Child↗
PubMed1997

Language disorders in children with autism.

Language development is delayed in most children on the autistic spectrum. The children are dysphasic as well as autistic. Comprehension and pragmatics are invariably affected. Lower level mixed receptive/expressive disorders involve phonological and syntactical processing, whereas higher level processing disorders involve semantics and formulation of discourse. In some children, lower level disorders may be so severe as to preclude speech, whereas in others phonology may be deficient in spontaneous production but not in repetition. Abnormal features of autistic language include aberrant prosody, immediate and delayed echolalia (scripts), and perseveration. Electrophysiological studies indicate that brainstem-evoked potentials are normal. Even in fully verbal individuals with autism, early and late cortical components of auditory, but not visual, event-related potentials are abnormal. Appropriate intervention must address language and behavioral issues. In children with severely defective auditory language, provision of visual language to supplement speech is essential.

Autistic Disorder↗
PubMed1988

The role of the school psychologist in the examination of complex language disorders.

In this article we shall first attempt to show in a summary fashion how the concept of language has changed over the last 20 to 40 years. This will serve as a background and aid to understanding the current view that language disturbances are of such a complex nature that they can only be understood, analysed and treated by means of an interdisciplinary approach. A look at the recent developments in the sciences that touch upon the comprehension of language disturbances elucidates our current view of them. It can help to clarify the role of the psychologist, especially the school psychologist who works with children and adolescents in the diagnosis, counseling, in some cases in the treatment and often in cooperation with other professionals of lingual disturbances. Conclusions can also be drawn as to the specific professional qualifications required and as to the methodology of the psychological examination.

Child↗
PubMedDate not supplied

Emotional satisfaction of parents and speech-language therapists with outcome of training intervention in children with speech and language disorders.

The compliance of children and their parents is very important for the outcome of speech-language therapy in children. We analyzed 169 questionnaires of parents whose children had received speech-language therapy and 140 questionnaires of speech-language therapists (logopedists) concerning their satisfaction with the outcome of the intervention. Treatment was usually once weekly. We found that the majority of the parents was very satisfied with the outcome of the speech-language therapy, the professional knowledge of the speech-language therapists and the type of therapy. The speech-language therapists were in most cases pleased with the compliance of the parents. Speech-language therapists who have been working for many years tend to spend less time with parents, to consider insufficient progress as a challenge and to treat less frequently.

Female↗
PubMed1986

A model for clinical-quantitative classification. Generation I: Application to language-disordered preschool children.

A model is presented for the integration of clinical-inferential and quantitative approaches to classification. In this, the first application of the proposed model, preschool children with developmental language disorders were classified on the basis of clinical interpretations of performance on psychometric subtests. Five hypothesized subgroups were validated on the basis of (a) consensus among five clinical neuropsychologists, (b) language pathologists' reports, (c) comparisons with subgroups defined by a cluster analytic approach, and (d) comparisons among subgroups on variables not used for classification. Results are discussed in terms of the feasibility of the integrated approach, commonalities with other typologies, and the implications of this work to issues of subtype stability, remediation, predictions of later reading achievement, brain-behavior relationships, and generalizability to other clinical groups.

Auditory Perception↗
PubMed1982

Profiles of children with severe oral language disorders.

The major purpose of this study is to determine whether children assigned to classes for severe oral language handicaps in California by a multidisciplinary diagnostic team exhibit a characteristic ITPA performance profile or a number of distinct profiles. A factor analysis and a cluster analysis was made on the scores of 237 children. It was found that on the factor analysis the results showed a clear auditory-vocal factor and a visual-motor factor. All five tests in the visual-motor channel were superior to the five tests in the auditory-vocal channel. Within the auditory-vocal channel the lowest scores were in auditory association and grammatic closure. Ninety-seven percent of the oral language handicapped children had the lowest scores on these two subtests. It appears from these results that the major deficit of children assigned to severe oral language classes is a deficit in the central organization process, formerly referred to as "central aphasia, or inner language".

Child↗