PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Prothionamide”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

230 records · Page 13Linked to original sources
PubMed1980

[Epidemiology, diagnosis, and treatment of renal tuberculosis. A report of 213 cases].

The renal tuberculosis is one of the most important manifestations of the extrapulmonary tuberculosis. There was no decrease in the number of new cases in recent years. A report is given on 213 patients with renal tuberculosis, who were treated stationary in the years 1968 and 1978. Chemotherapy was in renal tuberculosis as successful as in pulmonary tuberculosis. Nephrectomy was performed in 17.3% of the cases. Early nephrectomy is a thing of the past. The duration of hospitalisation is shortened to about 3 months. Chemotherapy should take about one year.

Ethambutol↗
PubMed1995

[Ofloxacin-cycloserine-protionamide-INH combination against treatment refractory lung tuberculosis].

Multiresistant tuberculoses are on the increase. The conversion rates in "additional" therapy are only modest. 17 multiresistant patients and 6 treatment-refractory tuberculoses were treated by us with ofloxacin-cycloserin-protionamide-INH. 16 of these patients were HIV positive. 21 patients converted after 3 months of treatment by the latest. 3 patients died of HIV syndrome. There was otherwise no difference between HIV positive and HIV negative patients. As a rule, the combination was well tolerated. In multiresistant tuberculosis, it is mandatory to administer at least 3 drugs to which there is no resistance.

AIDS-Related Opportunistic Infections↗
PubMed1993

A simple and rapid technique for the detection of rifampin resistance in Mycobacterium leprae.

The rifampin resistance of Mycobacterium leprae is due to missense mutations in the rpoB gene encoding the beta-subunit of the essential enzyme RNA polymerase. A rapid and very simple method has been developed to detect rifampin resistance in small numbers of M. leprae present in biopsies. It involves polymerase chain reaction amplification of a defined region of the rpoB gene followed by single-strand conformational polymorphism analysis (PCR-SSCP). The reliability of the method has been tested on a sample of known drug-resistant and susceptible isolates of M. leprae.

Alleles↗
PubMed1993

Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients.

IgG antibodies against antigens 85A and 85B from Mycobacterium bovis BCG, IgM antibodies against phenolic glycolipid-I (PGL-I) and circulating PGL-I antigen were measured in the serum of 11 patients with lepromatous leprosy receiving multidrug therapy (MDT). Before treatment, 6 patients were reactive to antigen 85A, 10 patients to antigen 85B, and 11 patients to PGL-I; circulating PGL-I was detected in the sera of all of them. After 2 years of MDT PGL-I antigen could no longer be detected in all of the patients, except for two who were not compliant with treatment. IgG antibodies directed against the 85A and 85B antigens and IgM antibodies against the PGL-I antigen also decreased significantly during treatment but more slowly. The determination of circulating PGL-I antigen remains the most appropriate tool for monitoring lepromatous leprosy under MDT.

Antibodies, Bacterial↗