[Characteristics of sex chromatin of "unchanged" mucosa and in adenocarcinoma of the rectum].
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Using directly and indirectly standardized mortality indexes in selected sex- and age groups, this paper analyses the age and sex characteristics and the geographical distribution among the 43 Belgian districts of the striking increase in Belgian reported suicide mortality between 1968-72 and 1979-81. Suicide mortality is obviously increasing more in females and in younger age groups, although the increase is still considerable in older age groups. The geographical pattern of generally higher mortality in central and southern districts seem consistent over time and between sexes but differences grow smaller over time, especially in females. A particular epidemiological situation for younger age groups is further suggested by our data.
The long-acting analogue of luteinizing hormone releasing hormone, D-Trp6-Pro9-NEt-LHRH (LHRHa), is effective in the short-term treatment of central precocious puberty. We report the results of two to four years of LHRHa therapy in 27 children with this disorder. Secondary sex characteristics regressed in most patients. Sex steroid levels and basal and LHRH-stimulated gonadotropin levels remained suppressed compared with pretreatment values. Linear growth rates decreased from 11.0 +/- 0.8 (SEM) cm/yr before treatment to 5.7 +/- 0.4 cm/yr at two years of treatment and 3.7 +/- 0.7 cm/yr at four years of treatment. Predicted heights by the Bayley-Pinneau method increased from 156.4 +/- 2.0 cm before treatment to 162.3 +/- 2.3 cm at two years and 163.4 +/- 2.4 cm at three years. Five patients treated for four years had a mean increase in predicted height of 5.5 cm. To date no adverse effects have been observed. However, the ultimate safety of this analogue is not known. We conclude that LHRHa appears to be an effective long-term therapy for central precocious puberty.
Brains and types of behavior among sexually mature vertebrates are portrayed as having two phenotypic states: male and female. However, mating systems and the behavioral tactics employed by the two sexes are far more diverse than conveyed by this simple intersexual dichotomy. For example, in many species, sexually mature males may practice one of two alternative mating tactics. Recent studies of a sound-producing teleost fish now show that intrasexual dimorphism of vocal motor phenotypes among males accompanies the intrasexual divergence of types of reproductive behavior. Thus, one group of males, like females and juveniles, lacks the behavioral, neurophysiological and morphological traits typical of the sexually differentiated vocal motor pathway of the second group. The results are an explicit demonstration that for any one species: (1) alternative mating tactics can be paralleled by alternative phenotypes for the neurons that determine tactic-specific types of behavior, and (2) reproductive maturation is not obligatorily linked to the expression of neuronal secondary sex characteristics.
This study examined motivation (prosocial goals), individual characteristics (sex, ethnicity, and grade), and friendship characteristics (affective quality, interaction frequency, and friendship stability) in relation to middle adolescents' prosocial behavior over time. Ninth- and 10th-grade students (N = 208) attending a suburban, mid-Atlantic public high school and having at least 1 reciprocated friendship were followed for 1 year. Hierarchical regression analyses revealed that a friend's behavior is related to an individual's prosocial goal pursuit, which in turn, is related to an individual's prosocial behavior. Further, the affective quality of a friendship and the frequency with which friends interact moderate relations of a friend's prosocial behavior to an individual's prosocial goal pursuit.
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Gonad maturation in boys is not characterized by a critical visible event such as menarche in girls. Establishing spermatogenesis by masturbation in maturing boys may be considered inappropriate. In order to estimate the median age of spermarche, a group of 155 normal schoolboys were examined twice (ages 12 and 13 years) for the occurrence of sperm in the first voided morning urine. The boys were requested to bring a daily sample for 10 consecutive days. Over 90% brought at least two samples and 50% brought 5-10 samples. The rate of boys with spermaturia at each age was calculated by the life-table method to adjust for the varying number of samples. New spermaturia was detected with each additional sample in the boys who brought in a greater number of samples. The urine examination carried a considerable false negative rate; even in boys who brought five or more samples, over 40% of boys positive at age 12 were negative at age 13. The rate of spermaturia at age 12 years was 37.5%, and at age 13 it was 68.9%. Our previous report showed the rate at age 11 years to be less than 1%. Because of an uncertain number of false negatives, these are probably under estimates of the true rate of spermatogenesis. The occurrence of spermarche was significantly associated with maturation of secondary sex characteristics.
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Male rough-skinned newts (Taricha granulosa) were collected from the same natural population every second week from early April to mid-June. They were either field-tested for their sexual responsiveness or used to measure the plasma concentrations of androgens and corticosterone, the brain concentrations of immunoreactive (ir) gonadotropin-releasing hormone (GnRH) and arginine vasotocin (AVT), and morphological parameters. During the experimental period, the percentage of sexually responsive males gradually declined from 100 to 4%, concurrent with a decrease of plasma concentrations of androgens, but not corticosterone. Concentrations of irGnRH in two brain regions (medial septum; ventral telencephalon containing the nervus terminalis) did not change significantly during this time. In the infundibulum, irGnRH concentrations increased from the end of May to mid-June, which coincided with an increase in plasma androgen concentrations, a marked increase in testis weights, and a decrease of the proportion of males with spermatozoa in their vas deferens. During this period, no changes in irAVT concentrations in four brain regions (infundibulum; pars distalis of the pituitary; interpeduncular nucleus; cerebrospinal fluid) were detected, but significant changes were observed for irAVT in the dorsal preoptic area that were not correlated with the seasonal changes in behavior. Also, during this period, there were decreases in mean body weight and tail height, and in the proportion of males with smooth skin and dark nuptial pads. These results are discussed in view of our current knowledge of the endocrine mechanisms that regulate sexual behaviors and secondary sex characteristics in male amphibians.
The authors compared acute nicotine self-administration among 4 groups varying in current or past dependence: dependent smokers, nondependent smokers, ex-smokers who had quit at least 1 year ago, and nonsmokers. Nicotine (0 vs. 12 microg/kg/8 sprays) available by nasal spray was self-administered with a choice procedure. Self-administration also was related to participant characteristics (sex, alcohol and caffeine intake, sensation-seeking score) and to subjective responses to initial nicotine spray exposure. Nicotine self-administration was similar between dependent and nondependent smokers but was greater in those groups than in ex-smokers and nonsmokers, who did not differ from each other. Self-administration was unrelated to most other participant characteristics. In nonsmokers, self-administration was related directly to pleasurable effects but inversely to aversive effects. Few effects were related to self-administration in the other groups.
In puberty, the growth spurt and the appearance of secondary sex characteristics occur concomitantly with an increase of sex steroids, growth hormone (GH) and insulin-like growth factor I (IGF-I). A number of experiments indicate that sex steroids exert a stimulatory action on the somatotropic axis. This effect is due to an amplifying action of oestradiol (secreted by the ovaries or after testosterone aromatization) on the neuroendocrine regulation of pulsatile GH release.
Previous studies show that men endorse instrumental beliefs about aggression to a greater extent than women, whereas women endorse expressive beliefs to a greater extent than men. However, men and women indicate that they have different opponents in mind when thinking about aggression, and existing measures may emphasize physical forms of aggression. Therefore, beliefs about aggression were examined when the type of aggression (physical or verbal) and the sex of the opponent (same sex or opposite-sex partner) were specified, among a sample of 200 students. Expressive beliefs were higher and instrumental beliefs lower for an opposite-sex partner and for physical aggression. The characteristic sex difference applied across all manipulations for expressive beliefs, but not for instrumental ones: men showed higher scores than women only for same-sex physical aggression. Higher instrumental (but not lower expressive) scores were also found among those who based their responses on real rather than hypothetical events. The sex difference in instrumental beliefs for same-sex physical aggression was largely confined to respondents using a hypothetical event. As in previous studies, instrumental and expressive beliefs were relatively independent of one another. The position that the beliefs represent rhetorical devices is assessed in the light of these findings.
The study was carried out on 13-17 years old school children from Warsaw elementary and secondary schools (vocational schools, technical schools and general education secondary schools). Statistical analysis of following parameters was estimated: 1. Respondent characteristics (sex, age, type of school, grade); 2. Characteristics of cigarette smoking (nonsmoking, age of first experience of smoking, frequency of smoking, planning the cigarette smoking in future); 3. Psychosocial factors (frequency of cigarette smoking among social environment of respondents, attitude toward smoking, estimating of psychophysical self-confidence, estimating of interpersonal relationships with other significant people and environments and estimating of social role playing in youth. The obtained results showed: 1. Cigarette smoking is one element of the global strategy that smoker uses to cope with interpersonal problems in process of socialization. 2. Smoking is a process conditioned by many factors influencing each other. Among this factors, psychosocial elements are very important. 3. The sources of this process are harmful relations with parents in early childhood, especially with mother. 4. The necessary condition of intaking regular smoking is cigarette smoking by social environments of youth. Frequency of this phenomenon is condited by sociocultural factors.
BACKGROUND: The use of computers in general practice consultations is becoming widespread. AIM: A qualitative study was undertaken to determine how patients in one practice responded to the use of computers, and the issues which particularly concerned them when doctors used computers in the consultation. METHOD: Thirty patients whose age-sex characteristics were proportional to the age-sex distribution of one practice were selected to be interviewed within two weeks of a consultation. The interviews were taped, transcribed and analysed. RESULTS: Patients had seen or used computers in many other places and accepted their role in data management. Patients with more experience of computers were more aware of their limitations, particularly with regard to the possibility of loss of confidentiality. Patients did not think the use of a computer led to a loss of the personal touch in the consultation as long as verbal skills and eye contact were maintained. However, they did expect doctors using computers to have acquired computer skills. All but one patient said they wanted to see what was on the screen, although 11 did not know they had the right to read their notes on the screen. CONCLUSION: Patients regarded the use of computers by their doctors as normal and indicative of the doctors being up to date. Most respondents were concerned about possible loss of confidentiality. This concern, and their expressed preference for computer details to be visible and shared, pose challenges to doctors' technical and communication skills.
Parents' attributions for children's behavior are of interest both as a form of adult social cognition and as possible contributors to children's development. This article reviews work on the determinants and the effects of parents' attributions. Included in the discussion of possible determinants are characteristics of the target (e.g., age and sex), characteristics of the judge (e.g., mothers vs. fathers), and characteristics of the behavior to be explained (e.g., positive or negative). Included in the discussion of possible effects are effects on parents' affect and behavior and on children's development. The evidence suggests that parents do form attributions for their children's behavior and that these attributions vary in predictable (although not perfectly consistent) ways across judges, targets, and outcomes. The evidence also suggests, although less certainly, that attributions affect both parents' behavior and children's development. The review concludes with suggestions for future research.
Six phenotypic female patients characterized by an average stature, infantile body constitution, underdeveloped external and internal reproductive organs and secondary sex characteristics and amenorrhoea are described. In each of them laparotomy and histological study disclosed ovarian hypoplasia. The karyotype was 46,XX in all patients except one. However, the metaphase analysis extending over a greater than usual number of cells revealed an autosomal ring (15) in 5 to 26% of cells. The patients also showed phenotype signs of D chromosome anomalies. The authors agree with the previously suggested autosomal gene effect in sex differentiation.
Analyses of 24-hour specimens of urine from healthy adult males for androsterone and etiocholanolone produced values which, when calculated as discriminant scores, discriminated between heterosexual and exclusively homosexual individuals. This confirms a previous study.No significant differences were found between heterosexuals and homosexuals in parental ages, secondary sex characteristics, genitalia, anthropometry, 17-ketosteroids, and 17-ketogenic steroids.A significant difference was found between the heterosexual group and homosexual group in the number of homosexual relatives in the immediate and extended families.
The female specific cytochrome P-45015 beta and the male specific cytochrome P-45016 alpha are the major constitutive P-450 forms in rat liver. Their expression is pretranslationally regulated by the sex specific plasma pattern of GH. To measure the mRNA levels of these hemoproteins in studies on their regulation and expression we set up specific solution hybridization assays with in vitro transcribed cRNA probes. An extensive tissue distribution study showed that both P-45015 beta and P-45016 alpha are specifically expressed in the liver. Investigation of the developmental regulation of respective mRNA showed that the onset of sexual differentiation of P-45015 beta and P-45016 alpha expression coincides with the start of puberty. To assess the level(s) of the pretranslational GH regulation of P-45015 beta and P-45016 alpha nuclear run-on transcription analysis was performed. Sex characteristic administration of GH to hypophysectomized rats indicated that GH exerts its dual effects via both transcriptional and postranscriptional mechanisms.