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PubMed2004

Sarcomas of the mandible. Literature review and case reports.

Sarcomas of the maxillofacial region are rare tumors presenting with wide variety of histopathological and clinical features. The authors treated six patients with sarcomas of the mandible over a period of ten years: 2 patients with fibrosarcomas, 2 with lymphosarcomas, one with osteogenic sarcoma and one with chondrosarcoma. The patients' ages ranged from 28 to 65 years, one was male and five - female. The present study reports three cases (osteogenic sarcoma, fibrosarcoma, chondrosarcoma) with specific clinical and radiographic characteristics, demonstrating the differences between the various types of sarcomas. Special attention is paid to the first clinical signs and symptoms, and to the differential diagnosis with inflammatory conditions (post-extraction alveolitis, chronic odontogenic osteomyelitis), benign tumors (osteoblastoclastoma, ameloblastoma, odontogenic cysts, fibrous dysplasia) and centrally developing jaw carcinomas. Particular emphasis is given to CT imaging and morphological examinations in making an accurate diagnosis and providing adequate treatment. Early diagnosis and precise surgical treatment (total resection or hemiexarticulation, or neck dissection if submandibular or cervical metastases are present) are essential to achieve satisfactory management of these malignant neoplasms. The radiotherapy and chemotherapy administered according to the histologic features of the tumor are also of significance.

Adult↗
PubMed1986

Malignant lymphoma in Olmsted County, Minnesota, 1970 through 1977.

A study of the incidence of malignant lymphoma in Olmsted County, Minnesota, revealed 91 new cases during the period 1970 through 1977. On the basis of the analyzed data, the overall average annual incidence rate per 100,000 population was 12.2 for males and 14.2 for females. The rates for both sexes combined (unadjusted for age) were 1.5 for Hodgkin's disease, 6.2 for lymphosarcoma, and 5.5 for reticulum cell sarcoma. The incidence rate for Hodgkin's disease decreased insignificantly, whereas that for both lymphosarcoma and reticulum cell sarcoma increased significantly during the period 1970 through 1977 in comparison with rates from the period 1945 through 1969. The largest increase was for rural males, for whom the rates for all three histologic types of lymphoma were substantially higher than those for urban males.

Female↗
PubMed1987

[Synthesis and antitumor properties of rubomycin 13-cyclohexylidene hydrazone].

Rubomycin 13-cyclohexylidene hydrazone (RCH) was synthesized by interaction of rubomycin 13-hydrazone with cyclohexane. Antitumor activity of RCH was studied in comparison to that of the initial rubomycin on mice with ascitic lymphadenosis NK/Ly, Ehrlich carcinoma, hemocytoblastosis La, leukemia P-388, solid lymphosarcoma LIO-1 and sarcoma 180. It was shown that RCH was actually equal to rubomycin by its selective activity against lymphadenosis NK/Ly and sarcoma 180 on its 4- and 2-fold intravenous administration, respectively. RCH was superior to rubomycin by its selective activity against lymphosarcoma LIO-1 and Ehrlich carcinoma and was more efficient in treatment of hemocytoblastosis La. RCH was inferior to rubomycin by its efficacy in treatment of lymphadenosis NK/Ly on its 2-fold oral administration and against leukemia P-388 on its 2-fold intravenous administration. Comparison of RCH with an analogous derivative of carminomycin showed that analogous changes in the chemical structure of rubomycin and carminomycin induced different changes in the chemotherapeutic properties of the initial substances.

Animals↗