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Results for “PLASMOCYTOMA”

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At least 235 records · Page 13Linked to original sources
PubMed1992

Electroconvulsive therapy in a geriatric patient with multiple bone fractures and generalized plasmocytoma.

Electroconvulsive therapy (ECT) is a highly effective treatment for patients with severe major depressive disorder. ECT can safely be administered even to medically ill, high-risk patients; we report on the complete remission of depressive psychopathology following five unilateral ECT treatments in a suicidal geriatric patient with concurrent prior venous thrombosis, coronary heart disease, multiple myeloma, glaucoma, bilateral petrous bone fractures, and a femoral neck fracture. Most medical complications during ECT can be managed with interdisciplinary cooperation.

Aged↗
PubMed1992

[Magnetic resonance tomographic screening studies of the bone marrow with gradient-echo sequences. II. Gadolinium-DTPA-supported studies of plasmocytoma patients].

MR imaging was performed in 19 patients with proven multiple myeloma. Both plain and Gd-DTPA enhanced in-phase and opposed-phase gradient-echo techniques were used (0.1 mmol Magnevist/kg body weight). Plain, opposed-phase imaging demonstrated more lesions than plain in-phase imaging (35 vs. 16); enhanced opposed-phase imaging demonstrated more lesions than plain opposed-phase and enhanced in-phase imaging (47 vs. 35 and 17 lesions). These results suggest that enhanced opposed-phase images which have a high contrast between normal and infiltrated bone marrow are especially suited for MR screening in multiple myeloma.

Bone Marrow↗
PubMed1997

[Acute renal failure in IgM plasmocytoma with hyperviscosity syndrome].

HISTORY AND CLINICAL FINDINGS: Two days after starting withdrawal treatment for alcohol and drug abuse a 56-year-old woman developed acute renal failure. The patient was in a poor general condition and disoriented as to time and place. She had uraemic oral fetor and leg oedema. She had previously fractured both arms 3 months before. INVESTIGATIONS: Biochemical tests indicated renal failure: creatine 1791 mumol/l, urea 51.7 mmol/l, potassium 5.3 mmol/l, phosphate 1.86 mmol/l. Serum protein electrophoresis suggested paraproteinaemia with M gradients in the gamma-fraction. Immune fixation electrophoresis demonstrated monoclonal IgM gammopathy of kappa-type (IgM 44.1 g/l). Haemoglobin level was reduced to 66 g/l. Bone marrow biopsy showed replacement of normal haematopoiesis by highly atypical plasma cells (> 30% of cell population). Magnetic resonance imaging revealed diffuse changes in the pelvis and vertebrae suggesting plasmacytoma, confirming the diagnosis of IgM plasmacytoma of kappa-type. TREATMENT AND COURSE: Focal neurological symptoms (e.g. intermittent anisocoria and visual disturbances) suggested a hyperviscosity syndrome, although the serum protein level was nearly normal. Plasma viscosity was 2.2 mPas (normal range 1.2-1.38 mPas), lowered to 1.5 mPas by plasmapheresis, after which the neuropsychiatric symptoms improved. Chemotherapy for the plasmacytoma in stage IIIB was initiated (VAD scheme) and dialysis became necessary for terminal renal failure. CONCLUSION: Due to the raised level of IgM protein level and its high molecular size a hyperviscosity syndrome with paraproteinemic coma may occur, even though total plasma protein is nearly normal.

Acute Kidney Injury↗
PubMed1970

Differentiation of mouse plasmocytomas in vitro: two phenotypically stabilized variants of the same cell.

Mouse myelomas from Balb/c and C3H mice were established in tissue culture for more than 200 passages. When allowed to attach to a surface, they differentiated into two stabilized forms, one of which was fibroblast-shaped, grew without contact inhibition, and could be transplanted back to mice. The other had the morphology of epithelial cells, showed contact inhibition, and was not transplantable back to mice. For one strain (MOPC 173) it was demonstrated that both types of cells synthesize molecules with idiotypic determinants of the original myeloma protein. The relationship between the host cells and a leukemia-type virus present in the original tumor cells has been studied during different stages of cellular differentiation.

Animals↗
PubMed1978

Osteosclerotic "plasmocytoma" with polyneuropathy, hypertrichosis and diabetes.

The combination of osteosclerosis, polyneuropathy, monoclonal immunoglobulin, hypertrichosis, serositis and a number of other symptoms is described. It seems probable that this is a special type of myeloma. Similar cases have been described in Japan and out findings are compared with the Japanese picture. The age of the patients is unusually low. The M-component in the plasma is small. There is very little Bence Jones protein in the urine and osteolytic lesions in the skull do not seem to have occurred. The polyneuropathy may improve during treatment with cytostatic drugs.

Aged↗