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Identification of Ippy as a Lassa-fever-related virus.
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Clinical presentation of Lassa fever cases during the hospital epidemic at Zorzor, Liberia, March-April 1972.
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Lassa fever in the Eastern Province of Sierra Leone, 1970-1972. I. Epidemiologic studies.
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Lassa fever in the Eastern Province of Sierra Leone, 1970-1972. II. Clinical observations and virological studies on selected hospital cases.
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A hospital epidemic of Lassa fever in Zorzor, Liberia, March-April 1972.
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The pathology of Lassa fever.
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Lassa fever. A study of 23 hospital cases.
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Lassa fever. Epidemiological aspects of the 1970 epidemic, Jos, Nigeria.
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Lassa fever. Virological and serological studies.
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Update on emerging infections: news from the Centers for Disease Control and Prevention. Imported Lassa fever--New Jersey, 2004.
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A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus.
The subtilase subtilisin kexin isozyme-1 (SKI-1)/site 1 protease (S1P), has been implicated in the processing of Lassa virus glycoprotein C (GP-C) precursor into GP1 and GP2 that are responsible for viral fusion with the host cell membrane. Here, we studied in vitro the kinetics of this cleavage by hSKI-1 using an intramolecularly quenched fluorogenic (IQF) peptide, Q-GPC(251-263) [Abz-(251)Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu/Gly-Thr-Phe-Thr(263)-3-NitroTyr-Ala-CONH(2)], containing the identified site. The measured V(max (app))/K(m (app)) was compared to those for other IQF SKI-substrates. Q-GPC(251-263) is cleaved 10-fold more efficiently than the previously known best SKI-substrate, Q-hproSKI(134-142). This study confirmed the role of SKI-1 in GP-C processing and provides a novel, rapid and efficient enzymatic assay of SKI-1.
Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings.
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Lassa fever, a new virus disease of man from West Africa. II. Report of a laboratory-acquired infection treated with plasma from a person recently recovered from the disease.
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Lassa fever, a new virus disease of man from West Africa. 3. Isolation and characterization of the virus.
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An outbreak of Lassa fever on the Jos plateau, Nigeria, in January-February 1970. A preliminary report.
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