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Case report 659: Metastatic osteoblastic carcinoid tumor (primary in pancreas or gallbladder).

The only plain radiographic skeletal features in this 71-year-old man were those of a solitary sclerotic lumbar vertebral body which grossly underestimated the extent of metastatic carcinoid involvement of the lumbar spine and elsewhere described in the text. The primary focus in this case was either the pancreas or gallbladder resulting in disseminated metastases to the skeleton and many visceral areas. It was emphasized that these skeletal metastases are principally blastic and that those carcinoids arising in the bronchi and foregut-related structures (e.g., stomach) most often metastasize to the skeleton.

Aged↗

Epithelioid hemangioendothelioma of bone. A report of two cases and review of the literature.

Epithelioid hemangioendothelioma is the prototype of a group of vascular tumors characterized by epithelioid or histiocytoid endothelial cells. Epithelioid hemangioendothelioma of bone is a rare lesion that constitutes fewer than 1% of primary malignant skeletal neoplasms. We describe two cases that illustrate the spectrum of radiographic features seen with this neoplasm, and also present its appearance on magnetic resonance imaging.

Adult↗

Negative scintigraphy with positive magnetic resonance imaging in bone metastases.

We report three patients with known primary tumor in whom radionuclide skeletal imaging for metastatic disease was normal with or without clinical symptomatology referable to this area. Magnetic resonance imaging (MRI) of the spine demonstrated focal areas of abnormal signal intensity in the vertebral bodies of these patients. In all three patients, biopsy confirmed metastatic disease. All the patients received radiation or chemotherapy depending upon the etiology. These preliminary data suggest that MR imaging may be useful in evaluating patients with known primary tumor in whom clinical suspicion persists despite a negative radionuclide bone scan.

Bone Marrow↗

Retroperitoneal liposarcoma simulating a prolapsed intervertebral disc. A case report.

A metastatic liposarcoma presented with the clinical features of a prolapsed intervertebral disc. The tumour had spread from the retroperitoneal space in front of the sacrum by way of the first sacral foramen and along the dural sleeve of the first sacral root. Such a presentation has not previously been reported, and we make the point that it is important always to send material removed during operation on discs for histological examination.

Adult↗

Outcome after limited posterior surgery for thoracic and lumbar spine metastases.

The efficacy of 'limited posterior surgery' for metastases in the thoracic and lumbar spine was studied prospectively in 51 patients (32 men and 19 women, mean age 64 years). The most common primary tumors were prostate, breast, and renal carcinoma, 37 patients had metastases in the thoracic spine and 14 in the lumbar spine. Indications for surgery were severe pain or neurologic deficit. Of the 46 patients with neurologic symptoms, 25 were unable to walk. Surgery was confined to direct or indirect decompression and stabilization with a pedicle screw fixator over few segments as possible. Pain, as well as a variety of functional performance parameters and residential status were registered preoperatively and after surgery at 3, 6, 9, and 12 months, and at 6-monthly intervals thereafter. Pain was rated by the patient on a Visual Analog Scale, and functional performance was assessed with the Eastern Co-operative Oncology Group (ECOG) Performance Status Scale. We had no perioperative neurologic deterioration or death. Nineteen of the 25 nonambulatory patients regained their walking ability. Postoperative pain relief was significant and lasting over time. Nearly half of the patients attained improvement in functional performance. The median survival was 8 months. Older age and intact postoperative walking ability were positive factors for survival.

Bone Screws↗

Embolization with "Ethibloc" of vascular tumors and arteriovenous malformations in the head and neck.

"Ethibloc" has been used almost exclusively until now for embolization of tumors and bleeding vessels in the liver and kidney. Unlike with Gelfoam-particles, there is no recanalization. The resorption occurs so slowly that there is no interference with the necrosis of the embolized tumor. Due to its low viscosity, it passes catheters with thin lumina and fills the capillary bed of the tumor without danger danger of reaching the venous vessels. In this paper we describe a new technic of percutaneous catheter-embolization with Ethibloc using a coaxial catheter which we believe enhances safety and effectiveness. It has been successfully used in five patients. In the meantime two more patients have been treated successfully.

Adult↗

Computed tomography of the intervertebral foramen.

52 cases with pathologic lesions in the intervertebral foramen, studied with CT, are analyzed. The most frequent lesions are intraforaminal disc herniations. These are characterized by their hyperdensity in comparison to the dural sac (34 of 34 cases) and their broad contact with the intervertebral disc space (31 of 34 cases). Foraminal size and contour are usually normal. In contradistinction to disc herniations, benign tumors often show bone erosion of the pressure-type with enlargement of the foramen. Bone infiltration was seen only in malignant lesions and in the single case of Echinococcosis. Preoperative diagnosis of vascular lesions which present with foraminal enlargement is most important for the choice of the appropriate operative approach. Correct CT diagnosis of such vascular lesions is only possible with dynamic CT.

Diagnosis, Differential↗

Intraoperative sonography in spinal surgery: current state of the art.

Intraoperative spinal sonography (IOSS) has significant impact on the surgical management of spinal lesions. This paper describes the techniques involved, illustrates the sonographic anatomy of the spinal canal and its contents and discusses the role of IOSS in the surgical management of spinal trauma, spinal tumors, spinal stenosis and congenital anomalies.

Adult↗

[Metastases of the cervico-occipital junction. The value of tomographic detection of prefracture forms (author's transl)].

The authors stress the frequency of metastases of the cervico-occipital junction unrecognized in medical literature: 30 cases have been diagnosed within four months. They report their different patterns and complications and insist on the prefractured pattern with osteolysis of the body of C-2 which can be shown only by polytomography. The authors propose that a tomographic study of the cervico-occipital junction should be systematically included in every analysis of metastatic extension of osteophilic tumors.

Cervical Vertebrae↗

Role of surgical treatment in 70 patients with vertebral metastasis causing cord or root compression.

Spinal metastasis plays an important role in the survival rate and general condition of cancer patients. In this paper, we present 70 patients with metastatic spinal tumors, diagnosed and surgically treated in the Departments of Neurosurgery and Orthopedics of Ankara Numune State Hospital between 1984 and 1993. Our clinical observations suggest that the survival rate is influenced by the type of the primary lesion, pathology, and the patient's preoperative physical and neurological status.

Adult↗

Experimental and clinical studies on differential diagnosis of bone diseases with nucleomedical procedures.

This report is a study of the differential diagnosis of bone diseases using nucleomedical procedures. Experimental and clinical studies on the accumulation of 201Tl and 67Ga in bone inflammation and bone tumors were performed. Also, the degree of deposition of 99mTc-phosphorous compounds represented as a color difference was evaluated for a differentiation between malignant and benign diseases of the spine and shoulder. Uptake of 201Tl in inflammation of the spine and in tumor of the pelvis of rabbits was very low, while that of 67Ga was high. Uptake of 67Ga decreased gradually with lapse of time after the onset of inflammation. These experimental results agreed with clinical studies. The detectability of malignant tumors with 201Tl was inferior to that with 99mTc-label and 67Ga, although osteolytic lesions were occasionally 201Tl-positive. In terms of color range, the difference was 2 or less in spines of normal subjects and 3 or more in the metastatic bone disease and compression fracture. This difference was not statistically significant. Since 67Ga scan was occasionally negative in compression fracture, a differentiation was considered to be possible in such a case. A combined study of bone imaging with 99mTc-phosphorous compound including color difference, 67Ga imaging, bone-marrow imaging and radiography are considered to be helpful for the differentiation.

Animals↗

The problem of stabilization after sacrectomy.

After sacrectomy, mobilization of the patient is only possible if a stable connection between the spine and pelvis can be obtained. We have developed an instrumentation to fix the pelvis to the spine. Two DHS screws connected to each other were implanted in the pelvis (one DHS screw into each ilium). An internal spine fixator, anchored in L3 and L4 through transpedicular Schanz screws, was attached to these DHS screws. Two patients were stabilized with this implant after sacrectomy. One patient was able to walk with crutches; the other patient was able to walk even without crutches.

Adult↗

Three-dimensional spiral CT for neurosurgical planning.

We carried out 22 examinations to determine the value of three-dimensional (3D) volumetric CT (spiral CT) for planning neurosurgical procedures. All examinations were carried out on a of the first generation spiral CT. A tube model was used to investigate the influence of different parameter settings. Bolus injection of nonionic contrast medium was used when vessels or strongly enhancing tumours were to be delineated. 3D reconstructions were carried out using the integrated 3D software of the scanner. We found a table feed of 3 mm/s with a slice thickness of 2 mm and an increment of 1 mm to be suitable for most purposes. For larger regions of interest a table feed of 5 mm was the maximum which could be used without blurring of the 3D images. Particular advantages of 3D reconstructed spiral scanning were seen in the planning of approaches to the lower clivus, acquired or congenital bony abnormalities and when the relationship between vessels, tumour and bone was important.

Adult↗

Traumatic fascicular neuroma.

A 72-year-old man had developed amiodarone neuropathy. He was found, at biopsy, to have a fascicular neuroma of his right sural nerve, unassociated with his underlying neuropathy, apparently due to blunt trauma, as electroneurographic needling of this nerve could safely be ruled out by the patient and his physicians. Such fascicular neuromas, which may remain without sensory deficits, may develop at an unknown frequency, and may only be uncovered by biopsy--or autopsy--in a coincidental neuropathic process.

Aged↗

Sacrococcygeal chordomas: problems in diagnosis and management.

Chordomas are rare, insidious, and slow-growing but locally aggressive, malignant tumors originating from the primitive notochord and localized along the axial skeleton. Between 1988 and 1993, four patients with sacrococcygeal chordomas were treated at the Ankara Numune State Hospital. There was a median 17-month interval between the onset of symptoms and diagnosis. In all patients, a posterior approach was used. In addition, two patients were treated with adjuvant radiation therapy. There were no serious intra- or postoperative complications. Early diagnosis and surgery plus radiation therapy seem to provide the best results in terms of survival.

Adult↗

CT whole-body scanning in pediatric radiology.

In an 8 month period 57 scans in 28 children have been performed using an EMI-CT 5005 General Purpose Scanner. Thirteen primary malignant tumours were evaluated, and scanning was of great value in localizing and delineating the lesion, and hence predicting the operability. Furthermore, secondary spread of malignant tumours was easily detected. In the continuing evaluation of treated malignant tumours CT has been used to estimate regression and relapse.

Abdominal Neoplasms↗