[Oral manifestations in leukemia].
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OBJECTIVES: Describe the oral diseases in HIV-infected individuals in London, UK and identify social and medical factors related to the presence of specific oral diseases. DESIGN: Dental clinics. SUBJECTS: Consecutive sample of 456 patients with HIV infection. METHODS: Social and medical history and clinical examinations. Univariate and logistic regression analysis. OUTCOMES: Presence of HIV-associated oral disease. RESULTS: 80% of patients with AIDS and 50% of patients with HIV had a specific oral disease. The most common diseases were hairy leukoplakia (30%), erythematous candidiasis (24%), pseudomembranous candidiasis (14%), angular chielitis (6%), necrotising periodontal disease (8%) and non-recurrent ulceration (6%). CONCLUSIONS: The presence of erythematous candidiasis was not related to advanced HIV disease. Pseudo-membranous candidiasis, hairy leukoplakia and mucosal ulceration were significantly associated with advanced HIV disease. Smoking was also identified as a strong aetiological factor in oral diseases. Longitudinal studies are required to further explore the prognostic significance of oral diseases in HIV infection.
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Oral lesions are an important clinical finding in Crohn's disease. We describe a patient who had extensive involvement of the oral mucosa and esophagus and histologically confirmed Crohn's ileocolitis. The patient had exquisitely tender, edematous, ulcerating lesions involving the lips, tongue, buccal mucosa, and posterior pharynx. Rapid and dramatic improvement of both the oral and the intestinal manifestations occurred after systemic corticosteroid therapy.