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PubMed1992

Calcium and phosphorus metabolism in full-term infants.

Appropriate intake of dietary calcium and phosphorus is essential for the maintenance of mineral homeostasis and support of adequate bone mineralization in growing infants. Disturbances of calcium homeostasis such as newborn hypocalcemia, have been shown to be secondary to high oral phosphate intake. The incidence of hypocalcemic tetany has changed from epidemic proportions in newborns, who were formerly fed evaporated cow's milk formula, to the present sporadic occurrence in newborns who are now fed humanized cow's milk formula, with a calcium concentration of about 50 mg/dl and a phosphorus concentration of about 35 mg/dl. Human milk, provided vitamin D intake is adequate, has been shown to maintain calcium-phosphorus homeostasis and support adequate bone mineralization at least in the first 6 months of life. After this, the phosphorus content of breast milk could limit mineral accretion in exclusively breast fed infants. The present concentration of calcium and phosphorus in the humanized cow's milk formulas support adequate mineral homeostasis and bone mineralization throughout the first year of life. As bone calcium content is proportional to calcium intake, feeding whole cow's milk from early infancy onward is associated with abnormal bone mineralization. The adequacy of bone mineralization in infants fed soy formula is still controversial.

Bone Density↗
PubMed1994

Multiple effects of glycerol on plant cell metabolism. Phosphorus-31 nuclear magnetic resonance studies.

The effects of glycerol on plant cell metabolism were studied with sycamore (Acer pseudoplatanus L.) cells using 31P nuclear magnetic resonance spectroscopy. After a long period of sucrose starvation, the addition of 50 mM glycerol to the medium did not restore the original glucose-6-P pool and led to a rapid accumulation of sn-glycerol-3-P in the cytoplasmic compartment. The synthesis of sn-glycerol-3-P was rapid and occurred first at the expense of cytoplasmic P(i). Accumulated sn-glycerol-3-P competitively inhibited glucose-6-phosphate isomerase activity when fructose-6-P was the varied substrate. Such a situation prevented the rapid recycling of triose phosphates back to hexose phosphates and led to an arrest of the functioning of the cytosolic and plastidial pentose phosphate pathways. Under these conditions, the flow of carbon to drive cell respiration derived almost exclusively from glycerol, and this polyalcohol was not used as a source of carbon skeletons for biosynthesis. Glycerol also induced the accumulation of O-phosphohomoserine in the cytoplasmic compartment as long as the cell culture medium contained sucrose. Finally glycerol added to sucrose-starved cells stopped the accumulation of phosphocholine (Roby, C., Martin J.-B., Bligny, R., and Douce, R. (1987) J. Biol. Chem. 262, 5000-5007) and prevented a further decline in the uncoupled rate of O2 consumption by the cells (Journet, E. P., Bligny, R., and Douce, R. (1986) J. Biol. Chem. 261, 3193-3199). These last observations strongly suggest that glycerol prevented the triggering of autophagy induced by sucrose starvation in sycamore cells.

Adenosine Triphosphate↗
PubMed1989

Calcium, magnesium, and phosphorus metabolism in dogs given intravenous triacetin.

Previous studies suggested that acetate in parenteral solutions may adversely affect mineral metabolism by causing sequestration of inorganic phosphate and calcium in the liver. In this study, triacetin, a short-chain triglyceride of acetate and a potential parenteral nutrient, was infused for 3 h at an isocaloric rate in mongrel dogs (n = 6) to test its effects on serum phosphorus, calcium, and magnesium metabolism. There was no change in serum P or Ca. The serum Mg concentration decreased from 0.7 +/- 0.03 to 0.57 +/- 0.03 mmol/L (p less than 0.001) by 90 min and remained at this level for the remainder of the study. The triacetin infusion did not influence fractional urinary Mg excretion; thus, the decrease in serum Mg was likely because of an increase in cellular transport of this cation. A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism.

Acetates↗