PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Model performance”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 235 records · Page 13Linked to original sources

SLAM: a connectionist model for attention in visual selection tasks.

SLAM, the SeLective Attention Model, performs visual selective attention tasks, an analysis of which shows that two processes, object and attribute selection, are both necessary and sufficient. It is based upon the McClelland and Rumelhart (1981) model for visual word recognition, with the addition of a response selection and evaluation mechanism. The responses may be correct or incorrect and, in particular conditions, SLAM may not make a response at all. Moreover, it allows for the generation of specific responses in time. SLAM's main characteristics are parallelism restricted by competition within modules, heterarchical processing in a hierarchical structure, and generation of responses as a result of relaxation given the conjoint constraints of stimulation, object, and attribute selection. The model is considered to represent an individual subject performing filtering tasks and demonstrates appropriate selective behavior. It is also tested quantitatively using a single tentative set of model parameters. The study reports simulations of four different filtering experiments, modeling response latencies, and error proportions. Specifications are made to take account of instructions, previous trials, and the effect of a barmarker cue and of asynchronies in stimulus and cue onsets. The model is then extended in order to provide simulations of a number of Stroop experiments, which can be regarded as filtering tasks with nonequivalent stimuli. The extension required for Stroop simulations is the addition of direct connections between compatible stimulus and response aspects. The direct connections do not affect the simulation of simpler filtering tasks. A variety of different experiments carried out by different authors is simulated. The model is discussed in terms of how modular architecture and the interaction of excitation and inhibition generate facilitation or inhibition of response latencies.

Arousal↗

Do severity measures explain differences in length of hospital stay? The case of hip fracture.

OBJECTIVE: To examine whether judgments about hospital length of stay (LOS) vary depending on the measure used to adjust for severity differences. DATA SOURCES/STUDY SETTING: Data on admissions to 80 hospitals nationwide in the 1992 MedisGroups Comparative Database. STUDY DESIGN: For each of 14 severity measures, LOS was regressed on patient age/sex, DRG, and severity score. Regressions were performed on trimmed and untrimmed data. R-squared was used to evaluate model performance. For each severity measure for each hospital, we calculated the expected LOS and the z-score, a measure of the deviation of observed from expected LOS. We ranked hospitals by z-scores. DATA EXTRACTION: All patients admitted for initial surgical repair of a hip fracture, defined by DRG, diagnosis, and procedure codes. PRINCIPAL FINDINGS: The 5,664 patients had a mean (s.d.) LOS of 11.9 (8.9) days. Cross-validated R-squared values from the multivariable regressions (trimmed data) ranged from 0.041 (Comorbidity Index) to 0.165 (APR-DRGs). Using untrimmed data, observed average LOS for hospitals ranged from 7.6 to 23.9 days. The 14 severity measures showed excellent agreement in ranking hospitals based on z-scores. No severity measure explained the differences between hospitals with the shortest and longest LOS. CONCLUSIONS: Hospitals differed widely in their mean LOS for hip fracture patients, and severity adjustment did little to explain these differences.

Aged↗

Stability and change in longitudinal water-level task performance.

Three longitudinal samples of children (N = 481), 8 to 16 years old, were assessed 3 times at yearly intervals on 8 water-level items. The within-child change in task performance over age is viewed as a stochastic process of the child changing or remaining in 1 of 3 latent (strategy) states: (a) bottom-parallel responders, (b) random responders, or (c) accurate responders. A random-effects binomial mixture distribution is used to model performance at each age. Change over age is gauged by a stochastic transition model. Although there was improvement in task performance over age, the more general finding is that strategy stability, not change, is most typical.

Adolescent↗

Predicting protein structure using hidden Markov models.

We discuss how methods based on hidden Markov models performed in the fold-recognition section of the CASP2 experiment. Hidden Markov models were built for a representative set of just over 1,000 structures from the Protein Data Bank (PDB). Each CASP2 target sequence was scored against this library of HMMs. In addition, an HMM was built for each of the target sequences and all of the sequences in PDB were scored against that target model, with a good score on both methods indicating a high probability that the target sequence is homologous to the structure. The method worked well in comparison to other methods used at CASP2 for targets of moderate difficulty, where the closest structure in PDB could be aligned to the target with at least 15% residue identity.

Markov Chains↗

Modeling the phenotype in parametric linkage analysis of bipolar disorder.

The definition of phenotype is a major problem in genetic studies of psychiatric disorders. Most linkage studies in bipolar disorder have defined the phenotype as a dichotomous trait and have usually employed different hierarchical classifications in order to overcome uncertainty resulting from phenotypic variability. In this study we explored the advantages of maximizing the evidence for linkage over different phenotypic definitions when conducting parametric linkage analysis of a complex trait. The GAW10 Problem 1 was used, focusing on chromosome 18 data sets. Three major phenotypic models were analyzed: quasi-quantitative, liability-based and affection-status models. Overall, no single phenotypic model performed consistently better than the others (i.e., lod scores greater than 1.0). Each model yielded higher lod scores than the others in particular instances, suggesting that it might be useful in exploratory data analysis, where the phenotype is variable, to maximize evidence for linkage over different phenotypic models.

Bipolar Disorder↗

Speech-discrimination scores modeled as a binomial variable.

Many studies have reported variability data for tests of speech discrimination, and the disparate results of these studies have not been given a simple explanation. Arguments over the relative merits of 25- vs 50-word tests have ignored the basic mathematical properties inherent in the use of percentage scores. The present study models performance on clinical tests of speech discrimination as a binomial variable. A binomial model was developed, and some of its characteristics were tested against data from 4120 scores obtained on the CID Auditory Test W-22. A table for determining significant deviations between scores was generated and compared to observed differences in half-list scores for the W-22 tests. Good agreement was found between predicted and observed values. Implications of the binomial characteristics of speech-discrimination scores are discussed.

Humans↗

Estimation of youth smoking behaviours in Canada.

This study estimated the prevalence of current smoking and smoking initiation among Canadian youth. Logistic regression was used to relate socio-demographic predictors to the occurrence of the smoking indicators among youth (15-24 years) in the 1994/95 National Population Health Survey (NPHS). Models were then applied to provincial youth populations in the 1996/97 NPHS and the 1996 census of Canada. Model-generated estimates were compared with direct estimates obtained from NPHS data. The models accurately predicted provincial rates of current youth smoking for 1994/95. When applied to the 1996/97 NPHS, the current smoking models performed reasonably well, but were less predictive when applied to 1996 census data. Modelling of youth smoking initiation was not successful. This suggests that although simple estimation models of youth smoking can be derived, these models may not be portable across different populations or time periods.

Adolescent↗

Improving health-based payment for Medicaid beneficiaries: CDPS.

This article describes the Chronic Illness and Disability Payment System (CDPS), a diagnostic classification system that Medicaid programs can use to make health-based capitated payments for TANF and disabled Medicaid beneficiaries. The authors describe the diversity of diagnoses and different burdens of illness among disabled and AFDC Medicaid beneficiaries. Claims from seven States are analyzed, and payment weights are provided that States can use when adjusting HMO payments. The authors also compare the taxonomy and statistical performance of CDPS to other leading diagnostic classification systems and find that the new model performs better in a number of respects.

Adult↗

Three-dimensional anatomy and renal concentrating mechanism. II. Sensitivity results.

A mathematical model has been developed to simulate hypertonic urine formation in the renal medulla. The model uses published values of membrane transport parameters, as have other models, but is unique in its representation of the three-dimensional anatomy of the medulla. The model successfully predicts measured fluid flows, osmolarities, and NaCl and urea concentrations. The model results are presented in the companion to this paper [A. S. Wexler, R. E. Kalaba, D. J. Marsh. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29): F368-F383, 1991.]. In this paper we provide tests of the sensitivity of model performance to variations in the description of the anatomy and in membrane transport parameters. From these studies we conclude that 1) strict counterflow arrangements are required in the outer stripe to prevent loss of NaCl to the systemic circulation, 2) the radial organization in the inner stripe materially improves performance of the inner medulla, 3) radial organization of the inner medulla is essential to hypertonic urine formation there, 4) the model is most sensitive to variation in collecting duct parameters, and 5) reabsorption of urea in the distal tubule improves system performance. The results support the claim that the three-dimensional structure, as captured in the model, provides a crucial framework for the production of hypertonic urine.

Absorption↗

Neural model of adaptive hand-eye coordination for single postures.

A neural network model has been developed that achieves adaptive visual-motor coordination of a multijoint arm, without a teacher. The model learns to position an arm so that it reaches a cylinder arbitrarily positioned in space. The model uses a new neural architecture and a new algorithm for modifying neural-connection strengths. Computer simulations show that the model performs with an average position error of 4% of the arm's length and with an average orientation error of 4 degrees. The model is designed to be generalized for coordinating any number of topographic sensory inputs with limbs of any number of joints.

Humans↗

Dataset Readiness Assessment With Large Language Model (DRAFT-LLM): A Multi-Axis Audit Guided by LLM.

This article details the Dataset Readiness Assessment for Training (DRAFT), a systematic method for determining whether a high-dimensional biological dataset is suitable for developing reliable, equitable (i.e., the extent to which model performance, error patterns, and potential benefits or harms are evaluated and found to be acceptably distributed across relevant demographic, biological, clinical, and contextual subgroups), and scientifically meaningful machine-learning models, and DRAFT Large Language Model (DRAFT-LLM), its optional human-in-the-loop extension for calibrating study-specific audits through structured, critically reviewed LLM guidance. Standard model validation often fails to detect when apparent performance is driven by spurious correlations, technical artifacts, or hidden stratification, leading to irreproducible and inequitable findings. DRAFT-LLM addresses this gap by shifting the focus from model tuning to structured dataset auditing, organized around Support Protocols 1 to 4 that capture the scientific intent, data structure, and governance constraints of a given study. These Support Protocols: (1) elicit and formalize investigator input into a study intake and dataset card; (2) compute standardized dataset statistics and structural summaries suitable for downstream analysis and LLM context; (3) configure the language model using form-based responses, safety guardrails, and governance rules; and (4) generate personalized instructions, prompts, and code templates for running DRAFT audits. Basic Protocols 1 to 3 are instantiated from this support layer for generalization, equity, and stability: they are reusable execution patterns whose concrete behavior is determined by the cards, statistics, and configurations defined in the Support Protocols. DRAFT-LLM and DRAFT are demonstrated in this article through an end-to-end case study on The Cancer Genome Atlas (TCGA). © 2026 Wiley Periodicals LLC. Support Protocol 1: Study intake and dataset card construction Support Protocol 2: Dataset structure and advanced summary statistics for LLM context Support Protocol 3: LLM configuration using structured form responses Support Protocol 4: Generation of personalized instructions for DRAFT audits Basic Protocol 1: Generalization audit Basic Protocol 2: Equity audit Basic Protocol 3: Stability audit.

Large Language Models↗

[Multifocal intraocular lenses--an assessment of current status].

UNLABELLED: Besides the diffractive multifocals, which produce a second focus for near vision by means of diffraction rings, there are different refractive multifocal IOL types with 2-7 refractive zones or an aspheric/spherical construction principle. Long-term results: 2 years after implantation of diffractive multifocal IOLs, the corrected distance and near acuities were unchanged compared to the 3-month results. The uncorrected distance acuity was, however, slightly decreased due to a minus shift of refraction to -1.2 D. The contrast sensitivity was improved after 2 years. Multi- versus monofocal IOLs: After diffractive multifocal IOL implantation, the near acuity with distance correction only was markedly improved compared to monofocal IOLs. All other acuity data did not differ between multi- or monofocal lenses. The contrast sensitivity (at low contrasts and high spatial frequencies) and mesopic visual acuity (without and with glare) were reduced compared to monofocal pseudophakic eyes. Near aniseikonia and binocular functions: In unilateral multifocal pseudophakia (monofocal IOL in fellow eye), a near aniseikonia up to 8% was found. The width of fusion was significantly lower than in bilateral multifocal pseudophakia, whereas the stereopsis showed no difference. Determinants of bifocal function: In 7.1% of our cases, no bifocal function (BFF) was present after implantation of diffractive multifocal IOLs. These patients exhibited a significantly higher age as well as higher pre- and postoperative astigmatism, when compared to patients with good BFF. Optical performance of different multifocal IOLs: By means of an optical system, described by Reiner, images of intraocular lenses can be projected into the eye ("optical implantation"); thus, the optical performance of IOLs can be judged subjectively. Using this method, the refractive 2- and 3-zone models performed best within the multifocal group (contrast sensitivity not significantly worse than that of monofocal IOL), when viewing a low-contrast chart (Regan 4%). All other multifocal lenses (diffractive, aspheric/spherical, refractive 5- and 7-zone models) were significantly inferior to the monofocal IOL. CONCLUSIONS: Implantation of multifocal IOLs should presently be restricted to special indications, particularly to the distinct patient request to dispense with wearing near or bifocal glasses, if possible. Because of the reduction in contrast sensitivity and mesopic vision and the increased glare sensibility, multifocal IOLs should not be implanted especially in professional car drivers. There are, however, differences in optical performance between the various multifocal IOL types. Further improvements, in particular concerning lens technology, will presumably extend the present spectrum of indications.

Contrast Sensitivity↗

Lumbar muscle force estimation using a subject-invariant 5-parameter EMG-based model.

The use of electromyographic measures, in concert with modeled or empirical representations of muscle physiology, is a common approach for estimation of muscle force. Existing models of the lumbar musculature have allowed model parameters to vary for an individual subject. While this approach improves apparent predictive ability, it loses some degree of construct validity since parameter variability may not be physiologically justifiable. An EMG-based five-parameter model, adapted and generalized from earlier reports, is presented here. Inherent in the model is the requirement of subject-invariant modeling parameters. As a practical analysis tool was desired, the model relies on relatively few calibration constants whose determination is described. Empirical evaluation was undertaken using a database of 398 experimental trials involving lifting and transferring objects of moderate mass. Model performance, evaluated by comparison of measured and predicted lumbar moments, was comparable to earlier models, with r2 mean (S.D.) values of 0.76(0.15) for sagittal plane moments, and rms mean (S.D.) errors of 14.1(7.4), 9.7(5.3), and 8.6(3.6) Nm in the sagittal, frontal, and horizontal planes, respectively. These empirical results and the argument of physiological veracity support the use of a subject-invariant model.

Adult↗

Secondary diagnoses as predictive factors for survival or mortality in Medicare patients with acute pneumonia.

We wished to determine if a claims-based method for severity adjustment would predict mortality or survival in pneumonia based on age, gender, and secondary diagnoses. We used a discriminant analysis model of severity of illness developed from Medicare Part A claims data. Our data base was taken from a hospitalized population age 65 years or older coded as DRG 89 (pneumonia with complications/comorbidities). There were 35,677 cases with a mortality = 11.2% in the derivation cohort from 1989 to 1990, and 19,915 cases with a mortality = 9.8% in the validation cohort from 1991. In the derivation cohort, 98% of patients predicted to live, lived, whereas 18% of patients predicted to die, died. Of the three variables, secondary diagnoses had greatest explanatory power. Receiver operating characteristic curves showed that the model performed best at 40% survival. Results were confirmed with the 1991 validation cohort. The model could be applied to hospitals with as few as 172 discharges. This simple, claims-based method can predict survival in pneumonia. It may be useful in selecting medical records for intensified review of medical quality.

Aged↗

Implementation of sulfate adsorption in the SAFE model.

An SO4(2-) adsorption submodel has been implemented in the dynamic soil chemistry model SAFE. The submodel calculates pH-dependent SO4(2-) and H+ adsorption to the soil, as well as the net surface charge development due to uneven adsorption of SO4(2-) and H+, using the empirical equations derived from an electrostatic model (Extended Constant Capacitance Model, ECCM) of SO4(2-) adsorption. The resulting new SAFE model was applied on a roof experiment plot in the Norway spruce [Picea abies (L.) H. Karst.] stand at Solling, Germany, where atmospheric S and N deposition was artificially reduced by the roof construction. The model performance was compared with the previous versions that used a pH-independent Freudlich model of SO4(2-) adsorption or assumed no SO4(2-) adsorption. With the ECCM-based SO4(2-) adsorption submodel, SAFE simulated soil solution SO4(2-) concentration and base saturation better, in comparison with measured data, than with the previous SO4(2-) adsorption formulations. Through the model application, also, need of additional improvement was suggested, such as calibration of mass transfer coefficients.

Adsorption↗

The predictive performance of a system model for enflurane closed-circuit inhalational anesthesia.

BACKGROUND: Previously, the authors described a system model for closed-circuit inhalational anesthesia, and demonstrated close agreement between end-tidal isoflurane concentrations measured in their clinical study and those predicted by the model. The predictive performance of their model has not, however, been tested for anesthetics featuring nonpulmonary elimination (NPE). METHODS: The authors quantified the predictive performance of two versions (A and C) of the model in 50 patients by comparing the predicted and the measured alveolar concentration-time profiles after bolus injections of liquid enflurane into the expiratory limb of the closed system. Version A did not incorporate NPE, but version C emulated NPE by adopting the irreversible loss of a fraction of the enflurane present in the arterial hepatic blood flow (0.131, derived from a mass balance study performed by others). For each concentration measured by mass spectrometry, the authors used computer simulations of version A and C to calculate a predicted concentration for both versions. For each patient, the authors calculated the bias (indicating systematic over- or underprediction) and the scatter of the prediction errors (indicating typical error size). RESULTS: The authors administered a total of 379 ml of liquid enflurane via 466 injections. A total of 18,432 alveolar concentrations (one per 10-s period; average concentration = 0.96 vol%) were measured. The bias and the scatter, both given as mean (and SD), were 10.0 (13.1)% and 11.8 (3.9)% for version A and -0.8 (11.4)% and 11.4 (2.8)% for C. The bias for version C was closer to zero; the scatters were similar. CONCLUSIONS: Version C incorporating NPE performs better than version A. The accuracy that was obtained should encourage the use of version C for clinical, teaching, research, economic, and ecologic purposes.

Adult↗

Neural networks as predictors of outcomes in alcoholic patients with severe liver disease.

We developed and evaluated neural networks as predictors of outcomes in alcoholic patients with severe liver disease using commonly available clinical and laboratory values. Hospital charts of 144 patients were reviewed. Nine variables (five laboratory, four clinical) were recorded along with in-hospital death or survival. Data were organized into separate development and validation sets. Neural network predictions of survival were compared with those of the Maddrey discriminant function and logistic regression models developed on the same data. Model performance was evaluated by comparing areas under receiver-operating characteristic (ROC) curves and the distributions of model scores. Survivors had significantly different laboratory and clinical characteristics, the most important being a higher prothrombin time, lower bilirubin, and lower incidence of encephalopathy. Neural network performance was significantly better than that of the Maddrey score (ROC areas, 81.5% vs. 73.8%; P = .04). The ROC area for neural networks was similar to that of logistic regression (ROC area 78.2%; P = .3), but the neural networks were more successful in classifying patients into low- and high-risk groups (P < .001). A neural network score with laboratory data from hospital-day 7 improved prognostic accuracy further to 84.3%. After adjusting for baseline risk, the neural network change in illness severity was still a significant predictor of mortality (P = .001). Neural networks using clinical and laboratory data showed a high prognostic accuracy for predicting mortality in alcoholic patients with severe liver disease.

Adult↗

Studies of parallel barrier performance by acoustical modeling.

An investigation is presented into the performance of parallel barrier configurations, using acoustical scale modeling. A realistic geometry is investigated, with the source being positioned over a paved roadway and the receiver over grass-covered ground. The grass-covered ground surface was properly modeled in terms of its impedance. Results were obtained for a range of barrier types, and demonstrate that frequency dependent effects are evident in barrier insertion loss data. In most cases, the barrier on the far side of the source did not significantly affect sound levels at the receiver. The most effective barrier design was found to be that of a gradual grass-covered slope up to an upright, thin barrier.

Acoustics↗