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Empathy in families of women with borderline personality disorder, anorexia nervosa, and a control group.

This is a study of empathy in the families of 27 women with borderline personality disorder (BPD), 28 women with restricting anorexia nervosa (AN), and 27 women without a clinical diagnosis (NC). The daughters and both parents responded to the Interpersonal Reactivity Index (IRI), an instrument for assessing four dimensions of empathy. In addition, they were personally interviewed, with the Family Interview for Protectiveness and Empathy (FIPE), about the extent of empathy expressed by the parents to their daughter during her development. On the IRI, women with BPD scored highest on the immature and lowest on the mature aspects of empathy, whereas scores of AN and NC women were all within normal limits. Parents of BPDs had the lowest IRI scores, while parents of AN and NC groups were similar to each other and to criterion group scores. IRI scores of AN daughters were positively correlated with their parents' scores whereas BPDs' scores were negatively correlated with those of their parents. There were no correlations between the IRI scores of NC subjects and their parents. On the FIPE, borderline daughters and parents agreed about the relative absence of empathic parenting, whereas AN and NC daughters and parents agreed as to the presence of empathic parenting. The theoretical and clinical implications of these contrasting findings are discussed.

Adolescent↗

Treatment with granulocyte colony-stimulating factor decreases the capacity of hematopoietic progenitor cells for generation of lymphocytes in human immunodeficiency virus-infected persons.

An obstacle to stem cell gene therapy for AIDS is the limited numbers of hematopoietic progenitors available. Granulocyte colony-stimulating factor (G-CSF) is used for mobilization of progenitors, but little is known about the functional characteristics of mobilized progenitors, and immature and T cell progenitors may not be mobilized. This study examined the effect of G-CSF on the function of progenitors. Ten human immunodeficiency virus-infected patients received G-CSF (filgrastim, 300 microgram/day) for 5 days. Absolute numbers of immature and T cell progenitors did not increase. The ability of CD34+ progenitor cells to generate lymphocytes was examined by use of thymic organ cultures. The mean number of lymphocytes generated per CD34+ cell on day 0 was 0.72 and on day 4 was 0.09 (P<.003). The number of CD4+ cells generated per CD34+ cell was significantly reduced after G-CSF treatment. Thus, G-CSF increased the number of mature progenitor cells but did not increase T cell progenitors.

Animals↗

Myopia among the Inuit population of East Greenland. Longitudinal Study 1950-1994.

PURPOSE: To follow the refraction values in an indigenous population group over the course of the past 50 years. METHOD: Case records from a population investigation carried out in Ammasalik, East Greeland, by Erik Skeller in 1950 were studied initially, a total of 1123 eyes were examined by sciascopy and 244 eyes could be followed sufficiently until about 1990-94. RESULT: The mean refraction was initially +0.08 D, while at the last examination the mean had increased to +0.69 D. Initially, there was no myopia, defined as at least -1.5 D, and at follow-up it was a maximum of 1%, and presumably due to immature cataract. A tendency to myopia (< -1.5 D) was found initially in 36%, but in only 22% at follow-up. CONCLUSION: The myopinizing factor in East Greenland has not affected persons born prior to 1942, even if they had a tendency to myopia (< -1.5 D).

Adolescent↗

The role of psychosocial factors in the development of breast carcinoma: Part I. The cancer prone personality.

BACKGROUND: The authors conducted the current study to determine whether personality predisposes some individuals to develop cancer. METHODS: The current study examined the role of personality variables in 2224 older women recalled for assessment after routine mammography in a breast screening program. Using a semiprospective design, subjects completed self-report measures of defense style, locus of control, emotional expression and control, self-esteem, trait anxiety, and state anxiety and depression while waiting for medical examination. Multivariate analysis of variance was used to control for known risk factor variables and to examine differences between 3 control groups (normal tissue controls, benign/cystic controls not requiring biopsy, and benign biopsy controls) and 298 breast carcinoma subjects. RESULTS: No differences were detected between breast carcinoma subjects and controls based on measures of mature, immature, and neurotic defense style; locus of control of behavior; emotional expression-in, emotional expression-out, and emotional control; self-esteem; anxiety; or depression. CONCLUSIONS: The results of the current study found no evidence to support an independent association between these personality measures and the development of breast carcinoma. [See accompanying article on pages 686-97, this issue.]

Aged↗

Antibody to hepatitis A antigen in institutionalized mentally retarded patients.

Institutionalized patients with Down syndrome and matched controls with other causes of mental retardation were tested by immune adherence hemagglutination for the presence of antibody to hepatitis A antigen (anti-HA). Altogether 75.1% (175 of 233) exhibited presence of anti-HA, with no differences by sex or age. Patients reactive for hepatitis B surface antigen (HBsAg) or its antibody (anti-HBs) were reactive for anti-HA significantly more frequently than those with a negative reaction for these markers. In contrast to serologic markers of hepatitis type B, prevalence of anti-HA does not depend on the cause of mental retardation or on the age at primary infection. The rate of anti-HA positivity was found to be closely correlated with duration of institutionalization. The study confirmed that many closed institutions for the mentally retarded are hyperendemic for hepatitis type A and that formation of anti-HA is not greatly affected by either immune deficiency or immune immaturity.

Adolescent↗

Juveniles' competence to stand trial: a comparison of adolescents' and adults' capacities as trial defendants.

Abilities associated with adjudicative competence were assessed among 927 adolescents in juvenile detention facilities and community settings. Adolescents' abilities were compared to those of 466 young adults in jails and in the community. Participants at 4 locations across the United States completed a standardized measure of abilities relevant for competence to stand trial (the MacArthur Competence Assessment Tool--Criminal Adjudication) as well as a new procedure for assessing psychosocial influences on legal decisions often required of defendants (MacArthur Judgment Evaluation). Youths aged 15 and younger performed more poorly than young adults, with a greater proportion manifesting a level of impairment consistent with that of persons found incompetent to stand trial. Adolescents also tended more often than young adults to make choices (e.g., about plea agreements) that reflected compliance with authority, as well as influences of psychosocial immaturity. Implications of these results for policy and practice are discussed, with an emphasis on the development of legal standards that recognize immaturity as a potential predicate of incompetence to stand trial.

Adolescent↗

Changes in abundance and behaviour of vector mosquitoes induced by land use during the development of an oil palm plantation in Sarawak.

Surveys were conducted of adult and immature mosquitoes in an area undergoing oil palm development in north Sarawak. Point prevalence data from 2 sites were collected annually, coinciding with annual phases of forest clearing, burning/cultivation, and maintenance. Major habitat perturbation during the forest/clearing transition shifted the major mosquito faunal equilibrium in terms of species composition, relative density and occurrence. Analyses of variance showed that the mean numbers of 4 species of Anopheles decreased significantly after forest clearing. Relative densities of immature stages decreased after forest clearing, but A. letifer and Culex tritaeniorhynchus remained relatively unchanged after the second year. Comparisons with the pre-development forest stage showed that the reductions in person-biting rates, adult survival and combined entomological inoculation rates (EIR) of A. donaldi and A. letifer decreased the risk of malaria transmission by 90% over the 4 years period. Concomitant reductions in EIR and annual malaria incidence were also correlated. This study highlighted the 'law of unintended consequences', since 2 contrasting effects were observed: reduction of malaria vectors but concomitant increase of dengue vectors.

Animals↗

An empirically derived hierarchy of adaptive mechanisms and its usefulness as a potential diagnostic axis.

This report empirically examines the utility of the model of ego mechanisms of defense to explain psychological resilience in 307 middle aged men with socially disadvantaged childhoods. The sample has been prospectively followed for forty years. The model arranges defense mechanisms along a hierarchy reflecting severity of psychopathology and hypothetical immaturity. The value of this hierarchy of defenses in relation to diagnosis is discussed.

Adaptation, Psychological↗

Differentiation associated changes in isozyme expression of amino acid naphthylamidase in myeloid cells.

Triton X-100 resistant isozymes of amino acid naphthylamidase were studied by polyacrylamide gel electrophoresis, gel filtration and affinity chromatography in samples from 12 human haematopoietic cell lines, 8 leukaemic patients and 4 healthy persons. Affinity to WGA-Sepharose seemed to be correlated to differentiation in the myeloid series, indicating differences in the N-acetyl-glucose-amine content of the enzyme molecules in mature and immature cells. A high carbohydrate content might be characteristic for mature myeloid cells. By trypsin digestion of intact cells and analysis of released enzyme activities into the medium new information on isozyme expression of amino acid naphthylamidase in the granulocyte-monocyte lineages could be achieved.

Aminopeptidases↗

The knowledge of pedagogic students on suicidal behaviors in adolescents.

Suicide, taking one's own life, seems to be in contradiction with the will to live. However, it is not so obvious, as there is not the same patterns of behavior for all people. People differ from one another as far as reactions, behavior, and actions are concerned. Some are mobilized, others are discouraged by failures. It is often thought that suicidal behavior occurs due to a mental disorder. The purpose of the study was to check the knowledge of IV-year-students of Pedagogy and Psychology of The University in Bialystok concerning suicidal behavior. Danger of suicidal phenomenon among young people was also to be noticed and discussed. The examination was conducted in the group of 50 students of the IV year of Pedagogy and Psychology of The University in Bialystok in 2002. Students, 21-25 years of age, comprised the most numerous group. Women were the majority (84%) while men were 16%. The examination tool was the questionnaire of 29 open and closed questions. The analysis of the results points to the fact that making a decision of suicide is a result of long reflections expanded in time. Personal and family problems are most common causes of suicidal behavior given by the responders. Social isolation and bad mental condition were behaviors indicating the will to commit suicide. Lonely people, chronically ill, emotionally immature and the young people were those of the high risk groups. According to the examined students, pain connected with physical suffering may influence suicidal behavior.

Adolescent↗

Correlations between the Temperament and Character Inventory and the Self-rating Depression Scale among Japanese Students.

The Temperament and Character Inventory measures four dimensions of temperament and three of character. The 125-item short version and the Self-rating Depression Scale were administered to 306 Japanese students. Their scores on the latter were significantly highly correlated with the scores on both temperament and character scales, positively correlated with Harm-Avoidance score, and negatively correlated with Self-directedness and Cooperativeness scores. It is suggested that scores on depression were related to Harm-Avoidance, particularly to fatigability, and immaturity of the autonomous self and cooperative interpersonal relationship.

Adolescent↗

[Depersonalization and self-injury].

Patients with deliberate self harm syndrome and with factitious disorders often describe depersonalisation phenomena, during which they have a diminished pain sensitivity or analgesia. The self-mutilating act can stop the depersonalisation temporarily. Concerning the psychodynamic processes there are common traits between depersonalisation and self-mutilation. The connections between depersonalisation and self-mutilating behaviour are described. Depersonalisation is understood as a defense mechanism, ranging between mature and immature defense mechanisms. An illustrative case is demonstrated.

Adult↗

Relation of body fat distribution to hyperinsulinemia in children and adolescents: the Bogalusa Heart Study.

The relation of body fat distribution to plasma levels of glucose and insulin during an oral glucose tolerance test was examined in 355 Black and White school-age children. Both central and peripheral fat were similarly related to fasting, 30-min, and 1-h glucose. Unlike peripheral fat, central body fat was more strongly related to the 1-h insulin response (r = 0.35 vs 0.26); this association remained significant for central fat independent of peripheral fat (r = 0.18). The strong relation of central fat to insulin response was noted in both races and sexes but not in either sexually immature or relatively thin children. These findings indicate that, even in early life, a central body fat pattern relates positively to insulin response to glucose load. Thus, knowledge of body fat localization may help identify persons most susceptible to hyperinsulinemia in early life.

Adipose Tissue↗

Maturity of personality and family communication.

The psychodynamic and the communication/systemic perspectives are commonly considered as two entirely different approaches to psychopathology. The current study is an effort to bridge these opposing perspectives empirically. Maturity of personality, measured according to psychoanalytic principles by the Consensus Couples Rorschach, and relationship control in family communication, as measured by a new coding system (RCC) in an observational study, were related. The results indicate that low level of maturity is associated with egocentric and self-disqualifying communication in situations of conflict, but not in situations involving no or moderate conflict. Additionally, mature wives were prone to react to situations involving perceptual conflict by communicating dominantly, whereas immature wives communicated in more submissive ways. Reversely, the more mature the husbands were, the more they displayed a submissive style of communicating when in conflict.

Adolescent↗

MMPI-A structural summary characteristics of male juvenile delinquents.

The Minnesota Multiphasic Personal Inventory-Adolescent Structural Summary factor scores for 655 male juvenile delinquents were determined. These Structural Summary scores were compared to the Structural Summary scores in the normative sample of boys. Elevations on Factor 2 (Immaturity) were most characteristic, with half of delinquents' scores being elevated by at least one standard deviation. Discriminant analyses suggested that linear combinations of the Structural Summary scores are as capable of distinguishing between the normative and delinquent samples as were linear combinations of the clinical scales. Furthermore, use of Structural Summary scores provided incremental validity in distinguishing between the two samples, increasing positive predictive power by 20% to 40% as compared to use of only the clinical, content, and supplementary scales.

Adolescent↗

[Psychoneuroses of paternity. Puerperal psychoneuroses in man].

Psychotic, neurotic and psychosomatic disturbances, directly promoted by fatherhood condition, seem more frequent than the small number of publications about this subject allow to suppose. Twenty original observations are expounded and discussed; they allow the importance of basic psychological ground; it is necessary to differentiate distinctly between initial paternity disturbances, among immature patients, inducing total disorder, and multiple paternity perturbations where anxiety and culpability feeling prevail. Regarding these disturbances and the sociological phenomenon of the "couvade", the real puerperality in men is investigated in connection with the personal and relational structure of the individual.

Adult↗

Repetitive stereotyped behaviors.

This paper points to factors that determine whether repetitive stereotyped behavior occur in the behavior repertoire. The analysis pits an "intrinsic oscillator" mechanism against a "self-stimulation" theory and chooses to emphasize the latter. The paper accounts for the repetitive and rhythmic nature of stereotypy by suggesting that repetition in a rhythmic way is the most efficient way of self-stimulation. It proposes that rhythm may be a reinforcement in at least some cases. It raises the question of whether control of stimulation by the person is a necessary condition for maintaining stereotypy. The paper recognizes the possibility that stereotyped behaviors may have their origin in the common repetitive behaviors of infancy but emphasizes that pathological stereotypy may involve more than immature repetition. It suggests that there is reason to believe that early intervention to prevent pathological stereotyped behavior might be effective but that we do not know much about how stereotypies get started.

Animals↗

Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl.

AIM: To describe an unusual but treatable cause of behavioural disturbance in adolescence. METHODS: The case is reported of a 15-y-old girl presenting with acute confusion, memory problems and psychotic symptoms following an 18-mo history of change in personality, school failure and running away from home. A review of the literature is also presented. RESULTS: Microbiology, toxicology, computed tomography and magnetic resonance imaging did not show any pathology of the central nervous system. Bilateral ovarian immature teratomas were eventually diagnosed and removed. The rapid improvement in the patient's mental and cognitive functions after corticosteroid treatment and the abnormality shown on the single photon emission computed tomography suggested a diagnosis of paraneoplastic limbic encephalitis. CONCLUSION: Paediatricians and neurologists should be aware of this rare disease entity among the more common conditions of behavioural problems and substance abuse in adolescents.

Adolescent↗