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Results for “Yang Deficiency”

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At least 235 records · Page 13Linked to original sources

PubMed2002

[Comparative study on regulation patterns of compound prescriptions for kidney tonifying and for blood circulation activating on T-cell apoptosis related gene expression in aged rats].

OBJECTIVE: To investigate the regulation pattern of the two compound prescriptions for Kidney tonifying, Yougui Yin and Bushen Yishou capsule, in down-regulating T-cell apoptosis gene expression in aged rats. METHODS: Expressions of T-cell apoptosis promoting and inhibiting genes, including Fas, FasL, Bcl-2, Bax, TNFR1 and TNFR2, as well as activity of cysteine proteinase in cascade connection, such as Caspase 8 and Caspase 3 were determined by TUNEL labeled flow cytometry and fluorescence real-time quantitative RT-PCR technique. The difference between old and young rats was compared, and the different regulation patterns of the two compound prescriptions for Kidney tonifying and their effects on Caspase activity were compared with those of compound prescription for blood circulation activating. RESULTS: The two compound prescriptions for Kidney tonifying could effectively lower T-cell over-apoptosis in old rats, down-regulate FasL and TNFR1 gene transcription, and decrease the activity of Caspase 8 and Caspase 3, while the compound prescription for blood circulation activating showed insignificant effect on T-cell over-apoptosis. CONCLUSION: Kidney-deficiency is closely related to the T-cell over-apoptosis. The T-cell over-apoptosis in old rats could be effectively improved by the two compound prescription for Kidney tonifying through down-regulating the apoptosis promoting genes FasL and TN-FR1 transcription. That is the unique regulation pattern of Kidney tonifying principle to T-cell apoptosis related gene in old rats.

Aging↗

PubMed2006

[Research on gene expression of warm-hot drug treating cold syndrome].

OBJECTIVE: To study the therapeutic molecular mechanism of the warm-hot drugs treating cold syndrome. METHOD: A brother and his sister with deficiency-cold syndrome were chosen and treated with appropriate Chinese formula consisted chiefly of warm-hot drugs for 45 days. Then microarray technique was applied for comparing the gene expression difference of sister who had significant effect, the data was dialed with multiple analysis method and the results were mined though gene function and pathway. RESULT: 276 differential genes were obtained, which were related to metabolism and 18 pathways. CONCLUSION: Warm-hot drugs work on the gene expression of metabolism. It may be exerting the curative action by gene network and there is distinct difference between gene expression of curative effect and syndrome.

Drugs, Chinese Herbal↗

PubMed1993

[Experimental research of acupuncture manipulation of reinforcing and reducing by lifting and thrusting needle on the animal].

The experiment were performed on model rabbits injected with large dosage of Dexamethasone (DXM) for 5 days. Reinforcing manipulation (RIM), reducing manipulation (RDM), and electric stimulation (ES) were respectively used to puncture Zusanli (ST 36) points for 5 days to observe the change on temperature, body weight, corticosterone assay, testosterone assay, and the amplitude of the plethysmogram. The result showed that there was a similar syndrome of the kidney deficiency after injecting DXM. The body weight was increased in the DXM control group, decreased in the RDM group and had no significant influence in the other groups. The body weights between the reinforcing manipulation and the reducing manipulation groups had obvious difference. But the other indices of observation had no significant influence among the different groups. So there wasn't significant difference on most of observed signs among the RIM group, the RDM group and ES group. The study of acupuncture manipulation will have yet to be further done.

Acupuncture Therapy↗

PubMed1995

[Correlation between kidney deficiency syndrome and bone density].

In order to study the relationship between Kidney Deficiency Syndrome (KDS)and bone density (BD), the BD of 2068 subjects (40-69 years old)was measured with SPA-IIC type monophoton BD scanning device made in China. The subjects including 1144 cases of KDS (320 males and 824 females); 608 cases without KDS (306 males and 302 females); 164 cases of Lung Deficiency (80 males and 84 females); 152 cases of Spleen Deficiency (76 males and 76 females). Through comparison with the same sex and age group, it was found that BD in KDS patients was significantly lower than that in the normal subjects and those without KDS, also lower than that in the Lung and Spleen Deficiency patients. It indicated that KDS had the corresponding BD changes, which confirmed the TCM classical theory "The Kidney governs the bone". Based on the measuring data, the authors took the lower limit of BD normal value minus two folds of SD as the critical value for KDS diagnosis in 40-49 years age group, i. e., male BD < 0.6 g/cm2, female BD < 0.5 g/cm2. The clinical feedback showed that the male and female related coincident rates were 76% and 80% respectively. Therefore, the critical value could be taken as an objective index for KDS diagnosis after excluding other affecting factors.

Adult↗

PubMed1992

[Determination of partially cellular and local immune function in patients with spleen deficiency syndrome].

The immune function status as reflected by the peripheral blood OKT system T cell subset classification and the lymphocyte in vitro interleukin 2 (IL2) secretory function were determined in 30 patients with Spleen deficiency syndrome and 20 normal subjects in this study. Experimental results decreased cellular immune function and disturbance of immune regulatory mechanism in the patients. Its manifestations were decreased number of total T lymphocytes and helper T cells (Th), relatively increased suppressor T cells (Ts), abnormal rate of Th to Ts, no marked change of IL2 secretory function of T cell in vitro, increased SIgA level before stimulating with acid but marked decreased SIgA level after stimulating. All these suggest the compensatory stage of local immune function.

Adult↗

PubMed1993

[Effect of menopausal time on osteal density].

Osteal density of 189 Kidney Deficiency (KD) women displayed after menopause as determined by the method of gamma-ray absorption. The result showed that the osteal density of the KD women was significantly lower than those women of same ages without KD (P < 0.001) and the osteal density of the women whose menopause occurred before the age of 45 was lower than that after 45 (P < 0.05). This suggested that the prematurity of ovarial function and the decrease of estrogen ahead of time might be the cause. Therefore, the earlier the menopause, the lower the osteal density, as well as the more serious the KD well be.

Age Factors↗

PubMed2006

[Preliminary study on differential expressed genes in T lymphocyte of chronic obstructive pulmonary disease patients with Fei-qi deficiency syndrome].

OBJECTIVE: To study T lymphocyte related genes with differential expression in patients with chronic obstructive pulmonary disease (COPD) of Fei-qi deficiency (FQD) syndrome type by gene chips. METHODS: Lymphocytes in peripheral blood were isolated by Ficoll technique from blood samples collected from COPD patients of FQD syndrome type, Fei-yin deficiency (FYD) syndrome type, and also from healthy subjects for control. They were sorted and purified by flow cytometry, and the different expressed genes were screened from them by gene chip technique. RESULTS: There were 15 genes with high differential expression between patients of FQD type and those of FYD syndrome type, and between patients of FQD type and healthy subjects. CONCLUSION: Gene chip technique could be used for studying the gene expression profiles of TCM syndrome, and the T-lymphocyte related genes with differential expression in COPD patients with FQD were screened preliminarily.

Adult↗

PubMed2002

[Effect of wuzi yanzong Pill on mitochondrial DNA deletion and respiratory chain enzyme complex activity in peripheral leukocyte of aged male with kidney deficiency syndrome].

OBJECTIVE: To investigate the effect of Wuzi Yanzong Pill (WZYZP) on mitochondrial DNA (mtDNA) deletion and respiratory chain enzyme complex (RCZC) in peripheral blood leukocyte of aged male with Kidney Deficiency Syndrome (KDS). METHODS: Single-blinded study was conducted in 38 aged male with KDS, who were randomly divided into 2 groups treated with WZYZP and placebo respectively for 3 months. Levels of mtDNA deletion and RCZC were determined by polymerase chain reaction (PCR) and enzyme kinetics technique respectively. RESULTS: WZYZP could reduce the mtDNA deletion and raise the activity of mitochondrial RCZC I, IV in peripheral blood leukocyte of aged male with KDS (P < 0.05, P < 0.01). CONCLUSION: WZYZP has protective effect on mtDNA from oxidative damage in leukocyte of aged male with KDS.

Aged↗

PubMed1994

[Changes in serum free amino acid level in patients with spleen deficiency syndrome].

Eighteen kinds of serum free amino acid (SFAA) were measured in 32 patients with Spleen-Deficiency (SD) Syndrome. Several obvious changes were noticed as compared with 20 healthy adults: (1) The levels of total FAA, essential amino acids and free branched-chain amino acids of SD group were significantly lower than that of the control group (P < 0.01); (2) Total FAA, essential amino acids and branched-chain amino acids were all positively correlated to D-xylose absorptivity, serum protein and immune function. The above results suggested that the decrease of various SFAA level might be related to malabsorption in patients with SD. It is possible that the decrease of serum protein and immune function was due to the lowering of SFAA.

Amino Acids↗

PubMed1998

[Efficacy of epimedium compound pills in the treatment of the aged patients with kidney deficiency syndrome of ischemic cardio-cerebral vascular diseases].

One hundred-twenty aged patients with kidney deficiency syndrome of ischemic cardio-cerebral vascular diseases were treated with Epimedium compound granules. The results showed that after therapeutic period the total and marked effective rates were 96.7%, 39.5% respectively in treatment group. The rates of improvement were 70% in electrocardiogram of the patients with coronary heart diseases, and 75% in electro-encephalogram of the patients with cerebral arterosclerosis. The therapeutic effectiveness in treatment group was better than that in control group treated with Su-Guan-Bian. According to experimental observation, the therapeutic effectiveness was related to the facts that Epimedium compound granules lower blood lipid have anti-free radicals and adjust balance between prostacyctin I2 and thromboxane A2(TXA2/PGI2).

Aged↗

PubMed1992

[Relation among syndrome of spleen deficiency and stagnation of liver-qi and electrogastrogram, gastric mucosal pathology and pulse-cardiovascular function in chronic gastric diseases].

In this research, Syndrome of Deficiency of Spleen (DS) and Stagnation of Liver-Qi (SLQ) as well as observations of electrogastrogram (EGG), gastric mucosal pathology and pulse cardiovascular examination were investigated in 56 cases of chronic gastric diseases (CGD). The results showed: (1) In SLQ with DS the amplitude of EGG was significantly higher than that of the control group (P < 0.01), it often indicated the active period of pathologic change, but in DS with SLQ, the amplitude of EGG was significantly lower than that of the control group (P < 0.01), it frequently denoted the static period. In case that DS equalled to SLQ, the amplitude of EGG was significantly higher than that of the control group (P < 0.01). It revealed that there were no significant difference between the patient's number of static and active periods (P > 0.05). It is valuable in Syndrome Differentiation of Deficiency and Excess and analysis of Superficiality and Origin in CGD. (2) Cardiovascular function was also affected in Syndrome differentiation of DS and SLQ. DS with SLQ manifested itself as reduction of left ventricle pump and declination for metabolism of microcirculation, they had significant difference as compared with the control group (P < 0.05), while SLQ with DS or equality between DS and SLQ had the normal function of left ventricle pump and metabolism of microcirculation, even though cardiac output were higher than that of control group (P < 0.05). It showed that the traditional Chinese medicine theory of interrelation among Heart and Spleen, Liver had their own hemodynamic bases.

Adult↗

PubMed1997

[Studies on neuro-immunologic regulation of senile rats by using the principle of replenishing qi and promoting blood circulation].

OBJECTIVE: To study the mechanism of delaying senility by using the principle of replenishing Qi and promoting blood circulation(RQPBC). METHODS: The following determinations were carried out in the natural-senile animals which have Qi deficiency and blood stasis Syndrome(24 month old rat) after the treatment. Hemorheological indexes, brain noradrenaline (NE), adrenocorticotropine(ACTH), beta endorphin, cortisol, estradiol, testosterone, interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen's lymphocyte transformation and induction of IL-2 and the activity of natural killer cells (NKC). RESULTS: The senile rat's above indexes decreased obviously (control: young rats), and by using this principle, all indexes were improved respectively. But these indexes in the young rats cannot be changed by applying this principle. CONCLUSION: The results indicated that this principle could improve senile body's regulation of neuro-immuno endocrinologic network and keep homeostasis.

Adrenocorticotropic Hormone↗

PubMed1993

[Xianbai buyang Huanwu decoction used for treating hypertension with kidney qi deficiency and blood stasis].

UNLABELLED: 80 patients of presenium hypertension with geriatric Kidney Qi Deficiency and Blood Stasis were randomly divided into two groups. (1) Traditional Chinese Medicine group (TCMG, 50 cases) treated with Xianbai Buyang Huanwu Decoction (XBH); (2) Western medicine group (WMG, 30 cases) treated with compound hypotensor tablets and gamma-evening primrose-E oil capsules. RESULTS: The difference between the two groups was not significant (P > 0.05). After treatment, in TCMG, serum cholesterol and triglyceride, fibrinogen, whole blood viscosity and plasma viscosity, plasma and erythrocyte LPO activity lowered significantly, and plasma SOD and erythrocyte SOD raised significantly (P < 0.001-0.05), while in WMG, only showed the plasma LPO dropped (P < 0.05). The results suggested that XBH has the effects of reducing blood pressure, lowering the blood lipid, improving hemorrheological parameters and antioxidation.

Aged↗

PubMed1994

[Gastroelectric activity and gastric motility in experimental spleen deficiency rats].

Using electrode and highly sensitive strain sensor to record alterations of gastroelectric activity and gastric motility, during experimental Spleen Deficiency (SD) rats was conducted. As compared with control, frequency of slow wave (time/3 min) did not obviously change (11.71 +/- 0.71 and 12.50 +/- 0.55, P < 0.05), but amplitude (mV) of which reduced significantly (0.14 +/- 0.05 and 0.37 +/- 0.04, P < 0.01), while that of fast wave also decreased. In self-recovered group, the amplitude of slow wave recovered slightly (0.22 +/- 0.08 and 0.37 +/- 0.04, P > 0.005). After treatment with modified Sijunzi Tang ([symbol: see text]), the gastric activities of SD rats elevated to levels of control (P > 0.05), but gastric motility remained weak in SD group. Although the motility of self-recovered group improved to a certain degree, however, the main indices had no significant difference from SD group (P > 0.05). It suggested that there were significant changes of gastric activity in SD and Chinese herbs could improve the syndrome apparently.

Animals↗

PubMed1997

[Effect of sijunzi decoction on motilin and pharmacokinetic characteristics of tetramethylpyrazine in rat model of spleen deficiency syndrome].

OBJECTIVE: To explore relationship between the essence of Spleen Deficiency Syndrome (SDS) and pharmacokinetic characteristics (PK). METHODS: The level of motilin in serum and intestine, and PK of tetramethylpyrazine phosphate (TMPP) in rat model of SDS were observed simultaneously and treated with Sijunzi decoction (SJZD) for confirmation. RESULTS: The atrioventricular model of TMPP in SDS, normal and SJZD treated rats all belonged to the open double ventricular type; there were insignificant differences between normal and SJZD treated rats in motilin level and PK of TMPP, but the differences of these parameters between normal and SDS model rats were significantly (P < 0.01). The SDS state could markedly affect the absorption, distribution, metabolism and elimination of TMPP in rat; SJZD could normalize the abnormal PK of TMPP in SDS model rats. CONCLUSIONS: A supplementary scientific evidence for the hypothesis of "Pharmacokinetics of Syndrome Differentiation" is provided.

Animals↗

PubMed2000

[Effect of yimai jiangya extract on plasma neuropeptide Y level in patients of senile hypertension with qi-deficiency and blood stasis syndrome].

OBJECTIVE: To observe the effect of Yimai Jiangya extract (YMJYE) on plasma neuropeptide Y (NPY) level in patients of senile hypertension at stage II with Qi-Deficiency and blood stasis Syndrome (QDBSS). METHODS: Sixty-eight patients were randomly divided into two groups, 36 patients in the treated group treated with YMJYE and 32 patients in the control group treated with captopine. Radioimmunoassay was used to examine the level of plasma NPY before and after treatment in the two groups. RESULTS: Before treatment, plasma NPY level was significantly higher in both groups than that in the old healthy persons (P < 0.01), it lowered significantly after treatment and the decrement was more obvious in the treated group in comparing with that in the control group (P < 0.01). Blood pressure was significantly lowered in both groups after treatment (P < 0.01) but with no significant difference between them. CONCLUSION: Plasma NPY level was increased in patients of senile hypertension with QDBSS. YMJYE had good effect in lowering plasma NPY level and reducing blood pressure. It is presumed that the NPY lowering effect of YMJYE might be one of its mechanisms in lowering blood pressure.

Aged↗

PubMed1992

[The influence of different acupuncture manipulations on the plethysmogram of the patient with kidney deficiency].

In order to prove the specific property between the tonifying manipulation (TM) and reducing manipulation (RM), and search further for the key in improving the effect of manipulation, the influence of to on two different manipulations. The plethysmogram in the same body-condition (kidney-deficiency) One was TM with slow-trusting and quick lefting; the other was RM with the converse movement. Randomized block design, cross-over design and single-blind design were used. The result showed that the TM increased the amplitude of the plethysmogram obviously, whereas the RM had no significant influence on it. There was significant difference not only between the TM group and the central group, but also between the TM group and RM group (P less than 0.01 or P less than 0.05). The difference between the RM group and the control group was not significant (P greater than 0.05). Meanwhile, it was recommended that "mind concentration" on acupuncture manipulation is important. In conclusion, the experiment demonstrated the experimental evidence for explaining the mechanism of TM and RM. It was suggested that acupuncture manipulations are worthy to pay attention so as to improve clinical effect.

Acupuncture Therapy↗

PubMed1994

[Pharmacokinetic characteristics of tetramethylpyrazine and study on hemorheology in rat model of spleen deficiency syndrome].

UNLABELLED: In this experiment, the essence of Spleen Deficiency Syndrome (SDS) was explored with the rat model of SDS using tetramethylpyrazine (TMP). 120 Wistar rats were divided into two groups, 60 each for control and test group, they were treated with normal saline and reserpine respectively. The hemorheological parameters were also studied in 6 each of both groups. The pharmacokinetic properties were investigated in the remaining control group and test group. RESULTS: (1) Two-compartment open model of the control group was turned into that of one-compartment in test group; (2) The SDS model significantly affected the absorption and distribution of TMP in rats. AUC was much higher and serum concentration of TMP increased significantly than that of control. Hemorheological parameters (viscosity of whole blood, fibrinogen, etc.) increased significantly (P < 0.05-0.01), it demonstrated that the SDS model was in a state of Blood Stasis. It might be one of the pharmacokinetic mechanisms of TMP in the SDS model of rats.

Animals↗